iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013365

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin-conjugating enzyme E2 W; E2 ubiquitin-conjugating enzyme W; N-terminal E2 ubiquitin-conjugating enzyme; N-terminus-conjugating E2; Ubiquitin carrier protein W; Ubiquitin-protein ligase W

Genbank Nucleotide ID

BC146162

Gene Name

UBE2W

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000008260.5	ENSBTAT00000010872.4	ENSBTAP00000010872.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	1.30e-36	125.6	7	140

Active Site

Position(s)	Description	Evidence
91	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    Rlkkelkelekdppegisakpvdesd.ltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltk..ifhPnvyenGkvClsil 86
           Rl+kel +l++dpp+g++++ ++ ++ +t+w v ++G ++t Yeg++F+l ++f+++YPf++P+v+f+ +    hP+vy+nG++Clsil
   Q: 7    RLQKELLALQNDPPPGMTLNEKSVQNsITQWIVDMEGAPGTLYEGEKFQLLFKFSSRYPFDSPQVMFTGEniPVHPHVYSNGHICLSIL 95
           9*********************99989*****************************************99989**************** PP
   S: 87   keeekWspalsvesvllsiqsll..aepnpesplneeaaellkknre 131
           +  e+Wspalsv+sv+lsi+s+l  ++ + + p n+  +++++kn++
   Q: 96   T--EDWSPALSVQSVCLSIISMLssCKEKRRPPDNSFYVRTCNKNPK 140
           9..********************655577788999999999999987 PP

Organism

Bos taurus

Functional Description
(View)

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Transfers ubiquitin in complex with RING/U-box type E3s that do not have active site cysteine residues to form thioester bonds with ubiquitin, and preferentially ubiquitinates the N-terminus of substrates, such as ATXN3, STUB1 and SUMO2.

Protein Sequence
(Fasta)

MASMQKRLQK ELLALQNDPP PGMTLNEKSV QNSITQWIVD MEGAPGTLYE GEKFQLLFKF 60
SSRYPFDSPQ VMFTGENIPV HPHVYSNGHI CLSILTEDWS PALSVQSVCL SIISMLSSCK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCATCATGG CGTCAATGCA GGTAAGAGGA GTTTGCAGCA TCTGGGCGGG CTCCGTTGCC 60
GCGGGGAGGA TGAGAGCCTT TCCTCTGGGG GTGTGTCTGG GTCTGTGGGG CACCCGGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0071218--P:cellular response to misfolded protein
GO:0006281--P:DNA repair
GO:0006515--P:misfolded or incompletely synthesized protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination

KEGG

bta:613423

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000363	Aegilops tauschii	42.18	9.00e-31	127.00
IUUC-Aml-002375	Ailuropoda melanoleuca	96.60	8.00e-84	302.00
IUUC-Apl-003950	Anas platyrhynchos	94.70	2.00e-84	304.00
IUUC-Aly-006450	Arabidopsis lyrata	51.03	5.00e-41	159.00
IUUC-Ath-007383	Arabidopsis thaliana	51.72	6.00e-35	139.00
IUUC-Acl-008034	Aspergillus clavatus	34.87	4.00e-23	100.00
IUUC-Afl-008476	Aspergillus flavus	37.82	1.00e-26	111.00
IUUC-Afu-008827	Aspergillus fumigatus	36.54	2.00e-25	108.00
IUUC-Ani-009244	Aspergillus nidulans	35.97	2.00e-20	91.30
IUUC-Ang-009545	Aspergillus niger	36.84	2.00e-23	101.00
IUUC-Aor-009924	Aspergillus oryzae	36.62	4.00e-23	100.00
IUUC-Ate-010478	Aspergillus terreus	30.17	1.00e-19	89.00
IUUC-Ame-011757	Astyanax mexicanus	98.01	7.00e-88	315.00
IUUC-Bgr-012004	Blumeria graminis	39.10	2.00e-27	114.00
IUUC-Bci-013609	Botrytis cinerea	37.91	6.00e-25	106.00
IUUC-Bdi-014373	Brachypodium distachyon	51.72	2.00e-41	160.00
IUUC-Bol-016083	Brassica oleracea	51.72	9.00e-41	159.00
IUUC-Bra-017578	Brassica rapa	52.74	3.00e-35	140.00
IUUC-Cel-018273	Caenorhabditis elegans	61.38	5.00e-55	206.00
IUUC-Cja-018997	Callithrix jacchus	97.28	4.00e-84	303.00
IUUC-Cfa-020790	Canis familiaris	100.00	4.00e-89	319.00
IUUC-Cpo-021615	Cavia porcellus	98.63	5.00e-84	302.00
IUUC-Cre-022615	Chlamydomonas reinhardtii	43.05	5.00e-29	119.00
IUUC-Csa-024236	Chlorocebus sabaeus	100.00	5.00e-89	319.00
IUUC-Cho-024448	Choloepus hoffmanni	86.96	1.00e-66	244.00
IUUC-Cin-025579	Ciona intestinalis	67.12	9.00e-59	218.00
IUUC-Cgl-026554	Colletotrichum gloeosporioides	40.40	1.00e-26	112.00
IUUC-Cne-026943	Cryptococcus neoformans	56.16	8.00e-21	92.40
IUUC-Cme-027157	Cyanidioschyzon merolae	50.00	6.00e-39	153.00
IUUC-Dre-027411	Danio rerio	97.35	2.00e-87	313.00
IUUC-Dno-029321	Dasypus novemcinctus	100.00	5.00e-89	319.00
IUUC-Dor-030985	Dipodomys ordii	99.11	3.00e-65	239.00
IUUC-Dse-031193	Dothistroma septosporum	41.67	6.00e-28	116.00
IUUC-Dme-032116	Drosophila melanogaster	72.60	1.00e-65	241.00
IUUC-Ete-032344	Echinops telfairi	100.00	5.00e-86	309.00
IUUC-Eca-033939	Equus caballus	100.00	4.00e-83	299.00
IUUC-Eeu-034593	Erinaceus europaeus	100.00	5.00e-86	309.00
IUUC-Fca-035457	Felis catus	98.61	1.00e-83	301.00
IUUC-Fal-037512	Ficedula albicollis	98.45	9.00e-75	271.00
IUUC-Fox-038001	Fusarium oxysporum	40.38	4.00e-27	113.00
IUUC-Fso-038237	Fusarium solani	39.74	2.00e-26	111.00
IUUC-Gmo-039574	Gadus morhua	98.68	5.00e-88	315.00
IUUC-Ggr-040091	Gaeumannomyces graminis	39.07	2.00e-27	115.00
IUUC-Gga-040125	Gallus gallus	99.34	1.00e-88	317.00
IUUC-Gac-041300	Gasterosteus aculeatus	95.24	2.00e-82	297.00
IUUC-Gma-043703	Glycine max	51.03	2.00e-34	138.00
IUUC-Ggo-044461	Gorilla gorilla	93.21	3.00e-86	310.00
IUUC-Hsa-046710	Homo sapiens	100.00	8.00e-89	318.00
IUUC-Itr-048816	Ictidomys tridecemlineatus	100.00	3.00e-87	313.00
IUUC-Kpa-049405	Komagataella pastoris	41.06	4.00e-31	127.00
IUUC-Lch-050426	Latimeria chalumnae	95.97	2.00e-84	303.00
IUUC-Lpe-051342	Leersia perrieri	51.72	3.00e-41	160.00
IUUC-Loc-052247	Lepisosteus oculatus	99.32	9.00e-86	308.00
IUUC-Lma-053151	Leptosphaeria maculans	40.67	1.00e-26	113.00
IUUC-Laf-053849	Loxodonta africana	100.00	4.00e-83	299.00
IUUC-Mcc-055520	Macaca mulatta	93.21	3.00e-86	310.00
IUUC-Mor-057224	Magnaporthe oryzae	38.82	1.00e-28	118.00
IUUC-Mpo-057368	Magnaporthe poae	38.41	4.00e-27	113.00
IUUC-Mtr-058312	Medicago truncatula	50.34	3.00e-34	137.00
IUUC-Mla-059112	Melampsora laricipopulina	49.07	1.00e-32	132.00
IUUC-Mga-059919	Meleagris gallopavo	99.32	1.00e-85	307.00
IUUC-Mvi-060408	Microbotryum violaceum	48.72	2.00e-37	147.00
IUUC-Mmr-061136	Microcebus murinus	100.00	2.00e-86	310.00
IUUC-Mdo-062768	Monodelphis domestica	99.34	1.00e-88	317.00
IUUC-Mmu-063097	Mus musculus	99.34	4.00e-88	316.00
IUUC-Mac-064973	Musa acuminata	50.34	4.00e-41	160.00
IUUC-Mpu-066887	Mustela putorius furo	100.00	8.00e-86	308.00
IUUC-Mlu-067762	Myotis lucifugus	98.01	7.00e-87	312.00
IUUC-Nfi-068242	Neosartorya fischeri	34.87	3.00e-23	101.00
IUUC-Ncr-068788	Neurospora crassa	39.74	9.00e-29	119.00
IUUC-Nle-070082	Nomascus leucogenys	100.00	7.00e-89	319.00
IUUC-Ont-072026	Oreochromis niloticus	99.34	3.00e-89	320.00
IUUC-Oan-073013	Ornithorhynchus anatinus	98.45	7.00e-75	271.00
IUUC-Ocu-074009	Oryctolagus cuniculus	97.28	6.00e-84	302.00
IUUC-Oba-075077	Oryza barthii	51.72	1.00e-41	161.00
IUUC-Obr-076142	Oryza brachyantha	50.34	4.00e-40	156.00
IUUC-Ogl-077944	Oryza glaberrima	51.72	1.00e-41	161.00
IUUC-Ogu-078453	Oryza glumaepatula	51.72	1.00e-41	161.00
IUUC-Oin-079726	Oryza indica	51.72	3.00e-41	160.00
IUUC-Olo-080356	Oryza longistaminata	51.72	1.00e-41	161.00
IUUC-Ome-081601	Oryza meridionalis	51.72	1.00e-41	161.00
IUUC-Oni-082554	Oryza nivara	51.72	1.00e-41	161.00
IUUC-Opu-083614	Oryza punctata	51.72	1.00e-41	162.00
IUUC-Oru-085028	Oryza rufipogon	51.72	1.00e-41	161.00
IUUC-Osa-085386	Oryza sativa	51.72	1.00e-41	161.00
IUUC-Ola-086845	Oryzias latipes	98.06	3.00e-58	215.00
IUUC-Oga-087990	Otolemur garnettii	100.00	3.00e-87	313.00
IUUC-Oar-090149	Ovis aries	100.00	7.00e-84	302.00
IUUC-Ptr-090701	Pan troglodytes	100.00	8.00e-86	308.00
IUUC-Pan-092007	Papio anubis	93.21	2.00e-86	310.00
IUUC-Psi-093380	Pelodiscus sinensis	97.35	9.00e-87	311.00
IUUC-Pma-094682	Petromyzon marinus	86.75	1.00e-79	288.00
IUUC-Ppa-095667	Physcomitrella patens	53.10	4.00e-35	140.00
IUUC-Pfo-097000	Poecilia formosa	98.68	3.00e-88	316.00
IUUC-Pab-098188	Pongo abelii	100.00	5.00e-89	319.00
IUUC-Pop-099724	Populus trichocarpa	48.97	3.00e-32	130.00
IUUC-Pca-100346	Procavia capensis	100.00	7.00e-82	295.00
IUUC-Ppe-101296	Prunus persica	51.03	2.00e-34	138.00
IUUC-Pva-102207	Pteropus vampyrus	100.00	2.00e-65	240.00
IUUC-Pgr-103668	Puccinia graminis	44.17	3.00e-33	134.00
IUUC-Pte-104294	Pyrenophora teres	39.26	3.00e-23	100.00
IUUC-Pyt-104534	Pyrenophora triticirepentis	39.26	9.00e-24	102.00
IUUC-Rno-105466	Rattus norvegicus	100.00	4.00e-86	309.00
IUUC-Sha-106707	Sarcophilus harrisii	95.92	1.00e-83	301.00
IUUC-Smo-109161	Selaginella moellendorffii	53.79	1.00e-42	165.00
IUUC-Sit-110749	Setaria italica	53.42	3.00e-43	167.00
IUUC-Sly-111213	Solanum lycopersicum	51.03	1.00e-34	139.00
IUUC-Stu-112148	Solanum tuberosum	51.03	3.00e-34	137.00
IUUC-Sar-113531	Sorex araneus	100.00	8.00e-86	308.00
IUUC-Sbi-114432	Sorghum bicolor	52.05	8.00e-36	142.00
IUUC-Sre-114974	Sporisorium reilianum	43.87	2.00e-33	134.00
IUUC-Ssc-115770	Sus scrofa	98.68	5.00e-88	315.00
IUUC-Tgu-117316	Taeniopygia guttata	97.95	1.00e-84	304.00
IUUC-Tru-117640	Takifugu rubripes	96.62	1.00e-84	305.00
IUUC-Tsy-119222	Tarsius syrichta	99.30	2.00e-83	300.00
IUUC-Tni-120737	Tetraodon nigroviridis	98.01	4.00e-88	316.00
IUUC-Tca-121226	Theobroma cacao	50.34	6.00e-34	136.00
IUUC-Tre-121998	Trichoderma reesei	39.47	2.00e-20	91.70
IUUC-Tvi-122565	Trichoderma virens	38.16	1.00e-24	105.00
IUUC-Tae-124081	Triticum aestivum	51.72	3.00e-41	160.00
IUUC-Tur-126577	Triticum urartu	51.13	8.00e-38	148.00
IUUC-Tme-127110	Tuber melanosporum	40.13	2.00e-27	114.00
IUUC-Tbe-127701	Tupaia belangeri	98.65	6.00e-86	308.00
IUUC-Ttr-128279	Tursiops truncatus	93.71	8.00e-76	275.00
IUUC-Uma-129371	Ustilago maydis	43.87	7.00e-33	132.00
IUUC-Vda-129698	Verticillium dahliae	38.41	2.00e-27	114.00
IUUC-Vpa-130053	Vicugna pacos	93.28	2.00e-72	263.00
IUUC-Vvi-131254	Vitis vinifera	51.03	4.00e-35	140.00
IUUC-Xtr-132804	Xenopus tropicalis	72.60	1.00e-59	221.00
IUUC-Xma-133451	Xiphophorus maculatus	98.68	3.00e-88	316.00
IUUC-Yli-134332	Yarrowia lipolytica	45.45	2.00e-29	121.00
IUUC-Zma-135814	Zea mays	52.05	6.00e-42	162.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence