iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pma-094394

UUCD1 version

UUC-PeM-00551

Ensembl Protein ID

ENSPMAP00000005237.1

UniProt Accession

S4RJ55; S4RJ55_PETMA

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Gene Name

pan2; PAN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPMAG00000004731.1	ENSPMAT00000005256.1	ENSPMAP00000005237.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	7.70e-22	77.1	428	817

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.gyeq 89
           Gl+ +    Y+NS++Q+L++++++r+ + +   + +++      + +l+++l  lf  l  sk    + +++l+a++++ e    +   
   Q: 428  GLETHIPNAYCNSMIQVLYFLEPVRRSIQS---HLCQK------EFCLACELGFLFYMLDLSKGDPCQASNFLRAFRTIPEASAlSLIL 507
           555566667*********************...55654......57*************9*****************999985455556 PP
   S: 90   qDaqEflafl.ldqleeelkk.eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpv 176
            D+ E +  + l ql ++ ++   ++  +e++e++   + ++   + + +++s++s+lF+ +l +  +c +c++++sr ++ l ++l+ 
   Q: 508  ADSDEATGKVnLGQLIQSWNRfILTQLHQEMQEQEGMPAYRSITGSAQASSESVVSQLFGTELDNCSTC-RCGKETSRVSSSLLFTLHH 595
           66666654333666666666654444444445566666777788999*********************9.8****************** PP
   S: 177  pgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfc 265
           p+ ++ ++ +l +  e   +   l+++ + +ce c+k+q ++++ kl++lP+vL+++ +    s + +   ++++++ + + ++ ++  
   Q: 596  PDTSKDEPGKLYEFVELLRRSICLDQSTQAWCEVCEKYQPTVQTRKLRRLPDVLVINCQVN--SPKDCEFWRNQSEIAYRRLVSKEEAE 682
           *********************************************************9988..66666666788999997555555433 PP
   S: 266  ts.....peekqke................................................................kkkYeLiavvv 285
            +           +                                                                 + Y L a v 
   Q: 683  GTkahppA-----KipewypppeglelgsnldemknvwipfafrtklaedgslditpwmdehkplwlvqvedgeddggGRVYHLAASVA 766
           33345550.....15555555555555555555556666666666666666666666666666677777777777777*********** PP
   S: 286  HsG.slssGHYvayvkn...........ekgkWllfdDskVtevkeeevle 324
           H   +  +G  +a+v+            ++++W+lf+D  ++++++ e ++
   Q: 767  HVLdQRTGGNLMAHVRVgetyhhrkegvTHFQWYLFNDFLIEPIDKFEAVQ 817
           ***9*************999998888877889*******999998755444 PP

Organism

Petromyzon marinus

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.

Protein Sequence
(Fasta)

GRVASYYGPA MERYSAFVVH PADEVRQVQS LDNGVLLLTK NNLKCFSRGG LIMCDYMTEE 60
AHEMHCMLLT SNNSLLIGGQ QNHILELDLS SAQEMQKYDV ETTGVTIMKQ ANRFFFCGHA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCCGCGTCG CCTCGTACTA TGGGCCAGCG ATGGAGCGCT ACTCGGCGTT CGTCGTGCAC 60
CCCGCGGACG AGGTGCGGCA GGTGCAGAGC CTGGACAATG GCGTGCTCCT CCTTACCAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-0539--Nucleus

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	69.43	0.00e+00	1541.00
IUUC-Apl-003500	Anas platyrhynchos	69.53	0.00e+00	1412.00
IUUC-Aca-004930	Anolis carolinensis	69.03	0.00e+00	1532.00
IUUC-Acl-008214	Aspergillus clavatus	31.09	6.00e-144	503.00
IUUC-Afu-009112	Aspergillus fumigatus	30.31	2.00e-133	469.00
IUUC-Ang-009531	Aspergillus niger	30.88	2.00e-141	495.00
IUUC-Ame-011259	Astyanax mexicanus	67.57	0.00e+00	1490.00
IUUC-Bta-012371	Bos taurus	69.13	0.00e+00	1533.00
IUUC-Bci-013684	Botrytis cinerea	44.59	3.00e-70	258.00
IUUC-Cja-019297	Callithrix jacchus	67.67	0.00e+00	1492.00
IUUC-Cfa-020489	Canis familiaris	69.22	0.00e+00	1528.00
IUUC-Cpo-022392	Cavia porcellus	69.32	0.00e+00	1531.00
IUUC-Csa-023220	Chlorocebus sabaeus	69.62	0.00e+00	1540.00
IUUC-Csv-025841	Ciona savignyi	44.57	0.00e+00	867.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	31.52	2.00e-148	518.00
IUUC-Cne-026932	Cryptococcus neoformans	41.67	4.00e-71	261.00
IUUC-Dre-028482	Danio rerio	66.88	0.00e+00	1488.00
IUUC-Dno-029398	Dasypus novemcinctus	69.04	0.00e+00	1524.00
IUUC-Dor-030307	Dipodomys ordii	66.28	0.00e+00	923.00
IUUC-Dme-032111	Drosophila melanogaster	39.57	0.00e+00	831.00
IUUC-Eca-033985	Equus caballus	69.22	0.00e+00	1533.00
IUUC-Eeu-034928	Erinaceus europaeus	66.00	4.00e-154	537.00
IUUC-Fca-035587	Felis catus	69.43	0.00e+00	1549.00
IUUC-Fal-037587	Ficedula albicollis	70.07	0.00e+00	1528.00
IUUC-Fso-038133	Fusarium solani	31.35	1.00e-86	313.00
IUUC-Gmo-039076	Gadus morhua	66.88	0.00e+00	1460.00
IUUC-Ggr-039957	Gaeumannomyces graminis	31.95	3.00e-136	478.00
IUUC-Gga-040948	Gallus gallus	70.32	0.00e+00	1528.00
IUUC-Gac-042396	Gasterosteus aculeatus	66.46	0.00e+00	1482.00
IUUC-Ggo-045412	Gorilla gorilla	69.53	0.00e+00	1540.00
IUUC-Hsa-046076	Homo sapiens	69.43	0.00e+00	1540.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	63.99	0.00e+00	1370.00
IUUC-Kpa-049178	Komagataella pastoris	40.48	2.00e-65	243.00
IUUC-Lch-050279	Latimeria chalumnae	62.41	0.00e+00	1352.00
IUUC-Loc-052872	Lepisosteus oculatus	68.88	0.00e+00	1503.00
IUUC-Lma-052986	Leptosphaeria maculans	32.28	5.00e-144	503.00
IUUC-Laf-054181	Loxodonta africana	67.30	0.00e+00	1503.00
IUUC-Mcc-054812	Macaca mulatta	69.59	0.00e+00	1531.00
IUUC-Meu-056325	Macropus eugenii	69.71	0.00e+00	1541.00
IUUC-Mor-057246	Magnaporthe oryzae	29.39	8.00e-118	417.00
IUUC-Mpo-057464	Magnaporthe poae	31.46	7.00e-134	470.00
IUUC-Mla-058911	Melampsora laricipopulina	45.76	2.00e-71	263.00
IUUC-Mga-059335	Meleagris gallopavo	70.08	0.00e+00	1510.00
IUUC-Mvi-060461	Microbotryum violaceum	34.63	6.00e-138	483.00
IUUC-Mmr-060636	Microcebus murinus	69.32	0.00e+00	1528.00
IUUC-Mmu-063503	Mus musculus	68.73	0.00e+00	1534.00
IUUC-Mpu-066670	Mustela putorius furo	69.41	0.00e+00	1536.00
IUUC-Mlu-068119	Myotis lucifugus	68.49	0.00e+00	1551.00
IUUC-Nfi-068398	Neosartorya fischeri	30.84	1.00e-143	502.00
IUUC-Ncr-068927	Neurospora crassa	29.05	5.00e-113	401.00
IUUC-Nle-069651	Nomascus leucogenys	66.27	0.00e+00	1461.00
IUUC-Opr-070614	Ochotona princeps	68.64	0.00e+00	1508.00
IUUC-Ont-072433	Oreochromis niloticus	66.40	0.00e+00	1494.00
IUUC-Oan-073283	Ornithorhynchus anatinus	62.16	0.00e+00	1181.00
IUUC-Ocu-074401	Oryctolagus cuniculus	69.06	0.00e+00	1536.00
IUUC-Ola-087522	Oryzias latipes	66.94	0.00e+00	1487.00
IUUC-Oga-088226	Otolemur garnettii	68.78	0.00e+00	1543.00
IUUC-Oar-089241	Ovis aries	69.07	0.00e+00	1556.00
IUUC-Pan-092297	Papio anubis	70.16	0.00e+00	1477.00
IUUC-Psi-094043	Pelodiscus sinensis	66.06	0.00e+00	1409.00
IUUC-Pno-095053	Phaeosphaeria nodorum	31.89	2.00e-136	478.00
IUUC-Ppa-095188	Physcomitrella patens	31.02	4.00e-151	527.00
IUUC-Pfo-097517	Poecilia formosa	67.24	0.00e+00	1509.00
IUUC-Pca-100471	Procavia capensis	69.62	0.00e+00	1565.00
IUUC-Pva-102805	Pteropus vampyrus	61.77	0.00e+00	1326.00
IUUC-Pte-104021	Pyrenophora teres	31.89	2.00e-146	512.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	32.04	6.00e-146	510.00
IUUC-Rno-105471	Rattus norvegicus	68.96	0.00e+00	1541.00
IUUC-Sce-106235	Saccharomyces cerevisiae	39.05	2.00e-59	223.00
IUUC-Sha-106883	Sarcophilus harrisii	69.17	0.00e+00	1533.00
IUUC-Spo-108169	Schizosaccharomyces pombe	46.78	2.00e-72	266.00
IUUC-Sar-113323	Sorex araneus	70.39	0.00e+00	1233.00
IUUC-Sre-115075	Sporisorium reilianum	32.66	4.00e-101	361.00
IUUC-Ssc-116363	Sus scrofa	68.73	0.00e+00	1553.00
IUUC-Tru-118427	Takifugu rubripes	66.94	0.00e+00	1524.00
IUUC-Tni-120218	Tetraodon nigroviridis	66.58	0.00e+00	1511.00
IUUC-Tre-122177	Trichoderma reesei	30.89	1.00e-139	489.00
IUUC-Tme-127176	Tuber melanosporum	32.26	3.00e-137	481.00
IUUC-Tbe-127641	Tupaia belangeri	56.58	1.00e-125	442.00
IUUC-Ttr-128888	Tursiops truncatus	70.40	0.00e+00	1033.00
IUUC-Uma-129361	Ustilago maydis	52.70	1.00e-64	240.00
IUUC-Xtr-132811	Xenopus tropicalis	67.57	0.00e+00	1488.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence