iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-011884

Ensembl Protein ID

ENSAMXP00000006326.1

UniProt Accession

W5KFG5; W5KFG5_ASTMX

Genbank Protein ID

ENSAMXP00000006326

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

APWO01117815

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000006154.1	ENSAMXT00000006326.1	ENSAMXP00000006326.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.00e-86	289.5	323	914
UBD/Alpha-Helix/UIM	9.60e-09	34.5	770	787

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgy 87
           +G++NlgNtCYmN++LQ+L+++p++ ++ll+   + ++++    p ++ll+ +++l+++    + + k+   r++++a++++ae+fsgy
   Q: 323  QGFSNLGNTCYMNAILQSLFSLPSFSNDLLK---QGIPWK--RVPINALLRRFAHLLAKKDisSPEVKKDLLRRVKNAISSTAERFSGY 406
           69*****************************...*****9..56999999999999998867788999999****************** PP
   S: 88   eqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslp 175
           +q+Da+Efl+++ldql+e+++k +++ k+e +  ++ + ++  +e ++ + ++++++ +++++++++i+c++c++v +++e+f+dls++
   Q: 407  MQNDAHEFLSQCLDQLKEDVEKVNKSCKSEPFAWEEPQGTRLtEEPDTSRIYTCPVTVNMEFEVQHTITCKSCGEVVTKREQFNDLSID 495
           ********************884444444444444333333336677788899************************************ PP
   S: 176  vpgkeetkke.slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp 263
           +p++++t ++ s+qd+L+ f++ ee+e    y+cekc++k+ a+ ++k+++lP+vLilhLkR+s++ + + ++k+ ++v +p+ L+l +
   Q: 496  LPRRKKTLPLrSIQDSLDLFFRMEEIE----YSCEKCNGKT-ATVTHKFSRLPRVLILHLKRYSYNAQLSLNSKLGQQVLIPKYLTLLS 579
           **999887645***************9....*********9.9********************************************** PP
   S: 264  fcts..................................................................................... 267
           +ct+                                                                                     
   Q: 580  HCTEntrpplslgwnaqtalsrtlktsqcvnsstlrkgstksentasilcdsdseedltrkvsskhrlsesltdddrveevqqngpveh 668
           ****9999999999999999999999999999999999999999999999888888888888888888888888888888888888888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 669  peftgmnddemlaavlemsrqeagvsgpqddeptsspdtgfgdadaqeltqhldllegdkpsgdvlgsldltmdenkenqtpdgaqgel 757
           88888888888888887777777777777777777777777777777777777777777777777777777766655555555555555 PP
   S: 268  ........peekqke.......................................................................... 274
                   +     +                                                                          
   Q: 758  dwvqqynlD-----Qereeqelqqalaqslqehearemredddlkratelslqefnnslpdllcsdedsgnedtldmeyseaeaeelkr 841
           555555550.....055555566666666666677777777777777777777777888888888888888888888888888889999 PP
   S: 275  .......kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkrr 338
                  +++++Li+vv+H G s+ssGHY+++v++ k++ Wl+++D  V+ ++e++v++++++++Y++fY++r
   Q: 842  nsecgdlPNSFRLISVVSHIGtSSSSGHYISDVYDMKKQsWLTYNDLDVSRTQEATVQRDRDRSGYIFFYMHR 914
           9999999****************************88888******************************985 PP

UBD/Alpha-Helix/UIM

   S: 2    EdeeLqlAlalSlqEeee 19
           E++eLq+Ala+SlqE+e 
   Q: 770  EEQELQQALAQSLQEHEA 787
           9***************96 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

MAVAIPKLSS GSAVRIRITS LDVGTSRWKE GIFEIYERDN KSNLVLKFNS GGTPKKFQQL 60
SHNVKNVGYT QTHSLTRLAL TLKDSSVVTF EKLSIMVAKK LKDYLETIKQ GKQTALKTNQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAATAGAGG AGGAAGTCTC GCGTGACTGG CTCTGCTTCT CGCCTCCCAT TTCCTCTGAG 60
TTTTTGGTTC CCGCCATCAC CGCAGCGCGC CGCATGCCGG CAGCTCTCCG CCTCCGACTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR003903--UIM_dom
IPR032069--USP37-like_PH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF16674--UCH_N
PF02809--UIM

SMART

SM00726--UIM

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001400	Ailuropoda melanoleuca	57.74	0.00e+00	972.00
IUUC-Apl-004033	Anas platyrhynchos	58.98	0.00e+00	992.00
IUUC-Aca-005370	Anolis carolinensis	57.02	0.00e+00	979.00
IUUC-Bta-012725	Bos taurus	58.84	0.00e+00	960.00
IUUC-Cja-019939	Callithrix jacchus	57.72	0.00e+00	955.00
IUUC-Cfa-020835	Canis familiaris	58.54	0.00e+00	983.00
IUUC-Cpo-022067	Cavia porcellus	57.03	0.00e+00	875.00
IUUC-Cre-022867	Chlamydomonas reinhardtii	30.80	5.00e-29	122.00
IUUC-Csa-023085	Chlorocebus sabaeus	58.43	0.00e+00	968.00
IUUC-Cho-024390	Choloepus hoffmanni	54.71	1.00e-68	255.00
IUUC-Cin-025496	Ciona intestinalis	33.78	3.00e-49	189.00
IUUC-Csv-025812	Ciona savignyi	33.15	2.00e-43	170.00
IUUC-Dre-028255	Danio rerio	79.47	0.00e+00	1423.00
IUUC-Dno-028986	Dasypus novemcinctus	57.11	0.00e+00	956.00
IUUC-Dor-031062	Dipodomys ordii	47.27	3.00e-140	492.00
IUUC-Ete-032359	Echinops telfairi	52.53	3.00e-132	466.00
IUUC-Eca-033964	Equus caballus	58.00	0.00e+00	961.00
IUUC-Eeu-034492	Erinaceus europaeus	57.09	5.00e-134	472.00
IUUC-Fca-036359	Felis catus	57.94	0.00e+00	967.00
IUUC-Fal-037640	Ficedula albicollis	59.39	0.00e+00	965.00
IUUC-Gmo-039600	Gadus morhua	71.88	0.00e+00	1254.00
IUUC-Gga-040126	Gallus gallus	58.38	0.00e+00	938.00
IUUC-Gac-041557	Gasterosteus aculeatus	71.72	0.00e+00	1250.00
IUUC-Ggo-045571	Gorilla gorilla	55.07	0.00e+00	854.00
IUUC-Hsa-046043	Homo sapiens	57.54	0.00e+00	962.00
IUUC-Itr-048207	Ictidomys tridecemlineatus	57.63	0.00e+00	959.00
IUUC-Lch-050357	Latimeria chalumnae	56.22	0.00e+00	834.00
IUUC-Loc-052849	Lepisosteus oculatus	73.24	0.00e+00	1244.00
IUUC-Laf-054570	Loxodonta africana	57.70	0.00e+00	945.00
IUUC-Mcc-054989	Macaca mulatta	57.03	0.00e+00	881.00
IUUC-Meu-056273	Macropus eugenii	49.02	2.00e-47	184.00
IUUC-Mga-059814	Meleagris gallopavo	57.06	0.00e+00	943.00
IUUC-Mmr-061726	Microcebus murinus	58.03	0.00e+00	969.00
IUUC-Mdo-062974	Monodelphis domestica	58.66	0.00e+00	992.00
IUUC-Mmu-064069	Mus musculus	57.10	0.00e+00	938.00
IUUC-Mpu-066008	Mustela putorius furo	57.33	0.00e+00	960.00
IUUC-Mlu-068224	Myotis lucifugus	34.92	4.00e-117	416.00
IUUC-Nle-069259	Nomascus leucogenys	57.81	0.00e+00	958.00
IUUC-Opr-070882	Ochotona princeps	75.57	5.00e-92	332.00
IUUC-Ont-072441	Oreochromis niloticus	73.99	0.00e+00	1297.00
IUUC-Oan-073151	Ornithorhynchus anatinus	67.61	2.00e-93	335.00
IUUC-Ocu-074879	Oryctolagus cuniculus	57.39	0.00e+00	952.00
IUUC-Ola-087007	Oryzias latipes	69.39	0.00e+00	1166.00
IUUC-Oga-088385	Otolemur garnettii	57.92	0.00e+00	969.00
IUUC-Oar-090305	Ovis aries	58.95	0.00e+00	975.00
IUUC-Ptr-091299	Pan troglodytes	57.55	0.00e+00	960.00
IUUC-Pan-091996	Papio anubis	58.47	0.00e+00	951.00
IUUC-Psi-093176	Pelodiscus sinensis	59.01	0.00e+00	981.00
IUUC-Pma-094331	Petromyzon marinus	46.55	0.00e+00	713.00
IUUC-Ppa-095732	Physcomitrella patens	29.92	2.00e-24	107.00
IUUC-Pfo-096503	Poecilia formosa	70.70	0.00e+00	1200.00
IUUC-Pab-098543	Pongo abelii	61.54	1.00e-163	570.00
IUUC-Pca-101099	Procavia capensis	56.42	0.00e+00	778.00
IUUC-Pva-103163	Pteropus vampyrus	56.12	0.00e+00	648.00
IUUC-Rno-105766	Rattus norvegicus	57.13	0.00e+00	940.00
IUUC-Sha-106610	Sarcophilus harrisii	55.37	0.00e+00	897.00
IUUC-Sar-113624	Sorex araneus	46.01	3.00e-56	213.00
IUUC-Ssc-116353	Sus scrofa	57.66	0.00e+00	945.00
IUUC-Tgu-116971	Taeniopygia guttata	59.59	0.00e+00	950.00
IUUC-Tru-117932	Takifugu rubripes	51.79	0.00e+00	808.00
IUUC-Tsy-119185	Tarsius syrichta	54.25	0.00e+00	656.00
IUUC-Tni-119842	Tetraodon nigroviridis	69.44	5.00e-132	464.00
IUUC-Tbe-127281	Tupaia belangeri	44.24	3.00e-83	303.00
IUUC-Ttr-128177	Tursiops truncatus	63.21	0.00e+00	829.00
IUUC-Vpa-130031	Vicugna pacos	58.76	0.00e+00	976.00
IUUC-Xtr-132949	Xenopus tropicalis	56.75	0.00e+00	936.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence