iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089749

Ensembl Protein ID

ENSOARP00000018511.1

UniProt Accession

W5Q719; W5Q719_SHEEP

Genbank Protein ID

ENSOARP00000018511

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01088303

Gene Name

HECW1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000017240.1	ENSOART00000018773.1	ENSOARP00000018511.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.70e-121	403.8	1263	1595

Active Site

Position(s)	Description	Evidence
1563	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+++fvgEegld++G++ref++lls+el+np++glf+ys+nd++t+q++p s +  ++hl++F+f Gr+lg+al ++ lld
   Q: 1263 ELQRNKLYITFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWFRFSGRILGLALIHQYLLD 1348
           567899****************************************************985.6************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ +++l+dle +d+e+++sl+++k+n   +i+++ ldltf+v+ee++g+++e+eLk+gG+n++Vt++Nk+eY+++
   Q: 1349 AFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDN---NITDI-LDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIER 1431
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v +r+++g+ +q+ea+ +Gf+ev++ +l+s+F+++elel+i G++eid+ d++++++y+ggy++ + +i+wFw ++e+f++e+r +
   Q: 1432 MVRWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLADWRNNAEYRGGYHDGHLVIRWFWAAVERFNNEQRLR 1518
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+     r+f+i+k+++ ++lP+++TCfn+L+LP+Y+s++ l+ekLl+A+eet+ F+l+
   Q: 1519 LLQFVTGTSSVPYEGFAALRgsngLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1595
           ************************999***********************************************985 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

PLLTVCLPPQ NLYQNRFLGL AAMASPSRNS QNRRRCKEPL RHSYNPGQYH SVAIRTGPHG 60
AGTIPRSTSD TDLVTSDSRS TLMVSSSYYS IGHSQDLVIH WDIKEEVDAG DWIGMYLIDE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCCTGCTGA CTGTCTGTTT GCCCCCACAG AATCTGTACC AGAACAGGTT CTTAGGCCTG 60
GCCGCCATGG CATCTCCATC TAGAAACTCC CAGAATCGAC GCCGGTGCAA GGAGCCGCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001636	Ailuropoda melanoleuca	87.03	0.00e+00	2197.00
IUUC-Apl-003299	Anas platyrhynchos	79.35	0.00e+00	2414.00
IUUC-Aca-005024	Anolis carolinensis	79.00	0.00e+00	2370.00
IUUC-Bta-012604	Bos taurus	98.12	0.00e+00	2874.00
IUUC-Cja-019880	Callithrix jacchus	84.92	0.00e+00	2239.00
IUUC-Cfa-021216	Canis familiaris	89.41	0.00e+00	1805.00
IUUC-Cpo-021466	Cavia porcellus	96.21	0.00e+00	1707.00
IUUC-Csa-023080	Chlorocebus sabaeus	90.00	0.00e+00	2661.00
IUUC-Cho-024740	Choloepus hoffmanni	91.81	0.00e+00	1129.00
IUUC-Dre-028750	Danio rerio	74.16	0.00e+00	1549.00
IUUC-Dno-030019	Dasypus novemcinctus	87.15	0.00e+00	2618.00
IUUC-Dor-031030	Dipodomys ordii	72.83	0.00e+00	1122.00
IUUC-Ete-032352	Echinops telfairi	93.12	0.00e+00	1251.00
IUUC-Eca-033948	Equus caballus	88.98	0.00e+00	2570.00
IUUC-Eeu-034474	Erinaceus europaeus	70.08	0.00e+00	830.00
IUUC-Fca-036148	Felis catus	91.95	0.00e+00	2621.00
IUUC-Fal-036957	Ficedula albicollis	80.16	0.00e+00	2397.00
IUUC-Gmo-038714	Gadus morhua	69.30	0.00e+00	1020.00
IUUC-Gga-041194	Gallus gallus	79.99	0.00e+00	2392.00
IUUC-Gac-041366	Gasterosteus aculeatus	77.73	0.00e+00	1367.00
IUUC-Ggo-045442	Gorilla gorilla	81.97	0.00e+00	1639.00
IUUC-Hsa-045730	Homo sapiens	90.06	0.00e+00	2657.00
IUUC-Itr-048439	Ictidomys tridecemlineatus	89.79	0.00e+00	2652.00
IUUC-Lch-050185	Latimeria chalumnae	73.02	0.00e+00	1391.00
IUUC-Loc-052744	Lepisosteus oculatus	80.02	0.00e+00	1562.00
IUUC-Laf-054368	Loxodonta africana	97.81	0.00e+00	1492.00
IUUC-Mcc-055487	Macaca mulatta	90.00	0.00e+00	2655.00
IUUC-Meu-056751	Macropus eugenii	91.08	0.00e+00	725.00
IUUC-Mga-059545	Meleagris gallopavo	80.21	0.00e+00	2385.00
IUUC-Mmr-061078	Microcebus murinus	88.29	0.00e+00	2490.00
IUUC-Mdo-062176	Monodelphis domestica	84.43	0.00e+00	1689.00
IUUC-Mmu-063513	Mus musculus	85.22	0.00e+00	2468.00
IUUC-Mpu-065786	Mustela putorius furo	91.27	0.00e+00	2643.00
IUUC-Mlu-067780	Myotis lucifugus	84.62	0.00e+00	2393.00
IUUC-Nle-069213	Nomascus leucogenys	89.37	0.00e+00	2599.00
IUUC-Opr-070208	Ochotona princeps	96.41	0.00e+00	1481.00
IUUC-Ont-072132	Oreochromis niloticus	81.57	0.00e+00	1362.00
IUUC-Oan-072807	Ornithorhynchus anatinus	84.40	0.00e+00	1782.00
IUUC-Ocu-074745	Oryctolagus cuniculus	85.91	0.00e+00	2533.00
IUUC-Ola-086981	Oryzias latipes	73.79	0.00e+00	1477.00
IUUC-Oga-087965	Otolemur garnettii	93.03	0.00e+00	1831.00
IUUC-Ptr-091243	Pan troglodytes	89.88	0.00e+00	2653.00
IUUC-Pan-092201	Papio anubis	89.52	0.00e+00	2652.00
IUUC-Psi-093511	Pelodiscus sinensis	78.29	0.00e+00	2367.00
IUUC-Pfo-097001	Poecilia formosa	78.23	0.00e+00	1379.00
IUUC-Pab-098728	Pongo abelii	87.16	0.00e+00	2539.00
IUUC-Pca-100129	Procavia capensis	81.42	0.00e+00	1256.00
IUUC-Pva-102250	Pteropus vampyrus	79.95	0.00e+00	2170.00
IUUC-Rno-105031	Rattus norvegicus	85.88	0.00e+00	2498.00
IUUC-Tgu-117515	Taeniopygia guttata	79.60	0.00e+00	2402.00
IUUC-Tru-117914	Takifugu rubripes	77.13	0.00e+00	1374.00
IUUC-Tsy-119379	Tarsius syrichta	78.60	0.00e+00	786.00
IUUC-Tni-120178	Tetraodon nigroviridis	77.52	0.00e+00	1395.00
IUUC-Tbe-127762	Tupaia belangeri	82.37	0.00e+00	1974.00
IUUC-Ttr-128806	Tursiops truncatus	93.92	0.00e+00	1746.00
IUUC-Xtr-132903	Xenopus tropicalis	81.39	0.00e+00	1709.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence