• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations

Tag Content
UUCD2 ID IUUC-Mmu-064369
UUCD1 version UUC-MuM-00567
Ensembl Protein ID ENSMUSP00000058233.6
UniProt Accession Q7TQF2; A2ANI6; Q6AXG0; Q7TQM0; FBX10_MOUSE
Genbank Protein ID CAM17797.1; AAH52485.1; AAH54731.1; AAH79571.1
Protein Name F-box only protein 10
Genbank Nucleotide ID AL824706; BC052485; BC054731; BC079571
Gene Name Fbxo10; Gm634
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000048232.12 ENSMUST00000052236.12 ENSMUSP00000058233.6
ENSMUSG00000048232.12 ENSMUST00000140008.1 ENSMUSP00000119862.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RAID2
Protein-protein Interaction
IID
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/SCF/F-box 92.57 0.00e+00 1746.00 IUUC-Hsa-045742
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description



     Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2.
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2.
Protein Sequence
(Fasta)
METGGLPLEL WRMILAYLHL PDLGRCSLVC RAWYELILSL DSTRWRQLCL GCTECRHPNW 60
PNQPDVEPES WREAFKQHYL ASKTWTKNAL DLESSICFSL FRRKKERRTL SVGPGHEFDS 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Mmu-064369|E3,F-box|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGGGCGGGG CTCGCGGCGA AGTCGGACCC CGCTGTGGCC GAGCGCCGCA GTCCTCCGGC 60
AGCCCTGCGG CTTCCAGGGC GTCGCGGCCG CGGCCGGGCA GCGCCGCTCC CTGAGGTAAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Mmu-064369|E3,F-box|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR006633--Carb-bd_sugar_hydrolysis-dom
IPR001810--F-box_dom
IPR007742--NosD_dom
IPR022441--Para_beta_helix_rpt-2
IPR006626--PbH1
IPR012334--Pectin_lyas_fold
IPR011050--Pectin_lyase_fold/virulence

PROSITE

PS50181--FBOX

Pfam

PF12937--F-box-like
PF05048--NosD

SMART

SM00722--CASH
SM00256--FBOX
SM00710--PbH1

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006915--P:apoptotic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0042981--P:regulation of apoptotic process

KEGG mmu:269529
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001558 Ailuropoda melanoleuca 92.57 0.00e+00 1727.00
IUUC-Aca-004917 Anolis carolinensis 65.05 0.00e+00 1243.00
IUUC-Ame-011129 Astyanax mexicanus 51.62 0.00e+00 957.00
IUUC-Bta-012928 Bos taurus 88.55 0.00e+00 1620.00
IUUC-Cja-019383 Callithrix jacchus 92.38 0.00e+00 1158.00
IUUC-Cfa-020855 Canis familiaris 91.53 0.00e+00 1694.00
IUUC-Cpo-021873 Cavia porcellus 90.29 0.00e+00 1686.00
IUUC-Cre-022959 Chlamydomonas reinhardtii 22.64 9.60e-02 32.00
IUUC-Csa-024199 Chlorocebus sabaeus 92.57 0.00e+00 1743.00
IUUC-Dre-028495 Danio rerio 51.41 0.00e+00 958.00
IUUC-Dno-029707 Dasypus novemcinctus 91.00 0.00e+00 1721.00
IUUC-Dor-030668 Dipodomys ordii 88.20 0.00e+00 1664.00
IUUC-Ete-032489 Echinops telfairi 78.85 0.00e+00 912.00
IUUC-Eca-033534 Equus caballus 91.32 0.00e+00 1721.00
IUUC-Eeu-034536 Erinaceus europaeus 77.75 1.00e-156 547.00
IUUC-Fca-035906 Felis catus 92.57 0.00e+00 1724.00
IUUC-Gmo-039471 Gadus morhua 44.67 0.00e+00 679.00
IUUC-Gac-041496 Gasterosteus aculeatus 43.19 3.00e-180 625.00
IUUC-Ggo-044503 Gorilla gorilla 92.47 0.00e+00 1739.00
IUUC-Hsa-045742 Homo sapiens 92.57 0.00e+00 1739.00
IUUC-Itr-048727 Ictidomys tridecemlineatus 93.72 0.00e+00 1758.00
IUUC-Lch-049641 Latimeria chalumnae 64.40 0.00e+00 1245.00
IUUC-Loc-052060 Lepisosteus oculatus 54.77 0.00e+00 1023.00
IUUC-Laf-054216 Loxodonta africana 92.67 0.00e+00 1741.00
IUUC-Mcc-055122 Macaca mulatta 92.57 0.00e+00 1741.00
IUUC-Meu-056537 Macropus eugenii 63.41 0.00e+00 745.00
IUUC-Mmr-061489 Microcebus murinus 92.26 0.00e+00 1701.00
IUUC-Mdo-062954 Monodelphis domestica 66.05 0.00e+00 1297.00
IUUC-Mpu-065774 Mustela putorius furo 92.05 0.00e+00 1717.00
IUUC-Mlu-067093 Myotis lucifugus 94.12 0.00e+00 1749.00
IUUC-Nle-068989 Nomascus leucogenys 89.64 0.00e+00 1671.00
IUUC-Opr-070263 Ochotona princeps 88.24 0.00e+00 1743.00
IUUC-Ont-071949 Oreochromis niloticus 52.95 0.00e+00 967.00
IUUC-Oan-073316 Ornithorhynchus anatinus 59.35 2.00e-102 365.00
IUUC-Ocu-074369 Oryctolagus cuniculus 93.59 0.00e+00 1751.00
IUUC-Ome-081815 Oryza meridionalis 43.18 1.80e-01 33.50
IUUC-Ola-086354 Oryzias latipes 50.98 0.00e+00 910.00
IUUC-Olu-087743 Ostreococcus lucimarinus 31.11 2.00e-04 40.80
IUUC-Oga-088392 Otolemur garnettii 92.68 0.00e+00 1740.00
IUUC-Oar-089595 Ovis aries 88.66 0.00e+00 1626.00
IUUC-Ptr-091635 Pan troglodytes 92.47 0.00e+00 1737.00
IUUC-Pan-091939 Papio anubis 92.47 0.00e+00 1738.00
IUUC-Psi-093872 Pelodiscus sinensis 70.45 5.00e-137 480.00
IUUC-Pma-094149 Petromyzon marinus 44.84 9.00e-124 437.00
IUUC-Ppa-095311 Physcomitrella patens 42.86 6.10e-02 32.30
IUUC-Pfo-097082 Poecilia formosa 50.80 0.00e+00 934.00
IUUC-Pab-098093 Pongo abelii 90.39 0.00e+00 1688.00
IUUC-Pca-101065 Procavia capensis 87.02 0.00e+00 1665.00
IUUC-Pva-102398 Pteropus vampyrus 88.49 0.00e+00 1075.00
IUUC-Rno-105341 Rattus norvegicus 98.32 0.00e+00 1819.00
IUUC-Sha-107170 Sarcophilus harrisii 62.57 0.00e+00 946.00
IUUC-Sar-112976 Sorex araneus 87.31 2.00e-129 456.00
IUUC-Ssc-115623 Sus scrofa 68.23 0.00e+00 1069.00
IUUC-Tru-118657 Takifugu rubripes 52.52 0.00e+00 965.00
IUUC-Tsy-119410 Tarsius syrichta 77.90 1.00e-180 626.00
IUUC-Tni-119696 Tetraodon nigroviridis 51.87 0.00e+00 969.00
IUUC-Tca-121485 Theobroma cacao 47.06 1.20e-02 34.70
IUUC-Tbe-128027 Tupaia belangeri 92.96 0.00e+00 1009.00
IUUC-Ttr-129142 Tursiops truncatus 88.20 0.00e+00 862.00
IUUC-Vpa-130738 Vicugna pacos 75.20 3.00e-104 372.00
IUUC-Xtr-132546 Xenopus tropicalis 63.16 0.00e+00 1251.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved