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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046015
UUCD1 version UUC-HoS-01245
Ensembl Protein ID ENSP00000483236.1
UniProt Accession P61962; B4E039; D3DU14; O15491; Q9DAE4; DCAF7_HUMAN
Genbank Protein ID AAC18913.1; BAG64301.1; EAW94305.1; EAW94306.1; AAH01264.1
Protein Name DDB1- and CUL4-associated factor 7; WD repeat-containing protein 68; WD repeat-containing protein An11 homolog
Genbank Nucleotide ID U94747; AK303212; AC113554; CH471109; BC001264
Gene Name DCAF7; HAN11; WDR68
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000136485.14 ENST00000614556.4 ENSP00000483236.1
ENSG00000136485.14 ENST00000415273.2 ENSP00000403920.2
ENSG00000136485.14 ENST00000615512.1 ENSP00000480250.1
Annotation
Cancer Mutation
TCGAICGCCGAPIntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
THPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDBioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 17588513
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 9.20e-17 62.1 265 296
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf...sdtllvsGsdDgtikvWDl 30
           H + v+++a+   s++++++++dD++  +WD+
   Q: 265  HRACVNGIAWaphSSCHICTAADDHQALIWDI 296
           9999*******8644****************6 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
 Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Protein Sequence
(Fasta)
MSLHGKRKEI YKYEAPWTVY AMNWSVRPDK RFRLALGSFV EEYNNKVQLV GLDEESSEFI 60
CRNTFDHPYP TTKLMWIPDT KGVYPDLLAT SGDYLRVWRV GETETRLECL LNNNKNSDFC 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046015|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAAACGGAAG GTGGTTGTCG TCCGTTCCCA AGCTGGTTTG AAACTAGGGG TCGGGCTCGG 60
CCGTCGTCGT TGTTTGTCGC CGCATCCCCG CTTCCGGGTT AGGCCGTTCC TGCCCGCCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046015|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0016363--C:nuclear matrix
GO:0005654--C:nucleoplasm
GO:0043234--C:protein complex
GO:0007275--P:multicellular organism development
GO:0016567--P:protein ubiquitination
KEGG hsa:10238
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000420 Aegilops tauschii 46.36 1.00e-24 104.00
IUUC-Aml-002310 Ailuropoda melanoleuca 99.66 2.00e-179 621.00
IUUC-Atr-002576 Amborella trichopoda 59.48 8.00e-117 413.00
IUUC-Apl-003746 Anas platyrhynchos 99.66 2.00e-179 621.00
IUUC-Aca-005293 Anolis carolinensis 99.71 0.00e+00 717.00
IUUC-Aly-006500 Arabidopsis lyrata 58.84 9.00e-115 406.00
IUUC-Ath-006739 Arabidopsis thaliana 58.55 3.00e-114 404.00
IUUC-Ago-007732 Ashbya gossypii 32.84 3.00e-44 172.00
IUUC-Acl-008299 Aspergillus clavatus 33.82 5.00e-42 166.00
IUUC-Afl-008470 Aspergillus flavus 32.60 7.00e-39 155.00
IUUC-Afu-008896 Aspergillus fumigatus 35.40 4.00e-39 156.00
IUUC-Ani-009375 Aspergillus nidulans 33.09 4.00e-39 156.00
IUUC-Ang-009687 Aspergillus niger 33.01 4.00e-43 169.00
IUUC-Aor-010198 Aspergillus oryzae 32.20 2.00e-38 154.00
IUUC-Ate-010363 Aspergillus terreus 33.50 8.00e-36 145.00
IUUC-Ame-010643 Astyanax mexicanus 85.96 5.00e-175 606.00
IUUC-Bgr-012055 Blumeria graminis 35.14 2.00e-46 181.00
IUUC-Bta-013199 Bos taurus 100.00 0.00e+00 718.00
IUUC-Bci-013840 Botrytis cinerea 34.61 3.00e-43 170.00
IUUC-Bdi-014374 Brachypodium distachyon 50.12 2.00e-105 375.00
IUUC-Bol-015620 Brassica oleracea 51.62 2.00e-85 309.00
IUUC-Bra-017922 Brassica rapa 57.97 7.00e-113 400.00
IUUC-Cel-018487 Caenorhabditis elegans 62.97 1.00e-135 476.00
IUUC-Cja-018736 Callithrix jacchus 100.00 0.00e+00 718.00
IUUC-Cfa-020446 Canis familiaris 100.00 0.00e+00 718.00
IUUC-Cpo-022424 Cavia porcellus 100.00 0.00e+00 718.00
IUUC-Cre-022609 Chlamydomonas reinhardtii 57.30 3.00e-108 384.00
IUUC-Csa-024013 Chlorocebus sabaeus 99.67 0.00e+00 640.00
IUUC-Cho-024507 Choloepus hoffmanni 98.99 9.00e-176 608.00
IUUC-Cin-025620 Ciona intestinalis 88.76 0.00e+00 643.00
IUUC-Csv-026111 Ciona savignyi 88.17 0.00e+00 640.00
IUUC-Cgl-026588 Colletotrichum gloeosporioides 34.99 4.00e-46 179.00
IUUC-Cne-026871 Cryptococcus neoformans 31.10 2.00e-38 153.00
IUUC-Cme-027345 Cyanidioschyzon merolae 36.21 4.00e-57 215.00
IUUC-Dre-027940 Danio rerio 97.95 0.00e+00 708.00
IUUC-Dno-029520 Dasypus novemcinctus 100.00 0.00e+00 718.00
IUUC-Dor-030262 Dipodomys ordii 100.00 2.00e-56 212.00
IUUC-Dse-031207 Dothistroma septosporum 34.63 3.00e-38 153.00
IUUC-Dme-031639 Drosophila melanogaster 85.67 6.00e-179 619.00
IUUC-Ete-032605 Echinops telfairi 83.14 7.00e-158 549.00
IUUC-Eca-033668 Equus caballus 91.55 0.00e+00 645.00
IUUC-Fca-035942 Felis catus 100.00 0.00e+00 718.00
IUUC-Fal-037544 Ficedula albicollis 100.00 0.00e+00 718.00
IUUC-Fox-037852 Fusarium oxysporum 37.04 7.00e-49 188.00
IUUC-Fso-038173 Fusarium solani 35.78 3.00e-46 179.00
IUUC-Gmo-038850 Gadus morhua 98.25 0.00e+00 708.00
IUUC-Ggr-040072 Gaeumannomyces graminis 36.22 1.00e-44 174.00
IUUC-Gga-040439 Gallus gallus 100.00 0.00e+00 718.00
IUUC-Gac-041776 Gasterosteus aculeatus 97.66 0.00e+00 706.00
IUUC-Gma-043558 Glycine max 58.89 1.00e-115 409.00
IUUC-Ggo-044490 Gorilla gorilla 100.00 0.00e+00 718.00
IUUC-Hvu-047667 Hordeum vulgare 49.38 6.00e-105 374.00
IUUC-Itr-048428 Ictidomys tridecemlineatus 100.00 0.00e+00 718.00
IUUC-Kpa-049347 Komagataella pastoris 32.06 3.00e-46 179.00
IUUC-Lch-049754 Latimeria chalumnae 99.12 0.00e+00 711.00
IUUC-Lpe-050741 Leersia perrieri 50.50 1.00e-106 379.00
IUUC-Loc-052351 Lepisosteus oculatus 96.51 0.00e+00 693.00
IUUC-Lma-053005 Leptosphaeria maculans 36.36 2.00e-41 164.00
IUUC-Laf-054077 Loxodonta africana 100.00 0.00e+00 718.00
IUUC-Mcc-055728 Macaca mulatta 100.00 0.00e+00 718.00
IUUC-Meu-056685 Macropus eugenii 85.89 4.00e-161 560.00
IUUC-Mor-057075 Magnaporthe oryzae 35.12 6.00e-45 175.00
IUUC-Mpo-057336 Magnaporthe poae 35.38 3.00e-44 172.00
IUUC-Mtr-057654 Medicago truncatula 56.98 7.00e-113 400.00
IUUC-Mla-058866 Melampsora laricipopulina 32.01 1.00e-49 190.00
IUUC-Mga-059566 Meleagris gallopavo 99.66 2.00e-179 621.00
IUUC-Mvi-060379 Microbotryum violaceum 42.79 2.00e-36 147.00
IUUC-Mmr-060831 Microcebus murinus 100.00 0.00e+00 718.00
IUUC-Mdo-062612 Monodelphis domestica 100.00 0.00e+00 718.00
IUUC-Mmu-063399 Mus musculus 100.00 0.00e+00 718.00
IUUC-Mac-065226 Musa acuminata 51.82 8.00e-97 347.00
IUUC-Mpu-065951 Mustela putorius furo 100.00 0.00e+00 718.00
IUUC-Mlu-067858 Myotis lucifugus 99.42 0.00e+00 712.00
IUUC-Nfi-068302 Neosartorya fischeri 34.07 1.00e-40 161.00
IUUC-Ncr-068642 Neurospora crassa 35.48 5.00e-47 182.00
IUUC-Nle-070059 Nomascus leucogenys 100.00 0.00e+00 718.00
IUUC-Opr-070572 Ochotona princeps 99.42 0.00e+00 709.00
IUUC-Ont-071420 Oreochromis niloticus 91.23 0.00e+00 668.00
IUUC-Ocu-074105 Oryctolagus cuniculus 100.00 0.00e+00 718.00
IUUC-Oba-075409 Oryza barthii 51.01 2.00e-107 382.00
IUUC-Obr-076284 Oryza brachyantha 48.46 1.00e-89 323.00
IUUC-Ogl-076984 Oryza glaberrima 51.01 2.00e-107 382.00
IUUC-Ogu-078283 Oryza glumaepatula 51.01 3.00e-107 382.00
IUUC-Oin-080194 Oryza indica 44.89 3.00e-75 275.00
IUUC-Olo-080234 Oryza longistaminata 44.32 1.00e-74 273.00
IUUC-Ome-081174 Oryza meridionalis 51.01 3.00e-107 382.00
IUUC-Oni-082033 Oryza nivara 51.01 2.00e-107 382.00
IUUC-Opu-084034 Oryza punctata 51.02 8.00e-107 380.00
IUUC-Oru-084908 Oryza rufipogon 50.14 2.00e-94 340.00
IUUC-Osa-085678 Oryza sativa 51.01 2.00e-107 382.00
IUUC-Ola-086324 Oryzias latipes 97.95 0.00e+00 708.00
IUUC-Olu-087620 Ostreococcus lucimarinus 61.05 7.00e-116 410.00
IUUC-Oga-088446 Otolemur garnettii 100.00 0.00e+00 718.00
IUUC-Oar-090168 Ovis aries 100.00 0.00e+00 718.00
IUUC-Ptr-090691 Pan troglodytes 99.71 0.00e+00 711.00
IUUC-Pan-092772 Papio anubis 100.00 0.00e+00 718.00
IUUC-Psi-093304 Pelodiscus sinensis 100.00 1.00e-161 561.00
IUUC-Pma-094292 Petromyzon marinus 94.93 8.00e-173 599.00
IUUC-Pno-094967 Phaeosphaeria nodorum 34.82 3.00e-41 163.00
IUUC-Ppa-095734 Physcomitrella patens 60.23 3.00e-121 428.00
IUUC-Pfo-097157 Poecilia formosa 97.95 0.00e+00 708.00
IUUC-Pab-097898 Pongo abelii 99.67 0.00e+00 638.00
IUUC-Pop-099943 Populus trichocarpa 59.13 1.00e-115 409.00
IUUC-Pca-100404 Procavia capensis 99.42 0.00e+00 709.00
IUUC-Ppe-102015 Prunus persica 57.22 4.00e-113 401.00
IUUC-Pva-102938 Pteropus vampyrus 71.93 4.00e-131 461.00
IUUC-Pgr-103490 Puccinia graminis 33.33 1.00e-54 207.00
IUUC-Ptt-103946 Puccinia triticina 36.94 2.00e-53 203.00
IUUC-Pte-104094 Pyrenophora teres 36.65 5.00e-41 162.00
IUUC-Pyt-104726 Pyrenophora triticirepentis 36.93 5.00e-41 162.00
IUUC-Rno-104961 Rattus norvegicus 100.00 0.00e+00 718.00
IUUC-Sce-106252 Saccharomyces cerevisiae 36.20 4.00e-48 185.00
IUUC-Sha-107196 Sarcophilus harrisii 63.79 3.00e-132 464.00
IUUC-Sja-107768 Schizosaccharomyces japonicus 37.46 3.00e-48 186.00
IUUC-Spo-108014 Schizosaccharomyces pombe 35.22 2.00e-54 206.00
IUUC-Ssl-108466 Sclerotinia sclerotiorum 34.95 9.00e-44 171.00
IUUC-Smo-109596 Selaginella moellendorffii 62.79 6.00e-117 413.00
IUUC-Sit-110625 Setaria italica 48.73 3.00e-74 271.00
IUUC-Sly-111410 Solanum lycopersicum 58.84 1.00e-116 412.00
IUUC-Stu-112854 Solanum tuberosum 59.13 9.00e-117 413.00
IUUC-Sar-113705 Sorex araneus 88.30 1.00e-170 592.00
IUUC-Sbi-114474 Sorghum bicolor 50.25 6.00e-104 370.00
IUUC-Sre-114968 Sporisorium reilianum 34.70 1.00e-45 178.00
IUUC-Ssc-116028 Sus scrofa 100.00 0.00e+00 718.00
IUUC-Tgu-117189 Taeniopygia guttata 100.00 0.00e+00 718.00
IUUC-Tru-117581 Takifugu rubripes 97.66 0.00e+00 707.00
IUUC-Tsy-119425 Tarsius syrichta 79.73 3.00e-133 468.00
IUUC-Tni-120649 Tetraodon nigroviridis 97.37 0.00e+00 701.00
IUUC-Tca-121561 Theobroma cacao 58.55 3.00e-115 408.00
IUUC-Tre-121987 Trichoderma reesei 38.03 3.00e-48 186.00
IUUC-Tvi-122586 Trichoderma virens 38.03 7.00e-49 188.00
IUUC-Tae-125627 Triticum aestivum 49.38 1.00e-104 373.00
IUUC-Tur-126531 Triticum urartu 50.77 3.00e-107 382.00
IUUC-Tme-126973 Tuber melanosporum 36.02 5.00e-41 162.00
IUUC-Tbe-127919 Tupaia belangeri 99.42 0.00e+00 709.00
IUUC-Ttr-129135 Tursiops truncatus 80.35 5.00e-130 456.00
IUUC-Uma-129362 Ustilago maydis 35.58 7.00e-50 192.00
IUUC-Vda-130025 Verticillium dahliae 36.34 2.00e-44 173.00
IUUC-Vpa-130486 Vicugna pacos 63.85 6.00e-99 353.00
IUUC-Vvi-131265 Vitis vinifera 58.31 1.00e-114 406.00
IUUC-Xtr-132175 Xenopus tropicalis 99.71 0.00e+00 715.00
IUUC-Xma-134129 Xiphophorus maculatus 97.95 0.00e+00 708.00
IUUC-Yli-134419 Yarrowia lipolytica 39.88 5.00e-60 224.00
IUUC-Zma-135092 Zea mays 49.88 3.00e-104 372.00
Created Date 25-Jun-2017

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