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Tag Content
UUCD2 ID IUUC-Eca-033560
UUCD1 version UUC-EqC-00022
Ensembl Protein ID ENSECAP00000009554.1
UniProt Accession F7AK40; F7AK40_HORSE
Protein Name Uncharacterized protein
Gene Name CUL3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSECAG00000011374.1 ENSECAT00000012128.1 ENSECAP00000009554.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/Cullin 1.90e-230 766.9 15 643
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/Cullin
   S: 2    lreavkkilrqesvkkeyeelytavynlclskvgaklYkklkevleefi.kqvkkkveesedeqlLktynreWekfreqlkvlrkifay 89
           l++a+++i+r++++  ++eely+++y+++l+k+g+klY+ l+ev++e++ ++v+++v +s ++++L+t+n++W++++++++++r+i++y
   Q: 15   LKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLiNKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMY 103
           799*********************************************99*************************************** PP
   S: 90   ldrtyvkkskkvsevrkLaldlwrkeived..ikkrllelllklieaeRkgeavdrrllsgvveslveLslnklaiykesFEakfleat 176
           +dr+yv++ ++v++v++L+l ++r+++v++  i+++l ++ll++i++eRkge+vdr  +++++++l+ L+l+ +++y+e+FEa+fle++
   Q: 104  MDRVYVQQ-NNVENVYNLGLIIFRDQVVRYgcIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMS 191
           ********.******************************************************************************** PP
   S: 177  qefykaesaeflqenevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesll....aelvallrdkktedlsrmykL 261
           +ef+++es++fl+en+ + Y+kkvear+nee er++++l++ste+++++vve+eli+kh+++++    ++lv++l++ ktedl++mykL
   Q: 192  AEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVemenSGLVHMLKNGKTEDLACMYKL 280
           ****************************************************************99999******************** PP
   S: 262  lsrvlngleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlkaakspE 350
           +srv+ngl++++++++s+++eqgka++++e + k+p++y++ ll+lk++++++++e+Fnnd+ F ++++ +fe+f+n n     ++spE
   Q: 281  FSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFNNDRLFKQTIAGDFEYFLNLN-----SRSPE 364
           *******************************************************************************.....***** PP
   S: 351  llAryiDqlLrksskglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksasseaEesviekLkeecgaeftskLerMfq 439
           +l+ +iD++L+k++kglte+e+e++ldk++++f++++ekdvFe+yYk+hLa+RLl++ks+s+++E+++i+kLk+ecg++ftskLe+Mf+
   Q: 365  YLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFR 453
           ***************************************************************************************** PP
   S: 440  dlkvSedlnrqFkeekentees.esvelsvlvLsagaWptasetekvsLPaelektiekfeefYlekhsgRkLqWqhtlgraelkael. 526
           d+++S++++++F+++ ++t  s  +v+l+v+vL++g+Wpt+s+t+k+++P+  ++++e+f++fYl khsgR+L++qh++g+a+l+a++ 
   Q: 454  DMSISNTTMDEFRQHLQATGVSlGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFy 542
           ********************99889**************************************************************** PP
   S: 527  .....................kkgkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvssk..kqvlkkepeskei 592
                                +++k++lqVstfQm++L++fnn+ek+++ee++++t++pe+eL r+lqsL+++k  ++vl+kep+skei
   Q: 543  gpvkkedgsevgvggaqvtgsNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKptQRVLTKEPKSKEI 631
           *********999999998888888***************************************************************** PP
   S: 593  eeedlfsvNqef 604
           e++++f+vN++f
   Q: 632  ENGHVFTVNDQF 643
           **********99 PP
   
Organism Equus caballus
Protein Sequence
(Fasta)
MTMDEKYVNS IWDLLKNAIQ EIQRKNNSGL SFEELYRNAY TMVLHKHGEK LYTGLREVVT 60
EHLINKVRED VLNSLNNNFL QTLNQAWNDH QTAMVMIRDI LMYMDRVYVQ QNNVENVYNL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Eca-033560|E3,Cullin|Equus caballus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGACCATGG ATGAAAAATA TGTAAACAGC ATTTGGGACC TTCTGAAAAA TGCAATTCAA 60
GAAATCCAGC GTAAGAATAA CAGTGGTCTT AGTTTTGAGG AGCTCTATAG AAATGCATAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Eca-033560|E3,Cullin|Equus caballus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2
Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8
SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0031461--C:cullin-RING ubiquitin ligase complex
GO:0070062--C:extracellular exosome
GO:0000139--C:Golgi membrane
GO:0005634--C:nucleus
GO:0005827--C:polar microtubule
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0016477--P:cell migration
GO:0048208--P:COPII vesicle coating
GO:0040016--P:embryonic cleavage
GO:0044346--P:fibroblast apoptotic process
GO:0007369--P:gastrulation
GO:0007229--P:integrin-mediated signaling pathway
GO:0072576--P:liver morphogenesis
GO:0007080--P:mitotic metaphase plate congression
GO:0035024--P:negative regulation of Rho protein signal transduction
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0032467--P:positive regulation of cytokinesis
GO:0045842--P:positive regulation of mitotic metaphase/anaphase transition
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0017145--P:stem cell division
GO:0043149--P:stress fiber assembly
GO:0001831--P:trophectodermal cellular morphogenesis
GO:0071630--P:ubiquitin-dependent catabolism of misfolded proteins by nucleus-associated proteasome
GO:0016055--P:Wnt signaling pathway
KEGG ecb:100061420
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000335 Aegilops tauschii 47.07 0.00e+00 686.00
IUUC-Aml-002278 Ailuropoda melanoleuca 99.33 0.00e+00 1518.00
IUUC-Atr-002616 Amborella trichopoda 53.35 0.00e+00 771.00
IUUC-Apl-004172 Anas platyrhynchos 99.73 0.00e+00 1521.00
IUUC-Aca-004309 Anolis carolinensis 99.73 0.00e+00 1520.00
IUUC-Aly-005566 Arabidopsis lyrata 52.21 0.00e+00 768.00
IUUC-Ath-007587 Arabidopsis thaliana 52.61 0.00e+00 772.00
IUUC-Ago-007795 Ashbya gossypii 25.33 6.00e-48 185.00
IUUC-Acl-008317 Aspergillus clavatus 36.87 3.00e-145 508.00
IUUC-Afl-008727 Aspergillus flavus 36.53 6.00e-145 508.00
IUUC-Afu-008879 Aspergillus fumigatus 37.96 6.00e-133 468.00
IUUC-Ani-009393 Aspergillus nidulans 35.99 2.00e-135 476.00
IUUC-Ang-009626 Aspergillus niger 36.44 3.00e-141 496.00
IUUC-Aor-010207 Aspergillus oryzae 36.53 1.00e-144 506.00
IUUC-Ate-010305 Aspergillus terreus 37.16 1.00e-140 493.00
IUUC-Ame-011805 Astyanax mexicanus 97.45 0.00e+00 1486.00
IUUC-Bgr-012098 Blumeria graminis 36.27 3.00e-121 429.00
IUUC-Bta-013445 Bos taurus 99.87 0.00e+00 1522.00
IUUC-Bci-013612 Botrytis cinerea 36.73 2.00e-139 489.00
IUUC-Bdi-014269 Brachypodium distachyon 53.29 0.00e+00 745.00
IUUC-Bol-015350 Brassica oleracea 52.74 0.00e+00 769.00
IUUC-Bra-016763 Brassica rapa 52.88 0.00e+00 773.00
IUUC-Cel-018641 Caenorhabditis elegans 48.75 0.00e+00 718.00
IUUC-Cja-019175 Callithrix jacchus 99.73 0.00e+00 1519.00
IUUC-Cfa-020905 Canis familiaris 99.87 0.00e+00 1522.00
IUUC-Cpo-021293 Cavia porcellus 99.73 0.00e+00 1520.00
IUUC-Cre-022776 Chlamydomonas reinhardtii 48.74 0.00e+00 697.00
IUUC-Csa-023800 Chlorocebus sabaeus 99.60 0.00e+00 1518.00
IUUC-Cho-024839 Choloepus hoffmanni 98.82 0.00e+00 1354.00
IUUC-Cin-025201 Ciona intestinalis 71.74 0.00e+00 1003.00
IUUC-Csv-026107 Ciona savignyi 71.52 0.00e+00 1092.00
IUUC-Cgl-026630 Colletotrichum gloeosporioides 35.43 9.00e-125 441.00
IUUC-Cne-027048 Cryptococcus neoformans 34.80 2.00e-117 417.00
IUUC-Cme-027254 Cyanidioschyzon merolae 31.23 4.00e-88 319.00
IUUC-Dre-028488 Danio rerio 97.99 0.00e+00 1496.00
IUUC-Dno-029784 Dasypus novemcinctus 99.87 0.00e+00 1522.00
IUUC-Dor-030682 Dipodomys ordii 92.49 0.00e+00 1368.00
IUUC-Dse-031326 Dothistroma septosporum 35.74 2.00e-128 453.00
IUUC-Dme-032112 Drosophila melanogaster 69.63 0.00e+00 1076.00
IUUC-Ete-032347 Echinops telfairi 82.71 0.00e+00 1194.00
IUUC-Eeu-034502 Erinaceus europaeus 97.79 0.00e+00 1345.00
IUUC-Fca-035544 Felis catus 99.87 0.00e+00 1523.00
IUUC-Fal-036751 Ficedula albicollis 99.87 0.00e+00 1523.00
IUUC-Fox-037857 Fusarium oxysporum 36.92 1.00e-137 483.00
IUUC-Fso-038163 Fusarium solani 36.75 2.00e-141 496.00
IUUC-Gmo-039270 Gadus morhua 97.34 0.00e+00 1497.00
IUUC-Ggr-039999 Gaeumannomyces graminis 33.88 5.00e-128 451.00
IUUC-Gga-040329 Gallus gallus 99.73 0.00e+00 1521.00
IUUC-Gac-041510 Gasterosteus aculeatus 97.34 0.00e+00 1490.00
IUUC-Gma-043659 Glycine max 53.08 0.00e+00 746.00
IUUC-Ggo-044903 Gorilla gorilla 99.46 0.00e+00 1513.00
IUUC-Hsa-046000 Homo sapiens 99.60 0.00e+00 1518.00
IUUC-Hvu-047831 Hordeum vulgare 52.46 0.00e+00 701.00
IUUC-Itr-049067 Ictidomys tridecemlineatus 99.78 0.00e+00 942.00
IUUC-Kpa-049372 Komagataella pastoris 34.94 2.00e-115 409.00
IUUC-Lch-050458 Latimeria chalumnae 99.60 0.00e+00 1516.00
IUUC-Lpe-051396 Leersia perrieri 52.62 0.00e+00 756.00
IUUC-Loc-052186 Lepisosteus oculatus 99.33 0.00e+00 1516.00
IUUC-Lma-053030 Leptosphaeria maculans 38.55 5.00e-144 504.00
IUUC-Laf-053684 Loxodonta africana 99.87 0.00e+00 1523.00
IUUC-Mcc-055770 Macaca mulatta 99.60 0.00e+00 1518.00
IUUC-Meu-056852 Macropus eugenii 99.73 0.00e+00 762.00
IUUC-Mor-057273 Magnaporthe oryzae 34.76 4.00e-133 468.00
IUUC-Mpo-057403 Magnaporthe poae 34.00 9.00e-130 457.00
IUUC-Mtr-058317 Medicago truncatula 52.21 0.00e+00 751.00
IUUC-Mla-059055 Melampsora laricipopulina 37.40 3.00e-133 469.00
IUUC-Mga-060076 Meleagris gallopavo 98.12 0.00e+00 1489.00
IUUC-Mvi-060470 Microbotryum violaceum 33.64 1.00e-135 477.00
IUUC-Mmr-060976 Microcebus murinus 99.87 0.00e+00 1522.00
IUUC-Mdo-062741 Monodelphis domestica 99.87 0.00e+00 1522.00
IUUC-Mmu-063905 Mus musculus 99.60 0.00e+00 1518.00
IUUC-Mac-064718 Musa acuminata 51.48 0.00e+00 730.00
IUUC-Mpu-066356 Mustela putorius furo 99.87 0.00e+00 1523.00
IUUC-Mlu-067768 Myotis lucifugus 99.33 0.00e+00 1517.00
IUUC-Nfi-068285 Neosartorya fischeri 37.20 1.00e-146 513.00
IUUC-Ncr-068883 Neurospora crassa 36.54 2.00e-138 486.00
IUUC-Nle-069638 Nomascus leucogenys 99.60 0.00e+00 1517.00
IUUC-Opr-070333 Ochotona princeps 90.75 0.00e+00 1270.00
IUUC-Ont-071601 Oreochromis niloticus 98.53 0.00e+00 1540.00
IUUC-Oan-073281 Ornithorhynchus anatinus 99.68 0.00e+00 1303.00
IUUC-Ocu-074504 Oryctolagus cuniculus 99.87 0.00e+00 1523.00
IUUC-Oba-075332 Oryza barthii 53.04 0.00e+00 748.00
IUUC-Obr-076435 Oryza brachyantha 53.12 0.00e+00 716.00
IUUC-Ogl-077655 Oryza glaberrima 53.02 0.00e+00 757.00
IUUC-Ogu-078458 Oryza glumaepatula 53.04 0.00e+00 749.00
IUUC-Oin-079567 Oryza indica 52.89 0.00e+00 755.00
IUUC-Olo-080930 Oryza longistaminata 53.02 0.00e+00 758.00
IUUC-Ome-081353 Oryza meridionalis 53.02 0.00e+00 757.00
IUUC-Oni-082378 Oryza nivara 53.02 0.00e+00 757.00
IUUC-Opu-084055 Oryza punctata 53.02 0.00e+00 758.00
IUUC-Oru-084202 Oryza rufipogon 53.04 0.00e+00 749.00
IUUC-Osa-085290 Oryza sativa 53.02 0.00e+00 757.00
IUUC-Ola-087562 Oryzias latipes 98.26 0.00e+00 1502.00
IUUC-Olu-087866 Ostreococcus lucimarinus 37.79 1.00e-139 489.00
IUUC-Oga-088833 Otolemur garnettii 99.87 0.00e+00 1523.00
IUUC-Oar-089958 Ovis aries 99.87 0.00e+00 1523.00
IUUC-Ptr-091013 Pan troglodytes 99.60 0.00e+00 1518.00
IUUC-Pan-091796 Papio anubis 98.93 0.00e+00 1506.00
IUUC-Psi-093564 Pelodiscus sinensis 98.12 0.00e+00 1486.00
IUUC-Pno-094939 Phaeosphaeria nodorum 38.22 2.00e-138 486.00
IUUC-Ppa-095920 Physcomitrella patens 52.68 0.00e+00 765.00
IUUC-Pfo-097498 Poecilia formosa 93.97 0.00e+00 1486.00
IUUC-Pab-098164 Pongo abelii 99.60 0.00e+00 1518.00
IUUC-Pop-099497 Populus trichocarpa 53.95 0.00e+00 787.00
IUUC-Pca-100702 Procavia capensis 91.69 0.00e+00 1348.00
IUUC-Ppe-101271 Prunus persica 52.88 0.00e+00 743.00
IUUC-Pva-103129 Pteropus vampyrus 100.00 0.00e+00 1522.00
IUUC-Pgr-103684 Puccinia graminis 36.44 2.00e-110 394.00
IUUC-Ptt-103961 Puccinia triticina 36.62 1.00e-109 390.00
IUUC-Pte-104325 Pyrenophora teres 38.06 8.00e-136 477.00
IUUC-Pyt-104746 Pyrenophora triticirepentis 37.09 7.00e-134 471.00
IUUC-Rno-105935 Rattus norvegicus 99.73 0.00e+00 1521.00
IUUC-Sce-106354 Saccharomyces cerevisiae 26.88 7.00e-53 202.00
IUUC-Sha-106569 Sarcophilus harrisii 99.42 0.00e+00 1385.00
IUUC-Sja-107676 Schizosaccharomyces japonicus 38.75 3.00e-154 538.00
IUUC-Spo-108135 Schizosaccharomyces pombe 37.91 6.00e-138 484.00
IUUC-Smo-109555 Selaginella moellendorffii 53.62 0.00e+00 790.00
IUUC-Sit-110763 Setaria italica 53.69 0.00e+00 761.00
IUUC-Sly-111090 Solanum lycopersicum 52.34 0.00e+00 763.00
IUUC-Stu-112351 Solanum tuberosum 52.48 0.00e+00 765.00
IUUC-Sar-113144 Sorex araneus 100.00 0.00e+00 1119.00
IUUC-Sbi-114690 Sorghum bicolor 52.89 0.00e+00 760.00
IUUC-Sre-115005 Sporisorium reilianum 38.04 3.00e-135 476.00
IUUC-Ssc-116053 Sus scrofa 99.64 0.00e+00 1142.00
IUUC-Tgu-116523 Taeniopygia guttata 99.87 0.00e+00 1523.00
IUUC-Tru-118189 Takifugu rubripes 94.24 0.00e+00 1408.00
IUUC-Tsy-118962 Tarsius syrichta 93.67 0.00e+00 1390.00
IUUC-Tni-120614 Tetraodon nigroviridis 57.49 0.00e+00 874.00
IUUC-Tca-121282 Theobroma cacao 53.27 0.00e+00 768.00
IUUC-Tre-122201 Trichoderma reesei 35.88 3.00e-134 472.00
IUUC-Tvi-122321 Trichoderma virens 36.36 1.00e-134 473.00
IUUC-Tae-124292 Triticum aestivum 52.62 0.00e+00 740.00
IUUC-Tur-126800 Triticum urartu 52.48 0.00e+00 739.00
IUUC-Tme-127053 Tuber melanosporum 40.61 1.00e-156 546.00
IUUC-Tbe-127427 Tupaia belangeri 85.21 0.00e+00 1164.00
IUUC-Ttr-128662 Tursiops truncatus 97.99 0.00e+00 1481.00
IUUC-Uma-129597 Ustilago maydis 38.54 7.00e-135 474.00
IUUC-Vda-129726 Verticillium dahliae 35.26 4.00e-134 472.00
IUUC-Vpa-130809 Vicugna pacos 100.00 0.00e+00 746.00
IUUC-Vvi-131194 Vitis vinifera 52.87 0.00e+00 762.00
IUUC-Xtr-131887 Xenopus tropicalis 98.93 0.00e+00 1508.00
IUUC-Xma-133517 Xiphophorus maculatus 98.39 0.00e+00 1506.00
IUUC-Yli-134576 Yarrowia lipolytica 33.46 3.00e-111 395.00
IUUC-Zma-135030 Zea mays 53.29 0.00e+00 768.00
Created Date 25-Jun-2017

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