iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
AREsite	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
miRNAMap	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	Mentha
Post-translational Modifications (PTMs)
dbPAF	mUbiSiDa
Protein Expression/Proteomics
THPA	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	2.40e-18	67.9	256	361
E2/UEV	7.90e-66	222.0	230	368

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E2/UBC

   S: 17   isakpvdesd..ltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.Gkv...ClsilkeeekWspalsvesvl 102
           +s +++d++d  lt+w  +i+Gp++t+Ye+++++l+ie+ ++YP  PP v+f+tki    v+++ G v    +s+l    kW+  +s++ vl
   Q: 256  VSWGLEDDEDmtLTRWTGMIIGPPRTIYENRIYSLKIECGPKYPEAPPFVRFVTKINMNGVNSSnGVVdprAISVL---AKWQNSYSIKVVL 344
           55666777776689*****************************************999999988798866668888...5************ PP
   S: 103  lsiqsll.aepnpespl 118
            ++ +l+ ++ n++ p+
   Q: 345  QELRRLMmSKENMKLPQ 361
           *****996667777665 PP

E2/UEV

   S: 7    lkvvvprnfrlleeleegekglgdgtvsygldDgddilllsltgtIigpertayegrIyqlklfvgkkYPekPPtvrfsskinmaevndsnG 98
           + v+vprnfrlleeleeg+kg+gdgtvs+gl+D++d++l+++tg+Iigp+rt ye+rIy+lk+++g+kYPe+PP+vrf++kinm++vn+snG
   Q: 230  TGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTIYENRIYSLKIECGPKYPEAPPFVRFVTKINMNGVNSSNG 321
           579***************************************************************************************** PP
   S: 99   vvdpralpvLanWkreysievvlvqlkkellskenrklqqPpeGnlf 145
           vvdpra++vLa+W+++ysi+vvl++l++ ++sken+kl+qPpeG+++
   Q: 322  VVDPRAISVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQCY 368
           *********************************************98 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MAGAENWPGQ QLELDEDEAS CCRWGAQHAG ARELAALYSP GKRLQEWCSV ILCFSLIAHN 60
LVHLLLLARW EDTPLVILGV VAGALIADFL SGLVHWGADT WGSVELPIVG KAFIRPFREH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGGCG CCGAGAACTG GCCGGGCCAG CAGCTGGAGC TGGACGAGGA CGAGGCGTCT 60
TGTTGCCGCT GGGGCGCGCA GCACGCCGGG GCCCGCGAGC TGGCTGCGCT CTACTCGCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR019547--TMEM189_B_dmain
IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF10520--TMEM189_B_dmain
PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016021--C:integral component of membrane
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0006301--P:postreplication repair
GO:0070534--P:protein K63-linked ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001242	Ailuropoda melanoleuca	96.48	0.00e+00	683.00
IUUC-Apl-003600	Anas platyrhynchos	100.00	8.00e-74	268.00
IUUC-Aca-005104	Anolis carolinensis	95.83	3.00e-79	286.00
IUUC-Csa-024275	Chlorocebus sabaeus	98.65	0.00e+00	679.00
IUUC-Dor-030185	Dipodomys ordii	94.47	8.00e-107	379.00
IUUC-Ete-033017	Echinops telfairi	72.59	5.00e-98	351.00
IUUC-Eeu-035327	Erinaceus europaeus	85.18	5.00e-178	616.00
IUUC-Fal-037350	Ficedula albicollis	99.29	4.00e-74	270.00
IUUC-Gga-040746	Gallus gallus	97.22	3.00e-74	270.00
IUUC-Gac-042619	Gasterosteus aculeatus	74.21	1.00e-100	358.00
IUUC-Ggo-045491	Gorilla gorilla	98.65	0.00e+00	701.00
IUUC-Itr-048139	Ictidomys tridecemlineatus	100.00	1.00e-73	268.00
IUUC-Lch-050494	Latimeria chalumnae	87.86	4.00e-73	266.00
IUUC-Loc-052024	Lepisosteus oculatus	82.81	3.00e-176	610.00
IUUC-Mcc-055788	Macaca mulatta	98.92	0.00e+00	682.00
IUUC-Meu-056842	Macropus eugenii	74.42	8.00e-142	496.00
IUUC-Mga-059951	Meleagris gallopavo	97.20	1.00e-73	268.00
IUUC-Mmr-060769	Microcebus murinus	91.64	0.00e+00	668.00
IUUC-Mmu-063234	Mus musculus	92.45	0.00e+00	633.00
IUUC-Mlu-067269	Myotis lucifugus	91.56	7.00e-73	265.00
IUUC-Opr-070859	Ochotona princeps	90.84	0.00e+00	652.00
IUUC-Ola-086519	Oryzias latipes	76.92	1.00e-164	572.00
IUUC-Oga-087972	Otolemur garnettii	97.24	6.00e-74	269.00
IUUC-Oar-090166	Ovis aries	95.45	0.00e+00	644.00
IUUC-Pab-098403	Pongo abelii	99.39	0.00e+00	627.00
IUUC-Pca-100723	Procavia capensis	94.07	0.00e+00	699.00
IUUC-Pva-102393	Pteropus vampyrus	90.84	0.00e+00	660.00
IUUC-Sha-107363	Sarcophilus harrisii	97.90	3.00e-74	270.00
IUUC-Tgu-117289	Taeniopygia guttata	93.67	3.00e-116	410.00
IUUC-Tsy-119103	Tarsius syrichta	96.67	1.00e-65	242.00
IUUC-Tbe-128105	Tupaia belangeri	83.51	5.00e-174	603.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence