iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Spo-108225

Ensembl Protein ID

SPBC3B9.09.1:pep

UniProt Accession

O43038; VPS36_SCHPO

Genbank Protein ID

CAA17789.1

Protein Name

Vacuolar protein-sorting-associated protein 36

Genbank Nucleotide ID

CU329671

Gene Name

vps36; SPBC3B9.09

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPBC3B9.09	SPBC3B9.09.1	SPBC3B9.09.1:pep

Annotation

mRNA Expression
GEO
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/ZnF/NZF	NZF	15029239; 17660439

Classification

Family	E-value	Score	Start	End
UBD/ZnF/NZF	2.50e-12	44.2	138	162

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 4    qWaCsaCTflNePeavkCemCsrpR 28
           q  C+aCTf+N+P+++ Ce+C+++ 
   Q: 138  QGLCTACTFQNYPDLNTCEICGNQL 162
           678*******************985 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Component of the ESCRT-II complex, which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin plays a central role in endosomal sorting of ubiquitinated cargo proteins by the ESCRT complexes (By similarity). Required for vacuolar sorting of carboxypeptidase S (CPS).

Protein Sequence
(Fasta)

MAFYLETTPS NLPVLDPSEE ILLVQDQVGL YFGDEKSFRH NNGTLYLTKK HIFYVDSVDP 60
KKNSLKIKIS DIRDVQHTSR YFRSSPKIRL SLRHVEKSWA CKICTFINVG DPINPCRNCG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATACAGTGTA TCTTTGATGA ATTCGTTGAC ATTATATATT GACTGCTAAG TCTATATCTG 60
TAAATCAAAG TCTTTTAATT CCTTAAAGGC TTTTTCCAAA TTCAGGTTAA ATCTTGACAA 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0333--Golgi apparatus
KW-0479--Metal-binding
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR007286--EAP30
IPR021648--GLUE_dom
IPR011993--PH_dom-like
IPR011991--WHTH_DNA-bd_dom
IPR001876--Znf_RanBP2

PROSITE

PS51495--GLUE

Pfam

PF04157--EAP30
PF11605--Vps36_ESCRT-II

SMART

SM00547--ZnF_RBZ

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000814--C:ESCRT II complex
GO:0005794--C:Golgi apparatus
GO:0031902--C:late endosome membrane
GO:0032266--F:phosphatidylinositol-3-phosphate binding
GO:0043130--F:ubiquitin binding
GO:0008270--F:zinc ion binding
GO:0045324--P:late endosome to vacuole transport
GO:0045053--P:protein retention in Golgi apparatus
GO:0043328--P:protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

KEGG

spo:SPBC3B9.09

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000963	Aegilops tauschii	23.36	7.00e-08	48.50
IUUC-Aml-002313	Ailuropoda melanoleuca	23.37	8.00e-15	72.80
IUUC-Atr-003096	Amborella trichopoda	26.14	8.00e-04	35.80
IUUC-Apl-003218	Anas platyrhynchos	24.83	2.00e-15	74.30
IUUC-Aca-004580	Anolis carolinensis	22.76	6.00e-14	69.70
IUUC-Aly-006398	Arabidopsis lyrata	26.19	5.00e-18	83.20
IUUC-Ath-006907	Arabidopsis thaliana	26.00	1.00e-17	82.40
IUUC-Ago-007840	Ashbya gossypii	27.02	3.00e-34	137.00
IUUC-Acl-008117	Aspergillus clavatus	24.71	2.00e-38	152.00
IUUC-Afl-008595	Aspergillus flavus	26.67	3.00e-41	160.00
IUUC-Afu-008918	Aspergillus fumigatus	22.72	8.00e-28	116.00
IUUC-Ani-009206	Aspergillus nidulans	24.10	9.00e-35	139.00
IUUC-Ang-009784	Aspergillus niger	25.12	1.00e-34	139.00
IUUC-Aor-010126	Aspergillus oryzae	28.07	2.00e-42	164.00
IUUC-Ate-010303	Aspergillus terreus	25.16	3.00e-37	147.00
IUUC-Ame-011190	Astyanax mexicanus	25.26	9.00e-16	75.90
IUUC-Bgr-011979	Blumeria graminis	23.93	2.00e-30	125.00
IUUC-Bta-012661	Bos taurus	23.37	4.00e-15	73.60
IUUC-Bci-013982	Botrytis cinerea	24.60	2.00e-34	138.00
IUUC-Bdi-014753	Brachypodium distachyon	25.32	3.00e-15	74.30
IUUC-Bol-015465	Brassica oleracea	25.90	9.00e-17	79.30
IUUC-Bra-016794	Brassica rapa	25.79	3.00e-17	80.90
IUUC-Cel-018514	Caenorhabditis elegans	21.83	6.00e-16	76.30
IUUC-Cja-019285	Callithrix jacchus	23.45	2.00e-15	74.30
IUUC-Cfa-020746	Canis familiaris	23.37	4.00e-15	73.60
IUUC-Cpo-022005	Cavia porcellus	23.71	3.00e-15	73.90
IUUC-Csa-023520	Chlorocebus sabaeus	23.37	4.00e-15	73.90
IUUC-Cho-024957	Choloepus hoffmanni	23.02	2.00e-14	71.20
IUUC-Cin-025240	Ciona intestinalis	33.33	1.10e-02	34.30
IUUC-Csv-025942	Ciona savignyi	22.79	1.00e-09	55.50
IUUC-Cgl-026558	Colletotrichum gloeosporioides	25.32	1.00e-35	142.00
IUUC-Cne-026915	Cryptococcus neoformans	20.58	2.00e-08	51.60
IUUC-Cme-027099	Cyanidioschyzon merolae	29.17	3.00e-07	47.80
IUUC-Dre-027753	Danio rerio	24.83	2.00e-16	77.80
IUUC-Dno-029922	Dasypus novemcinctus	23.37	2.00e-14	71.60
IUUC-Dor-030643	Dipodomys ordii	21.65	2.00e-10	58.20
IUUC-Dse-031368	Dothistroma septosporum	23.65	7.00e-34	136.00
IUUC-Dme-031977	Drosophila melanogaster	23.89	3.00e-08	50.80
IUUC-Ete-032381	Echinops telfairi	23.08	3.00e-09	53.90
IUUC-Eca-033937	Equus caballus	23.79	5.00e-15	73.20
IUUC-Eeu-034483	Erinaceus europaeus	22.41	3.00e-16	77.40
IUUC-Fca-035496	Felis catus	23.37	1.00e-15	75.50
IUUC-Fal-036743	Ficedula albicollis	24.39	7.00e-16	76.30
IUUC-Fox-037685	Fusarium oxysporum	22.70	3.00e-28	117.00
IUUC-Fso-038421	Fusarium solani	23.39	2.00e-28	118.00
IUUC-Gmo-039456	Gadus morhua	21.40	2.00e-10	58.20
IUUC-Ggr-039763	Gaeumannomyces graminis	23.29	6.00e-32	130.00
IUUC-Gga-040556	Gallus gallus	24.48	1.00e-14	72.40
IUUC-Gac-041481	Gasterosteus aculeatus	21.61	3.00e-08	50.80
IUUC-Gma-044185	Glycine max	22.27	8.00e-15	72.80
IUUC-Ggo-044849	Gorilla gorilla	23.37	4.00e-15	73.60
IUUC-Hsa-046228	Homo sapiens	23.37	4.00e-15	73.60
IUUC-Itr-048692	Ictidomys tridecemlineatus	23.37	2.00e-15	74.30
IUUC-Kpa-049240	Komagataella pastoris	22.98	4.00e-20	90.50
IUUC-Lch-050293	Latimeria chalumnae	24.79	1.00e-13	68.20
IUUC-Lpe-051363	Leersia perrieri	27.27	2.00e-16	77.80
IUUC-Loc-052866	Lepisosteus oculatus	23.10	2.00e-12	64.30
IUUC-Lma-053139	Leptosphaeria maculans	25.78	2.00e-32	132.00
IUUC-Laf-053881	Loxodonta africana	23.71	2.00e-15	74.70
IUUC-Mcc-055158	Macaca mulatta	23.37	3.00e-15	73.90
IUUC-Meu-056126	Macropus eugenii	20.66	8.00e-08	48.90
IUUC-Mor-057092	Magnaporthe oryzae	23.20	7.00e-32	130.00
IUUC-Mpo-057629	Magnaporthe poae	27.76	5.00e-15	73.20
IUUC-Mtr-058039	Medicago truncatula	23.39	2.00e-14	72.00
IUUC-Mla-058913	Melampsora laricipopulina	24.15	5.00e-22	97.40
IUUC-Mga-059956	Meleagris gallopavo	23.79	4.00e-15	73.60
IUUC-Mvi-060570	Microbotryum violaceum	40.79	1.00e-11	62.80
IUUC-Mmr-061769	Microcebus murinus	23.71	1.00e-15	75.10
IUUC-Mdo-062751	Monodelphis domestica	22.52	2.00e-14	70.90
IUUC-Mmu-063115	Mus musculus	24.14	3.00e-15	73.90
IUUC-Mac-064979	Musa acuminata	24.02	6.00e-12	63.20
IUUC-Mpu-066904	Mustela putorius furo	21.97	9.00e-06	41.60
IUUC-Mlu-067474	Myotis lucifugus	23.02	1.00e-14	71.60
IUUC-Nfi-068588	Neosartorya fischeri	23.92	3.00e-32	131.00
IUUC-Ncr-068855	Neurospora crassa	24.51	8.00e-31	126.00
IUUC-Nle-069660	Nomascus leucogenys	23.37	2.00e-15	74.30
IUUC-Opr-070695	Ochotona princeps	23.37	4.00e-14	70.50
IUUC-Ont-071837	Oreochromis niloticus	23.18	2.00e-11	61.60
IUUC-Oan-072903	Ornithorhynchus anatinus	24.14	8.00e-16	75.90
IUUC-Ocu-074833	Oryctolagus cuniculus	23.37	1.00e-14	72.40
IUUC-Oba-075899	Oryza barthii	27.63	5.00e-17	79.30
IUUC-Obr-076125	Oryza brachyantha	26.84	2.00e-15	74.70
IUUC-Ogl-077538	Oryza glaberrima	26.85	3.00e-09	54.30
IUUC-Ogu-078272	Oryza glumaepatula	27.27	1.00e-16	79.30
IUUC-Oin-079158	Oryza indica	26.46	3.00e-16	77.80
IUUC-Olo-080496	Oryza longistaminata	26.75	5.00e-15	72.80
IUUC-Ome-081440	Oryza meridionalis	27.63	1.00e-16	78.20
IUUC-Oni-083069	Oryza nivara	26.46	3.00e-16	77.80
IUUC-Opu-083838	Oryza punctata	27.63	7.00e-17	79.00
IUUC-Oru-084377	Oryza rufipogon	27.27	1.00e-16	79.00
IUUC-Osa-085976	Oryza sativa	27.27	1.00e-16	79.00
IUUC-Ola-086431	Oryzias latipes	22.88	2.00e-11	61.60
IUUC-Olu-087789	Ostreococcus lucimarinus	26.82	7.00e-14	68.60
IUUC-Oga-089152	Otolemur garnettii	23.71	2.00e-15	75.10
IUUC-Oar-089198	Ovis aries	23.37	3.00e-15	73.90
IUUC-Ptr-091123	Pan troglodytes	23.37	4.00e-15	73.60
IUUC-Pan-092866	Papio anubis	23.63	1.00e-13	68.60
IUUC-Psi-093384	Pelodiscus sinensis	23.78	7.00e-15	72.80
IUUC-Pma-094435	Petromyzon marinus	25.77	9.00e-03	34.30
IUUC-Pno-094773	Phaeosphaeria nodorum	26.28	6.00e-34	136.00
IUUC-Ppa-095753	Physcomitrella patens	22.71	3.00e-09	54.30
IUUC-Pfo-096028	Poecilia formosa	22.22	1.00e-11	62.40
IUUC-Pop-098915	Populus trichocarpa	22.22	2.00e-12	64.70
IUUC-Pca-100422	Procavia capensis	23.10	7.00e-14	69.30
IUUC-Ppe-101564	Prunus persica	23.60	2.00e-16	78.20
IUUC-Pva-103019	Pteropus vampyrus	21.99	1.00e-08	52.00
IUUC-Pgr-103670	Puccinia graminis	30.50	2.00e-11	62.00
IUUC-Ptt-103958	Puccinia triticina	33.33	4.80e-02	30.40
IUUC-Pte-104343	Pyrenophora teres	25.30	7.00e-43	166.00
IUUC-Pyt-104554	Pyrenophora triticirepentis	25.44	2.00e-37	148.00
IUUC-Rno-105775	Rattus norvegicus	23.79	3.00e-15	73.90
IUUC-Sce-106148	Saccharomyces cerevisiae	23.37	1.00e-31	129.00
IUUC-Sha-106468	Sarcophilus harrisii	23.81	1.00e-15	75.10
IUUC-Sja-107850	Schizosaccharomyces japonicus	38.24	9.00e-88	315.00
IUUC-Ssl-108412	Sclerotinia sclerotiorum	26.28	5.00e-26	110.00
IUUC-Smo-108898	Selaginella moellendorffii	24.32	1.00e-14	72.00
IUUC-Sit-110126	Setaria italica	25.86	6.00e-14	70.10
IUUC-Sly-110884	Solanum lycopersicum	25.00	7.00e-12	63.20
IUUC-Stu-112573	Solanum tuberosum	22.47	2.00e-11	62.00
IUUC-Sar-113114	Sorex araneus	25.69	2.00e-04	37.40
IUUC-Sbi-114331	Sorghum bicolor	24.39	3.00e-08	50.80
IUUC-Sre-115135	Sporisorium reilianum	25.44	1.00e-17	83.20
IUUC-Ssc-116158	Sus scrofa	23.37	3.00e-15	73.90
IUUC-Tgu-116962	Taeniopygia guttata	24.39	7.00e-16	76.30
IUUC-Tru-117567	Takifugu rubripes	21.37	6.00e-11	59.70
IUUC-Tsy-119357	Tarsius syrichta	21.98	2.00e-06	44.70
IUUC-Tni-120047	Tetraodon nigroviridis	20.51	9.00e-10	55.80
IUUC-Tca-121097	Theobroma cacao	24.90	2.00e-16	78.20
IUUC-Tre-122075	Trichoderma reesei	23.65	4.00e-35	140.00
IUUC-Tvi-122623	Trichoderma virens	25.28	2.00e-43	168.00
IUUC-Tae-123785	Triticum aestivum	24.68	6.00e-15	73.20
IUUC-Tur-125988	Triticum urartu	27.22	3.00e-13	67.00
IUUC-Tme-126936	Tuber melanosporum	24.46	7.00e-44	169.00
IUUC-Tbe-127481	Tupaia belangeri	21.59	1.00e-07	48.90
IUUC-Ttr-128160	Tursiops truncatus	23.45	5.00e-15	73.20
IUUC-Uma-129428	Ustilago maydis	29.56	9.00e-17	80.10
IUUC-Vda-129877	Verticillium dahliae	27.13	5.00e-14	70.90
IUUC-Vpa-130358	Vicugna pacos	23.37	6.00e-15	72.80
IUUC-Vvi-131406	Vitis vinifera	24.19	4.00e-16	77.40
IUUC-Xtr-132548	Xenopus tropicalis	22.95	1.00e-12	65.50
IUUC-Xma-133352	Xiphophorus maculatus	21.79	2.00e-11	61.20
IUUC-Yli-134466	Yarrowia lipolytica	25.70	2.00e-35	141.00
IUUC-Zma-135081	Zea mays	25.43	1.00e-12	65.90

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence