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Tag Content
UUCD2 ID IUUC-Cfa-021003
UUCD1 version UUC-CaF-00963
Ensembl Protein ID ENSCAFP00000031121.2
UniProt Accession E2R3W8; E2R3W8_CANLF
Genbank Protein ID ENSCAFP00000031121
Protein Name Ubiquitin carboxyl-terminal hydrolase
Genbank Nucleotide ID AAEX03012197
Gene Name BAP1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSCAFG00000009520.4 ENSCAFT00000035819.3 ENSCAFP00000031121.2
ENSCAFG00000009520.4 ENSCAFT00000015130.3 ENSCAFP00000014002.3
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/UCH 3.20e-170 566.4 3 729
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/UCH
   S: 6    kewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqv 94
           k+wleLesdPglftllvedfgvk++ qvee+y+L++++    q+pv+g+++lFk++e+r+s+rk++++++d++v+d+di++++ffa+q+
   Q: 3    KGWLELESDPGLFTLLVEDFGVKGV-QVEEIYDLQSKC----QGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQL 86
           89***********************.************....*********************************************** PP
   S: 95   igNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsy 183
           i+NsCat+Allsvllnc+++  dlG+tlsr+k++tk++spe+k++a+gn+++l+++hns+ar+e+r++pe+q+++++++t+eafhfvsy
   Q: 87   IPNSCATHALLSVLLNCSSV--DLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSY 173
           ********************..******************************************************************* PP
   S: 184  vningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesde....irfnllaivadrrviktlrlnvlkid......... 259
           v+i+grl+eldglk++P+d+g+++e+ee++dk+++v+  +eri+l++++e    irfnl+a+v+drr+++++rl+vlk++         
   Q: 174  VPITGRLFELDGLKVYPIDHGPWGEDEEWTDKARRVI--MERIGLATAGEpyhdIRFNLMAVVPDRRIKYEARLHVLKVNrqtvlealq 260
           *************************************..************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 261  qlirvtqpeliqthksqepqlpeeskpassksplaldagrataasegthtdgveevagscsqapthsppskpklvvkppgsslngvppn 349
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 350  ptpivqrlpafldnhnyakspmqeeedlaagvgrsrvpvrppqqysddeddyeddedddvqntnsairykrkgpgkpgplsgsgdgqls 438
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 439  vlqpntinvlaeklkesqkdlsiplsiktssgaaspavavpthsqpsptpsnestdtaseigsafnsplrspirsanptrpsspvtshi 527
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 528  skvlfgeddsllrvdcirynravrdlgpvistgllhlaedgvlsplalteggkgsspcsrpsqgsqgssspeekevveavdsrekpgla 616
           ***************************************************************************************** PP
   S: 260  .............keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveetisevrefgvn 335
                        keLl+Llk++e+e++++ea+l++e+ekrkkfkidd+rRt+nydefic+fi++la+eg+l++lve++is++r++gv+
   Q: 617  rpgeplsgekyspKELLALLKCVEAEIANYEACLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLANLVEQNISVRRRQGVS 705
           ***************************************************************************************** PP
   S: 336  egrlakqrkqgrekkirplkrkrk 359
           +grl+kqrk++r+k++rp+k+kr+
   Q: 706  IGRLHKQRKPDRRKRSRPYKAKRQ 729
           **********************97 PP
   
Organism Canis familiaris
Protein Sequence
(Fasta)
MNKGWLELES DPGLFTLLVE DFGVKGVQVE EIYDLQSKCQ GPVYGFIFLF KWIEERRSRR 60
KVSTLVDDTS VIDDDIVNNM FFAHQLIPNS CATHALLSVL LNCSSVDLGP TLSRMKDFTK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cfa-021003|DUB,UCH|Canis familiaris
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGAATAAGG GCTGGCTGGA GCTGGAGAGC GACCCTGGTG AGGAGGGCGC TGGGCGGGCC 60
GGGGGCTGGG GAGGCCTGGT GCGCCCGAAA CGCGCCCGCC TGACCACCGC CTGCCCCTCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cfa-021003|DUB,UCH|Canis familiaris
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR001578--Peptidase_C12_UCH
Pfam

PF01088--Peptidase_C12
PRINTS

PR00707--UBCTHYDRLASE
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0035517--C:PR-DUB complex
GO:0003682--F:chromatin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0061519--P:macrophage homeostasis
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0016579--P:protein deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0051726--P:regulation of cell cycle
GO:0001558--P:regulation of cell growth
GO:1900015--P:regulation of cytokine production involved in inflammatory response
GO:0010035--P:response to inorganic substance
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG cfa:484737
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001263 Ailuropoda melanoleuca 96.47 0.00e+00 1229.00
IUUC-Apl-003405 Anas platyrhynchos 70.17 0.00e+00 636.00
IUUC-Aca-004836 Anolis carolinensis 80.49 0.00e+00 1153.00
IUUC-Ame-011946 Astyanax mexicanus 63.51 0.00e+00 879.00
IUUC-Bta-013131 Bos taurus 92.71 0.00e+00 1077.00
IUUC-Cja-019599 Callithrix jacchus 96.30 0.00e+00 1313.00
IUUC-Cpo-022143 Cavia porcellus 95.34 0.00e+00 1285.00
IUUC-Csa-023477 Chlorocebus sabaeus 96.16 0.00e+00 1286.00
IUUC-Cho-024734 Choloepus hoffmanni 83.20 0.00e+00 746.00
IUUC-Csv-025842 Ciona savignyi 57.88 9.00e-94 337.00
IUUC-Dre-027793 Danio rerio 65.62 0.00e+00 905.00
IUUC-Dno-029253 Dasypus novemcinctus 95.57 0.00e+00 1276.00
IUUC-Dor-030891 Dipodomys ordii 88.75 0.00e+00 1188.00
IUUC-Dme-031796 Drosophila melanogaster 59.01 2.00e-92 332.00
IUUC-Ete-032646 Echinops telfairi 86.25 7.00e-169 587.00
IUUC-Eca-033805 Equus caballus 96.71 0.00e+00 1276.00
IUUC-Eeu-035216 Erinaceus europaeus 94.22 4.00e-145 508.00
IUUC-Fca-035611 Felis catus 98.19 0.00e+00 1172.00
IUUC-Fal-037186 Ficedula albicollis 81.41 0.00e+00 997.00
IUUC-Gmo-038824 Gadus morhua 70.76 2.00e-180 625.00
IUUC-Gga-040875 Gallus gallus 82.19 0.00e+00 1122.00
IUUC-Gac-042226 Gasterosteus aculeatus 67.34 0.00e+00 935.00
IUUC-Ggo-045122 Gorilla gorilla 95.75 0.00e+00 1316.00
IUUC-Hsa-045882 Homo sapiens 96.02 0.00e+00 1318.00
IUUC-Itr-048185 Ictidomys tridecemlineatus 96.84 0.00e+00 1294.00
IUUC-Lch-049960 Latimeria chalumnae 72.49 0.00e+00 1006.00
IUUC-Loc-052408 Lepisosteus oculatus 76.17 0.00e+00 660.00
IUUC-Laf-054187 Loxodonta africana 96.30 0.00e+00 1260.00
IUUC-Mcc-055273 Macaca mulatta 95.20 0.00e+00 1278.00
IUUC-Meu-056267 Macropus eugenii 82.85 0.00e+00 1168.00
IUUC-Mga-059958 Meleagris gallopavo 88.24 1.00e-154 538.00
IUUC-Mmr-061280 Microcebus murinus 96.03 0.00e+00 1264.00
IUUC-Mdo-062625 Monodelphis domestica 89.71 0.00e+00 1276.00
IUUC-Mmu-063853 Mus musculus 93.69 0.00e+00 1275.00
IUUC-Mlu-067771 Myotis lucifugus 95.88 0.00e+00 1244.00
IUUC-Opr-070741 Ochotona princeps 93.83 0.00e+00 1292.00
IUUC-Ont-072172 Oreochromis niloticus 65.58 0.00e+00 940.00
IUUC-Oan-073167 Ornithorhynchus anatinus 80.52 0.00e+00 1148.00
IUUC-Ocu-074176 Oryctolagus cuniculus 95.60 0.00e+00 1237.00
IUUC-Ola-087203 Oryzias latipes 85.23 5.00e-135 473.00
IUUC-Oga-089153 Otolemur garnettii 95.43 0.00e+00 1271.00
IUUC-Oar-090008 Ovis aries 93.55 0.00e+00 1245.00
IUUC-Ptr-091234 Pan troglodytes 96.02 0.00e+00 1321.00
IUUC-Pan-092005 Papio anubis 96.43 0.00e+00 1307.00
IUUC-Psi-093995 Pelodiscus sinensis 84.20 0.00e+00 658.00
IUUC-Pma-094110 Petromyzon marinus 47.98 3.00e-120 425.00
IUUC-Pfo-097418 Poecilia formosa 65.56 0.00e+00 922.00
IUUC-Pab-098267 Pongo abelii 96.02 0.00e+00 1294.00
IUUC-Pca-101084 Procavia capensis 93.87 0.00e+00 1210.00
IUUC-Pva-102292 Pteropus vampyrus 96.89 0.00e+00 917.00
IUUC-Rno-105251 Rattus norvegicus 91.91 0.00e+00 1244.00
IUUC-Sha-107100 Sarcophilus harrisii 88.47 0.00e+00 1271.00
IUUC-Sar-113559 Sorex araneus 87.65 0.00e+00 1086.00
IUUC-Ssc-115688 Sus scrofa 96.02 0.00e+00 1289.00
IUUC-Tgu-117424 Taeniopygia guttata 80.06 0.00e+00 1120.00
IUUC-Tru-118585 Takifugu rubripes 67.62 0.00e+00 926.00
IUUC-Tsy-119299 Tarsius syrichta 84.57 0.00e+00 964.00
IUUC-Tni-120808 Tetraodon nigroviridis 66.53 0.00e+00 917.00
IUUC-Tbe-127705 Tupaia belangeri 95.97 0.00e+00 632.00
IUUC-Ttr-128225 Tursiops truncatus 95.88 0.00e+00 1252.00
IUUC-Vpa-130193 Vicugna pacos 96.75 2.00e-132 466.00
IUUC-Xtr-132449 Xenopus tropicalis 71.13 0.00e+00 939.00
Created Date 25-Jun-2017

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