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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Hsa-045703
UUCD1 version UUC-HoS-00065
Ensembl Protein ID ENSP00000488872.1
UniProt Accession P35227; A6NGD8; PCGF2_HUMAN
Genbank Protein ID BAA03074.1; EAW60528.1; AAH04858.1; AAH24255.1
Protein Name Polycomb group RING finger protein 2; DNA-binding protein Mel-18; RING finger protein 110; Zinc finger protein 144
Genbank Nucleotide ID D13969; BX647429; BC004858; BC024255
Gene Name PCGF2; MEL18; RNF110; ZNF144
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000278644.2 ENST00000631566.1 ENSP00000488872.1
ENSG00000278644.2 ENST00000632316.1 ENSP00000487834.1
ENSG00000278644.2 ENST00000632510.1 ENSP00000487929.1
Annotation
Cancer Mutation
TCGACGAPIntOGen
mRNA Expression
TCGAICGCTHPAHPM
DNA & RNA Element
UTRdbcircRNADbCircNetRepTar
miRcodeRAID2
Protein-protein Interaction
IIDPINAMenthaInWeb_IM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18211895
ULD/UDP/UFD/RAWUL RAWUL 18588675; 21282530; 22325352
Classification
Family E-value Score Start End
E3 activity/RING/RING 6.70e-06 28.2 18 56
ULD/UDP/UFD/RAWUL 2.60e-28 100.0 131 228
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
    Ca+C f d + ++ C H f+++C+ ++ ++ +CP C
   Q: 18 CALCGGYFIDATTIVECLHSFCKTCIVRY------LETNKYCPMC 56
    ********999999***************......********** PP
   


   ULD/UDP/UFD/RAWUL

   S: 1    islsLeplesnkakddsk............lkkkylrcsarltVkhlkkflaeklklsssyevdllcedevLednetLeeikyifiwkkegp 80
    +sls+e++e ++++d++k + ++lrc+a++tV+hl kfl++k++++s+y+v++l+ede+L++++tL++i+yi+ w+++gp
   Q: 131 VSLSIEFYEGARDRDEKKgplengdgdkekTGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMDIAYIYPWRRNGP 222
    58899999999999988899999999999999************************************************************ PP
   S: 81 LvLqYr 86
    L+L+Yr
   Q: 223 LPLKYR 228
    *****9 PP
   

Organism Homo sapiens
Functional Description
(View)

Functional Description



     Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Is not functionally redundant with BMI1; unlike BMI1 does not stimulate the E3 ubiquitin-protein ligase activity in a reconstituted PRC1-like complex (By similarity).
Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Is not functionally redundant with BMI1; unlike BMI1 does not stimulate the E3 ubiquitin-protein ligase activity in a reconstituted PRC1-like complex (By similarity).
Protein Sequence
(Fasta)
MHRTTRIKIT ELNPHLMCAL CGGYFIDATT IVECLHSFCK TCIVRYLETN KYCPMCDVQV 60
HKTRPLLSIR SDKTLQDIVY KLVPGLFKDE MKRRRDFYAA YPLTEVPNGS NEDRGEVLEQ 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Hsa-045703|E3,RING;ULD,RAWUL|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTGGCTGCAG GCTCGAGCTG GGGTCACTCG GCGGCCAGTG TGCGCAGGTC TCCTGGTCGC 60
CGGCCAGAGG GCGAAAGCAT TCACCCGAGG CCCCCAGCTT CGCGGCTGCC TTGGCTGCGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Hsa-045703|E3,RING;ULD,RAWUL|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR032443--RAWUL
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF16207--RAWUL

SMART

SM00184--RING

Gene Ontology

GO:0016604--C:nuclear body
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0031519--C:PcG protein complex
GO:0035102--C:PRC1 complex
GO:0001739--C:sex chromatin
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0009952--P:anterior/posterior pattern specification
GO:0070301--P:cellular response to hydrogen peroxide
GO:0048704--P:embryonic skeletal system morphogenesis
GO:0016573--P:histone acetylation
GO:0001701--P:in utero embryonic development
GO:2001234--P:negative regulation of apoptotic signaling pathway
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated

KEGG hsa:7703
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002051 Ailuropoda melanoleuca 94.48 3.00e-157 547.00
IUUC-Aca-004230 Anolis carolinensis 74.72 3.00e-141 494.00
IUUC-Aly-005613 Arabidopsis lyrata 40.96 2.00e-12 66.60
IUUC-Bta-013298 Bos taurus 96.51 4.00e-165 573.00
IUUC-Cja-019674 Callithrix jacchus 98.84 7.00e-168 582.00
IUUC-Cfa-020865 Canis familiaris 89.94 3.00e-148 517.00
IUUC-Cpo-022149 Cavia porcellus 94.48 6.00e-162 563.00
IUUC-Csa-024153 Chlorocebus sabaeus 99.42 2.00e-168 584.00
IUUC-Dno-029941 Dasypus novemcinctus 94.48 4.00e-158 550.00
IUUC-Dor-030557 Dipodomys ordii 96.51 1.00e-162 565.00
IUUC-Eca-033878 Equus caballus 97.91 2.00e-153 534.00
IUUC-Eeu-035039 Erinaceus europaeus 92.15 2.00e-151 528.00
IUUC-Fca-036531 Felis catus 90.14 3.00e-143 501.00
IUUC-Gga-040311 Gallus gallus 84.09 7.00e-130 456.00
IUUC-Ggo-045132 Gorilla gorilla 99.71 2.00e-168 584.00
IUUC-Itr-048008 Ictidomys tridecemlineatus 98.55 2.00e-166 578.00
IUUC-Lch-050240 Latimeria chalumnae 73.47 3.00e-129 454.00
IUUC-Laf-053589 Loxodonta africana 97.38 4.00e-163 567.00
IUUC-Mcc-055228 Macaca mulatta 99.13 5.00e-167 580.00
IUUC-Meu-056268 Macropus eugenii 81.10 7.00e-135 473.00
IUUC-Mga-059555 Meleagris gallopavo 77.78 8.00e-84 303.00
IUUC-Mmr-060605 Microcebus murinus 97.96 4.00e-165 573.00
IUUC-Mdo-061947 Monodelphis domestica 81.90 5.00e-155 540.00
IUUC-Mmu-063845 Mus musculus 95.91 8.00e-162 563.00
IUUC-Mpu-066061 Mustela putorius furo 96.51 2.00e-164 571.00
IUUC-Mlu-067426 Myotis lucifugus 86.97 3.00e-145 507.00
IUUC-Nle-069772 Nomascus leucogenys 92.05 4.00e-159 553.00
IUUC-Ocu-074159 Oryctolagus cuniculus 86.12 4.00e-145 507.00
IUUC-Oga-088514 Otolemur garnettii 97.97 2.00e-166 578.00
IUUC-Oar-090406 Ovis aries 89.24 1.00e-164 572.00
IUUC-Ptr-091467 Pan troglodytes 99.42 9.00e-168 582.00
IUUC-Psi-093492 Pelodiscus sinensis 83.24 4.00e-154 537.00
IUUC-Pab-098045 Pongo abelii 93.66 1.00e-146 512.00
IUUC-Pca-100551 Procavia capensis 97.09 3.00e-165 574.00
IUUC-Pva-102686 Pteropus vampyrus 96.80 2.00e-165 575.00
IUUC-Rno-105679 Rattus norvegicus 95.91 5.00e-162 563.00
IUUC-Sha-107443 Sarcophilus harrisii 73.56 2.00e-136 478.00
IUUC-Ssc-115591 Sus scrofa 75.22 3.00e-139 488.00
Created Date 25-Jun-2017

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