iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062383

UUCD1 version

UUC-MoD-00940

Ensembl Protein ID

ENSMODP00000011801.2

UniProt Accession

F7FZM7; F7FZM7_MONDO

Protein Name

Uncharacterized protein

Gene Name

SOCS2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000009444.3	ENSMODT00000012024.3	ENSMODP00000011801.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.40e-14	53.8	153	197

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 4    lwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
           +++l ++ ++LqhLCRl+I++c+ +     i++LPLP +LkdYL++++yq
   Q: 153  TKPLYTSTPTLQHLCRLSINKCTAK-----IWELPLPTRLKDYLKEYQYQ 197
           67889999****************9.....8****************986 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MTLRSHESTV DGAEGTRSQW GATGTAEEQP SEVTRLATAM RELSQAGWYW GSMTVNEAKE 60
KLKDAPEGTF LIRDSSHSDY LLTISVKTSA GPTNLRIEYQ DGKFRLDSII CVKSRLKQFD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGATGTGACC ATTCGTTCCT TTCAATGTCA TGGGCTTCTA TTCCCCCTCC CTGGGGAAAA 60
TCGGCGCCTT AGTGTGAGAA AGGAGACACA CTCCAGCAGA ACGAAGAGGG CTCTCGGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028410--SOCS2
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

PRINTS

PR00401--SH2DOMAIN

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0060396--P:growth hormone receptor signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0016567--P:protein ubiquitination
GO:0001558--P:regulation of cell growth
GO:0032355--P:response to estradiol

KEGG

mdo:100011895

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002075	Ailuropoda melanoleuca	81.31	1.00e-91	328.00
IUUC-Apl-003484	Anas platyrhynchos	82.24	5.00e-74	269.00
IUUC-Aca-004253	Anolis carolinensis	73.78	1.00e-73	268.00
IUUC-Ath-007106	Arabidopsis thaliana	35.59	3.90e-02	32.30
IUUC-Ame-011267	Astyanax mexicanus	62.65	2.00e-59	221.00
IUUC-Bta-013183	Bos taurus	81.31	6.00e-88	316.00
IUUC-Bra-017915	Brassica rapa	33.90	7.10e-02	31.60
IUUC-Cja-018862	Callithrix jacchus	81.31	2.00e-88	317.00
IUUC-Cfa-020226	Canis familiaris	81.22	2.00e-84	305.00
IUUC-Cpo-022414	Cavia porcellus	80.81	6.00e-89	319.00
IUUC-Csa-023758	Chlorocebus sabaeus	80.81	1.00e-89	322.00
IUUC-Cho-024471	Choloepus hoffmanni	78.21	9.00e-67	245.00
IUUC-Dre-028288	Danio rerio	59.70	2.00e-65	241.00
IUUC-Dno-029036	Dasypus novemcinctus	80.30	1.00e-91	328.00
IUUC-Dor-030447	Dipodomys ordii	88.08	5.00e-79	286.00
IUUC-Ete-033023	Echinops telfairi	79.80	7.00e-94	336.00
IUUC-Fca-036469	Felis catus	82.32	1.00e-88	318.00
IUUC-Fal-036642	Ficedula albicollis	81.17	1.00e-73	268.00
IUUC-Gmo-039331	Gadus morhua	64.58	6.00e-36	142.00
IUUC-Gga-040809	Gallus gallus	80.50	7.00e-76	275.00
IUUC-Gac-041398	Gasterosteus aculeatus	57.43	4.00e-62	230.00
IUUC-Ggo-045341	Gorilla gorilla	81.82	1.00e-88	318.00
IUUC-Hsa-046557	Homo sapiens	81.31	4.00e-96	343.00
IUUC-Itr-049013	Ictidomys tridecemlineatus	68.90	1.00e-80	291.00
IUUC-Lch-050160	Latimeria chalumnae	63.58	2.00e-53	201.00
IUUC-Loc-051825	Lepisosteus oculatus	59.11	8.00e-64	236.00
IUUC-Laf-053560	Loxodonta africana	81.82	2.00e-86	311.00
IUUC-Mcc-055890	Macaca mulatta	80.81	2.00e-87	314.00
IUUC-Meu-056218	Macropus eugenii	92.93	9.00e-110	388.00
IUUC-Mga-059755	Meleagris gallopavo	72.22	1.00e-73	269.00
IUUC-Mmr-061387	Microcebus murinus	82.83	2.00e-91	327.00
IUUC-Mmu-063443	Mus musculus	81.31	3.00e-89	320.00
IUUC-Mpu-066459	Mustela putorius furo	81.31	4.00e-87	313.00
IUUC-Mlu-068040	Myotis lucifugus	82.32	3.00e-93	333.00
IUUC-Nle-069016	Nomascus leucogenys	78.28	2.00e-86	311.00
IUUC-Opr-071087	Ochotona princeps	75.76	2.00e-87	314.00
IUUC-Ont-072340	Oreochromis niloticus	57.56	4.00e-64	237.00
IUUC-Oan-073443	Ornithorhynchus anatinus	88.20	3.00e-93	333.00
IUUC-Ocu-074539	Oryctolagus cuniculus	82.23	5.00e-88	317.00
IUUC-Ola-087004	Oryzias latipes	59.49	2.00e-55	207.00
IUUC-Oga-088438	Otolemur garnettii	80.81	1.00e-89	321.00
IUUC-Oar-089932	Ovis aries	81.31	8.00e-88	315.00
IUUC-Ptr-091037	Pan troglodytes	81.82	1.00e-88	318.00
IUUC-Pan-092767	Papio anubis	80.81	1.00e-87	315.00
IUUC-Psi-093099	Pelodiscus sinensis	83.02	7.00e-79	285.00
IUUC-Pma-094671	Petromyzon marinus	43.35	3.00e-36	144.00
IUUC-Pfo-097073	Poecilia formosa	52.00	8.00e-58	216.00
IUUC-Pab-098319	Pongo abelii	81.31	1.00e-92	332.00
IUUC-Pca-101117	Procavia capensis	80.30	3.00e-85	307.00
IUUC-Pva-102117	Pteropus vampyrus	80.81	6.00e-86	309.00
IUUC-Rno-105913	Rattus norvegicus	80.81	3.00e-88	317.00
IUUC-Sha-106500	Sarcophilus harrisii	94.42	9.00e-108	382.00
IUUC-Ssc-115252	Sus scrofa	81.82	5.00e-90	323.00
IUUC-Tgu-117524	Taeniopygia guttata	80.50	2.00e-74	270.00
IUUC-Tsy-119335	Tarsius syrichta	85.43	1.00e-77	281.00
IUUC-Tni-120263	Tetraodon nigroviridis	56.22	6.00e-58	216.00
IUUC-Tbe-127915	Tupaia belangeri	81.82	2.00e-85	307.00
IUUC-Ttr-128372	Tursiops truncatus	81.31	2.00e-89	321.00
IUUC-Vpa-130422	Vicugna pacos	88.74	3.00e-79	286.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence