iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059945

UUCD1 version

UUC-MeG-00400

Ensembl Protein ID

ENSMGAP00000008833.1

UniProt Accession

G1N8Z4; G1N8Z4_MELGA

Protein Name

Lissencephaly-1 homolog

Gene Name

PAFAH1B1; LIS1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000008599.1	ENSMGAT00000009639.1	ENSMGAP00000008833.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.00e-59	194.6	190	229
UBD/Beta-Prp	2.10e-95	319.1	107	410

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           gH   v+++a  ++ +++vs+s+D tik+W++ tg ++k+
   Q: 190  GHDHNVSSVAImPNgDHIVSASRDRTIKMWEVQTGYCVKT 229
           899*******99777********************99875 PP

UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
           h s++t v f+p  s+++++s+d+tikvwd++tg++ r+l+gh++ v++++f+++gk+l+++s D+tik+wd++ ++c++t++gh+++v
   Q: 107  HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHTGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNV 195
           5668888********************************************************************************** PP
   S: 98   lslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysl 186
            s++++p+gd++vs+s+drti++w+++tg+c++ t++gh+++v++v+ ++dg l++s+s+D+tvr+W ++t+++  +l++ h++ v+++
   Q: 196  SSVAIMPNGDHIVSASRDRTIKMWEVQTGYCVK-TFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELRE-HEHVVECI 282
           *********************************.*********************************************9.******** PP
   S: 187  sfdsng....................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgd 255
           s+ +++                    ++l+sgs+d+t+k+wd++tg c++tl gh+++v+ v f++ +++++s+++D+++r+Wd +++ 
   Q: 283  SWAPESsystiseatgsetkksgkpgPFLLSGSRDKTIKMWDISTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDFKNKR 371
           ***************************************************************************************** PP
   S: 256  llktlqlhnssvisvavlsfgdnvlvlgsedskvniwklk 295
           ++ktl+ h++ v+s ++ + + +++v+gs d++v++w+++
   Q: 372  CMKTLNAHEHFVTSLDF-HKTAPYVVTGSVDQTVKVWECR 410
           *****************.99*****************985 PP

Organism

Meleagris gallopavo

Functional Description
(View)

Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.

Protein Sequence
(Fasta)

MVLSQRQRDE LNRAIADYLR SNGYEEAYSV FKKEAELDVN EELDKKYAGL LEKKWTSVIR 60
LQKKVMELES KLNEAKEEFT SGGPLGQKRD PKEWIPRPPE KYALSGHRSP VTRVIFHPVF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATGGATTGA ATCTTCTGTG TTGAATGCCT CCAGGTTTTT CTGTTGGATT TCCCATCTGG 60
AGAAACAATT GTGCTTTGAG CCACTGTGGC AGACTGAATT GTGGATCCTA AGGCTTCAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0493--Microtubule
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0000235--C:astral microtubule
GO:1904115--C:axon cytoplasm
GO:0005938--C:cell cortex
GO:0031252--C:cell leading edge
GO:0005813--C:centrosome
GO:0070062--C:extracellular exosome
GO:0000776--C:kinetochore
GO:0005875--C:microtubule associated complex
GO:0031514--C:motile cilium
GO:0005635--C:nuclear envelope
GO:0048471--C:perinuclear region of cytoplasm
GO:0032420--C:stereocilium
GO:0001675--P:acrosome assembly
GO:0030036--P:actin cytoskeleton organization
GO:0008344--P:adult locomotory behavior
GO:0001667--P:ameboidal-type cell migration
GO:0060117--P:auditory receptor cell development
GO:0048854--P:brain morphogenesis
GO:0051301--P:cell division
GO:0007268--P:chemical synaptic transmission
GO:0090102--P:cochlea development
GO:0021540--P:corpus callosum morphogenesis
GO:0043622--P:cortical microtubule organization
GO:0000132--P:establishment of mitotic spindle orientation
GO:0042249--P:establishment of planar polarity of embryonic epithelium
GO:0021766--P:hippocampus development
GO:0021819--P:layer formation in cerebral cortex
GO:0007611--P:learning or memory
GO:0051661--P:maintenance of centrosome location
GO:0090176--P:microtubule cytoskeleton organization involved in establishment of planar polarity
GO:0031023--P:microtubule organizing center organization
GO:0007067--P:mitotic nuclear division
GO:0046329--P:negative regulation of JNK cascade
GO:0007405--P:neuroblast proliferation
GO:0050885--P:neuromuscular process controlling balance
GO:0001764--P:neuron migration
GO:0051081--P:nuclear envelope disassembly
GO:0036035--P:osteoclast development
GO:0001961--P:positive regulation of cytokine-mediated signaling pathway
GO:0061003--P:positive regulation of dendritic spine morphogenesis
GO:0040019--P:positive regulation of embryonic development
GO:0009306--P:protein secretion
GO:0043087--P:regulation of GTPase activity
GO:0070507--P:regulation of microtubule cytoskeleton organization
GO:0008090--P:retrograde axonal transport
GO:0019226--P:transmission of nerve impulse
GO:0047496--P:vesicle transport along microtubule

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001589	Ailuropoda melanoleuca	98.50	0.00e+00	827.00
IUUC-Apl-004024	Anas platyrhynchos	99.76	0.00e+00	855.00
IUUC-Aca-004564	Anolis carolinensis	98.54	0.00e+00	844.00
IUUC-Ago-007862	Ashbya gossypii	27.46	5.00e-39	154.00
IUUC-Acl-008360	Aspergillus clavatus	46.29	2.00e-104	372.00
IUUC-Afl-008502	Aspergillus flavus	46.21	1.00e-94	339.00
IUUC-Afu-008848	Aspergillus fumigatus	46.94	2.00e-106	378.00
IUUC-Ani-009173	Aspergillus nidulans	42.54	3.00e-90	325.00
IUUC-Ang-009873	Aspergillus niger	44.84	1.00e-94	339.00
IUUC-Aor-009973	Aspergillus oryzae	43.94	3.00e-92	331.00
IUUC-Ate-010523	Aspergillus terreus	42.11	1.00e-90	326.00
IUUC-Ame-010969	Astyanax mexicanus	94.39	0.00e+00	820.00
IUUC-Bgr-011972	Blumeria graminis	47.26	4.00e-105	374.00
IUUC-Bta-013106	Bos taurus	98.54	0.00e+00	849.00
IUUC-Bci-013615	Botrytis cinerea	44.34	1.00e-98	352.00
IUUC-Cel-018459	Caenorhabditis elegans	57.66	6.00e-149	520.00
IUUC-Cja-018755	Callithrix jacchus	96.10	0.00e+00	830.00
IUUC-Cfa-020749	Canis familiaris	98.54	0.00e+00	849.00
IUUC-Cpo-022371	Cavia porcellus	98.54	0.00e+00	849.00
IUUC-Cre-022578	Chlamydomonas reinhardtii	35.13	1.00e-49	189.00
IUUC-Csa-023524	Chlorocebus sabaeus	97.97	0.00e+00	716.00
IUUC-Cho-024764	Choloepus hoffmanni	88.41	0.00e+00	676.00
IUUC-Cin-025753	Ciona intestinalis	70.80	2.00e-180	624.00
IUUC-Csv-025817	Ciona savignyi	69.27	0.00e+00	633.00
IUUC-Cgl-026529	Colletotrichum gloeosporioides	46.57	1.00e-97	349.00
IUUC-Cne-027087	Cryptococcus neoformans	50.13	6.00e-110	390.00
IUUC-Dre-028314	Danio rerio	93.90	0.00e+00	817.00
IUUC-Dno-029050	Dasypus novemcinctus	98.78	0.00e+00	850.00
IUUC-Dor-030222	Dipodomys ordii	90.49	0.00e+00	766.00
IUUC-Dse-031164	Dothistroma septosporum	43.34	2.00e-101	362.00
IUUC-Dme-031745	Drosophila melanogaster	70.07	2.00e-172	597.00
IUUC-Ete-032508	Echinops telfairi	81.71	0.00e+00	682.00
IUUC-Eca-034288	Equus caballus	97.99	0.00e+00	823.00
IUUC-Eeu-034984	Erinaceus europaeus	90.24	0.00e+00	763.00
IUUC-Fca-036498	Felis catus	98.54	0.00e+00	849.00
IUUC-Fal-036920	Ficedula albicollis	99.76	0.00e+00	855.00
IUUC-Fox-037996	Fusarium oxysporum	46.41	9.00e-105	373.00
IUUC-Fso-038160	Fusarium solani	44.21	1.00e-99	356.00
IUUC-Gmo-038983	Gadus morhua	92.93	0.00e+00	806.00
IUUC-Ggr-040051	Gaeumannomyces graminis	45.11	3.00e-98	351.00
IUUC-Gga-040623	Gallus gallus	99.76	0.00e+00	855.00
IUUC-Gac-041613	Gasterosteus aculeatus	92.68	0.00e+00	806.00
IUUC-Ggo-045410	Gorilla gorilla	87.72	0.00e+00	718.00
IUUC-Hsa-046358	Homo sapiens	98.78	0.00e+00	850.00
IUUC-Itr-047890	Ictidomys tridecemlineatus	98.54	0.00e+00	849.00
IUUC-Kpa-049351	Komagataella pastoris	29.07	3.00e-43	169.00
IUUC-Lch-049936	Latimeria chalumnae	96.34	0.00e+00	830.00
IUUC-Loc-052476	Lepisosteus oculatus	95.49	0.00e+00	802.00
IUUC-Lma-053170	Leptosphaeria maculans	46.43	9.00e-101	360.00
IUUC-Laf-053713	Loxodonta africana	97.07	0.00e+00	833.00
IUUC-Mcc-054628	Macaca mulatta	98.05	0.00e+00	847.00
IUUC-Meu-055927	Macropus eugenii	84.84	4.00e-139	486.00
IUUC-Mor-056962	Magnaporthe oryzae	45.08	1.00e-98	352.00
IUUC-Mpo-057583	Magnaporthe poae	45.05	3.00e-94	338.00
IUUC-Mla-058819	Melampsora laricipopulina	48.31	1.00e-118	419.00
IUUC-Mvi-060403	Microbotryum violaceum	50.34	2.00e-129	455.00
IUUC-Mmr-061289	Microcebus murinus	98.50	0.00e+00	827.00
IUUC-Mdo-061912	Monodelphis domestica	97.80	0.00e+00	843.00
IUUC-Mmu-063253	Mus musculus	98.54	0.00e+00	849.00
IUUC-Mpu-066638	Mustela putorius furo	98.54	0.00e+00	849.00
IUUC-Mlu-067267	Myotis lucifugus	96.81	0.00e+00	832.00
IUUC-Nfi-068571	Neosartorya fischeri	45.32	9.00e-99	353.00
IUUC-Ncr-068895	Neurospora crassa	48.17	2.00e-105	375.00
IUUC-Nle-069087	Nomascus leucogenys	98.21	0.00e+00	692.00
IUUC-Opr-070579	Ochotona princeps	98.78	0.00e+00	850.00
IUUC-Ont-072432	Oreochromis niloticus	94.39	0.00e+00	820.00
IUUC-Oan-073072	Ornithorhynchus anatinus	98.54	0.00e+00	849.00
IUUC-Ocu-074180	Oryctolagus cuniculus	98.78	0.00e+00	850.00
IUUC-Ola-086772	Oryzias latipes	93.90	0.00e+00	811.00
IUUC-Oga-088219	Otolemur garnettii	96.33	0.00e+00	829.00
IUUC-Oar-090394	Ovis aries	98.54	0.00e+00	849.00
IUUC-Ptr-091517	Pan troglodytes	98.54	0.00e+00	849.00
IUUC-Pan-092421	Papio anubis	98.05	0.00e+00	847.00
IUUC-Psi-093370	Pelodiscus sinensis	99.02	0.00e+00	851.00
IUUC-Pma-094319	Petromyzon marinus	88.25	0.00e+00	640.00
IUUC-Pno-094815	Phaeosphaeria nodorum	47.02	2.00e-104	372.00
IUUC-Pfo-097089	Poecilia formosa	93.41	0.00e+00	812.00
IUUC-Pab-098421	Pongo abelii	98.54	0.00e+00	849.00
IUUC-Pca-100120	Procavia capensis	72.03	5.00e-163	566.00
IUUC-Pva-102960	Pteropus vampyrus	98.29	0.00e+00	846.00
IUUC-Pgr-103538	Puccinia graminis	47.43	2.00e-118	418.00
IUUC-Ptt-103990	Puccinia triticina	42.46	1.00e-44	174.00
IUUC-Pte-104261	Pyrenophora teres	47.26	2.00e-104	372.00
IUUC-Pyt-104780	Pyrenophora triticirepentis	47.49	8.00e-105	373.00
IUUC-Rno-105123	Rattus norvegicus	98.54	0.00e+00	849.00
IUUC-Sce-106208	Saccharomyces cerevisiae	27.72	2.00e-36	146.00
IUUC-Sha-107010	Sarcophilus harrisii	97.56	0.00e+00	841.00
IUUC-Sja-107899	Schizosaccharomyces japonicus	32.57	5.00e-65	241.00
IUUC-Ssl-108571	Sclerotinia sclerotiorum	44.47	3.00e-99	354.00
IUUC-Sar-113309	Sorex araneus	97.74	0.00e+00	818.00
IUUC-Sre-115003	Sporisorium reilianum	49.77	3.00e-125	441.00
IUUC-Ssc-116148	Sus scrofa	98.54	0.00e+00	849.00
IUUC-Tgu-117299	Taeniopygia guttata	99.51	0.00e+00	851.00
IUUC-Tru-118179	Takifugu rubripes	91.71	0.00e+00	805.00
IUUC-Tsy-119493	Tarsius syrichta	97.07	0.00e+00	833.00
IUUC-Tni-120355	Tetraodon nigroviridis	92.93	0.00e+00	780.00
IUUC-Tre-121977	Trichoderma reesei	43.64	2.00e-101	362.00
IUUC-Tvi-122661	Trichoderma virens	43.84	3.00e-100	358.00
IUUC-Tme-127031	Tuber melanosporum	49.14	1.00e-103	369.00
IUUC-Tbe-127492	Tupaia belangeri	81.54	1.00e-114	405.00
IUUC-Ttr-128929	Tursiops truncatus	98.54	0.00e+00	848.00
IUUC-Uma-129347	Ustilago maydis	47.49	6.00e-122	430.00
IUUC-Vda-129837	Verticillium dahliae	45.45	2.00e-99	355.00
IUUC-Vpa-130532	Vicugna pacos	84.46	0.00e+00	660.00
IUUC-Xtr-131985	Xenopus tropicalis	97.07	0.00e+00	840.00
IUUC-Xma-133314	Xiphophorus maculatus	93.90	0.00e+00	815.00
IUUC-Yli-134403	Yarrowia lipolytica	38.57	5.00e-74	271.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence