iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
PINA	HINT	Mentha
Post-translational Modifications (PTMs)
dbPPT
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	53.33	2.00e-10	64.30	IUUC-Mmu-063344

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Arabidopsis thaliana

Functional Description
(View)

Structural component of heterochromatin involved in gene repression, including several floral homeotic genes and FLT that regulates flowering time. Required for maintenance of vernalization-induced repression of FLC. As part of the PRC1-like complex, recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me), leading to epigenetic repression. PcG PRC1 complex maintains the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility.

Protein Sequence
(Fasta)

MKGASGAVKK KPQVLNEAGE AETAVETVGE SRKISGDGGF GSDDGGGGGG GGSGESILRE 60
IGDDRPTEDG DEEEEEDEDE DDGGDEEDEE GEGEGGQEER PKLDEGFYEI EAIRRKRVRK 120

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Nucleotide Sequence
(Fasta)

AAAGAGAATC CAAAAAAGTG AAAAAACTGG TCTTTGAGGT CAGGTCAGGT CTTCTTCCTG 60
CAAAAACAAA AACCTCAGAA ATAGAGAAAA AGTTTCAATC TTTCTTCATC TTCTTCCTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0287--Flowering
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation

Interpro

IPR000953--Chromo/chromo_shadow_dom
IPR017984--Chromo_dom_subgr
IPR023780--Chromo_domain
IPR008251--Chromo_shadow_dom
IPR016197--Chromodomain-like
IPR023779--Chromodomain_CS

PROSITE

PS00598--CHROMO_1
PS50013--CHROMO_2

Pfam

PF00385--Chromo

PRINTS

PR00504--CHROMODOMAIN

SMART

SM00298--CHROMO
SM00300--ChSh

Gene Ontology

GO:0009507--C:chloroplast
GO:0000791--C:euchromatin
GO:0005720--C:nuclear heterochromatin
GO:0003677--F:DNA binding
GO:0003935--F:GTP cyclohydrolase II activity
GO:0035064--F:methylated histone binding
GO:0030154--P:cell differentiation
GO:0006325--P:chromatin organization
GO:0006342--P:chromatin silencing
GO:0016569--P:covalent chromatin modification
GO:0009908--P:flower development
GO:0009825--P:multidimensional cell growth
GO:0009910--P:negative regulation of flower development
GO:0045814--P:negative regulation of gene expression, epigenetic
GO:0045857--P:negative regulation of molecular function, epigenetic
GO:0009648--P:photoperiodism
GO:0048573--P:photoperiodism, flowering
GO:0010016--P:shoot system morphogenesis
GO:0006351--P:transcription, DNA-templated
GO:0010048--P:vernalization response

KEGG

ath:AT5G17690

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-003112	Amborella trichopoda	80.00	3.00e-25	108.00
IUUC-Aca-004445	Anolis carolinensis	47.50	2.00e-08	53.50
IUUC-Aly-006366	Arabidopsis lyrata	94.78	2.00e-169	587.00
IUUC-Acl-008244	Aspergillus clavatus	28.00	2.50e-01	30.00
IUUC-Ame-010980	Astyanax mexicanus	51.11	3.00e-11	62.40
IUUC-Bta-013216	Bos taurus	53.33	8.00e-12	64.70
IUUC-Bdi-014604	Brachypodium distachyon	35.33	3.00e-47	182.00
IUUC-Bol-015449	Brassica oleracea	67.42	2.00e-107	382.00
IUUC-Bra-017229	Brassica rapa	70.59	7.00e-107	380.00
IUUC-Cja-018821	Callithrix jacchus	50.00	5.40e-02	32.00
IUUC-Csa-024090	Chlorocebus sabaeus	53.33	9.00e-12	64.30
IUUC-Dre-027769	Danio rerio	51.11	3.00e-11	62.40
IUUC-Gmo-038639	Gadus morhua	53.33	1.00e-04	40.80
IUUC-Gga-040221	Gallus gallus	53.33	1.00e-11	63.90
IUUC-Gac-042105	Gasterosteus aculeatus	46.43	9.00e-12	64.70
IUUC-Ggo-044433	Gorilla gorilla	56.41	1.00e-10	60.80
IUUC-Hsa-046374	Homo sapiens	53.33	1.00e-11	64.30
IUUC-Hvu-047395	Hordeum vulgare	63.51	8.00e-22	97.40
IUUC-Itr-048523	Ictidomys tridecemlineatus	53.33	9.00e-12	64.70
IUUC-Lch-050606	Latimeria chalumnae	53.33	2.00e-11	63.20
IUUC-Loc-052513	Lepisosteus oculatus	53.33	2.00e-11	61.60
IUUC-Mmr-060774	Microcebus murinus	53.33	1.00e-11	64.30
IUUC-Mdo-062825	Monodelphis domestica	40.00	2.00e-03	37.00
IUUC-Mmu-063344	Mus musculus	53.33	9.00e-12	64.70
IUUC-Ont-071531	Oreochromis niloticus	48.21	1.00e-11	63.90
IUUC-Oba-075909	Oryza barthii	37.60	4.00e-53	201.00
IUUC-Obr-076678	Oryza brachyantha	37.33	1.00e-50	193.00
IUUC-Ogl-077833	Oryza glaberrima	37.05	1.00e-51	196.00
IUUC-Ogu-078599	Oryza glumaepatula	37.33	2.00e-52	199.00
IUUC-Oni-082564	Oryza nivara	37.33	1.00e-52	199.00
IUUC-Opu-083875	Oryza punctata	37.33	9.00e-53	200.00
IUUC-Oru-084465	Oryza rufipogon	37.33	1.00e-52	199.00
IUUC-Osa-085995	Oryza sativa	37.33	1.00e-52	199.00
IUUC-Ola-086942	Oryzias latipes	48.21	1.00e-11	63.90
IUUC-Oga-088509	Otolemur garnettii	53.33	1.00e-11	63.90
IUUC-Ptr-091416	Pan troglodytes	53.33	1.00e-11	64.30
IUUC-Pan-092459	Papio anubis	53.33	9.00e-12	64.70
IUUC-Pfo-096252	Poecilia formosa	48.21	1.00e-11	64.30
IUUC-Pca-100744	Procavia capensis	53.66	1.00e-10	60.50
IUUC-Pte-104285	Pyrenophora teres	34.43	1.00e-04	38.90
IUUC-Rno-105878	Rattus norvegicus	53.33	1.00e-11	64.30
IUUC-Sit-110439	Setaria italica	71.43	3.00e-24	105.00
IUUC-Sly-111669	Solanum lycopersicum	69.41	9.00e-33	134.00
IUUC-Stu-112251	Solanum tuberosum	63.74	4.00e-31	128.00
IUUC-Ssc-115965	Sus scrofa	53.33	1.00e-11	64.30
IUUC-Tgu-117367	Taeniopygia guttata	44.64	1.00e-08	54.30
IUUC-Tru-118259	Takifugu rubripes	55.56	9.00e-12	64.30
IUUC-Tni-120129	Tetraodon nigroviridis	55.56	1.00e-11	64.30
IUUC-Tae-124603	Triticum aestivum	40.28	5.00e-21	94.70
IUUC-Vvi-131282	Vitis vinifera	45.22	2.00e-62	232.00
IUUC-Xtr-132586	Xenopus tropicalis	53.33	4.00e-12	65.10
IUUC-Xma-133102	Xiphophorus maculatus	48.21	1.00e-11	63.90

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence