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Tag Content
UUCD2 ID IUUC-Cja-019226
UUCD1 version UUC-CaJ-00234
Ensembl Protein ID ENSCJAP00000024536.2
UniProt Accession F7GSM7; F7GSM7_CALJA
Genbank Protein ID ENSCJAP00000024536
Protein Name Histone-lysine N-methyltransferase 2A
Genbank Nucleotide ID ACFV01080299
Gene Name KMT2A
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSCJAG00000013288.2 ENSCJAT00000025950.2 ENSCJAP00000024536.2
ENSCJAG00000013288.2 ENSCJAT00000025934.2 ENSCJAP00000024520.2
ENSCJAG00000013288.2 ENSCJAT00000025799.2 ENSCJAP00000024391.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 1.20e-25 90.4 1446 1499
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsek..wiCpkCrsk 54
           k+C+vCg++++ +k+l+eC+kCr+ +Hp+Cl+++ ++++p+++k  wiC+kC ++
   Q: 1446 KFCHVCGRQHQATKQLLECNKCRNSYHPECLGPN-YPTKPTKKKkvWICTKCVRC 1499
           58********************************.*****99999*******876 PP
   
Organism Callithrix jacchus
Functional Description
(View)

Functional Description


     Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis. Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-ARNTL/BMAL1 heterodimer. Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-ARNTL/BMAL1 to chromatin.
 Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis. Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-ARNTL/BMAL1 heterodimer. Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-ARNTL/BMAL1 to chromatin.
Protein Sequence
(Fasta)
KLLSRAVRFP ARPGNVYPGC GAGRRAGGGG PGLRMELQRP GVRGGGLRPL CRARGSARRP 60
SGSSGAGVPG GAAAASAASS SSASSSSSSS SSASSGPALL RVGPGFDAAM QVSAAIGTNL 120
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Protein Fasta Sequence


>IUUC-Cja-019226|E3,PHD|Callithrix jacchus
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Nucleotide Sequence
(Fasta)
AAGCTGCTCT CCCGGGCGGT TCGATTCCCA GCGCGTCCCG GGAACGTGTG TAACCGGCCT 60
CTCGGCGCTC AAGGCTGCAG GCGGCCCGGC TCCCTCCGCC TCCATCCTCC GCAGAGTCCT 120
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Nucleotide Fasta Sequence


>IUUC-Cja-019226|E3,PHD|Callithrix jacchus
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Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001487--Bromodomain
IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR016569--MeTrfase_trithorax
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50014--BROMODOMAIN_2
PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS51058--ZF_CXXC
PS50016--ZF_PHD_2
Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET
PF02008--zf-CXXC
SMART

SM00297--BROMO
SM00542--FYRC
SM00541--FYRN
SM00249--PHD
SM00508--PostSET
SM00317--SET
Gene Ontology

GO:0005829--C:cytosol
GO:0071339--C:MLL1 complex
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0045322--F:unmethylated CpG binding
GO:0008270--F:zinc ion binding
GO:0009952--P:anterior/posterior pattern specification
GO:0032922--P:circadian regulation of gene expression
GO:0060216--P:definitive hemopoiesis
GO:0006306--P:DNA methylation
GO:0035162--P:embryonic hemopoiesis
GO:0035640--P:exploration behavior
GO:0044648--P:histone H3-K4 dimethylation
GO:0080182--P:histone H3-K4 trimethylation
GO:0043984--P:histone H4-K16 acetylation
GO:0048873--P:homeostasis of number of cells within a tissue
GO:0008285--P:negative regulation of cell proliferation
GO:0018026--P:peptidyl-lysine monomethylation
GO:2001040--P:positive regulation of cellular response to drug
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032411--P:positive regulation of transporter activity
GO:0009791--P:post-embryonic development
GO:0006461--P:protein complex assembly
GO:0071440--P:regulation of histone H3-K14 acetylation
GO:1901674--P:regulation of histone H3-K27 acetylation
GO:2000615--P:regulation of histone H3-K9 acetylation
GO:0048172--P:regulation of short-term neuronal synaptic plasticity
GO:0048536--P:spleen development
GO:0008542--P:visual learning
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001054 Aegilops tauschii 34.74 9.00e-13 68.90
IUUC-Aml-002274 Ailuropoda melanoleuca 93.47 0.00e+00 6065.00
IUUC-Atr-002455 Amborella trichopoda 48.10 8.00e-39 155.00
IUUC-Apl-003478 Anas platyrhynchos 79.09 0.00e+00 3962.00
IUUC-Aca-005086 Anolis carolinensis 65.23 0.00e+00 2928.00
IUUC-Aly-006448 Arabidopsis lyrata 48.10 4.00e-39 156.00
IUUC-Ath-006690 Arabidopsis thaliana 47.40 4.00e-37 150.00
IUUC-Ame-011195 Astyanax mexicanus 43.89 0.00e+00 784.00
IUUC-Bta-012974 Bos taurus 92.58 0.00e+00 5964.00
IUUC-Bol-016540 Brassica oleracea 48.05 1.00e-37 151.00
IUUC-Cfa-021049 Canis familiaris 93.21 0.00e+00 5972.00
IUUC-Cpo-021459 Cavia porcellus 91.91 0.00e+00 4261.00
IUUC-Cre-022891 Chlamydomonas reinhardtii 50.00 1.00e-38 156.00
IUUC-Csa-023434 Chlorocebus sabaeus 95.96 0.00e+00 5680.00
IUUC-Cho-024652 Choloepus hoffmanni 88.99 0.00e+00 3856.00
IUUC-Cin-025724 Ciona intestinalis 54.46 2.00e-96 347.00
IUUC-Csv-026268 Ciona savignyi 37.11 2.00e-134 474.00
IUUC-Cme-027224 Cyanidioschyzon merolae 34.18 3.00e-12 67.40
IUUC-Dre-028180 Danio rerio 63.68 0.00e+00 1169.00
IUUC-Dno-029068 Dasypus novemcinctus 89.32 0.00e+00 5710.00
IUUC-Dor-030550 Dipodomys ordii 86.09 0.00e+00 5017.00
IUUC-Ete-032834 Echinops telfairi 83.59 0.00e+00 2737.00
IUUC-Eca-033615 Equus caballus 93.47 0.00e+00 5894.00
IUUC-Eeu-035136 Erinaceus europaeus 82.24 0.00e+00 1177.00
IUUC-Fca-036453 Felis catus 90.02 0.00e+00 2634.00
IUUC-Fal-037256 Ficedula albicollis 77.65 0.00e+00 4964.00
IUUC-Gmo-038641 Gadus morhua 67.66 0.00e+00 1098.00
IUUC-Gga-040828 Gallus gallus 78.45 0.00e+00 4922.00
IUUC-Gac-041452 Gasterosteus aculeatus 70.38 0.00e+00 1160.00
IUUC-Gma-043554 Glycine max 49.02 4.00e-38 153.00
IUUC-Ggo-045124 Gorilla gorilla 94.19 0.00e+00 5896.00
IUUC-Hsa-046143 Homo sapiens 96.30 0.00e+00 6131.00
IUUC-Itr-049024 Ictidomys tridecemlineatus 91.19 0.00e+00 5243.00
IUUC-Lch-049704 Latimeria chalumnae 63.46 0.00e+00 3840.00
IUUC-Loc-052181 Lepisosteus oculatus 79.64 0.00e+00 1320.00
IUUC-Laf-053946 Loxodonta africana 92.74 0.00e+00 5805.00
IUUC-Mcc-055508 Macaca mulatta 96.20 0.00e+00 6140.00
IUUC-Meu-056485 Macropus eugenii 80.81 0.00e+00 2991.00
IUUC-Mtr-058327 Medicago truncatula 41.96 4.00e-39 157.00
IUUC-Mga-059943 Meleagris gallopavo 75.75 0.00e+00 4567.00
IUUC-Mmr-061178 Microcebus murinus 92.53 0.00e+00 6004.00
IUUC-Mdo-063031 Monodelphis domestica 85.47 0.00e+00 3989.00
IUUC-Mmu-063650 Mus musculus 88.38 0.00e+00 4077.00
IUUC-Mpu-066495 Mustela putorius furo 93.57 0.00e+00 4096.00
IUUC-Mlu-068045 Myotis lucifugus 84.29 0.00e+00 5330.00
IUUC-Nle-069064 Nomascus leucogenys 96.16 0.00e+00 6192.00
IUUC-Opr-071043 Ochotona princeps 88.17 0.00e+00 3776.00
IUUC-Ont-072556 Oreochromis niloticus 69.88 0.00e+00 1130.00
IUUC-Oan-073324 Ornithorhynchus anatinus 76.14 0.00e+00 2155.00
IUUC-Ocu-074190 Oryctolagus cuniculus 92.71 0.00e+00 5894.00
IUUC-Oba-075647 Oryza barthii 49.36 3.00e-38 154.00
IUUC-Olo-080577 Oryza longistaminata 47.71 8.00e-36 145.00
IUUC-Ome-081214 Oryza meridionalis 49.36 3.00e-38 154.00
IUUC-Oni-083000 Oryza nivara 49.36 3.00e-38 154.00
IUUC-Opu-083842 Oryza punctata 49.36 3.00e-38 154.00
IUUC-Oru-084361 Oryza rufipogon 49.36 3.00e-38 154.00
IUUC-Ola-087176 Oryzias latipes 64.86 0.00e+00 1134.00
IUUC-Oga-088208 Otolemur garnettii 93.68 0.00e+00 5919.00
IUUC-Oar-090152 Ovis aries 92.41 0.00e+00 5975.00
IUUC-Ptr-091127 Pan troglodytes 96.33 0.00e+00 6102.00
IUUC-Pan-092679 Papio anubis 96.83 0.00e+00 4939.00
IUUC-Psi-094059 Pelodiscus sinensis 79.19 0.00e+00 5021.00
IUUC-Pma-094258 Petromyzon marinus 60.47 0.00e+00 684.00
IUUC-Pfo-096536 Poecilia formosa 68.73 0.00e+00 1119.00
IUUC-Pab-098262 Pongo abelii 96.30 0.00e+00 6205.00
IUUC-Pca-100358 Procavia capensis 88.30 0.00e+00 5477.00
IUUC-Pva-102522 Pteropus vampyrus 87.84 0.00e+00 4687.00
IUUC-Rno-105200 Rattus norvegicus 88.77 0.00e+00 4017.00
IUUC-Sha-107174 Sarcophilus harrisii 84.92 0.00e+00 5389.00
IUUC-Smo-109164 Selaginella moellendorffii 51.95 1.00e-40 162.00
IUUC-Sly-111176 Solanum lycopersicum 48.37 5.00e-36 146.00
IUUC-Stu-112529 Solanum tuberosum 48.37 2.00e-38 154.00
IUUC-Sar-113503 Sorex araneus 82.14 0.00e+00 3074.00
IUUC-Sbi-114254 Sorghum bicolor 26.92 9.00e-11 62.40
IUUC-Tgu-117047 Taeniopygia guttata 78.11 0.00e+00 4914.00
IUUC-Tru-118328 Takifugu rubripes 65.84 0.00e+00 1152.00
IUUC-Tsy-118953 Tarsius syrichta 88.31 0.00e+00 3049.00
IUUC-Tni-120837 Tetraodon nigroviridis 65.60 0.00e+00 1140.00
IUUC-Tbe-127950 Tupaia belangeri 87.35 0.00e+00 2840.00
IUUC-Ttr-128643 Tursiops truncatus 91.25 0.00e+00 5759.00
IUUC-Vpa-130660 Vicugna pacos 87.38 0.00e+00 1999.00
IUUC-Vvi-131476 Vitis vinifera 46.75 3.00e-39 157.00
IUUC-Xtr-132869 Xenopus tropicalis 62.59 0.00e+00 2290.00
Created Date 25-Jun-2017

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