iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000014703.3	ENSMMUT00000057272.1	ENSMMUP00000048681.1
ENSMMUG00000014703.3	ENSMMUT00000020615.3	ENSMMUP00000019289.3
ENSMMUG00000014703.3	ENSMMUT00000020614.3	ENSMMUP00000019288.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.50e-118	395.6	576	905

Active Site

Position(s)	Description	Evidence
876	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
           ++lk+ + v+f gEeg+++ Gv re+++ ls+e+ npd+ lf++s+ d +t+qpn++s++ np+hl++F+f+G++lg+al +++l+++ 
   Q: 576  AKLKQGIAVRFHGEEGMGQ-GVVREWFDILSNEIVNPDYALFTQSA-DGTTFQPNSNSYV-NPDHLNYFRFAGQILGLALNHRQLVNIY 661
           679999*************.**********************6666.67788*******9.89************************** PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           +++sfyk++lg +++++d++++dpe++k+l++i++n   di++lgl+ltfsv+++++g ++e+ LkpgG +i Vt++Nk eYv+lv+e+
   Q: 662  FTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDN---DISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTEL 747
           **********************************99...************************************************** PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvT 269
           r+++ i+ q++af +Gf+  ip++l++lF+e elell++G++eidv+d+ k+t+y++gy++++p+iqwFwev+e++++eer  +LqFvT
   Q: 748  RMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVT 836
           ***************************************************************************************** PP
   S: 270  gssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kg 332
           gssr+P+gGfa+++     + f+i     +++ lP+s+TC+n+LkLPeY+skeilk++Ll+A + +  g
   Q: 837  GSSRVPHGGFANIMggsgLQNFTIAAvPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGsYG 905
           ******************8888888868888********************************986555 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MERAMEQLNR LTRSLRRART VELPEDNETA VYTLMPMVMA DQHRSVSELL SNSKFDVNYA 60
FGRVKRSLLH IAANCGSVEC LVLLLKKGAN PNYQDISGCT PLHLAARNGQ KKCMSKLLEY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCCCCGCAG CAGCCGGGCC CCCGGACGCA GGACGTGGCC CCAGGTAGCC CTTGCAGCTC 60
AGTGCTGTAG CCAGGGCAAG CCCGCGCCTC CGCCTGCTGG AGTGGCCCGG GCGAGATGTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000569--HECT_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT

Pfam

PF12796--Ank_2
PF00632--HECT

PRINTS

PR01415--ANKYRIN

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0000139--C:Golgi membrane
GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007030--P:Golgi organization
GO:0061025--P:membrane fusion
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030334--P:regulation of cell migration

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001490	Ailuropoda melanoleuca	98.14	0.00e+00	1867.00
IUUC-Apl-003400	Anas platyrhynchos	88.03	0.00e+00	1153.00
IUUC-Aca-005375	Anolis carolinensis	91.32	0.00e+00	1736.00
IUUC-Ame-011847	Astyanax mexicanus	84.87	0.00e+00	1647.00
IUUC-Bta-012831	Bos taurus	97.86	0.00e+00	1826.00
IUUC-Cja-019160	Callithrix jacchus	99.56	0.00e+00	1894.00
IUUC-Cfa-020346	Canis familiaris	98.46	0.00e+00	1875.00
IUUC-Cpo-021766	Cavia porcellus	97.36	0.00e+00	1857.00
IUUC-Csa-023768	Chlorocebus sabaeus	99.89	0.00e+00	1900.00
IUUC-Cho-024688	Choloepus hoffmanni	94.02	0.00e+00	1181.00
IUUC-Cin-025417	Ciona intestinalis	51.07	2.00e-138	486.00
IUUC-Csv-025993	Ciona savignyi	44.55	0.00e+00	759.00
IUUC-Dre-027819	Danio rerio	85.64	0.00e+00	1635.00
IUUC-Dno-029027	Dasypus novemcinctus	97.60	0.00e+00	1852.00
IUUC-Dor-030327	Dipodomys ordii	90.26	0.00e+00	1634.00
IUUC-Ete-032966	Echinops telfairi	90.66	0.00e+00	1711.00
IUUC-Eca-034339	Equus caballus	98.46	0.00e+00	1874.00
IUUC-Eeu-034544	Erinaceus europaeus	70.50	0.00e+00	699.00
IUUC-Fca-035617	Felis catus	98.15	0.00e+00	1338.00
IUUC-Fal-036687	Ficedula albicollis	91.30	0.00e+00	1766.00
IUUC-Gmo-039508	Gadus morhua	88.15	0.00e+00	833.00
IUUC-Gga-040845	Gallus gallus	91.51	0.00e+00	1784.00
IUUC-Gac-041894	Gasterosteus aculeatus	85.14	0.00e+00	1585.00
IUUC-Ggo-044465	Gorilla gorilla	95.94	0.00e+00	1818.00
IUUC-Hsa-045731	Homo sapiens	99.89	0.00e+00	1901.00
IUUC-Itr-048716	Ictidomys tridecemlineatus	98.68	0.00e+00	1875.00
IUUC-Lch-050436	Latimeria chalumnae	89.27	0.00e+00	1701.00
IUUC-Loc-052287	Lepisosteus oculatus	85.49	0.00e+00	1671.00
IUUC-Laf-053846	Loxodonta africana	98.79	0.00e+00	1880.00
IUUC-Meu-056060	Macropus eugenii	98.27	0.00e+00	708.00
IUUC-Mga-059935	Meleagris gallopavo	94.00	0.00e+00	1763.00
IUUC-Mmr-060960	Microcebus murinus	99.01	0.00e+00	1887.00
IUUC-Mdo-061851	Monodelphis domestica	93.52	0.00e+00	1824.00
IUUC-Mmu-063657	Mus musculus	97.14	0.00e+00	1853.00
IUUC-Mpu-066161	Mustela putorius furo	99.50	0.00e+00	834.00
IUUC-Mlu-067354	Myotis lucifugus	96.36	0.00e+00	1798.00
IUUC-Nle-069112	Nomascus leucogenys	99.78	0.00e+00	1900.00
IUUC-Opr-070686	Ochotona princeps	89.52	0.00e+00	816.00
IUUC-Ont-072398	Oreochromis niloticus	84.64	0.00e+00	1586.00
IUUC-Oan-073194	Ornithorhynchus anatinus	95.66	0.00e+00	1750.00
IUUC-Ocu-074397	Oryctolagus cuniculus	86.54	0.00e+00	1585.00
IUUC-Ola-086777	Oryzias latipes	80.82	0.00e+00	1566.00
IUUC-Oga-088684	Otolemur garnettii	98.90	0.00e+00	1882.00
IUUC-Oar-089428	Ovis aries	97.77	0.00e+00	1833.00
IUUC-Ptr-090529	Pan troglodytes	99.78	0.00e+00	1900.00
IUUC-Pan-091702	Papio anubis	99.89	0.00e+00	1901.00
IUUC-Psi-093969	Pelodiscus sinensis	90.97	0.00e+00	1710.00
IUUC-Pfo-097364	Poecilia formosa	86.18	0.00e+00	1613.00
IUUC-Pab-098574	Pongo abelii	99.89	0.00e+00	1901.00
IUUC-Pca-100525	Procavia capensis	87.15	1.00e-179	623.00
IUUC-Pva-102365	Pteropus vampyrus	86.91	0.00e+00	1608.00
IUUC-Rno-105153	Rattus norvegicus	96.81	0.00e+00	1854.00
IUUC-Sha-107319	Sarcophilus harrisii	93.42	0.00e+00	1818.00
IUUC-Sar-113449	Sorex araneus	81.54	1.00e-178	620.00
IUUC-Ssc-115865	Sus scrofa	98.24	0.00e+00	1873.00
IUUC-Tgu-117225	Taeniopygia guttata	91.30	0.00e+00	1781.00
IUUC-Tru-118026	Takifugu rubripes	82.24	0.00e+00	1569.00
IUUC-Tsy-119407	Tarsius syrichta	85.81	0.00e+00	1581.00
IUUC-Tni-120234	Tetraodon nigroviridis	84.11	0.00e+00	1272.00
IUUC-Tur-126774	Triticum urartu	29.17	5.00e-46	179.00
IUUC-Tbe-127708	Tupaia belangeri	88.04	0.00e+00	879.00
IUUC-Ttr-128667	Tursiops truncatus	98.02	0.00e+00	1870.00
IUUC-Vpa-130200	Vicugna pacos	98.19	0.00e+00	1816.00
IUUC-Xtr-132176	Xenopus tropicalis	87.82	0.00e+00	1712.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence