iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004558

UUCD1 version

UUC-AnC-00400

Ensembl Protein ID

ENSACAP00000013937.3

UniProt Accession

H9GKS9; H9GKS9_ANOCA

Protein Name

Uncharacterized protein

Gene Name

HECW2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000014066.3	ENSACAT00000014223.3	ENSACAP00000013937.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.30e-121	406.1	1241	1573

Active Site

Position(s)	Description	Evidence
1541	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++l+s+el+np++glf+ys+nd++t+q++p s +   +h ++F+f Gr+lg+al ++ lld
   Q: 1241 DLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFV-DNHHEWFRFSGRILGLALIHQYLLD 1326
           456689****************************************************985.5************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+  ++l+dle +d+e+++sl+++k+n   di+++ ldltf+v+ee++g+++e+eLkpgG+nipVt++Nk+eY+++
   Q: 1327 AFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDN---DIHDI-LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIER 1409
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+e++ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++++ +i+wFw ++e+f++e+r +
   Q: 1410 MVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWGAVERFNNEQRLR 1496
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+    pr+f+++k+++ + lP+++TCfn+L+LP+Y+s + l+ekLl+A+eet+ F+l+
   Q: 1497 LLQFVTGTSSIPYEGFASLRgsngPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE 1573
           **************************************************************************985 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MTSSAREHLL FVRRRHPQLR YTLSPENLQS LASQGTVPEN MNLQRANSDT DLVTSDSRSS 60
LTASMYEYTL GQPQNLIIFW DIKEEVDPTD WIGLYHIDEN SPANFWDSKN RGVTGTQKGQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAATAGAGAG AAATCAGTGT GGAAACTGCA AGAGGTACCA TAGATCGCTG TACATGGAAA 60
TAAGGGTAGT AAATAGTTTT TGATTTATTA AATACAGTTA TATATTACAA TTATACATTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0072686--C:mitotic spindle
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030071--P:regulation of mitotic metaphase/anaphase transition

KEGG

acs:100560989

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001271	Ailuropoda melanoleuca	83.98	0.00e+00	2632.00
IUUC-Apl-003935	Anas platyrhynchos	86.51	0.00e+00	2730.00
IUUC-Ame-010893	Astyanax mexicanus	88.33	0.00e+00	1302.00
IUUC-Bta-013093	Bos taurus	94.70	0.00e+00	1554.00
IUUC-Cja-019651	Callithrix jacchus	83.10	0.00e+00	2508.00
IUUC-Cfa-021232	Canis familiaris	97.47	0.00e+00	1601.00
IUUC-Cpo-021770	Cavia porcellus	81.10	0.00e+00	2552.00
IUUC-Csa-023970	Chlorocebus sabaeus	83.67	0.00e+00	2602.00
IUUC-Cho-024512	Choloepus hoffmanni	76.90	0.00e+00	2328.00
IUUC-Csv-026127	Ciona savignyi	72.27	5.00e-155	540.00
IUUC-Dre-028275	Danio rerio	86.15	0.00e+00	1492.00
IUUC-Dno-029963	Dasypus novemcinctus	82.70	0.00e+00	2474.00
IUUC-Dor-030282	Dipodomys ordii	73.50	0.00e+00	1616.00
IUUC-Dme-032217	Drosophila melanogaster	71.71	0.00e+00	655.00
IUUC-Ete-033132	Echinops telfairi	81.06	0.00e+00	1232.00
IUUC-Eca-033978	Equus caballus	83.27	0.00e+00	2603.00
IUUC-Eeu-035278	Erinaceus europaeus	96.65	0.00e+00	735.00
IUUC-Fca-036157	Felis catus	83.75	0.00e+00	2604.00
IUUC-Fal-037110	Ficedula albicollis	84.51	0.00e+00	2412.00
IUUC-Gmo-039291	Gadus morhua	80.00	0.00e+00	1014.00
IUUC-Gga-040821	Gallus gallus	87.06	0.00e+00	2707.00
IUUC-Gac-042456	Gasterosteus aculeatus	80.74	0.00e+00	1356.00
IUUC-Ggo-044862	Gorilla gorilla	83.66	0.00e+00	2511.00
IUUC-Hsa-046219	Homo sapiens	83.80	0.00e+00	2654.00
IUUC-Lch-050526	Latimeria chalumnae	79.44	0.00e+00	2452.00
IUUC-Loc-052648	Lepisosteus oculatus	88.15	0.00e+00	1535.00
IUUC-Laf-054005	Loxodonta africana	83.58	0.00e+00	2632.00
IUUC-Mcc-055314	Macaca mulatta	83.46	0.00e+00	2600.00
IUUC-Meu-056356	Macropus eugenii	80.89	0.00e+00	794.00
IUUC-Mga-060074	Meleagris gallopavo	86.40	0.00e+00	2625.00
IUUC-Mmr-061526	Microcebus murinus	83.60	0.00e+00	2615.00
IUUC-Mdo-063017	Monodelphis domestica	85.03	0.00e+00	2632.00
IUUC-Mmu-064165	Mus musculus	82.80	0.00e+00	2581.00
IUUC-Mpu-065835	Mustela putorius furo	80.56	0.00e+00	1528.00
IUUC-Mlu-067709	Myotis lucifugus	81.66	0.00e+00	2520.00
IUUC-Nle-069308	Nomascus leucogenys	82.97	0.00e+00	2617.00
IUUC-Opr-070330	Ochotona princeps	71.12	0.00e+00	2117.00
IUUC-Ont-071918	Oreochromis niloticus	64.90	0.00e+00	1891.00
IUUC-Ocu-074775	Oryctolagus cuniculus	82.56	0.00e+00	2354.00
IUUC-Ola-087225	Oryzias latipes	72.05	0.00e+00	1343.00
IUUC-Oga-088177	Otolemur garnettii	81.92	0.00e+00	2523.00
IUUC-Oar-089452	Ovis aries	83.30	0.00e+00	2618.00
IUUC-Ptr-090806	Pan troglodytes	84.11	0.00e+00	2638.00
IUUC-Pan-091838	Papio anubis	83.53	0.00e+00	2487.00
IUUC-Psi-094090	Pelodiscus sinensis	86.87	0.00e+00	2710.00
IUUC-Pfo-096520	Poecilia formosa	66.29	0.00e+00	1949.00
IUUC-Pab-098405	Pongo abelii	83.86	0.00e+00	2628.00
IUUC-Pca-100441	Procavia capensis	75.91	0.00e+00	1949.00
IUUC-Pva-102324	Pteropus vampyrus	97.10	0.00e+00	1598.00
IUUC-Rno-105943	Rattus norvegicus	82.67	0.00e+00	2624.00
IUUC-Sha-106985	Sarcophilus harrisii	82.31	0.00e+00	2214.00
IUUC-Sar-113505	Sorex araneus	93.69	0.00e+00	1512.00
IUUC-Ssc-115439	Sus scrofa	76.56	0.00e+00	1634.00
IUUC-Tgu-117078	Taeniopygia guttata	86.00	0.00e+00	2625.00
IUUC-Tru-118671	Takifugu rubripes	83.35	0.00e+00	1456.00
IUUC-Tni-120619	Tetraodon nigroviridis	86.69	0.00e+00	1425.00
IUUC-Tbe-127975	Tupaia belangeri	79.35	0.00e+00	2106.00
IUUC-Ttr-128469	Tursiops truncatus	77.65	0.00e+00	2355.00
IUUC-Vpa-130498	Vicugna pacos	73.33	0.00e+00	2162.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence