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Tag Content
UUCD2 ID IUUC-Bta-012529
UUCD1 version UUC-BoT-01112
Ensembl Protein ID ENSBTAP00000012857.5
UniProt Accession Q2KHV7; UBP2_BOVIN
Genbank Protein ID AAI12867.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 2; 41 kDa ubiquitin-specific protease; Deubiquitinating enzyme 2; Ubiquitin thioesterase 2; Ubiquitin-specific-processing protease 2
Genbank Nucleotide ID BC112866
Gene Name USP2; UBP41
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000009749.5 ENSBTAT00000012857.5 ENSBTAP00000012857.5
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 2.20e-98 329.7 269 598
Active Site
Position(s) Description Evidence
277 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
558 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           Gl+NlgNtC+mNS+LQcLsn++elr+++l+  + ++l+++  +  +++l+++++kl++ +w +s + +vsp+e++++++++a++f gy+
   Q: 269  GLRNLGNTCFMNSILQCLSNTRELRDYCLQrLYLRDLSHS--SRAHTALMEEFAKLIQTIWtSSPNDVVSPSEFKTQIQRYAPRFVGYN 355
           9*****************************8888888887..57999**************889999********************** PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde...aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlsl 174
           qqDaqEfl+flld+l++e+++    pk+++e+ d+   +++    ++k  ++++s i dlF gqlks+++c +c+  s+ ++pf+dlsl
   Q: 356  QQDAQEFLRFLLDGLHNEVNRVIARPKSNTENLDHLPDDEKgrqMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSL 444
           *******************99777777777777744444437769******************************************** PP
   S: 175  pvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.Ldls 262
           p+ ++    + +l dc++ ftke+ l+g++k  c +c++++++ kk++++++P++L+lhLkRf  se++ + +k++  v+fpl+ Ldl+
   Q: 445  PITKRGYP-EVTLMDCMRLFTKEDVLDGDEKPTCCRCRARKRCIKKFSIQRFPKILVLHLKRF--SESRIRTSKLTAFVNFPLRdLDLR 530
           ****9976.779***************************************************..88899******************* PP
   S: 263  pfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetgstaYvlfYk 336
           +f +++++    +  Y+L+av +HsG++ +GHY+ay+++  +g+W +f+Ds+V++++ ++v +   s+aY+lfY+
   Q: 531  EFASENTN----HAVYNLYAVSNHSGTTMGGHYTAYCRSpVTGEWHTFNDSSVSPMSSSQVRT---SDAYLLFYE 598
           ****9553....78*************************44666*******************...********8 PP
   
Organism Bos taurus
Functional Description
(View)

Functional Description


     Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Possesses both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1.
 Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Possesses both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1.
Protein Sequence
(Fasta)
MSQLSSTLKR YTESARFTDA PFTKSSYGTY TPSSYGTNLA ASFLEKEKFG FKPSPPTSYL 60
TRPRTYGPPS ILDYDRGRPL LRPDVIGGGK RAESQTRGTE RPSGSGLSGG SGFSYGVTTS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Bta-012529|DUB,USP|Bos taurus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACTGCACTCC CTGCCCTGCC GGGGAAGGAG AAGCCCCCAG ATCCTGCCCA GTGTCCCCGG 60
ACACAGGTCA GTAACTGTCC CTTTGGTATC CAAACTTCAC AGGGCCGTTG TCCAGAGGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Bta-012529|DUB,USP|Bos taurus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0090--Biological rhythms
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0517--Myogenesis
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF00443--UCH
Gene Ontology

GO:0005938--C:cell cortex
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007049--P:cell cycle
GO:0048512--P:circadian behavior
GO:0032922--P:circadian regulation of gene expression
GO:0043153--P:entrainment of circadian clock by photoperiod
GO:0045475--P:locomotor rhythm
GO:0007517--P:muscle organ development
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045931--P:positive regulation of mitotic cell cycle
GO:0016579--P:protein deubiquitination
GO:0050821--P:protein stabilization
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG bta:522980
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001988 Ailuropoda melanoleuca 92.90 0.00e+00 1059.00
IUUC-Aca-005132 Anolis carolinensis 61.51 0.00e+00 679.00
IUUC-Ame-011102 Astyanax mexicanus 75.22 9.00e-145 506.00
IUUC-Cja-019016 Callithrix jacchus 87.54 0.00e+00 984.00
IUUC-Cfa-020714 Canis familiaris 92.57 0.00e+00 1078.00
IUUC-Cpo-021727 Cavia porcellus 88.45 0.00e+00 1000.00
IUUC-Csa-023071 Chlorocebus sabaeus 96.83 0.00e+00 657.00
IUUC-Cin-025797 Ciona intestinalis 50.72 1.00e-90 326.00
IUUC-Csv-026132 Ciona savignyi 51.48 4.00e-95 342.00
IUUC-Dre-027872 Danio rerio 74.48 5.00e-159 553.00
IUUC-Dno-029329 Dasypus novemcinctus 91.58 0.00e+00 1033.00
IUUC-Dor-030574 Dipodomys ordii 90.43 0.00e+00 1004.00
IUUC-Dme-032208 Drosophila melanogaster 47.31 4.00e-82 299.00
IUUC-Ete-032725 Echinops telfairi 80.39 1.00e-173 603.00
IUUC-Eca-033361 Equus caballus 93.56 0.00e+00 1068.00
IUUC-Eeu-035272 Erinaceus europaeus 76.14 0.00e+00 681.00
IUUC-Fca-036497 Felis catus 92.90 0.00e+00 1063.00
IUUC-Fal-036766 Ficedula albicollis 63.89 0.00e+00 676.00
IUUC-Gmo-039129 Gadus morhua 61.28 3.00e-122 431.00
IUUC-Gga-040889 Gallus gallus 81.45 3.00e-149 521.00
IUUC-Gac-042475 Gasterosteus aculeatus 69.54 2.00e-135 475.00
IUUC-Ggo-044814 Gorilla gorilla 91.09 6.00e-170 589.00
IUUC-Hsa-045937 Homo sapiens 89.11 0.00e+00 990.00
IUUC-Itr-048171 Ictidomys tridecemlineatus 91.01 0.00e+00 1057.00
IUUC-Lch-050527 Latimeria chalumnae 61.52 4.00e-180 624.00
IUUC-Loc-052697 Lepisosteus oculatus 78.29 1.00e-156 546.00
IUUC-Laf-054167 Loxodonta africana 85.39 0.00e+00 986.00
IUUC-Mcc-055584 Macaca mulatta 90.43 0.00e+00 1033.00
IUUC-Meu-056542 Macropus eugenii 85.67 0.00e+00 922.00
IUUC-Mga-060020 Meleagris gallopavo 60.10 0.00e+00 627.00
IUUC-Mmr-060989 Microcebus murinus 92.08 0.00e+00 1053.00
IUUC-Mdo-062761 Monodelphis domestica 85.67 0.00e+00 928.00
IUUC-Mmu-063710 Mus musculus 88.37 0.00e+00 1023.00
IUUC-Mpu-066573 Mustela putorius furo 93.40 0.00e+00 1068.00
IUUC-Nle-070013 Nomascus leucogenys 89.24 0.00e+00 979.00
IUUC-Opr-070907 Ochotona princeps 90.12 0.00e+00 993.00
IUUC-Ont-071944 Oreochromis niloticus 80.98 7.00e-159 553.00
IUUC-Oan-073105 Ornithorhynchus anatinus 78.99 1.00e-147 515.00
IUUC-Ocu-073941 Oryctolagus cuniculus 91.27 0.00e+00 1040.00
IUUC-Ola-087412 Oryzias latipes 75.00 1.00e-148 520.00
IUUC-Oga-088973 Otolemur garnettii 92.24 0.00e+00 1055.00
IUUC-Oar-089916 Ovis aries 98.35 0.00e+00 1131.00
IUUC-Ptr-090998 Pan troglodytes 89.44 0.00e+00 998.00
IUUC-Pan-092686 Papio anubis 90.59 0.00e+00 1035.00
IUUC-Psi-093284 Pelodiscus sinensis 71.61 5.00e-125 440.00
IUUC-Pma-094462 Petromyzon marinus 65.24 1.00e-75 275.00
IUUC-Pfo-097352 Poecilia formosa 78.93 3.00e-164 571.00
IUUC-Pab-098688 Pongo abelii 82.34 0.00e+00 892.00
IUUC-Pca-100205 Procavia capensis 92.51 2.00e-178 619.00
IUUC-Pva-103188 Pteropus vampyrus 91.91 0.00e+00 1018.00
IUUC-Rno-105853 Rattus norvegicus 89.00 0.00e+00 1046.00
IUUC-Sha-107237 Sarcophilus harrisii 85.01 0.00e+00 922.00
IUUC-Sar-113103 Sorex araneus 89.91 2.00e-173 600.00
IUUC-Ssc-115955 Sus scrofa 93.89 0.00e+00 1073.00
IUUC-Tgu-116894 Taeniopygia guttata 70.13 4.00e-179 620.00
IUUC-Tru-117703 Takifugu rubripes 65.79 9.00e-129 453.00
IUUC-Tsy-118879 Tarsius syrichta 93.50 0.00e+00 801.00
IUUC-Tni-119866 Tetraodon nigroviridis 73.01 2.00e-153 534.00
IUUC-Tbe-127367 Tupaia belangeri 84.91 0.00e+00 663.00
IUUC-Ttr-128773 Tursiops truncatus 91.42 0.00e+00 1051.00
IUUC-Vpa-130402 Vicugna pacos 83.05 0.00e+00 788.00
IUUC-Xtr-132658 Xenopus tropicalis 57.07 3.00e-175 608.00
Created Date 25-Jun-2017

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