iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089187

Ensembl Protein ID

ENSOARP00000003443.1

UniProt Accession

W5NZ45; W5NZ45_SHEEP

Genbank Protein ID

ENSOARP00000003443

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01039355

Gene Name

WSB2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000003233.1	ENSOART00000003507.1	ENSOARP00000003443.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	8.00e-15	54.7	367	414
E3 adaptor/Cullin RING/DCX/DWD	2.20e-32	109.9	162	195
UBD/Beta-Prp	4.50e-46	157.5	136	371

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 1    lsklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyed 51
           ++++w++++   SL+hLCR+a r++l+++++    +LP+Pk++k++L y++
   Q: 367  HVQFWTAPRVLSSLKHLCRKALRSFLTTYQV---LALPIPKKMKEFLTYRT 414
           689****************************...***************86 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDlr 31
           gH+d v++l+f  s+  +lvs+s+D+t+++WDl 
   Q: 162  GHQDVVRDLSFtpSGsLILVSASRDKTLRIWDLN 195
           8***********6556779*************85 PP

UBD/Beta-Prp

   S: 24   llatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk.ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfspsgdklv 110
           +latg  dg ik+w+v+tg ll  lsgh++ v++++f p+g+ ilv++s+D+t+++wdl+  gk++++l+gh + v+++s+sp+ + l 
   Q: 136  ILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSlILVSASRDKTLRIWDLNkHGKQIQVLSGHLQWVYCCSISPDCSMLC 224
           79****************************************9****************9789********************99**** PP
   S: 111  sGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl...........tgghtdsvyslsf 188
           s+   + + +w +++++ ++  l+gh+++v +  ++pd+ llv++s+D+ v +Wd  tg+ lr l           +  h +s +s+ f
   Q: 225  SAAGEKSVFLWSMRSYTLIR-KLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLhhtqlnppmddSDVHISSLRSVCF 312
           ********************.********************************************9999**99999778999999999* PP
   S: 189  dsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           +++g +l+++++d+ +++w l+ ++   +  +  +n ++  f+p++  +++g+ Dg +++W
   Q: 313  SPEGLYLATVADDRLLRIWALELKT--PIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFW 371
           *********************9885..7899****************************** PP

Organism

Ovis aries

Protein Sequence
(Fasta)

EAGYLQGYPA DVAGAEEPLL LAELKPGRPH QFDWKSSCET WSVAFSPDGS WFAWSQGHCI 60
VKLIPWPLEE QFIPKGFEAK SRSSKNETKG RGSPKEKTLD CGQIVWGLAF SPWPSPPSKK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAGCTGGTT ATCTGCAGGG TTACCCTGCA GATGTGGCTG GGGCAGGTCA GTTTTCTTGG 60
ATGAAGGAAC TAAACTGAGG AAGTCACCAG AAGTGAGAGC CCTGTCCTCA GCTCAGAACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR001496--SOCS_box
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50225--SOCS
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07525--SOCS_box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00253--SOCS
SM00969--SOCS_box
SM00320--WD40

Gene Ontology

GO:0005622--C:intracellular
GO:0035556--P:intracellular signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002221	Ailuropoda melanoleuca	98.25	0.00e+00	816.00
IUUC-Apl-004107	Anas platyrhynchos	68.77	2.00e-131	461.00
IUUC-Aca-004354	Anolis carolinensis	73.88	3.00e-169	587.00
IUUC-Bta-012627	Bos taurus	100.00	0.00e+00	785.00
IUUC-Cja-018897	Callithrix jacchus	97.17	0.00e+00	780.00
IUUC-Cfa-020122	Canis familiaris	98.50	0.00e+00	815.00
IUUC-Cpo-022540	Cavia porcellus	97.44	0.00e+00	788.00
IUUC-Csa-023719	Chlorocebus sabaeus	98.45	0.00e+00	790.00
IUUC-Cho-024367	Choloepus hoffmanni	97.65	6.00e-173	599.00
IUUC-Dno-029021	Dasypus novemcinctus	98.47	0.00e+00	796.00
IUUC-Dor-030321	Dipodomys ordii	97.42	0.00e+00	783.00
IUUC-Ete-032955	Echinops telfairi	97.49	0.00e+00	782.00
IUUC-Eca-033485	Equus caballus	98.72	0.00e+00	771.00
IUUC-Fca-035389	Felis catus	98.46	0.00e+00	794.00
IUUC-Fal-037184	Ficedula albicollis	84.45	4.00e-143	499.00
IUUC-Gga-041014	Gallus gallus	77.55	6.00e-177	613.00
IUUC-Ggo-045585	Gorilla gorilla	98.72	0.00e+00	800.00
IUUC-Hsa-046344	Homo sapiens	98.72	0.00e+00	799.00
IUUC-Itr-049085	Ictidomys tridecemlineatus	97.94	0.00e+00	791.00
IUUC-Lch-050131	Latimeria chalumnae	70.54	7.00e-168	583.00
IUUC-Loc-052807	Lepisosteus oculatus	54.24	3.00e-116	411.00
IUUC-Laf-053528	Loxodonta africana	97.95	0.00e+00	773.00
IUUC-Mcc-055665	Macaca mulatta	98.72	0.00e+00	799.00
IUUC-Meu-056054	Macropus eugenii	87.88	0.00e+00	697.00
IUUC-Mga-059326	Meleagris gallopavo	77.19	0.00e+00	630.00
IUUC-Mmr-060815	Microcebus murinus	96.42	0.00e+00	783.00
IUUC-Mdo-062000	Monodelphis domestica	90.32	0.00e+00	746.00
IUUC-Mmu-063927	Mus musculus	96.40	0.00e+00	780.00
IUUC-Mpu-065726	Mustela putorius furo	96.92	0.00e+00	779.00
IUUC-Mlu-067527	Myotis lucifugus	97.14	2.00e-119	421.00
IUUC-Nle-069680	Nomascus leucogenys	98.21	0.00e+00	791.00
IUUC-Opr-070356	Ochotona princeps	97.49	0.00e+00	800.00
IUUC-Oan-073647	Ornithorhynchus anatinus	83.94	3.00e-136	478.00
IUUC-Ocu-073973	Oryctolagus cuniculus	96.93	0.00e+00	782.00
IUUC-Oga-088797	Otolemur garnettii	98.21	0.00e+00	789.00
IUUC-Ptr-091317	Pan troglodytes	98.72	0.00e+00	798.00
IUUC-Pan-092694	Papio anubis	91.17	0.00e+00	682.00
IUUC-Psi-093392	Pelodiscus sinensis	79.90	0.00e+00	643.00
IUUC-Pab-098145	Pongo abelii	98.45	0.00e+00	790.00
IUUC-Pca-100454	Procavia capensis	89.47	0.00e+00	724.00
IUUC-Pva-102986	Pteropus vampyrus	89.72	0.00e+00	726.00
IUUC-Rno-104931	Rattus norvegicus	95.36	0.00e+00	771.00
IUUC-Sha-106476	Sarcophilus harrisii	91.77	0.00e+00	745.00
IUUC-Ssc-115643	Sus scrofa	99.23	0.00e+00	795.00
IUUC-Tgu-117522	Taeniopygia guttata	64.20	2.00e-136	478.00
IUUC-Tsy-119301	Tarsius syrichta	98.75	0.00e+00	813.00
IUUC-Ttr-128683	Tursiops truncatus	99.48	0.00e+00	797.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence