iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033985

UUCD1 version

UUC-EqC-01072

Ensembl Protein ID

ENSECAP00000017631.1

UniProt Accession

F7BTR4; F7BTR4_HORSE

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Gene Name

PAN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000019814.1	ENSECAT00000021410.1	ENSECAP00000017631.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.30e-21	76.5	525	907

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 9    tCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs............ 85
             Y+N+++Q+L++++++r+l+ +   + +++      + +l+++l  lf+ l  s+    + +++l+a++++ e               
   Q: 525  NAYCNCMIQVLYFLEPVRCLIQN---HLCQK------EFCLACELGFLFHMLDLSRGDPCQGSNFLRAFRTIPEASAlgliladsdeas 604
           56*********************...55654......57*************9****************99999866777777776666 PP
   S: 86   ..gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
             g+     q   +f+l ql++++++        +e  +  +      ++  ++++s+i +lF  ++++   c +c+++++r ++ l +
   Q: 605  gkGNLARLIQRWNRFILTQLHQDMQE--------LEVPQ--AYRGAGGSSFCSSGDSVIGQLFSCEMENCSLC-RCGSETVRASSTLLF 682
           66666666777888888888888833........22222..3344467899*****************99999.8************** PP
   S: 173  slpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdl 261
           +l+ p++++ k+ ++ ++L+     e+ +   + +c++c+k+q + ++  +++lP++L+++    s +e+   r  ++ +v f+  ++ 
   Q: 683  TLSYPEDKTGKNCDFAQVLKRSICLEQNT---QAWCDNCEKYQPTIQTRNIRHLPDILVINCEVNSLKEADFWR--VQAEVAFKMAIKK 766
           *******************9888766665...69*******************************998887776..6777777644555 PP
   S: 262  spfcts..........................................peekqke..........................kkkYeLia 282
           +   +s                                          +     +                           + Y+L+a
   Q: 767  RGGEISknkefaladwkelgspegmlmcpsieelknvwlpfsirmkmtK-----NkgldvcnwtdgdemqwgparaeeehgVYVYDLMA 850
           4322222344555555555666666666555555555555555555550.....0555555555555555555555555669******* PP
   S: 283  vvvHsG.slssGHYvayvkn...........ekgkWllfdDskVtevkeeevleetg 327
            vvH   s  +G  va++k            ++++W+lf+D  +++++++e +++  
   Q: 851  TVVHILdSRTGGSLVAHIKVgetyhqrkegvTHQQWYLFNDFLIEPIDKHEAVQFDM 907
           ******9*************999988877777888************9999888654 PP

Organism

Equus caballus

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.

Protein Sequence
(Fasta)

MNFEGLDPGL AEYAPAMHSA LDPVLDAHLN PSLLQNVELD PEGVALEALP VQESVHIMEG 60
VYSELHSVVA EVGVPVSVSH FDLHEEMLWV GSHGGHATSF FGPALERYSS FQVNGSDDIR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAACTTTG AGGGTCTGGA CCCTGGACTA GCAGAGTATG CCCCGGCCAT GCATTCTGCC 60
TTGGACCCTG TCCTGGATGC CCACCTGAAC CCAAGTCTAC TACAGAATGT GGAGCTGGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening
GO:0010606--P:positive regulation of cytoplasmic mRNA processing body assembly

KEGG

ecb:100052396

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	98.75	0.00e+00	2360.00
IUUC-Apl-003500	Anas platyrhynchos	86.21	0.00e+00	1891.00
IUUC-Aca-004930	Anolis carolinensis	84.33	0.00e+00	2019.00
IUUC-Acl-008214	Aspergillus clavatus	31.42	3.00e-157	549.00
IUUC-Afu-009112	Aspergillus fumigatus	31.43	2.00e-147	516.00
IUUC-Ang-009531	Aspergillus niger	31.01	1.00e-149	524.00
IUUC-Ame-011259	Astyanax mexicanus	76.43	0.00e+00	1834.00
IUUC-Bta-012371	Bos taurus	99.08	0.00e+00	2365.00
IUUC-Bci-013684	Botrytis cinerea	31.22	6.00e-134	471.00
IUUC-Cja-019297	Callithrix jacchus	95.19	0.00e+00	2282.00
IUUC-Cfa-020489	Canis familiaris	98.66	0.00e+00	2349.00
IUUC-Cpo-022392	Cavia porcellus	96.76	0.00e+00	2336.00
IUUC-Csa-023220	Chlorocebus sabaeus	97.92	0.00e+00	2347.00
IUUC-Csv-025841	Ciona savignyi	45.57	0.00e+00	902.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	32.47	7.00e-163	568.00
IUUC-Cne-026932	Cryptococcus neoformans	42.94	4.00e-73	270.00
IUUC-Dre-028482	Danio rerio	74.67	0.00e+00	1785.00
IUUC-Dno-029398	Dasypus novemcinctus	97.58	0.00e+00	2320.00
IUUC-Dor-030307	Dipodomys ordii	90.55	0.00e+00	1310.00
IUUC-Dme-032111	Drosophila melanogaster	41.38	0.00e+00	879.00
IUUC-Eeu-034928	Erinaceus europaeus	85.02	0.00e+00	780.00
IUUC-Fca-035587	Felis catus	98.67	0.00e+00	2361.00
IUUC-Fal-037587	Ficedula albicollis	84.88	0.00e+00	1986.00
IUUC-Fso-038133	Fusarium solani	29.61	3.00e-133	469.00
IUUC-Gmo-039076	Gadus morhua	74.30	0.00e+00	1747.00
IUUC-Ggr-039957	Gaeumannomyces graminis	32.29	1.00e-141	497.00
IUUC-Gga-040948	Gallus gallus	86.01	0.00e+00	2066.00
IUUC-Gac-042396	Gasterosteus aculeatus	74.98	0.00e+00	1798.00
IUUC-Ggo-045412	Gorilla gorilla	98.09	0.00e+00	2347.00
IUUC-Hsa-046076	Homo sapiens	98.09	0.00e+00	2352.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	91.14	0.00e+00	2118.00
IUUC-Kpa-049178	Komagataella pastoris	40.48	7.00e-67	249.00
IUUC-Lch-050279	Latimeria chalumnae	72.59	0.00e+00	1707.00
IUUC-Loc-052872	Lepisosteus oculatus	76.79	0.00e+00	1836.00
IUUC-Lma-052986	Leptosphaeria maculans	32.50	7.00e-160	558.00
IUUC-Laf-054181	Loxodonta africana	96.01	0.00e+00	2307.00
IUUC-Mcc-054812	Macaca mulatta	98.41	0.00e+00	2350.00
IUUC-Meu-056325	Macropus eugenii	92.60	0.00e+00	2214.00
IUUC-Mor-057246	Magnaporthe oryzae	29.32	2.00e-124	440.00
IUUC-Mpo-057464	Magnaporthe poae	31.34	3.00e-144	506.00
IUUC-Mla-058911	Melampsora laricipopulina	32.60	5.00e-100	359.00
IUUC-Mga-059335	Meleagris gallopavo	86.38	0.00e+00	2019.00
IUUC-Mvi-060461	Microbotryum violaceum	34.15	5.00e-143	502.00
IUUC-Mmr-060636	Microcebus murinus	98.33	0.00e+00	2345.00
IUUC-Mmu-063503	Mus musculus	95.85	0.00e+00	2277.00
IUUC-Mpu-066670	Mustela putorius furo	99.33	0.00e+00	2368.00
IUUC-Mlu-068119	Myotis lucifugus	98.00	0.00e+00	2378.00
IUUC-Nfi-068398	Neosartorya fischeri	32.11	1.00e-156	547.00
IUUC-Ncr-068927	Neurospora crassa	30.01	3.00e-130	460.00
IUUC-Nle-069651	Nomascus leucogenys	94.01	0.00e+00	2247.00
IUUC-Opr-070614	Ochotona princeps	96.93	0.00e+00	2293.00
IUUC-Ont-072433	Oreochromis niloticus	75.22	0.00e+00	1854.00
IUUC-Oan-073283	Ornithorhynchus anatinus	74.32	0.00e+00	1428.00
IUUC-Ocu-074401	Oryctolagus cuniculus	97.01	0.00e+00	2321.00
IUUC-Ola-087522	Oryzias latipes	74.88	0.00e+00	1796.00
IUUC-Oga-088226	Otolemur garnettii	96.94	0.00e+00	2330.00
IUUC-Oar-089241	Ovis aries	98.84	0.00e+00	2388.00
IUUC-Pan-092297	Papio anubis	98.39	0.00e+00	2103.00
IUUC-Psi-094043	Pelodiscus sinensis	82.63	0.00e+00	1929.00
IUUC-Pma-094394	Petromyzon marinus	69.13	0.00e+00	1555.00
IUUC-Pno-095053	Phaeosphaeria nodorum	31.98	2.00e-150	526.00
IUUC-Ppa-095188	Physcomitrella patens	32.46	9.00e-158	551.00
IUUC-Pfo-097517	Poecilia formosa	75.78	0.00e+00	1853.00
IUUC-Pca-100471	Procavia capensis	97.47	0.00e+00	2188.00
IUUC-Pva-102805	Pteropus vampyrus	94.42	0.00e+00	1858.00
IUUC-Pte-104021	Pyrenophora teres	32.12	6.00e-162	565.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	31.97	5.00e-161	561.00
IUUC-Rno-105471	Rattus norvegicus	95.99	0.00e+00	2279.00
IUUC-Sce-106235	Saccharomyces cerevisiae	38.05	1.00e-60	228.00
IUUC-Sha-106883	Sarcophilus harrisii	91.58	0.00e+00	2038.00
IUUC-Spo-108169	Schizosaccharomyces pombe	31.99	2.00e-142	499.00
IUUC-Sar-113323	Sorex araneus	96.63	0.00e+00	1730.00
IUUC-Sre-115075	Sporisorium reilianum	29.33	3.00e-67	250.00
IUUC-Ssc-116363	Sus scrofa	98.09	0.00e+00	2372.00
IUUC-Tru-118427	Takifugu rubripes	75.23	0.00e+00	1870.00
IUUC-Tni-120218	Tetraodon nigroviridis	75.66	0.00e+00	1867.00
IUUC-Tre-122177	Trichoderma reesei	31.81	3.00e-152	533.00
IUUC-Tme-127176	Tuber melanosporum	32.79	6.00e-141	495.00
IUUC-Tbe-127641	Tupaia belangeri	88.64	0.00e+00	808.00
IUUC-Ttr-128888	Tursiops truncatus	98.00	0.00e+00	1492.00
IUUC-Uma-129361	Ustilago maydis	38.42	2.00e-63	238.00
IUUC-Xtr-132811	Xenopus tropicalis	79.53	0.00e+00	1901.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence