iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000012803.7	ENSRNOT00000017239.7	ENSRNOP00000017239.6
ENSRNOG00000012803.7	ENSRNOT00000090439.1	ENSRNOP00000073674.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPTM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.50e-44	146.9	230	268
UBD/Beta-Prp	2.40e-73	247.3	12	303

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH+++v  +af +d t++vs+s D+++kvWD+ t ++++
   Q: 230  GHASWVLNVAFcPDdTHFVSSSSDKSVKVWDVGTRTCIH 268
           8***********777*****************9999887 PP

UBD/Beta-Prp

   S: 6    kghhksvitcvkf....spdksllatgsrdgtikvwdvttgkl..lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvh 88
           +++h++ i +v++    +++ + ++tgs d+ +kvw+++++ l   +sl+gh+ +v +v++s++ +i +++s D++i++wdl++gk++ 
   Q: 12   EQAHDDAIWSVAWetnkKENIETVVTGSLDDLVKVWKWRDERLelQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQMK 100
           56777788889998666666789******************998899****************************************** PP
   S: 89   tlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltg 177
           ++ +   ++++l+fsp++++l++G+h   ++++ +e+g++ +  l+ + +++ +++++pdg++l+sG+ D++++++d++tgkll+tl+g
   Q: 101  SIDAGPVDAWTLAFSPDSQHLATGTHMGKVNIFGVESGKKEY-SLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEG 188
           ******************************************.*********************************************9 PP
   S: 178  ghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnss 266
            h  +++sl+f+++++ lv++s+dg++k++d+q+ +   tl gh ++v+ v+f+p+d+++vs ssD+s+++Wd+ ++++++t+  h+++
   Q: 189  -HAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCIHTFFDHQDQ 276
           .**************************************************************************************** PP
   S: 267  visvavlsfgdnvlvlgsedskvniwkl 294
           v+ v++ + +++++v++++d++++++++
   Q: 277  VWGVKY-NGNGSKIVSVGDDQEIHVYDC 303
           ******.999****************98 PP

Organism

Rattus norvegicus

Functional Description
(View)

Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3), dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1C (By similarity).

Protein Sequence
(Fasta)

MTNQYSILFK QEQAHDDAIW SVAWETNKKE NIETVVTGSL DDLVKVWKWR DERLELQWSL 60
EGHQLGVVSV DISHTLPIAA SSSLDAHIRL WDLENGKQMK SIDAGPVDAW TLAFSPDSQH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCGGCTGTG CGGTGGTGAG TTGGTGTGCT GGGCAGTTGG GGAGTGGTTG TCGTTGGTGC 60
TGCTGCTTAC TAGCGTGGGA AGGCGAGTGA ACAGGAAGGA TTGGAGGCCG CCACTGCAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat
KW-0879--Wnt signaling pathway

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR027295--Quinoprotein_ADH-like_fam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0016593--C:Cdc73/Paf1 complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0055087--C:Ski complex
GO:0035327--C:transcriptionally active chromatin
GO:0080182--P:histone H3-K4 trimethylation
GO:0045638--P:negative regulation of myeloid cell differentiation
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:2001162--P:positive regulation of histone H3-K79 methylation
GO:0032968--P:positive regulation of transcription elongation from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
GO:0016055--P:Wnt signaling pathway

KEGG

rno:363064

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000774	Aegilops tauschii	33.43	4.00e-47	181.00
IUUC-Aml-002245	Ailuropoda melanoleuca	97.05	9.00e-166	575.00
IUUC-Atr-003142	Amborella trichopoda	50.93	3.00e-38	151.00
IUUC-Apl-003179	Anas platyrhynchos	88.52	6.00e-154	536.00
IUUC-Aca-004880	Anolis carolinensis	87.21	2.00e-155	541.00
IUUC-Aly-005956	Arabidopsis lyrata	37.50	1.00e-54	206.00
IUUC-Ath-007230	Arabidopsis thaliana	37.18	2.00e-50	192.00
IUUC-Acl-008297	Aspergillus clavatus	29.24	4.00e-24	105.00
IUUC-Ang-009702	Aspergillus niger	29.26	2.00e-29	122.00
IUUC-Ame-011511	Astyanax mexicanus	82.41	3.00e-147	514.00
IUUC-Bgr-012189	Blumeria graminis	30.11	1.00e-28	120.00
IUUC-Bta-012936	Bos taurus	96.72	1.00e-165	575.00
IUUC-Bdi-015020	Brachypodium distachyon	37.24	1.00e-46	179.00
IUUC-Bol-016345	Brassica oleracea	38.14	1.00e-55	209.00
IUUC-Bra-017323	Brassica rapa	38.14	8.00e-56	210.00
IUUC-Cja-019961	Callithrix jacchus	97.05	8.00e-166	575.00
IUUC-Cfa-020862	Canis familiaris	96.72	8.00e-165	572.00
IUUC-Cpo-021356	Cavia porcellus	96.69	5.00e-163	566.00
IUUC-Cre-022602	Chlamydomonas reinhardtii	41.25	1.00e-56	213.00
IUUC-Csa-024067	Chlorocebus sabaeus	96.72	2.00e-165	574.00
IUUC-Cho-024421	Choloepus hoffmanni	81.82	9.00e-82	295.00
IUUC-Cin-025261	Ciona intestinalis	64.59	2.00e-116	411.00
IUUC-Cne-026846	Cryptococcus neoformans	29.51	9.00e-25	107.00
IUUC-Dre-027706	Danio rerio	64.59	4.00e-108	384.00
IUUC-Dno-029084	Dasypus novemcinctus	96.74	5.00e-165	573.00
IUUC-Dor-030353	Dipodomys ordii	81.16	1.00e-121	429.00
IUUC-Dse-031348	Dothistroma septosporum	28.10	3.00e-25	108.00
IUUC-Dme-031836	Drosophila melanogaster	51.69	4.00e-87	314.00
IUUC-Ete-032261	Echinops telfairi	94.43	4.00e-159	553.00
IUUC-Eca-034231	Equus caballus	89.18	4.00e-150	523.00
IUUC-Eeu-034828	Erinaceus europaeus	96.22	2.00e-154	537.00
IUUC-Fca-036569	Felis catus	96.72	4.00e-165	573.00
IUUC-Fal-037469	Ficedula albicollis	90.16	2.00e-157	547.00
IUUC-Fox-038047	Fusarium oxysporum	31.65	1.00e-27	116.00
IUUC-Gmo-039579	Gadus morhua	83.28	5.00e-146	510.00
IUUC-Gga-040808	Gallus gallus	91.10	8.00e-151	526.00
IUUC-Gac-042100	Gasterosteus aculeatus	83.28	7.00e-147	513.00
IUUC-Gma-043509	Glycine max	40.31	4.00e-59	221.00
IUUC-Ggo-045227	Gorilla gorilla	97.05	8.00e-166	575.00
IUUC-Hsa-045839	Homo sapiens	97.05	8.00e-166	575.00
IUUC-Hvu-047591	Hordeum vulgare	37.66	2.00e-49	189.00
IUUC-Itr-048741	Ictidomys tridecemlineatus	97.38	2.00e-166	578.00
IUUC-Lch-049549	Latimeria chalumnae	83.61	3.00e-146	510.00
IUUC-Lpe-050746	Leersia perrieri	38.26	1.00e-47	183.00
IUUC-Loc-052540	Lepisosteus oculatus	85.25	4.00e-147	513.00
IUUC-Lma-052992	Leptosphaeria maculans	27.46	3.00e-26	112.00
IUUC-Laf-053907	Loxodonta africana	97.38	2.00e-166	578.00
IUUC-Mcc-055828	Macaca mulatta	90.77	1.00e-161	561.00
IUUC-Meu-056075	Macropus eugenii	94.12	3.00e-135	474.00
IUUC-Mtr-057728	Medicago truncatula	40.06	8.00e-56	210.00
IUUC-Mga-059872	Meleagris gallopavo	90.82	4.00e-158	550.00
IUUC-Mvi-060564	Microbotryum violaceum	31.77	8.00e-30	124.00
IUUC-Mmr-060985	Microcebus murinus	96.92	8.00e-158	549.00
IUUC-Mdo-062758	Monodelphis domestica	90.13	6.00e-158	549.00
IUUC-Mmu-063580	Mus musculus	99.67	3.00e-170	590.00
IUUC-Mac-064880	Musa acuminata	39.55	4.00e-57	214.00
IUUC-Mpu-066577	Mustela putorius furo	96.39	7.00e-164	569.00
IUUC-Nle-069573	Nomascus leucogenys	97.05	8.00e-166	575.00
IUUC-Opr-070216	Ochotona princeps	96.35	2.00e-162	564.00
IUUC-Ont-071981	Oreochromis niloticus	84.59	1.00e-148	518.00
IUUC-Oan-073223	Ornithorhynchus anatinus	93.43	5.00e-107	379.00
IUUC-Ocu-074199	Oryctolagus cuniculus	83.28	3.00e-137	480.00
IUUC-Oba-075255	Oryza barthii	39.62	4.00e-41	161.00
IUUC-Obr-076168	Oryza brachyantha	46.58	2.00e-35	142.00
IUUC-Ogl-077777	Oryza glaberrima	38.06	3.00e-48	185.00
IUUC-Ogu-078780	Oryza glumaepatula	38.06	3.00e-48	185.00
IUUC-Oin-079228	Oryza indica	38.06	8.00e-51	194.00
IUUC-Olo-080617	Oryza longistaminata	45.07	4.00e-29	119.00
IUUC-Ome-081421	Oryza meridionalis	38.06	2.00e-47	182.00
IUUC-Oni-082997	Oryza nivara	38.06	8.00e-51	194.00
IUUC-Opu-083931	Oryza punctata	38.39	3.00e-48	185.00
IUUC-Oru-084645	Oryza rufipogon	38.06	3.00e-48	185.00
IUUC-Osa-085842	Oryza sativa	38.06	8.00e-51	194.00
IUUC-Ola-086696	Oryzias latipes	83.93	3.00e-144	504.00
IUUC-Olu-087643	Ostreococcus lucimarinus	39.91	4.00e-41	160.00
IUUC-Oga-088272	Otolemur garnettii	95.72	4.00e-163	566.00
IUUC-Oar-089416	Ovis aries	96.72	1.00e-165	575.00
IUUC-Ptr-090944	Pan troglodytes	97.05	8.00e-166	575.00
IUUC-Pan-091861	Papio anubis	97.05	8.00e-166	575.00
IUUC-Psi-093750	Pelodiscus sinensis	91.48	2.00e-158	551.00
IUUC-Pma-094608	Petromyzon marinus	79.68	7.00e-135	473.00
IUUC-Pno-094832	Phaeosphaeria nodorum	31.70	2.00e-25	109.00
IUUC-Ppa-095737	Physcomitrella patens	41.03	2.00e-56	212.00
IUUC-Pfo-096479	Poecilia formosa	85.25	1.00e-142	498.00
IUUC-Pab-098179	Pongo abelii	97.05	8.00e-166	575.00
IUUC-Pop-099532	Populus trichocarpa	40.21	1.00e-55	209.00
IUUC-Pca-100664	Procavia capensis	75.00	2.00e-104	371.00
IUUC-Ppe-102056	Prunus persica	39.29	3.00e-57	215.00
IUUC-Pva-102859	Pteropus vampyrus	96.72	4.00e-165	573.00
IUUC-Pte-104236	Pyrenophora teres	34.44	1.00e-24	107.00
IUUC-Sha-106660	Sarcophilus harrisii	91.36	8.00e-152	529.00
IUUC-Sja-107800	Schizosaccharomyces japonicus	34.21	2.00e-36	146.00
IUUC-Spo-108244	Schizosaccharomyces pombe	31.72	1.00e-35	143.00
IUUC-Smo-109382	Selaginella moellendorffii	42.47	7.00e-61	227.00
IUUC-Sit-110048	Setaria italica	37.50	2.00e-40	159.00
IUUC-Sly-111618	Solanum lycopersicum	37.97	5.00e-52	197.00
IUUC-Stu-112543	Solanum tuberosum	38.46	3.00e-55	208.00
IUUC-Sar-113743	Sorex araneus	77.05	4.00e-128	450.00
IUUC-Sbi-114309	Sorghum bicolor	38.89	2.00e-41	162.00
IUUC-Ssc-115560	Sus scrofa	91.15	2.00e-152	531.00
IUUC-Tgu-117300	Taeniopygia guttata	90.49	5.00e-158	550.00
IUUC-Tru-117933	Takifugu rubripes	84.92	1.00e-149	522.00
IUUC-Tsy-119574	Tarsius syrichta	86.56	2.00e-142	498.00
IUUC-Tni-120191	Tetraodon nigroviridis	87.34	9.00e-114	402.00
IUUC-Tca-120983	Theobroma cacao	40.45	2.00e-57	216.00
IUUC-Tae-124056	Triticum aestivum	35.53	4.00e-49	188.00
IUUC-Tur-126711	Triticum urartu	35.74	4.00e-48	185.00
IUUC-Tme-127066	Tuber melanosporum	33.09	4.00e-33	135.00
IUUC-Tbe-127802	Tupaia belangeri	96.72	4.00e-165	573.00
IUUC-Ttr-128861	Tursiops truncatus	95.28	1.00e-54	206.00
IUUC-Vda-129720	Verticillium dahliae	28.92	4.00e-22	98.60
IUUC-Vpa-130618	Vicugna pacos	93.12	8.00e-133	465.00
IUUC-Vvi-130981	Vitis vinifera	39.74	4.00e-55	207.00
IUUC-Xtr-132460	Xenopus tropicalis	85.57	2.00e-145	508.00
IUUC-Xma-134154	Xiphophorus maculatus	85.25	7.00e-143	499.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence