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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046812
UUCD1 version UUC-HoS-01003
Ensembl Protein ID ENSP00000406286.2
UniProt Accession O15156; B4E3K5; D3DV83; J3KQQ3; Q68DR2; Q96EP2; ZBT7B_HUMAN
Genbank Protein ID AAC51847.1; BAG65517.1; CAH18158.1; CAI13266.1; EAW53149.1; EAW53150.1; EAW53151.1; AAH12070.1
Protein Name Zinc finger and BTB domain-containing protein 7B; Krueppel-related zinc finger protein cKrox; T-helper-inducing POZ/Krueppel-like factor; Zinc finger and BTB domain-containing protein 15; Zinc finger protein 67 homolog; Zinc finger protein 857B; Zinc finger protein Th-POK
Genbank Nucleotide ID AF007833; AK304762; CR749303; AL451085; CH471121; CH471121; CH471121; BC012070
Gene Name ZBTB7B; ZBTB15; ZFP67; ZNF857B
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000160685.13 ENST00000417934.6 ENSP00000406286.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteJASPARCircNet
miRTarBasemicroRNATRANSFACRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
GWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 2.30e-09 39.1 68 146
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmelees..............ksklmveikdvqpevfrallkFlYtgkld 66
           +D ++  +g e+++h++vLaa+S++F++lf+ +                     +  e++ v pe++ all+F Yt +l+
   Q: 68   CDLTIRTQGLEYRTHRAVLAACSHYFKKLFTEGGGGAvmgaggsgtatggaG-AGVCELDFVGPEALGALLEFAYTATLT 146
           89****************************776665578999******9854.88888888***************9986 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (By similarity).
 Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (By similarity).
Protein Sequence
(Fasta)
MLQPGPHPPS PQAAAPGEAW PGPSQAPWQS LEEKMGSPED DLIGIPFPDH SSELLSCLNE 60
QRQLGHLCDL TIRTQGLEYR THRAVLAACS HYFKKLFTEG GGGAVMGAGG SGTATGGAGA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046812|E3,BTB_Other|Homo sapiens
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Nucleotide Sequence
(Fasta)
AGGGAGGGGA GGGATGGGGG GAAAGCAAGC TGGAGGACAG GTGAGACAGC AGGACAGGTG 60
AGGCGGGCCC TGAGGGGGGG GCGGGTGGGA GCCAGGTGAA TGTACGGCTC TTGGCGGCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046812|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000210--BTB/POZ_dom
IPR023413--GFP-like
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF00651--BTB
SMART

SM00225--BTB
SM00355--ZnF_C2H2
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0030154--P:cell differentiation
GO:0007398--P:ectoderm development
GO:0007275--P:multicellular organism development
GO:0010628--P:positive regulation of gene expression
GO:0043370--P:regulation of CD4-positive, alpha-beta T cell differentiation
GO:0043376--P:regulation of CD8-positive, alpha-beta T cell differentiation
GO:0006366--P:transcription from RNA polymerase II promoter
KEGG hsa:51043
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aca-005247 Anolis carolinensis 56.65 6.00e-54 204.00
IUUC-Ame-010706 Astyanax mexicanus 85.25 3.00e-61 229.00
IUUC-Bta-013174 Bos taurus 92.62 0.00e+00 749.00
IUUC-Cja-019527 Callithrix jacchus 97.73 0.00e+00 854.00
IUUC-Cfa-021183 Canis familiaris 91.15 0.00e+00 856.00
IUUC-Cpo-021564 Cavia porcellus 94.49 0.00e+00 772.00
IUUC-Csa-024245 Chlorocebus sabaeus 99.26 0.00e+00 788.00
IUUC-Cgl-026382 Colletotrichum gloeosporioides 26.51 6.40e-02 31.60
IUUC-Dre-028292 Danio rerio 84.17 1.00e-60 227.00
IUUC-Dno-028864 Dasypus novemcinctus 93.32 0.00e+00 783.00
IUUC-Dor-031131 Dipodomys ordii 92.41 0.00e+00 771.00
IUUC-Eca-033561 Equus caballus 83.91 0.00e+00 676.00
IUUC-Eeu-035040 Erinaceus europaeus 79.79 1.00e-97 349.00
IUUC-Fal-036849 Ficedula albicollis 82.44 1.00e-93 337.00
IUUC-Gmo-038776 Gadus morhua 81.30 2.00e-58 219.00
IUUC-Gga-040853 Gallus gallus 90.41 4.00e-78 285.00
IUUC-Gac-041877 Gasterosteus aculeatus 67.43 2.00e-64 239.00
IUUC-Ggo-044434 Gorilla gorilla 99.83 0.00e+00 855.00
IUUC-Itr-048180 Ictidomys tridecemlineatus 94.43 0.00e+00 785.00
IUUC-Lch-049665 Latimeria chalumnae 52.92 6.00e-122 431.00
IUUC-Mcc-055723 Macaca mulatta 99.08 0.00e+00 765.00
IUUC-Meu-056152 Macropus eugenii 78.91 1.00e-137 483.00
IUUC-Mmr-061549 Microcebus murinus 95.93 0.00e+00 885.00
IUUC-Mdo-061946 Monodelphis domestica 80.79 0.00e+00 688.00
IUUC-Mmu-064201 Mus musculus 91.57 0.00e+00 753.00
IUUC-Mpu-066752 Mustela putorius furo 89.32 0.00e+00 773.00
IUUC-Nle-069749 Nomascus leucogenys 99.30 0.00e+00 856.00
IUUC-Ocu-074243 Oryctolagus cuniculus 96.45 3.00e-122 432.00
IUUC-Ola-087497 Oryzias latipes 70.91 2.00e-64 239.00
IUUC-Oga-088753 Otolemur garnettii 93.31 0.00e+00 791.00
IUUC-Ptr-091391 Pan troglodytes 100.00 0.00e+00 852.00
IUUC-Pan-092553 Papio anubis 98.95 0.00e+00 851.00
IUUC-Pfo-096585 Poecilia formosa 82.68 3.00e-63 236.00
IUUC-Pab-097962 Pongo abelii 99.13 0.00e+00 835.00
IUUC-Pva-102850 Pteropus vampyrus 88.60 0.00e+00 696.00
IUUC-Rno-105216 Rattus norvegicus 91.34 0.00e+00 751.00
IUUC-Sha-107232 Sarcophilus harrisii 81.11 0.00e+00 693.00
IUUC-Ssc-116341 Sus scrofa 91.18 4.00e-93 334.00
IUUC-Tni-120444 Tetraodon nigroviridis 81.34 5.00e-64 238.00
Created Date 25-Jun-2017

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