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Tag Content
iUUCD ID IUUC-Laf-054059
Ensembl Protein ID ENSLAFP00000002273.3
UniProt Accession G3SR12; G3SR12_LOXAF
Protein Name Uncharacterized protein
Gene Name PML
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSLAFG00000002717.3 ENSLAFT00000002715.3 ENSLAFP00000002273.3
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 76.75 0.00e+00 1202.00 IUUC-Hsa-045861
E3 activity/RING/RING 65.29 0.00e+00 994.00 IUUC-Mmu-063118
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Loxodonta africana
Protein Sequence
(Fasta)
IETALGSMQQ EPAPARSPGP QEDPALPDSP TMPPPGSPSE GHHLVLEYSP CPAKQIAEEE 60
FQFLRCQDCK AEAKCPKLLP CLHTLCSGCL EVAGVQCPIC QTPRSPGANA PALDNVFFES 120
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Protein Fasta Sequence



>IUUC-Laf-054059|E3,RING|Loxodonta africana
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Nucleotide Sequence
(Fasta)
ATCGAAACTG CGCTGGGTTC CATGCAGCAA GAGCCCGCAC CCGCCAGGTC TCCCGGGCCT 60
CAGGAGGACC CCGCACTGCC CGACTCGCCC ACTATGCCGC CCCCGGGGTC CCCCTCCGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Laf-054059|E3,RING|Loxodonta africana
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR021978--DUF3583
IPR012337--RNaseH-like_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF12126--DUF3583
PF00643--zf-B_box

SMART

SM00336--BBOX

Gene Ontology

GO:0005829--C:cytosol
GO:0042406--C:extrinsic component of endoplasmic reticulum membrane
GO:0000784--C:nuclear chromosome, telomeric region
GO:0016363--C:nuclear matrix
GO:0031965--C:nuclear membrane
GO:0005730--C:nucleolus
GO:0016605--C:PML body
GO:0008270--F:zinc ion binding
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0060444--P:branching involved in mammary gland duct morphogenesis
GO:0007050--P:cell cycle arrest
GO:0045165--P:cell fate commitment
GO:0071353--P:cellular response to interleukin-4
GO:0090398--P:cellular senescence
GO:0032922--P:circadian regulation of gene expression
GO:0007182--P:common-partner SMAD protein phosphorylation
GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0032469--P:endoplasmic reticulum calcium ion homeostasis
GO:0043153--P:entrainment of circadian clock by photoperiod
GO:0097191--P:extrinsic apoptotic signaling pathway
GO:0010761--P:fibroblast migration
GO:0045087--P:innate immune response
GO:0042771--P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0008631--P:intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0051457--P:maintenance of protein location in nucleus
GO:0030099--P:myeloid cell differentiation
GO:0016525--P:negative regulation of angiogenesis
GO:0030308--P:negative regulation of cell growth
GO:0008285--P:negative regulation of cell proliferation
GO:0050713--P:negative regulation of interleukin-1 beta secretion
GO:2000059--P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:1902187--P:negative regulation of viral release from host cell
GO:0030578--P:PML body organization
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:0048146--P:positive regulation of fibroblast proliferation
GO:0045345--P:positive regulation of MHC class I biosynthetic process
GO:0032206--P:positive regulation of telomere maintenance
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006461--P:protein complex assembly
GO:0010522--P:regulation of calcium ion transport into cytosol
GO:0030155--P:regulation of cell adhesion
GO:2000779--P:regulation of double-strand break repair
GO:0001932--P:regulation of protein phosphorylation
GO:0010332--P:response to gamma radiation
GO:0001666--P:response to hypoxia
GO:0009411--P:response to UV
GO:0048384--P:retinoic acid receptor signaling pathway
GO:0007184--P:SMAD protein import into nucleus
GO:0007179--P:transforming growth factor beta receptor signaling pathway

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001901 Ailuropoda melanoleuca 73.22 0.00e+00 1092.00
IUUC-Bta-012427 Bos taurus 69.78 0.00e+00 1103.00
IUUC-Cja-019029 Callithrix jacchus 76.85 0.00e+00 1150.00
IUUC-Cfa-021127 Canis familiaris 72.58 0.00e+00 1078.00
IUUC-Cpo-022553 Cavia porcellus 66.92 0.00e+00 950.00
IUUC-Csa-023187 Chlorocebus sabaeus 73.60 0.00e+00 789.00
IUUC-Cho-024937 Choloepus hoffmanni 70.07 1.00e-98 354.00
IUUC-Dno-029326 Dasypus novemcinctus 73.51 0.00e+00 1055.00
IUUC-Dor-030808 Dipodomys ordii 61.74 0.00e+00 690.00
IUUC-Ete-032746 Echinops telfairi 54.78 7.00e-175 607.00
IUUC-Eca-033234 Equus caballus 75.67 0.00e+00 1092.00
IUUC-Fca-035648 Felis catus 75.12 0.00e+00 1145.00
IUUC-Ggo-044927 Gorilla gorilla 76.64 0.00e+00 1184.00
IUUC-Hsa-045861 Homo sapiens 76.75 0.00e+00 1187.00
IUUC-Itr-047861 Ictidomys tridecemlineatus 75.00 0.00e+00 1180.00
IUUC-Loc-052276 Lepisosteus oculatus 34.03 1.00e-48 188.00
IUUC-Meu-056495 Macropus eugenii 53.56 3.00e-102 366.00
IUUC-Mga-059224 Meleagris gallopavo 32.97 2.00e-78 287.00
IUUC-Mmr-061507 Microcebus murinus 74.01 0.00e+00 1085.00
IUUC-Mdo-062196 Monodelphis domestica 47.15 0.00e+00 635.00
IUUC-Mmu-063118 Mus musculus 65.29 0.00e+00 1024.00
IUUC-Mpu-066024 Mustela putorius furo 69.63 0.00e+00 1061.00
IUUC-Mlu-066980 Myotis lucifugus 71.56 0.00e+00 1051.00
IUUC-Nle-069779 Nomascus leucogenys 76.52 0.00e+00 1129.00
IUUC-Ocu-074016 Oryctolagus cuniculus 64.45 0.00e+00 973.00
IUUC-Oga-089085 Otolemur garnettii 64.24 0.00e+00 979.00
IUUC-Oar-089980 Ovis aries 67.91 0.00e+00 1052.00
IUUC-Ptr-091681 Pan troglodytes 76.57 0.00e+00 1181.00
IUUC-Pan-091965 Papio anubis 75.23 0.00e+00 1110.00
IUUC-Psi-093577 Pelodiscus sinensis 37.35 1.00e-111 397.00
IUUC-Pab-098215 Pongo abelii 71.28 5.00e-173 601.00
IUUC-Pca-100883 Procavia capensis 77.98 0.00e+00 895.00
IUUC-Pva-102465 Pteropus vampyrus 68.10 0.00e+00 760.00
IUUC-Rno-105120 Rattus norvegicus 64.98 0.00e+00 1037.00
IUUC-Sar-113320 Sorex araneus 66.42 6.00e-82 298.00
IUUC-Ssc-116042 Sus scrofa 71.23 0.00e+00 1110.00
IUUC-Tbe-127880 Tupaia belangeri 67.93 6.00e-135 474.00
Created Date 25-Jun-2017

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