iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-094078

Ensembl Protein ID

ENSPSIP00000018619.1

UniProt Accession

K7GEA8; K7GEA8_PELSI

Genbank Protein ID

ENSPSIP00000018619

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AGCU01053048

Gene Name

USP44

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000016556.1	ENSPSIT00000018705.1	ENSPSIP00000018619.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.10e-59	200.5	272	577

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...kkkeklneenp............................................ 42
           tGl+NlgNtCYmNS+LQ+Ls++  +re++l+   ++++      +                                            
   Q: 272  TGLRNLGNTCYMNSILQVLSHLLIFRECFLKldlNQTQ------Ellatatsgktrsstkhppitgsafclnenqvklkgsssmrrpsl 354
           7******************************5552222......2233455788888889999************************** PP
   S: 43   ......................kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkk 109
                                 ++++ +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ lld++++el  
   Q: 355  ssglsggasksrnmeliqsrepSSKHISLCHELHTLFQVMWSGKWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKVQQEL-- 441
           ********9999999999999999999************************************************************.. PP
   S: 110  eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke........slqdc 190
                  e+++++  +l   +++k  k+  ++++++F+gql sq++cl+cdn+s++ epf+dlsl++p++ +++ +         l+++
   Q: 442  -------ETTGTRYPALIPTSQRKLIKQVLNVVNTIFHGQLLSQVTCLACDNKSNTIEPFWDLSLEFPERYHCNGKemafqypcLLTEM 523
           .......77888888999999**************************************************9988899*********** PP
   S: 191  Lesftkeeelegenkyycekckkkqe...........aekklklkklPevLilhL 234
           L++ft++e leg+  y c++c+ k++           a+k+l++ +lP+vL lhL
   Q: 524  LAKFTETEALEGKI-YACDQCNTKRRkfsskpiilteAQKQLMVCQLPQVLRLHL 577
           ***********965.*******999999999999999*****************9 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

MDKCKHIGRL RLAQDHSILN PQKWHCVDCN TTESVWACLS CSHVACGRYI EEHALKHFQE 60
SSHPVALEVN ELYVFCYLCD DYVLNDNATG DLKLLRSTLS AIKSQNYDCT TRSGRTLRSM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 60
NNNNNNNNNN NNNNNNGAGC AATGTCTCCA GCCTTCCCCC CTCTAGGTTT CAAGCAGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:1904667--P:negative regulation of ubiquitin protein ligase activity
GO:0016579--P:protein deubiquitination
GO:0090231--P:regulation of spindle checkpoint
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001220	Ailuropoda melanoleuca	77.12	0.00e+00	857.00
IUUC-Apl-003673	Anas platyrhynchos	90.29	0.00e+00	964.00
IUUC-Aca-004434	Anolis carolinensis	86.48	0.00e+00	964.00
IUUC-Bta-012774	Bos taurus	75.69	0.00e+00	858.00
IUUC-Cho-024877	Choloepus hoffmanni	74.11	0.00e+00	670.00
IUUC-Eeu-035225	Erinaceus europaeus	75.56	0.00e+00	841.00
IUUC-Fal-037207	Ficedula albicollis	86.83	0.00e+00	936.00
IUUC-Gga-040457	Gallus gallus	88.91	0.00e+00	923.00
IUUC-Itr-048737	Ictidomys tridecemlineatus	75.78	0.00e+00	846.00
IUUC-Mcc-055694	Macaca mulatta	75.86	0.00e+00	842.00
IUUC-Mga-059523	Meleagris gallopavo	89.25	0.00e+00	952.00
IUUC-Mdo-063018	Monodelphis domestica	86.14	0.00e+00	938.00
IUUC-Mpu-066207	Mustela putorius furo	76.26	0.00e+00	870.00
IUUC-Mlu-066929	Myotis lucifugus	73.83	0.00e+00	828.00
IUUC-Opr-070375	Ochotona princeps	74.68	0.00e+00	780.00
IUUC-Oan-073030	Ornithorhynchus anatinus	86.14	0.00e+00	926.00
IUUC-Oar-089953	Ovis aries	75.56	0.00e+00	866.00
IUUC-Pan-092748	Papio anubis	76.17	0.00e+00	849.00
IUUC-Pva-102984	Pteropus vampyrus	76.08	0.00e+00	885.00
IUUC-Sha-106965	Sarcophilus harrisii	85.96	0.00e+00	938.00
IUUC-Ssc-115299	Sus scrofa	76.43	0.00e+00	869.00
IUUC-Tgu-117160	Taeniopygia guttata	84.75	0.00e+00	938.00
IUUC-Tbe-128084	Tupaia belangeri	71.97	0.00e+00	818.00
IUUC-Ttr-128928	Tursiops truncatus	77.64	0.00e+00	872.00
IUUC-Vpa-130706	Vicugna pacos	77.99	0.00e+00	859.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence