iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
microRNA	TRANSFAC	TargetScan	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
ClinVar	GWASdb	OMIM
Drug and target
TTD	GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	6.50e-14	53.3	59	117

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +k+ v +lydy+a nd +L++ kG++++v+   +  ++W+ + +  +g++G +P+nFv+++e
   Q: 59   DKHFVVALYDYTAMNDRDLQMLKGEKLQVL---KGTGDWWLARSLVTGREGYVPSNFVARVE 117
           57899*************************...999************************97 PP

Organism

Homo sapiens

Functional Description
(View)

Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207'. Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C. With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation. In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose.

Protein Sequence
(Fasta)

MGLVSSKKPD KEKPIKEKDK GQWSPLKVSA QDKDAPPLPP LVVFNHLTPP PPDEHLDEDK 60
HFVVALYDYT AMNDRDLQML KGEKLQVLKG TGDWWLARSL VTGREGYVPS NFVARVESLE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGCCCTGGT GCACACAGAT GGCACATGGC AGAGCCCAAG CCCTCTCCAT GAGATCTGCA 60
GCGTTTGTCC ACACGGCAGG GCAAATTACC TTGTAGAGTC AGCATGGAGG TTTGCTAACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0219--Diabetes mellitus
KW-0418--Kinase
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0519--Myristate
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase
KW-0832--Ubl conjugation

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004713--F:protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0050853--P:B cell receptor signaling pathway
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0035556--P:intracellular signal transduction
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0032024--P:positive regulation of insulin secretion
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

hsa:640

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002133	Ailuropoda melanoleuca	89.48	0.00e+00	921.00
IUUC-Apl-003307	Anas platyrhynchos	75.51	0.00e+00	731.00
IUUC-Aca-004357	Anolis carolinensis	68.83	0.00e+00	667.00
IUUC-Ame-010642	Astyanax mexicanus	70.44	0.00e+00	683.00
IUUC-Bta-012400	Bos taurus	86.76	0.00e+00	904.00
IUUC-Cja-019717	Callithrix jacchus	88.21	0.00e+00	736.00
IUUC-Cfa-021056	Canis familiaris	87.92	0.00e+00	935.00
IUUC-Cpo-021779	Cavia porcellus	85.94	0.00e+00	862.00
IUUC-Csa-023557	Chlorocebus sabaeus	96.83	0.00e+00	965.00
IUUC-Dre-027517	Danio rerio	68.83	0.00e+00	690.00
IUUC-Eca-034218	Equus caballus	88.61	0.00e+00	906.00
IUUC-Eeu-035095	Erinaceus europaeus	68.51	0.00e+00	696.00
IUUC-Fca-036015	Felis catus	87.13	0.00e+00	923.00
IUUC-Fal-036946	Ficedula albicollis	75.28	0.00e+00	726.00
IUUC-Gga-040822	Gallus gallus	74.61	0.00e+00	735.00
IUUC-Ggo-044608	Gorilla gorilla	98.59	0.00e+00	872.00
IUUC-Itr-048323	Ictidomys tridecemlineatus	88.51	0.00e+00	909.00
IUUC-Lch-050114	Latimeria chalumnae	71.65	0.00e+00	693.00
IUUC-Loc-052326	Lepisosteus oculatus	67.25	0.00e+00	705.00
IUUC-Laf-053387	Loxodonta africana	85.94	0.00e+00	914.00
IUUC-Mcc-055026	Macaca mulatta	97.23	0.00e+00	967.00
IUUC-Mga-059427	Meleagris gallopavo	74.16	0.00e+00	723.00
IUUC-Mmr-061660	Microcebus murinus	89.31	0.00e+00	914.00
IUUC-Mdo-062318	Monodelphis domestica	74.56	0.00e+00	784.00
IUUC-Mmu-063325	Mus musculus	86.14	0.00e+00	909.00
IUUC-Mpu-066582	Mustela putorius furo	89.28	0.00e+00	919.00
IUUC-Nle-069624	Nomascus leucogenys	96.44	0.00e+00	932.00
IUUC-Opr-070656	Ochotona princeps	82.18	0.00e+00	809.00
IUUC-Ont-072266	Oreochromis niloticus	69.16	0.00e+00	676.00
IUUC-Ocu-073907	Oryctolagus cuniculus	85.94	0.00e+00	868.00
IUUC-Oga-088057	Otolemur garnettii	88.34	0.00e+00	911.00
IUUC-Oar-089332	Ovis aries	82.21	0.00e+00	863.00
IUUC-Ptr-091551	Pan troglodytes	97.94	0.00e+00	954.00
IUUC-Pan-092173	Papio anubis	96.63	0.00e+00	937.00
IUUC-Psi-093895	Pelodiscus sinensis	73.71	0.00e+00	736.00
IUUC-Pab-097598	Pongo abelii	97.23	0.00e+00	946.00
IUUC-Pva-102135	Pteropus vampyrus	89.66	0.00e+00	880.00
IUUC-Rno-104891	Rattus norvegicus	86.93	0.00e+00	880.00
IUUC-Sha-107192	Sarcophilus harrisii	77.36	0.00e+00	810.00
IUUC-Ssc-115696	Sus scrofa	86.96	0.00e+00	920.00
IUUC-Tgu-117056	Taeniopygia guttata	74.55	0.00e+00	721.00
IUUC-Tru-117621	Takifugu rubripes	67.48	0.00e+00	647.00
IUUC-Tbe-127520	Tupaia belangeri	87.83	0.00e+00	699.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence