iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000024317.14	ENSMUST00000072847.11	ENSMUSP00000072626.5
ENSMUSG00000024317.14	ENSMUST00000052396.5	ENSMUSP00000056641.5

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	16714285

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	9.30e-07	30.4	18	58

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C++C+e +k+++++  C+Hvf+++C+  ++          ++CPlCr
   Q: 18   CPVCQEVLKTPVRTAACQHVFCRKCFlTAM------RESGIHCPLCR 58
           **********999999*********96666......999*******8 PP

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination. Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination. Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination. According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway.

Protein Sequence
(Fasta)

MSEELSAATS YTEDDFYCPV CQEVLKTPVR TAACQHVFCR KCFLTAMRES GIHCPLCRGS 60
VTRRERACPE RALDLENIMR RFSGSCRCCS KKIKFYRMRH HYKSCKKYQD EYGVSSVIPN 120

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Nucleotide Sequence
(Fasta)

GCGGGCTGCG AGCCGCGCAA TGTCGCAGAC TGCGGCTCCG GGGGTGGGGG CTTCACGGTG 60
CTGCACGAGC CTCACTCGGG CTTAGTCCCA TGAGGCCTGC GCACCCCGGC ACTGAAACCA 120

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Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0879--Wnt signaling pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008598--Di19_Zn_binding_dom
IPR034734--ZF_C2HC_RNF
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51803--ZF_C2HC_RNF
PS50089--ZF_RING_2

Pfam

PF05605--zf-Di19

SMART

SM00184--RING

Gene Ontology

GO:0005634--C:nucleus
GO:0035861--C:site of double-strand break
GO:0019901--F:protein kinase binding
GO:0003697--F:single-stranded DNA binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0010792--P:DNA double-strand break processing involved in repair via single-strand annealing
GO:0000724--P:double-strand break repair via homologous recombination
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0016055--P:Wnt signaling pathway

KEGG

mmu:56515

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001267	Ailuropoda melanoleuca	94.29	3.00e-140	490.00
IUUC-Apl-003941	Anas platyrhynchos	66.94	1.00e-88	319.00
IUUC-Aca-005233	Anolis carolinensis	66.94	6.00e-100	357.00
IUUC-Bta-012999	Bos taurus	94.29	4.00e-141	493.00
IUUC-Cja-019489	Callithrix jacchus	93.88	2.00e-140	491.00
IUUC-Cfa-020567	Canis familiaris	93.97	8.00e-112	395.00
IUUC-Cpo-022165	Cavia porcellus	93.88	6.00e-140	489.00
IUUC-Csa-024096	Chlorocebus sabaeus	94.29	1.00e-140	492.00
IUUC-Cho-024686	Choloepus hoffmanni	85.58	3.00e-102	363.00
IUUC-Cgl-026426	Colletotrichum gloeosporioides	38.24	2.00e-08	53.50
IUUC-Dno-029625	Dasypus novemcinctus	93.88	2.00e-139	488.00
IUUC-Dor-030983	Dipodomys ordii	79.18	1.00e-110	392.00
IUUC-Ete-032453	Echinops telfairi	69.80	3.00e-96	344.00
IUUC-Eca-034367	Equus caballus	94.23	2.00e-118	417.00
IUUC-Eeu-034722	Erinaceus europaeus	75.96	2.00e-87	315.00
IUUC-Fca-036590	Felis catus	95.10	1.00e-141	495.00
IUUC-Fal-037287	Ficedula albicollis	69.60	3.00e-104	370.00
IUUC-Fox-037926	Fusarium oxysporum	43.28	2.00e-09	56.20
IUUC-Gga-041055	Gallus gallus	68.78	2.00e-100	358.00
IUUC-Ggo-045324	Gorilla gorilla	93.88	3.00e-140	490.00
IUUC-Hsa-046364	Homo sapiens	93.88	3.00e-140	490.00
IUUC-Itr-048181	Ictidomys tridecemlineatus	93.88	7.00e-139	485.00
IUUC-Loc-052428	Lepisosteus oculatus	38.60	4.00e-45	174.00
IUUC-Laf-054506	Loxodonta africana	94.29	4.00e-141	493.00
IUUC-Mcc-054595	Macaca mulatta	94.23	1.00e-118	418.00
IUUC-Mga-060068	Meleagris gallopavo	69.71	1.00e-99	355.00
IUUC-Mmr-061516	Microcebus murinus	92.34	1.00e-136	478.00
IUUC-Mdo-062243	Monodelphis domestica	84.15	8.00e-126	442.00
IUUC-Mpu-065869	Mustela putorius furo	95.10	1.00e-141	495.00
IUUC-Mlu-068157	Myotis lucifugus	92.79	4.00e-117	413.00
IUUC-Nle-069538	Nomascus leucogenys	79.18	7.00e-110	389.00
IUUC-Opr-070640	Ochotona princeps	91.84	3.00e-137	480.00
IUUC-Oan-072919	Ornithorhynchus anatinus	85.43	5.00e-96	343.00
IUUC-Ocu-074897	Oryctolagus cuniculus	94.69	2.00e-140	491.00
IUUC-Oga-088165	Otolemur garnettii	93.47	5.00e-140	489.00
IUUC-Oar-090364	Ovis aries	93.47	5.00e-113	399.00
IUUC-Ptr-090784	Pan troglodytes	93.88	3.00e-140	490.00
IUUC-Pan-091874	Papio anubis	94.29	1.00e-140	492.00
IUUC-Psi-093531	Pelodiscus sinensis	74.00	1.00e-104	372.00
IUUC-Pab-098013	Pongo abelii	93.88	3.00e-140	490.00
IUUC-Pca-100822	Procavia capensis	87.89	2.00e-116	410.00
IUUC-Pva-102936	Pteropus vampyrus	93.47	8.00e-140	489.00
IUUC-Sha-107403	Sarcophilus harrisii	90.45	5.00e-110	389.00
IUUC-Sar-113678	Sorex araneus	92.77	1.00e-43	169.00
IUUC-Ssc-116192	Sus scrofa	95.10	1.00e-141	495.00
IUUC-Tgu-116820	Taeniopygia guttata	69.36	1.00e-96	345.00
IUUC-Tsy-119211	Tarsius syrichta	76.92	2.00e-90	324.00
IUUC-Tbe-127480	Tupaia belangeri	60.00	9.00e-76	276.00
IUUC-Ttr-128859	Tursiops truncatus	95.92	4.00e-142	496.00
IUUC-Vda-129783	Verticillium dahliae	36.23	9.00e-09	55.10
IUUC-Vpa-130682	Vicugna pacos	89.39	3.00e-128	450.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence