iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053947

UUCD1 version

UUC-LoA-01089

Ensembl Protein ID

ENSLAFP00000026002.1

UniProt Accession

G3UDU4; G3UDU4_LOXAF

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP27X

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000021827.2	ENSLAFT00000021932.2	ENSLAFP00000026002.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.20e-90	304.4	183	525

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           Gl NlgNtC+mN+++Q+L+++p lr+++l+ ++++++    ++p+ +l++++ +lf+el++++ +   p +ll+ ++  a+++ gy+qq
   Q: 183  GLINLGNTCFMNCIVQALTHTPILRDFFLS-DRHRCEM---PSPELCLVCEMSSLFRELYSGNPSPHVPYKLLHLVWIHARHLAGYRQQ 267
           9*****************************.9999987...589********************************************* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           Da+Efl   ld l++++k                  +  +  +++++ +++i+++F g l+s+++c++c+ vs++ +p +d+sl++pg+
   Q: 268  DAHEFLIAALDVLHRHCKG----------------DDVGKAASNPNHCNCIIDQIFTGGLQSDVTCQACHGVSTTIDPCWDISLDLPGS 340
           *****************22................23446788999******************************************9 PP
   S: 180  eetkke...................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksreki 249
            ++  +                   +l+dcL+ ft++e+l ++ k++c +c+++qe++k+l+++klP v ++h+kRf  +++ k+r+ki
   Q: 341  CTSFWPvspgressvngeshipgitTLTDCLRRFTRPEHLGSNAKIKCGSCQSYQESTKQLTMNKLPVVACFHFKRF--EHSAKQRRKI 427
           9876669**********************************************************************..55667999** PP
   S: 250  nkkvefpleLdlspfcts............peekqkekkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevleet 326
           +++++fpleLd++pf++s            p+++ ++++kY+L+avv+H+G+l+sGHY+++++++k++W+++dD  +t+ + ++vl   
   Q: 428  TTYISFPLELDMTPFMASskesrmngqlqlPTSSGNNENKYSLFAVVNHQGTLESGHYTSFIRHHKDQWFKCDDAVITKASIKDVLD-- 514
           ******************5555555555554444444**************************************************.. PP
   S: 327  gstaYvlfYkrr 338
            s++Y+lfY+++
   Q: 515  -SEGYLLFYHKQ 525
           .********985 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

AAAATSPGGG CLDVDFAVGP PSCSHVNSFK VGENWRQELR LIYQCFVWCG TPETRKSKAK 60
SCICHVCGTH LNRLHSCLSC VFFGCFTEKH IHEHAETKQH NLAVDLYYGG IYCFMCKDYV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGCAGCAG CGACGAGGTT CCTCCCCCCA CCCTCCCCTT GGACCCGCCG CGGCCCCCCG 60
ATCCCTCTCC GCGTCGCAGT CGTGCTCCCC GCCGCCGACC CCGACCCCGG CCCCAGACCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0043065--P:positive regulation of apoptotic process
GO:0050821--P:protein stabilization
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002084	Ailuropoda melanoleuca	97.90	0.00e+00	1081.00
IUUC-Aly-006565	Arabidopsis lyrata	36.95	4.00e-73	268.00
IUUC-Ath-007536	Arabidopsis thaliana	34.50	2.00e-74	273.00
IUUC-Bol-016509	Brassica oleracea	37.23	1.00e-73	271.00
IUUC-Bra-016962	Brassica rapa	37.26	8.00e-73	267.00
IUUC-Cja-019954	Callithrix jacchus	87.36	0.00e+00	947.00
IUUC-Cfa-020956	Canis familiaris	95.43	0.00e+00	1005.00
IUUC-Cpo-022014	Cavia porcellus	97.92	0.00e+00	1094.00
IUUC-Dno-029905	Dasypus novemcinctus	95.07	0.00e+00	847.00
IUUC-Dor-030832	Dipodomys ordii	96.37	5.00e-111	394.00
IUUC-Eca-033957	Equus caballus	96.37	0.00e+00	1061.00
IUUC-Fca-035768	Felis catus	97.71	0.00e+00	1080.00
IUUC-Ggr-040044	Gaeumannomyces graminis	31.84	2.00e-57	216.00
IUUC-Gma-043933	Glycine max	36.09	9.00e-88	317.00
IUUC-Ggo-044925	Gorilla gorilla	98.09	0.00e+00	1083.00
IUUC-Mpu-066433	Mustela putorius furo	97.51	0.00e+00	1075.00
IUUC-Mlu-067330	Myotis lucifugus	97.14	0.00e+00	1071.00
IUUC-Nle-069084	Nomascus leucogenys	95.77	0.00e+00	853.00
IUUC-Ocu-074951	Oryctolagus cuniculus	95.77	0.00e+00	1055.00
IUUC-Olo-080811	Oryza longistaminata	41.05	7.00e-53	200.00
IUUC-Oga-088771	Otolemur garnettii	96.18	0.00e+00	1053.00
IUUC-Oar-089610	Ovis aries	95.63	0.00e+00	1008.00
IUUC-Pan-092253	Papio anubis	96.22	0.00e+00	1014.00
IUUC-Ppa-095413	Physcomitrella patens	34.01	1.00e-83	303.00
IUUC-Pab-098324	Pongo abelii	98.09	0.00e+00	1083.00
IUUC-Pop-099558	Populus trichocarpa	35.58	3.00e-88	319.00
IUUC-Pca-100329	Procavia capensis	98.28	0.00e+00	1081.00
IUUC-Ppe-102020	Prunus persica	36.78	2.00e-91	330.00
IUUC-Pva-102721	Pteropus vampyrus	92.69	0.00e+00	996.00
IUUC-Pgr-103657	Puccinia graminis	28.99	3.00e-38	153.00
IUUC-Smo-109310	Selaginella moellendorffii	35.73	2.00e-86	313.00
IUUC-Sly-111077	Solanum lycopersicum	37.96	5.00e-82	298.00
IUUC-Stu-112203	Solanum tuberosum	39.06	3.00e-76	278.00
IUUC-Sar-113174	Sorex araneus	91.26	0.00e+00	944.00
IUUC-Sre-115195	Sporisorium reilianum	27.56	7.00e-54	205.00
IUUC-Ssc-115315	Sus scrofa	95.98	0.00e+00	1052.00
IUUC-Tsy-119413	Tarsius syrichta	71.72	0.00e+00	763.00
IUUC-Tca-121154	Theobroma cacao	38.30	1.00e-92	333.00
IUUC-Ttr-129006	Tursiops truncatus	97.47	0.00e+00	1056.00
IUUC-Vvi-131477	Vitis vinifera	37.19	2.00e-77	283.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence