iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033863

UUCD1 version

UUC-EqC-01036

Ensembl Protein ID

ENSECAP00000008093.1

UniProt Accession

F6QXL3; F6QXL3_HORSE

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP44

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000010123.1	ENSECAT00000010483.1	ENSECAP00000008093.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.20e-97	326.4	256	654

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle............kkkeklneenp................................... 42
           tGl+NlgNtCYmNSvLQ+Ls++  +r+++l+                      +                                   
   Q: 256  TGLRNLGNTCYMNSVLQVLSHLLIFRQCFLKldlnrwlavtasD---------Ktrssykrlpvtdtvyqmneyqekdtgsfrsrrlsg 335
           7******************************8777665553330.........134444566778888888888888888888888888 PP
   S: 43   ................kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpk 115
                           +++  +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ lld+++ el        
   Q: 336  gasksrkmeliqlrepSSQCISLCHELHTLFQVMWSGKWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKIQHEL-------- 416
           888777777777766666666************************************************************........ PP
   S: 116  eeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.......slqdcLesftke 197
            e+++++  +l   +++k  k+  ++++++F+gql sq++cl+cdn+s++ epf+dlsl++p++ + + +        ++++L++ft++
   Q: 417  -ETTGTSLPALIPTSQRKAIKQVLNVVNNIFHGQLLSQVTCLACDNKSNTIEPFWDLSLEFPERYQYSGKdtaaqpcLVTEMLAKFTET 504
           .7889999999999************************************************777655556777777************ PP
   S: 198  eelegenkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke. 274
           e leg+  y c++c++k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c++++ k+ + 
   Q: 505  EALEGKI-YICDQCNSKRRrfsskpvvlteAQKQLMICHLPQVLRLHLKRFRWSGR-NNREKIGVHVGFEEILNMEPYCCRDSLKSLSp 591
           ****965.*******999999999999999***********************998.7778********************88887656 PP
   S: 275  .kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
            + +Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk + ++++ev++   ++aY+lfY++
   Q: 592  eCFIYDLSAVVMHHGkGFGSGHYTAYCYNSEGGfWVHCNDSKLSMCTMDEVCK---AQAYILFYTQ 654
           69***************************9999********************...********98 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MDKCKHIGQL QLAQDHSILN PQKWHCVDCN TTESIWACLS CSHVACGRYI QEHALRHFQE 60
SSHPVALEVN EMYVFCYFCD DYVLNDNATG DLKLLRSTLS ALKSQNYHCP TGSGRVLRSA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATAAGT GCAAACACAT TGGTCAGTTG CAGCTTGCTC AAGACCATTC CATCCTCAAC 60
CCTCAGAAAT GGCATTGTGT GGACTGCAAT ACAACTGAGT CGATTTGGGC TTGCCTTAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:1904667--P:negative regulation of ubiquitin protein ligase activity
GO:0016579--P:protein deubiquitination
GO:0090231--P:regulation of spindle checkpoint
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001220	Ailuropoda melanoleuca	88.15	0.00e+00	1255.00
IUUC-Apl-003673	Anas platyrhynchos	72.68	0.00e+00	1014.00
IUUC-Aca-004434	Anolis carolinensis	70.66	0.00e+00	1006.00
IUUC-Bta-012774	Bos taurus	86.99	0.00e+00	1220.00
IUUC-Cja-019619	Callithrix jacchus	87.32	0.00e+00	1219.00
IUUC-Cfa-020957	Canis familiaris	87.59	0.00e+00	1266.00
IUUC-Csa-023177	Chlorocebus sabaeus	87.04	0.00e+00	1217.00
IUUC-Cho-024877	Choloepus hoffmanni	83.33	0.00e+00	766.00
IUUC-Cin-025587	Ciona intestinalis	48.30	4.00e-107	382.00
IUUC-Csv-025814	Ciona savignyi	44.27	2.00e-152	532.00
IUUC-Dre-027878	Danio rerio	64.01	0.00e+00	827.00
IUUC-Dno-029832	Dasypus novemcinctus	87.17	0.00e+00	1241.00
IUUC-Ete-032627	Echinops telfairi	84.37	0.00e+00	1198.00
IUUC-Eeu-035225	Erinaceus europaeus	82.23	0.00e+00	1132.00
IUUC-Fca-036288	Felis catus	88.01	0.00e+00	1257.00
IUUC-Fal-037207	Ficedula albicollis	73.14	0.00e+00	1005.00
IUUC-Gga-040457	Gallus gallus	72.54	0.00e+00	986.00
IUUC-Ggo-044926	Gorilla gorilla	87.32	0.00e+00	1217.00
IUUC-Hsa-046079	Homo sapiens	87.04	0.00e+00	1213.00
IUUC-Itr-048737	Ictidomys tridecemlineatus	86.06	0.00e+00	1209.00
IUUC-Lch-050260	Latimeria chalumnae	65.50	0.00e+00	890.00
IUUC-Loc-051981	Lepisosteus oculatus	76.22	0.00e+00	656.00
IUUC-Laf-054491	Loxodonta africana	85.20	0.00e+00	1191.00
IUUC-Mcc-055694	Macaca mulatta	87.04	0.00e+00	1212.00
IUUC-Mga-059523	Meleagris gallopavo	72.96	0.00e+00	1007.00
IUUC-Mmr-060885	Microcebus murinus	89.15	0.00e+00	1269.00
IUUC-Mdo-063018	Monodelphis domestica	76.48	0.00e+00	1061.00
IUUC-Mmu-064012	Mus musculus	74.33	0.00e+00	1037.00
IUUC-Mpu-066207	Mustela putorius furo	86.46	0.00e+00	1260.00
IUUC-Mlu-066929	Myotis lucifugus	83.99	0.00e+00	1132.00
IUUC-Nle-069313	Nomascus leucogenys	77.58	0.00e+00	1040.00
IUUC-Opr-070375	Ochotona princeps	77.36	0.00e+00	1049.00
IUUC-Ont-071637	Oreochromis niloticus	63.48	0.00e+00	846.00
IUUC-Oan-073030	Ornithorhynchus anatinus	74.52	0.00e+00	812.00
IUUC-Ocu-074836	Oryctolagus cuniculus	82.96	0.00e+00	1170.00
IUUC-Oga-088367	Otolemur garnettii	87.75	0.00e+00	1229.00
IUUC-Oar-089953	Ovis aries	87.99	0.00e+00	1261.00
IUUC-Ptr-090980	Pan troglodytes	87.32	0.00e+00	1217.00
IUUC-Pan-092748	Papio anubis	87.59	0.00e+00	1224.00
IUUC-Pma-094155	Petromyzon marinus	56.90	8.00e-81	293.00
IUUC-Pab-098514	Pongo abelii	87.18	0.00e+00	1215.00
IUUC-Pva-102984	Pteropus vampyrus	86.91	0.00e+00	1207.00
IUUC-Rno-106019	Rattus norvegicus	76.08	0.00e+00	1076.00
IUUC-Sha-106965	Sarcophilus harrisii	75.49	0.00e+00	1055.00
IUUC-Ssc-115299	Sus scrofa	89.14	0.00e+00	1289.00
IUUC-Tgu-117160	Taeniopygia guttata	75.71	0.00e+00	1005.00
IUUC-Tru-118156	Takifugu rubripes	61.06	0.00e+00	815.00
IUUC-Tni-119733	Tetraodon nigroviridis	60.40	0.00e+00	828.00
IUUC-Tbe-128084	Tupaia belangeri	82.25	0.00e+00	1173.00
IUUC-Ttr-128928	Tursiops truncatus	88.58	0.00e+00	1275.00
IUUC-Vpa-130706	Vicugna pacos	88.15	0.00e+00	1268.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence