iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aml-001274

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ACTA01139845

Gene Name

FBXW8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000012492.1	ENSAMET00000013718.1	ENSAMEP00000013164.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.60e-12	47.2	389	421
UBD/Beta-Prp	3.70e-42	144.6	158	460

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 6    vtclaf..sd.tllvsGsdDgtikvWDlrtgvl 35
            tc+++  s  +l+vsG+ D  +++ Dlrt++ 
   Q: 389  FTCVNLrdSPpNLMVSGNMDRRVRIHDLRTDKI 421
           5899*9973359******************975 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkl.....lrslsgheae....vtavkfspdgkilvtgseDrtikvwdlst 83
           +l++ +++v+++v+   ++ ++++g+++g ++vwd++t+++      ++++++e++    v+ v+++++  + v + eD+++++wdl+t
   Q: 158  ELEHIPDAVLCDVHS--HDGVVIAGYTSGDVRVWDTRTWDYtapflESEYEEDEPGmqpyVSFVRINSS--LAVAAYEDGFLNIWDLRT 242
           567778999998888..9***********************7777433334444449999*********..9***************** PP
   S: 84   gkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkl 171
           gk+ ++  +h++++ +l++s+++ +++++s+ +++++   e+g++  + + + +++v ++++ pd+ ++ v+ ++ + + ++ lk ++ 
   Q: 243  GKYPVHRFEHDARIQALALSQEDATVATASAFDVVMLHPNEEGYWQITAEFEVQKLVDYLEIVPDTgRYPVAVATAGDL-VYLLKAEDS 330
           ***999999*********************************************************************9.5******** PP
   S: 172  lrtltgghtdsvyslsfdsng.....kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs.pnderlvsgssDgsiriWdlrsg 254
            rtl     ++v++l+++ ++     k+l ++ + +++ +++l++++c+ +l +    +++v++  +  +++vsg++D+ +ri+dlr++
   Q: 331  ARTLHYVYGQPVTCLDVSASQaafgvKSLGWVYEGNKILVYSLEAERCLSKLGNALGDFTCVNLRdSPPNLMVSGNMDRRVRIHDLRTD 419
           ****999************99******************************************9978899******************* PP
   S: 255  dllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkkne 298
           ++  +l+ h+  v++v++   +d+++v+g+e++ v +w++++++
   Q: 420  KIALSLSAHQLGVSAVQM---DDWKIVSGGEEGLVSVWDYRMSQ 460
           **********99999999...*******************9876 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

XQASGYLALA QGLLEGAGRP PAARATRAER QDAASRSRSP PAREGAGGGE QLVDQLIRDL 60
NEMDDVPFFD IQLPYELAIN IFQYLDRKEL GRCAQVSKTW KVIAEDEVLW YRLCQQEGHL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

NAGCAGGCCT CGGGGTACCT GGCGCTGGCA CAGGGCCTCT TGGAGGGTGC GGGGCGGCCC 60
CCGGCGGCGC GGGCGACCCG GGCCGAGAGG CAGGACGCGG CGAGCCGTTC CCGCTCCCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:1990393--C:3M complex
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008283--P:cell proliferation
GO:0007030--P:Golgi organization
GO:0060716--P:labyrinthine layer blood vessel development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0060712--P:spongiotrophoblast layer development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003239	Anas platyrhynchos	63.07	0.00e+00	728.00
IUUC-Aca-004756	Anolis carolinensis	62.44	2.00e-141	494.00
IUUC-Ame-011198	Astyanax mexicanus	46.09	2.00e-59	222.00
IUUC-Bta-012430	Bos taurus	58.06	3.00e-156	545.00
IUUC-Cja-019131	Callithrix jacchus	83.00	0.00e+00	882.00
IUUC-Cfa-021022	Canis familiaris	96.41	0.00e+00	1006.00
IUUC-Cpo-021898	Cavia porcellus	85.97	0.00e+00	974.00
IUUC-Csa-023452	Chlorocebus sabaeus	87.75	0.00e+00	974.00
IUUC-Cho-024759	Choloepus hoffmanni	79.92	0.00e+00	847.00
IUUC-Dre-028123	Danio rerio	47.85	2.00e-153	535.00
IUUC-Dno-029045	Dasypus novemcinctus	94.48	0.00e+00	899.00
IUUC-Dor-030433	Dipodomys ordii	83.74	0.00e+00	843.00
IUUC-Ete-032465	Echinops telfairi	89.70	0.00e+00	809.00
IUUC-Eca-034134	Equus caballus	95.49	0.00e+00	977.00
IUUC-Eeu-035047	Erinaceus europaeus	84.02	0.00e+00	847.00
IUUC-Fca-036574	Felis catus	94.67	0.00e+00	967.00
IUUC-Fal-037665	Ficedula albicollis	62.98	0.00e+00	641.00
IUUC-Gmo-039137	Gadus morhua	44.72	3.00e-71	261.00
IUUC-Gga-040711	Gallus gallus	61.93	0.00e+00	702.00
IUUC-Gac-041675	Gasterosteus aculeatus	54.30	3.00e-56	211.00
IUUC-Ggo-045331	Gorilla gorilla	87.09	0.00e+00	882.00
IUUC-Hsa-046240	Homo sapiens	87.93	0.00e+00	952.00
IUUC-Itr-048412	Ictidomys tridecemlineatus	94.06	0.00e+00	947.00
IUUC-Loc-052631	Lepisosteus oculatus	52.78	2.00e-175	609.00
IUUC-Laf-054127	Loxodonta africana	81.29	3.00e-62	229.00
IUUC-Mcc-055083	Macaca mulatta	88.30	0.00e+00	959.00
IUUC-Mga-060113	Meleagris gallopavo	65.38	0.00e+00	685.00
IUUC-Mmr-061780	Microcebus murinus	93.24	0.00e+00	983.00
IUUC-Mdo-063066	Monodelphis domestica	65.65	0.00e+00	767.00
IUUC-Mmu-063524	Mus musculus	87.78	0.00e+00	902.00
IUUC-Mpu-066913	Mustela putorius furo	97.49	0.00e+00	1024.00
IUUC-Mlu-067924	Myotis lucifugus	93.43	0.00e+00	1007.00
IUUC-Nle-069558	Nomascus leucogenys	87.64	0.00e+00	910.00
IUUC-Opr-070506	Ochotona princeps	90.57	0.00e+00	971.00
IUUC-Ont-071514	Oreochromis niloticus	47.49	3.00e-151	528.00
IUUC-Ocu-074477	Oryctolagus cuniculus	90.72	0.00e+00	932.00
IUUC-Ola-087416	Oryzias latipes	47.94	5.00e-151	527.00
IUUC-Oga-088643	Otolemur garnettii	94.22	0.00e+00	998.00
IUUC-Oar-090172	Ovis aries	93.85	0.00e+00	966.00
IUUC-Ptr-090870	Pan troglodytes	88.12	0.00e+00	950.00
IUUC-Pan-092017	Papio anubis	87.20	0.00e+00	972.00
IUUC-Psi-093794	Pelodiscus sinensis	67.01	0.00e+00	696.00
IUUC-Pfo-096192	Poecilia formosa	48.84	6.00e-154	537.00
IUUC-Pab-097882	Pongo abelii	86.84	0.00e+00	927.00
IUUC-Pca-100902	Procavia capensis	88.22	7.00e-155	540.00
IUUC-Pva-103139	Pteropus vampyrus	93.25	0.00e+00	1006.00
IUUC-Rno-105798	Rattus norvegicus	86.68	0.00e+00	923.00
IUUC-Sha-106576	Sarcophilus harrisii	66.35	0.00e+00	719.00
IUUC-Ssc-115923	Sus scrofa	83.97	0.00e+00	957.00
IUUC-Tgu-116667	Taeniopygia guttata	58.49	3.00e-123	434.00
IUUC-Tru-118323	Takifugu rubripes	47.02	6.00e-148	517.00
IUUC-Tsy-118818	Tarsius syrichta	77.60	2.00e-108	385.00
IUUC-Tni-120438	Tetraodon nigroviridis	45.97	2.00e-140	492.00
IUUC-Tbe-127784	Tupaia belangeri	95.15	1.00e-114	406.00
IUUC-Ttr-128288	Tursiops truncatus	85.03	0.00e+00	877.00
IUUC-Vpa-130307	Vicugna pacos	90.81	0.00e+00	853.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence