iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-063297

UUCD1 version

UUC-MuM-01091

Ensembl Protein ID

ENSMUSP00000022296.6

UniProt Accession

P52482; UB2E1_MOUSE

Genbank Protein ID

CAA63353.1; AAH03781.1

Protein Name

Ubiquitin-conjugating enzyme E2 E1; (E3-independent) E2 ubiquitin-conjugating enzyme E1; E2 ubiquitin-conjugating enzyme E1; UbcM3; Ubiquitin carrier protein E1; Ubiquitin-protein ligase E1

Genbank Nucleotide ID

X92665; BC003781

Gene Name

Ube2e1; Ubce5; Ubcm3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000021774.12	ENSMUST00000022296.6	ENSMUSP00000022296.6

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	8.20e-50	169.3	51	186

Active Site

Position(s)	Description	Evidence
131	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkee 89
           R++kel++++ dpp+++sa+p+ + +++ew+ +ilGp++++YeggvF l+i+f+++YPfkPPkv+f t+i+h+n++++G +Cl+ilk  
   Q: 51   RIQKELADITLDPPPNCSAGPKGD-NIYEWRSTILGPPGSVYEGGVFFLDITFTPEYPFKPPKVTFRTRIYHCNINSQGVICLDILK-- 136
           9***********************.9************************************************************9.. PP
   S: 90   ekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvre 139
           ++Wspal++++vllsi+sll+++np++pl  ++a+++ +nr+e+++++r+
   Q: 137  DNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYMTNRAEHDRMARQ 186
           *********************************************99985 PP

Organism

Mus musculus

Functional Description
(View)

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination.

Protein Sequence
(Fasta)

MSDDDSRAST SSSSSSSSNQ QTEKEGSTPK KKESKVSMSK NSKLLSTSAK RIQKELADIT 60
LDPPPNCSAG PKGDNIYEWR STILGPPGSV YEGGVFFLDI TFTPEYPFKP PKVTFRTRIY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGGAGGAGT GGCGCGGAGC GTGTGCGGCC GGGGAAGCCA TTGCCTGGTT AATAGTTGCT 60
GTTGCTGCAC TTCCGCTTCT CTCCCAGTGA GAGCGAGACA CGAGTGGCCA GGCCCAGTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0005524--F:ATP binding
GO:0042296--F:ISG15 transferase activity
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0033523--P:histone H2B ubiquitination
GO:0010390--P:histone monoubiquitination
GO:0032020--P:ISG15-protein conjugation
GO:0070936--P:protein K48-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination

KEGG

mmu:22194

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001532	Ailuropoda melanoleuca	98.86	9.00e-94	335.00
IUUC-Apl-004207	Anas platyrhynchos	99.43	5.00e-93	333.00
IUUC-Aca-005103	Anolis carolinensis	99.43	3.00e-93	333.00
IUUC-Cja-019311	Callithrix jacchus	98.86	1.00e-93	335.00
IUUC-Cfa-020017	Canis familiaris	98.86	1.00e-93	335.00
IUUC-Cpo-022266	Cavia porcellus	98.86	1.00e-93	335.00
IUUC-Csa-023538	Chlorocebus sabaeus	98.86	1.00e-93	335.00
IUUC-Cin-025161	Ciona intestinalis	84.38	2.00e-75	275.00
IUUC-Csv-025982	Ciona savignyi	84.38	3.00e-82	296.00
IUUC-Dno-029441	Dasypus novemcinctus	100.00	5.00e-75	272.00
IUUC-Dor-030450	Dipodomys ordii	100.00	5.00e-64	235.00
IUUC-Ete-032397	Echinops telfairi	97.14	9.00e-100	355.00
IUUC-Eca-033613	Equus caballus	100.00	2.00e-85	308.00
IUUC-Fca-035467	Felis catus	100.00	8.00e-94	335.00
IUUC-Fal-036907	Ficedula albicollis	99.43	3.00e-93	333.00
IUUC-Gga-040403	Gallus gallus	99.43	3.00e-93	333.00
IUUC-Ggo-045507	Gorilla gorilla	98.86	1.00e-93	335.00
IUUC-Hsa-046576	Homo sapiens	98.86	1.00e-93	335.00
IUUC-Itr-048197	Ictidomys tridecemlineatus	100.00	5.00e-75	272.00
IUUC-Lch-050322	Latimeria chalumnae	96.57	2.00e-99	354.00
IUUC-Laf-054313	Loxodonta africana	98.86	1.00e-93	335.00
IUUC-Meu-056590	Macropus eugenii	100.00	7.00e-85	305.00
IUUC-Mmr-060791	Microcebus murinus	98.86	1.00e-93	335.00
IUUC-Mpu-065698	Mustela putorius furo	98.86	7.00e-103	365.00
IUUC-Nle-069622	Nomascus leucogenys	98.86	1.00e-93	335.00
IUUC-Ont-072384	Oreochromis niloticus	90.29	5.00e-94	336.00
IUUC-Oan-073006	Ornithorhynchus anatinus	100.00	6.00e-75	272.00
IUUC-Ocu-074055	Oryctolagus cuniculus	98.86	1.00e-93	335.00
IUUC-Ola-086636	Oryzias latipes	92.94	2.00e-83	301.00
IUUC-Oga-088863	Otolemur garnettii	98.86	1.00e-93	335.00
IUUC-Oar-089803	Ovis aries	98.86	7.00e-103	365.00
IUUC-Ptr-090914	Pan troglodytes	98.86	1.00e-93	335.00
IUUC-Pan-092786	Papio anubis	98.86	1.00e-93	335.00
IUUC-Psi-093923	Pelodiscus sinensis	98.86	1.00e-93	335.00
IUUC-Pma-094642	Petromyzon marinus	95.24	6.00e-71	258.00
IUUC-Pfo-096966	Poecilia formosa	91.23	7.00e-83	299.00
IUUC-Pab-098614	Pongo abelii	98.86	1.00e-93	335.00
IUUC-Rno-105518	Rattus norvegicus	99.42	8.00e-102	362.00
IUUC-Sha-106897	Sarcophilus harrisii	100.00	1.00e-85	307.00
IUUC-Ssc-115844	Sus scrofa	86.71	6.00e-86	310.00
IUUC-Tgu-116958	Taeniopygia guttata	100.00	4.00e-89	320.00
IUUC-Tni-120349	Tetraodon nigroviridis	94.51	7.00e-82	296.00
IUUC-Tbe-127659	Tupaia belangeri	88.00	2.00e-80	291.00
IUUC-Ttr-128356	Tursiops truncatus	95.43	1.00e-88	318.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence