iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-093047

Ensembl Protein ID

ENSPSIP00000009616.1

UniProt Accession

K7FNK6; K7FNK6_PELSI

Genbank Protein ID

ENSPSIP00000009616

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGCU01072661

Gene Name

CYLD

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000008623.1	ENSPSIT00000009663.1	ENSPSIP00000009616.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	8.80e-25	87.6	523	879

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgyeq 89
           G++ + N+CY++S+L cL++++++ + +l + kek + e ++e+++ l +++ + ++     + +k ++ r++l+++++++    ++e+
   Q: 523  GIQGHYNSCYLDSTLFCLFSFSSVLDTVLLRPKEKNDVEYYSETQELLRTEIVNPLRIYGyVCATKIMKLRKILEKVEAASGF--TSEE 609
           999***************************99999999999999999999****999887899**************988875..899* PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksq.ik...clecdnvs.sreepfldls 173
           +D +Efl++l++++ +       k ++  ++ +++   ++  +k++k +  +i++l+++++ ++ +k    ++c  ++  r+ + +++ 
   Q: 610  KDPEEFLNILFHHILRVE--PLLKIRSAGQKVQDCYFYQIFMDKNEKVGVPTIQQLLEWSFINSsLKfaeAPSCLIIQmPRFGKDFKMF 696
           ****************99..88999999999999**************************9855144444799****999********9 PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenk.yycekckkkqeaekklklkklPe....vLilhLkRfsfseeqksrekinkkvefpl 257
            ++  + e    +++d+Le+  ++++++g  + y+c++c+++++ +   k+k++++      +lh kR          ++ ++ v++p+
   Q: 697  NKIFPSLEL---NITDLLEDTPRQCRICGGLAmYECRECYEDTDISAG-KIKQFCKtcntQVHLHPKRQ---------SHKFNPVSLPK 772
           999999988...***************987655**********85544.66666662223467777777.........34478999997 PP
   S: 258  eLdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk..WllfdD...........................skVtev 317
            L    + +        ++k eL+av++ +      HYva+vk  k++  Wl fd                                  
   Q: 773  DLPDWDWRHG----CIPCQKMELFAVLCIET----SHYVAFVKYGKDDsaWLFFDSmadrdggqngfnipqvipcpevgeylkM----- 848
           7533333333....2239**********999....9********6666779999988888888888888555555444433331..... PP
   S: 318  keeevleetg...................staYvlfYkr 337
                   +                    ++aY+++Y++
   Q: 849  --------SLeelhsldsrkiqgcarrllCDAYMCMYQS 879
           ........2233334444555566779999******985 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

MQIGLKLLEQ PHAVLFVDEK DVIEINEKLA ELLLAITNCE ERYSLFKSKS RLSKGLHIDV 60
GSPVRVQLRS GDDKFPGVVR FRGPLLQDRL LSGIFFGVEL LEEGRGQGFT DGQYQGKQLF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCAGGGTAG GTTTTACGGG CCGGGCCGGC TCTGAGGGGG TGGGTTACGC GGGTTGCCTC 60
GCTCTTGAGG AGTCCCGTGA GGGTGTCAGG TGGCTGGGAA AGTCCCCGCG CCAGCGGCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000938--CAP-Gly_domain
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50245--CAP_GLY_2
PS00972--USP_1
PS50235--USP_3

Pfam

PF01302--CAP_GLY
PF00443--UCH

SMART

SM01052--CAP_GLY

Gene Ontology

GO:0005813--C:centrosome
GO:0036064--C:ciliary basal body
GO:0097542--C:ciliary tip
GO:0005881--C:cytoplasmic microtubule
GO:0005829--C:cytosol
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0030496--C:midbody
GO:0005819--C:spindle
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0043369--P:CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
GO:0048872--P:homeostasis of number of cells
GO:0045087--P:innate immune response
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045581--P:negative regulation of T cell differentiation
GO:1903829--P:positive regulation of cellular protein localization
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:0045582--P:positive regulation of T cell differentiation
GO:0050862--P:positive regulation of T cell receptor signaling pathway
GO:1990108--P:protein linear deubiquitination
GO:0045577--P:regulation of B cell differentiation
GO:1902017--P:regulation of cilium assembly
GO:2001242--P:regulation of intrinsic apoptotic signaling pathway
GO:0070507--P:regulation of microtubule cytoskeleton organization
GO:0007346--P:regulation of mitotic cell cycle
GO:0043393--P:regulation of protein binding
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway
GO:1901026--P:ripoptosome assembly involved in necroptotic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001298	Ailuropoda melanoleuca	88.40	0.00e+00	1643.00
IUUC-Apl-003356	Anas platyrhynchos	94.99	0.00e+00	1705.00
IUUC-Aca-004402	Anolis carolinensis	84.61	0.00e+00	1485.00
IUUC-Ame-011581	Astyanax mexicanus	70.97	0.00e+00	1212.00
IUUC-Bta-012359	Bos taurus	88.70	0.00e+00	1645.00
IUUC-Cel-018528	Caenorhabditis elegans	34.90	2.00e-57	217.00
IUUC-Cja-018797	Callithrix jacchus	88.51	0.00e+00	1648.00
IUUC-Cfa-020264	Canis familiaris	88.59	0.00e+00	1642.00
IUUC-Cpo-022057	Cavia porcellus	88.29	0.00e+00	1643.00
IUUC-Csa-023093	Chlorocebus sabaeus	89.27	0.00e+00	1657.00
IUUC-Cho-024486	Choloepus hoffmanni	86.27	2.00e-160	559.00
IUUC-Cin-025179	Ciona intestinalis	44.10	6.00e-119	420.00
IUUC-Dre-028233	Danio rerio	71.13	0.00e+00	1234.00
IUUC-Dno-029496	Dasypus novemcinctus	88.36	0.00e+00	1641.00
IUUC-Dor-030919	Dipodomys ordii	83.56	0.00e+00	1527.00
IUUC-Dme-032159	Drosophila melanogaster	46.14	1.00e-123	436.00
IUUC-Ete-032734	Echinops telfairi	83.11	0.00e+00	1524.00
IUUC-Eca-033350	Equus caballus	89.15	0.00e+00	1659.00
IUUC-Eeu-034566	Erinaceus europaeus	94.62	2.00e-110	393.00
IUUC-Fca-035632	Felis catus	85.06	0.00e+00	1075.00
IUUC-Fal-037313	Ficedula albicollis	88.38	0.00e+00	1568.00
IUUC-Gmo-039239	Gadus morhua	71.16	0.00e+00	1187.00
IUUC-Gga-040668	Gallus gallus	94.42	0.00e+00	1692.00
IUUC-Gac-042630	Gasterosteus aculeatus	71.24	0.00e+00	1184.00
IUUC-Ggo-044462	Gorilla gorilla	88.63	0.00e+00	1647.00
IUUC-Hsa-045846	Homo sapiens	88.63	0.00e+00	1646.00
IUUC-Itr-048894	Ictidomys tridecemlineatus	86.77	0.00e+00	780.00
IUUC-Lch-050303	Latimeria chalumnae	73.28	0.00e+00	1261.00
IUUC-Loc-052190	Lepisosteus oculatus	73.37	0.00e+00	1254.00
IUUC-Laf-054480	Loxodonta africana	89.97	0.00e+00	742.00
IUUC-Mcc-055849	Macaca mulatta	89.08	0.00e+00	1652.00
IUUC-Meu-056755	Macropus eugenii	76.59	0.00e+00	815.00
IUUC-Mga-059561	Meleagris gallopavo	93.64	0.00e+00	1677.00
IUUC-Mmr-060942	Microcebus murinus	88.40	0.00e+00	1630.00
IUUC-Mdo-062618	Monodelphis domestica	88.96	0.00e+00	1654.00
IUUC-Mmu-063843	Mus musculus	86.71	0.00e+00	1566.00
IUUC-Mpu-066919	Mustela putorius furo	88.70	0.00e+00	1648.00
IUUC-Mlu-066983	Myotis lucifugus	85.31	0.00e+00	1571.00
IUUC-Nle-069893	Nomascus leucogenys	88.74	0.00e+00	1648.00
IUUC-Opr-071181	Ochotona princeps	80.53	0.00e+00	1357.00
IUUC-Ont-071697	Oreochromis niloticus	70.28	0.00e+00	1174.00
IUUC-Oan-073658	Ornithorhynchus anatinus	88.61	0.00e+00	1637.00
IUUC-Ocu-074954	Oryctolagus cuniculus	89.19	0.00e+00	1652.00
IUUC-Ola-086523	Oryzias latipes	69.21	0.00e+00	1147.00
IUUC-Oga-089003	Otolemur garnettii	88.85	0.00e+00	1653.00
IUUC-Oar-090376	Ovis aries	88.23	0.00e+00	1646.00
IUUC-Ptr-090520	Pan troglodytes	86.71	0.00e+00	1597.00
IUUC-Pan-092281	Papio anubis	89.27	0.00e+00	1657.00
IUUC-Pma-094575	Petromyzon marinus	54.79	3.00e-66	244.00
IUUC-Pfo-096358	Poecilia formosa	69.66	0.00e+00	1122.00
IUUC-Pab-097740	Pongo abelii	88.63	0.00e+00	1644.00
IUUC-Pca-100461	Procavia capensis	79.20	0.00e+00	1304.00
IUUC-Pva-102134	Pteropus vampyrus	78.15	0.00e+00	1423.00
IUUC-Rno-105807	Rattus norvegicus	85.88	0.00e+00	1537.00
IUUC-Sha-107236	Sarcophilus harrisii	89.17	0.00e+00	1598.00
IUUC-Sar-113366	Sorex araneus	95.33	0.00e+00	912.00
IUUC-Tgu-117201	Taeniopygia guttata	90.68	0.00e+00	1611.00
IUUC-Tru-117953	Takifugu rubripes	71.43	0.00e+00	1172.00
IUUC-Tsy-119610	Tarsius syrichta	86.60	0.00e+00	1602.00
IUUC-Tni-120743	Tetraodon nigroviridis	54.29	7.00e-138	484.00
IUUC-Tbe-128155	Tupaia belangeri	71.07	0.00e+00	682.00
IUUC-Ttr-128942	Tursiops truncatus	82.66	0.00e+00	1516.00
IUUC-Vpa-130281	Vicugna pacos	78.15	0.00e+00	1409.00
IUUC-Xtr-132627	Xenopus tropicalis	78.84	0.00e+00	1354.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence