iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-005223

UUCD1 version

UUC-AnC-00758

Ensembl Protein ID

ENSACAP00000012981.3

UniProt Accession

G1KNF1; G1KNF1_ANOCA

Protein Name

Uncharacterized protein

Gene Name

HERC3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000012970.3	ENSACAT00000013240.3	ENSACAP00000012981.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.90e-95	320.0	785	1108

Active Site

Position(s)	Description	Evidence
1077	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           dlkk l+v f gEe++d+gGvt+ef+ ll+kel np +g+f++ ++++  ++ +         + ++F+++G+++g+a+++  ++dl
   Q: 785  DLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTFYSESNLLWFSDTCFV-----EHNWFHLIGIICGLAIYNFTVVDL 866
           899*******************************************999999777554.....579********************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll++   ledl+e+ p   +sl++++++  +d+ee+ ++l f++  e++g t+++ L+p+G++i V ++N++e+v+++
   Q: 867  HFPLALYKKLLNVAPCLEDLKELSPMEGRSLQQLLDYPGEDVEET-FCLYFTICRESYGVTEQKSLIPDGDKIAVQKDNRQEFVDAY 952
           *************************************99999997.***************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y+++ +i+e ++af++Gf +v+  ++l+lF++ el+ +i G++++++++l++ t+ykg+y++++p++q+Fwe+++ef  e++k+f
   Q: 953  VNYIFNISIHEWYTAFSSGFLKVCGGKVLELFQPTELRAMIVGSSNYNWKELEESTTYKGDYSATHPTVQMFWEIFHEFPLEKKKKF 1039
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G+ +l+   +vi+  ++ ++ lP ++TC+n+L+LP+Ys+keil  +L+ Ai++ +gF+l
   Q: 1040 LLFLTGSDRIPIYGMSSLR---IVIQStSSGEEYLPVAHTCYNLLDLPKYSNKEILSTRLMQAIDNYEGFSL 1108
           *******************...8888867788**************************************97 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MEPWKVKWCQ TALKLRCRCN PCCRRSQGQT LYEQIFGRNS STGGKRQENK LDDFLKGKKM 60
LCWGYWSFGY PGTSSTVQPI ILEPRTSGFI HERSVKEVAC GGNHSIFLLE DGEVYTCGVN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGCCGT GGAAGGTAAA GTGGTGCCAA ACTGCATTAA AGCTACGGTG TAGATGCAAC 60
CCGTGCTGCA GAAGAAGTCA AGGGCAAACC CTTTATGAAC AAATCTTTGG GCGCAACTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001673	Ailuropoda melanoleuca	85.52	0.00e+00	1843.00
IUUC-Apl-003535	Anas platyrhynchos	89.14	0.00e+00	1900.00
IUUC-Ame-010816	Astyanax mexicanus	66.14	0.00e+00	1170.00
IUUC-Bta-013373	Bos taurus	85.43	0.00e+00	1841.00
IUUC-Cja-019609	Callithrix jacchus	85.43	0.00e+00	1837.00
IUUC-Cfa-021071	Canis familiaris	85.52	0.00e+00	1835.00
IUUC-Cpo-021548	Cavia porcellus	84.76	0.00e+00	1823.00
IUUC-Csa-023987	Chlorocebus sabaeus	85.71	0.00e+00	1839.00
IUUC-Cho-024325	Choloepus hoffmanni	87.26	0.00e+00	1079.00
IUUC-Dre-027472	Danio rerio	66.25	0.00e+00	1406.00
IUUC-Dno-029241	Dasypus novemcinctus	84.79	0.00e+00	1822.00
IUUC-Dor-030672	Dipodomys ordii	77.12	0.00e+00	965.00
IUUC-Ete-032642	Echinops telfairi	81.33	0.00e+00	1687.00
IUUC-Eca-033646	Equus caballus	85.43	0.00e+00	1838.00
IUUC-Eeu-035098	Erinaceus europaeus	73.81	0.00e+00	1202.00
IUUC-Fal-036952	Ficedula albicollis	88.86	0.00e+00	1893.00
IUUC-Gmo-039297	Gadus morhua	64.99	0.00e+00	1335.00
IUUC-Gga-040591	Gallus gallus	88.20	0.00e+00	1880.00
IUUC-Gac-041741	Gasterosteus aculeatus	64.52	0.00e+00	1375.00
IUUC-Ggo-044769	Gorilla gorilla	85.44	0.00e+00	1830.00
IUUC-Hsa-046066	Homo sapiens	85.52	0.00e+00	1833.00
IUUC-Itr-048311	Ictidomys tridecemlineatus	85.25	0.00e+00	1828.00
IUUC-Lch-050301	Latimeria chalumnae	72.57	0.00e+00	1596.00
IUUC-Loc-052803	Lepisosteus oculatus	67.56	0.00e+00	1456.00
IUUC-Laf-053364	Loxodonta africana	85.43	0.00e+00	1833.00
IUUC-Mcc-054930	Macaca mulatta	85.62	0.00e+00	1838.00
IUUC-Meu-056274	Macropus eugenii	73.39	0.00e+00	808.00
IUUC-Mga-059563	Meleagris gallopavo	88.86	0.00e+00	1895.00
IUUC-Mmr-060792	Microcebus murinus	84.48	0.00e+00	1796.00
IUUC-Mdo-062195	Monodelphis domestica	87.63	0.00e+00	1873.00
IUUC-Mmu-063855	Mus musculus	84.67	0.00e+00	1821.00
IUUC-Mpu-066308	Mustela putorius furo	85.71	0.00e+00	1842.00
IUUC-Mlu-066927	Myotis lucifugus	85.33	0.00e+00	1834.00
IUUC-Nle-070090	Nomascus leucogenys	85.62	0.00e+00	1837.00
IUUC-Opr-070891	Ochotona princeps	74.57	0.00e+00	1547.00
IUUC-Ont-072201	Oreochromis niloticus	63.89	0.00e+00	1341.00
IUUC-Ocu-074770	Oryctolagus cuniculus	85.33	0.00e+00	1839.00
IUUC-Ola-086550	Oryzias latipes	64.27	0.00e+00	1385.00
IUUC-Olu-087836	Ostreococcus lucimarinus	33.84	2.00e-42	165.00
IUUC-Oga-088831	Otolemur garnettii	85.43	0.00e+00	1832.00
IUUC-Oar-090449	Ovis aries	85.71	0.00e+00	1838.00
IUUC-Pan-092135	Papio anubis	85.63	0.00e+00	1834.00
IUUC-Psi-093832	Pelodiscus sinensis	85.82	0.00e+00	1867.00
IUUC-Pfo-097268	Poecilia formosa	64.80	0.00e+00	1379.00
IUUC-Pab-098249	Pongo abelii	85.24	0.00e+00	1828.00
IUUC-Pca-100855	Procavia capensis	80.33	0.00e+00	1241.00
IUUC-Pva-102506	Pteropus vampyrus	77.74	0.00e+00	1602.00
IUUC-Rno-105242	Rattus norvegicus	84.76	0.00e+00	1861.00
IUUC-Sha-107186	Sarcophilus harrisii	83.78	0.00e+00	1132.00
IUUC-Sar-113612	Sorex araneus	86.70	0.00e+00	676.00
IUUC-Ssc-115473	Sus scrofa	84.57	0.00e+00	1821.00
IUUC-Tgu-116974	Taeniopygia guttata	88.87	0.00e+00	1866.00
IUUC-Tru-118077	Takifugu rubripes	63.93	0.00e+00	1324.00
IUUC-Tsy-119619	Tarsius syrichta	75.24	0.00e+00	1623.00
IUUC-Tni-120807	Tetraodon nigroviridis	64.21	0.00e+00	1352.00
IUUC-Tbe-127640	Tupaia belangeri	82.19	0.00e+00	1716.00
IUUC-Ttr-129172	Tursiops truncatus	84.76	0.00e+00	1819.00
IUUC-Vpa-130442	Vicugna pacos	71.47	0.00e+00	1482.00
IUUC-Xtr-132194	Xenopus tropicalis	69.14	0.00e+00	1377.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence