iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000001774.4	ENSCAFT00000049857.2	ENSCAFP00000037446.1
ENSCAFG00000001774.4	ENSCAFT00000002791.3	ENSCAFP00000002587.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	4.60e-146	488.4	1089	1604

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 70   nreWekfreqlkvlrkifayldrtyvkkskkvsevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvveslveL 156
            ++W+ freql++++++f      y+++           +++w+++i+ed +++ll+l+++l+ a+R+++++++r+l++++++    
   Q: 1089 PTFWPVFREQLCRHTRLF------YMVR-----------AQAWSQDIAED-RRSLLHLSSRLNGALRQEQNFADRFLPDDEAA---- 1153
           689***************......****...........***********.********************************.... PP
   S: 157  slnklaiykesFEakfleatqefykaesaeflqe.nevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesllae 242
               +a++k+++Ea++++ +q++++++++ ++   + +d+Yl+++ea+ n+++++aa++++++++t+Ll++ve+++++        +
   Q: 1154 ----QALGKTCWEALVSPLVQNITSPDEDGISPLgWLLDQYLECREAAHNPQSRAAAFSSRVRRLTHLLVHVEPCEAP-------LP 1229
           ....**************************************************************************.......89 PP
   S: 243  lvallrdkktedlsrmykLlsrvln..gleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlk 327
             a +r k +++ +++++L++r+l+  ++++l+++++++++eq++++lt++++++d   +V+r++e+++ lqk++se+F+++a+Fl 
   Q: 1230 AAAAPRTKSRNRSHDWSSLATRGLPssIVRNLTRCWQAVVEEQVNNFLTSHWRDDD---FVPRYCEHFHNLQKSSSELFGPRAAFLL 1313
           999*********************999*****************************...**************************** PP
   S: 328  aldkafetfvnknsvlkaakspEllAryiDqlLrks.skglteeeleaqldkvllvfkyisekdv...FekyYkkhLakRLlsgksa 410
           al+++++  ++k ++lkaa+++E++Ar+iDq++++s ++g++++e++aql+++l+ + ++s++++   Fe+yY++++a+RLl   + 
   Q: 1314 ALQNGCAGGLLKLPFLKAAHVSEQFARHIDQRIQGSrIGGARGMEMLAQLQRCLETVLIFSGLEIattFEHYYQHYMADRLLG--VG 1398
           ***********************************************************************************..** PP
   S: 411  sseaEesviekLkeecgaeftskL.erMfqdlkvSedlnrqFk.................................eekenteeses 463
           ss++E++v+e++    g++f+++L ++M+q+l++Se+l+rqF+                                 e+++ ++e ++
   Q: 1399 SSWLEGAVLEQI----GPCFPNRLpQQMLQSLSTSEELQRQFHvyqlqrldqellkledtekkiqtnvveeeeeeeENEDLYYEGAM 1481
           ************....*********************************************************998889999***** PP
   S: 464  velsvlvLsagaWpta..set..ekvsLPaelektiekfeefY........lekhsgRkLqWqhtlgraelkaelkkgkyelqVstf 538
           +e+svlvLs+++Wp a  ++t  ++++LP++l+ t++++++fY        le++++R+LqW++ lgrael++    g ++l+Vst+
   Q: 1482 PEVSVLVLSPRCWPIAsiCHTlnPRTCLPSYLRGTLNRYSNFYsksqsypaLEQGPKRRLQWTW-LGRAELQF----GDQTLHVSTV 1563
           ****************9999899*****************************************.********....********** PP
   S: 539  QmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvssk 579
           Qm++LL++n+ ++vsve+l + ++l++++L++++ +L+s +
   Q: 1564 QMWLLLYLNDLQAVSVESLLALSGLSPDMLNQAITPLTSLR 1604
           **************************************966 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MVGELRYREF RVPLGPGLHA YPDELIRQRV GHDGHPEYQI RWLILRRGDE GEGGSSQVDC 60
KAEHILLWMS NDEIYANCHK MLGEDGQVIG PSQEITGEAG ALDKSVLGEM ETDVKSLIQR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACGGAAAGGA AGAGGAAAGG GCGGCGCAGA GGAAAAGGTG CCGCCCGTTG CCGAGGTGGC 60
ACCGGCGACT CCGCCCCAGC GCTCTCCTAG GGCCCCCAGC TTTCCGCTGG GTCAGCGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR004939--APC_su10/DOC_dom
IPR016024--ARM-type_fold
IPR021097--CPH_domain
IPR031223--CUL7
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR008979--Galactose-bd-like
IPR014722--Rib_L2_dom2
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50069--CULLIN_2
PS51284--DOC

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM01337--APC10
SM00884--Cullin_Nedd8

Gene Ontology

GO:1990393--C:3M complex
GO:0005813--C:centrosome
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0001837--P:epithelial to mesenchymal transition
GO:0000226--P:microtubule cytoskeleton organization
GO:0000281--P:mitotic cytokinesis
GO:0001890--P:placenta development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0016567--P:protein ubiquitination
GO:0007088--P:regulation of mitotic nuclear division
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0001570--P:vasculogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002360	Ailuropoda melanoleuca	90.91	0.00e+00	1847.00
IUUC-Bta-013285	Bos taurus	85.86	0.00e+00	1737.00
IUUC-Cja-019033	Callithrix jacchus	81.57	0.00e+00	1627.00
IUUC-Cpo-021513	Cavia porcellus	78.04	0.00e+00	1517.00
IUUC-Csa-023798	Chlorocebus sabaeus	85.36	0.00e+00	1692.00
IUUC-Dno-029587	Dasypus novemcinctus	86.01	0.00e+00	1539.00
IUUC-Dor-030234	Dipodomys ordii	83.80	0.00e+00	1721.00
IUUC-Ete-032612	Echinops telfairi	76.23	0.00e+00	823.00
IUUC-Eca-033408	Equus caballus	88.71	0.00e+00	1732.00
IUUC-Fca-035483	Felis catus	90.81	0.00e+00	1816.00
IUUC-Ggo-044721	Gorilla gorilla	87.03	0.00e+00	1658.00
IUUC-Hsa-046406	Homo sapiens	86.00	0.00e+00	1667.00
IUUC-Itr-048525	Ictidomys tridecemlineatus	87.73	0.00e+00	1671.00
IUUC-Laf-054068	Loxodonta africana	84.98	0.00e+00	1705.00
IUUC-Mcc-055464	Macaca mulatta	86.22	0.00e+00	1696.00
IUUC-Meu-056198	Macropus eugenii	57.31	0.00e+00	1074.00
IUUC-Mmr-061464	Microcebus murinus	88.12	0.00e+00	1742.00
IUUC-Mmu-063413	Mus musculus	77.06	0.00e+00	1535.00
IUUC-Mpu-066146	Mustela putorius furo	92.40	0.00e+00	1736.00
IUUC-Mlu-067036	Myotis lucifugus	85.09	0.00e+00	1757.00
IUUC-Opr-070670	Ochotona princeps	79.19	0.00e+00	1617.00
IUUC-Ocu-074155	Oryctolagus cuniculus	83.64	0.00e+00	1634.00
IUUC-Oga-089084	Otolemur garnettii	88.17	0.00e+00	1747.00
IUUC-Oar-090029	Ovis aries	85.54	0.00e+00	1741.00
IUUC-Ptr-091282	Pan troglodytes	86.38	0.00e+00	1673.00
IUUC-Pan-091883	Papio anubis	86.31	0.00e+00	1699.00
IUUC-Pab-098383	Pongo abelii	83.37	0.00e+00	1587.00
IUUC-Pca-100519	Procavia capensis	82.67	0.00e+00	795.00
IUUC-Pva-102417	Pteropus vampyrus	85.69	0.00e+00	1694.00
IUUC-Rno-105962	Rattus norvegicus	84.85	0.00e+00	1206.00
IUUC-Sar-113750	Sorex araneus	81.51	1.00e-173	604.00
IUUC-Ssc-115899	Sus scrofa	81.73	0.00e+00	1578.00
IUUC-Tsy-118860	Tarsius syrichta	83.36	0.00e+00	1126.00
IUUC-Tbe-127660	Tupaia belangeri	86.68	0.00e+00	886.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence