iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-027907

UUCD1 version

UUC-DaR-01229

Ensembl Protein ID

ENSDARP00000004327.6

UniProt Accession

Q6NX08; Q803T7; WDR12_DANRE

Genbank Protein ID

AAH44198.1; AAH67331.1; AAI55269.1

Protein Name

Ribosome biogenesis protein wdr12; WD repeat-containing protein 12

Genbank Nucleotide ID

BC044198; BC067331; BC155268

Gene Name

wdr12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000003287.6	ENSDART00000012903.6	ENSDARP00000004327.6

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.00e-41	140.0	340	375
UBD/Beta-Prp	1.50e-47	163.2	245	411

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sd.tllvsGsdDgtikvWDlrtgv 34
           H+++vt++++  s  + lvsGs D+++k+WD+r+++
   Q: 340  HNGWVTAVRWapSHeHQLVSGSLDNVVKLWDTRSCK 375
           9**********754688**************99876 PP

UBD/Beta-Prp

   S: 83   tgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkl 171
           t+++++tl+gh++ v s+ ++   d l s+s+d tir+wd etg   + tlsg + v nc++++p ++ l+sGs+Dr vrlWd ++++ 
   Q: 245  TRTPLMTLSGHNEAVSSVLWMD-ADELCSASWDHTIRLWDAETGGQKS-TLSGSK-VFNCISYSPLCRRLASGSTDRHVRLWDPRSKDG 330
           67899****************9.9***********************9.****87.99**************************66654 PP
   S: 172  lrtl...tgghtdsvyslsfdsng.kelvsgsldgtvklwdlq.tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
              l   t+ h++ v+ + + ++   +lvsgsld+ vklwd +  +  ++ l +h+d v++ + + ++ +++sg++D+ ++ +
   Q: 331  SLVLlslTS-HNGWVTAVRWAPSHeHQLVSGSLDNVVKLWDTRsCKAPLYDLAAHEDKVLCADWT-ENGLILSGGADNKLYTY 411
           333334387.**********9988788****************54566***************99.88899******988765 PP

Organism

Danio rerio

Functional Description
(View)

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Protein Sequence
(Fasta)

MSQLQARFFT ENKKYLVDDV PFSIPASSEV ADLSGVINKL LEAKNAGHKH VEFDFLVRGQ 60
FLRTSLDKHI ETENISTEEV VEIEYVEKFT APQPEECIMH DDWISSVEAD SEWILTGSYD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGTCGATTGC CATCTGCAAT CGACTGTCAT GCCTTCTCCA GGCACGCATT GGGAAACACA 60
TGGTGGCAAA GTATCCCCAT ACACACTGAA CTTCGCCGAT TCATTTATCG CGTGTTTTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR012972--NLE
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR028599--WDR12/Ytm1

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0070545--C:PeBoW complex
GO:0030687--C:preribosome, large subunit precursor
GO:0008283--P:cell proliferation
GO:0000460--P:maturation of 5.8S rRNA
GO:0000466--P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000470--P:maturation of LSU-rRNA
GO:0000463--P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

KEGG

dre:321652

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000532	Aegilops tauschii	33.73	3.00e-60	226.00
IUUC-Aml-001997	Ailuropoda melanoleuca	77.56	0.00e+00	629.00
IUUC-Atr-002544	Amborella trichopoda	34.52	4.00e-56	212.00
IUUC-Apl-003981	Anas platyrhynchos	79.68	2.00e-177	615.00
IUUC-Aca-004370	Anolis carolinensis	77.88	0.00e+00	688.00
IUUC-Aly-006455	Arabidopsis lyrata	33.73	5.00e-59	221.00
IUUC-Ath-006669	Arabidopsis thaliana	33.41	2.00e-54	206.00
IUUC-Ago-007864	Ashbya gossypii	29.77	2.00e-38	153.00
IUUC-Acl-008177	Aspergillus clavatus	29.41	3.00e-36	146.00
IUUC-Afl-008617	Aspergillus flavus	29.23	1.00e-35	144.00
IUUC-Afu-008752	Aspergillus fumigatus	28.97	3.00e-33	136.00
IUUC-Ani-009136	Aspergillus nidulans	28.79	7.00e-36	145.00
IUUC-Ang-009701	Aspergillus niger	29.23	1.00e-34	141.00
IUUC-Aor-009884	Aspergillus oryzae	28.97	6.00e-35	142.00
IUUC-Ame-011432	Astyanax mexicanus	90.76	0.00e+00	761.00
IUUC-Bgr-012218	Blumeria graminis	29.92	1.00e-34	140.00
IUUC-Bta-012829	Bos taurus	77.07	0.00e+00	652.00
IUUC-Bci-013953	Botrytis cinerea	29.67	6.00e-37	148.00
IUUC-Bdi-014351	Brachypodium distachyon	35.55	2.00e-57	216.00
IUUC-Bol-015618	Brassica oleracea	34.64	3.00e-56	212.00
IUUC-Bra-017876	Brassica rapa	35.06	9.00e-59	221.00
IUUC-Cel-018569	Caenorhabditis elegans	33.81	2.00e-52	200.00
IUUC-Cja-019468	Callithrix jacchus	76.83	0.00e+00	631.00
IUUC-Cfa-020471	Canis familiaris	78.25	0.00e+00	645.00
IUUC-Cpo-022260	Cavia porcellus	76.60	0.00e+00	635.00
IUUC-Cre-022614	Chlamydomonas reinhardtii	33.16	5.00e-43	168.00
IUUC-Csa-023989	Chlorocebus sabaeus	76.36	0.00e+00	631.00
IUUC-Cho-024426	Choloepus hoffmanni	75.87	1.00e-135	476.00
IUUC-Cin-025789	Ciona intestinalis	44.23	6.00e-98	351.00
IUUC-Cne-027063	Cryptococcus neoformans	24.74	1.00e-18	88.20
IUUC-Dno-029225	Dasypus novemcinctus	76.36	0.00e+00	646.00
IUUC-Dor-031082	Dipodomys ordii	64.07	1.00e-140	493.00
IUUC-Dse-031308	Dothistroma septosporum	29.61	5.00e-39	155.00
IUUC-Dme-032189	Drosophila melanogaster	41.95	8.00e-92	330.00
IUUC-Ete-032247	Echinops telfairi	73.52	2.00e-172	598.00
IUUC-Eca-034285	Equus caballus	77.54	0.00e+00	652.00
IUUC-Eeu-035322	Erinaceus europaeus	70.60	3.00e-159	554.00
IUUC-Fca-036114	Felis catus	77.54	0.00e+00	654.00
IUUC-Fal-036891	Ficedula albicollis	80.79	1.00e-166	578.00
IUUC-Fox-037965	Fusarium oxysporum	25.05	2.00e-34	140.00
IUUC-Fso-038244	Fusarium solani	25.49	4.00e-33	135.00
IUUC-Gmo-039040	Gadus morhua	84.87	0.00e+00	723.00
IUUC-Ggr-040093	Gaeumannomyces graminis	24.79	9.00e-12	65.10
IUUC-Gga-040610	Gallus gallus	78.49	0.00e+00	680.00
IUUC-Gac-042117	Gasterosteus aculeatus	82.98	0.00e+00	683.00
IUUC-Gma-043146	Glycine max	36.14	2.00e-64	239.00
IUUC-Ggo-045179	Gorilla gorilla	77.07	0.00e+00	636.00
IUUC-Hsa-046114	Homo sapiens	77.07	0.00e+00	635.00
IUUC-Hvu-047331	Hordeum vulgare	34.10	4.00e-55	208.00
IUUC-Itr-048275	Ictidomys tridecemlineatus	76.83	0.00e+00	653.00
IUUC-Kpa-049304	Komagataella pastoris	30.38	2.00e-44	173.00
IUUC-Lch-050655	Latimeria chalumnae	74.93	4.00e-144	504.00
IUUC-Lpe-051675	Leersia perrieri	35.17	7.00e-61	228.00
IUUC-Loc-052868	Lepisosteus oculatus	83.22	0.00e+00	702.00
IUUC-Lma-053258	Leptosphaeria maculans	26.78	2.00e-34	142.00
IUUC-Laf-053993	Loxodonta africana	78.25	0.00e+00	650.00
IUUC-Mcc-055128	Macaca mulatta	61.70	1.00e-138	486.00
IUUC-Meu-056501	Macropus eugenii	68.10	1.00e-144	506.00
IUUC-Mor-057114	Magnaporthe oryzae	26.34	2.00e-27	117.00
IUUC-Mtr-058367	Medicago truncatula	36.54	7.00e-61	228.00
IUUC-Mla-059107	Melampsora laricipopulina	26.78	3.00e-29	123.00
IUUC-Mga-059745	Meleagris gallopavo	77.27	0.00e+00	656.00
IUUC-Mvi-060362	Microbotryum violaceum	26.77	2.00e-28	120.00
IUUC-Mdo-062257	Monodelphis domestica	75.77	0.00e+00	667.00
IUUC-Mmu-063546	Mus musculus	77.07	0.00e+00	650.00
IUUC-Mac-065540	Musa acuminata	33.73	5.00e-58	218.00
IUUC-Mpu-066284	Mustela putorius furo	76.83	0.00e+00	650.00
IUUC-Mlu-067241	Myotis lucifugus	77.30	0.00e+00	649.00
IUUC-Nfi-068260	Neosartorya fischeri	29.49	3.00e-34	139.00
IUUC-Ncr-068719	Neurospora crassa	25.54	2.00e-26	114.00
IUUC-Nle-068981	Nomascus leucogenys	77.30	0.00e+00	632.00
IUUC-Opr-071218	Ochotona princeps	71.36	6.00e-169	587.00
IUUC-Ont-071646	Oreochromis niloticus	84.32	0.00e+00	716.00
IUUC-Oan-073453	Ornithorhynchus anatinus	78.96	0.00e+00	703.00
IUUC-Ocu-074008	Oryctolagus cuniculus	77.07	0.00e+00	651.00
IUUC-Oba-075712	Oryza barthii	30.36	4.00e-44	172.00
IUUC-Obr-076721	Oryza brachyantha	35.15	6.00e-61	228.00
IUUC-Ogl-077229	Oryza glaberrima	35.17	1.00e-60	227.00
IUUC-Ogu-078977	Oryza glumaepatula	30.12	2.00e-44	173.00
IUUC-Oin-079683	Oryza indica	35.17	4.00e-61	228.00
IUUC-Olo-080291	Oryza longistaminata	29.73	2.00e-27	116.00
IUUC-Ome-081834	Oryza meridionalis	35.65	4.00e-62	232.00
IUUC-Oni-082507	Oryza nivara	33.57	2.00e-56	213.00
IUUC-Opu-083396	Oryza punctata	35.17	2.00e-61	230.00
IUUC-Oru-085220	Oryza rufipogon	33.81	4.00e-56	212.00
IUUC-Osa-085767	Oryza sativa	35.17	4.00e-61	228.00
IUUC-Ola-087420	Oryzias latipes	81.80	0.00e+00	710.00
IUUC-Olu-087740	Ostreococcus lucimarinus	29.27	1.00e-38	154.00
IUUC-Oga-088264	Otolemur garnettii	76.36	0.00e+00	642.00
IUUC-Oar-089335	Ovis aries	76.60	0.00e+00	647.00
IUUC-Ptr-091320	Pan troglodytes	77.07	0.00e+00	635.00
IUUC-Pan-092833	Papio anubis	75.89	0.00e+00	626.00
IUUC-Psi-093504	Pelodiscus sinensis	78.96	0.00e+00	673.00
IUUC-Pma-094189	Petromyzon marinus	67.45	2.00e-169	588.00
IUUC-Pno-094929	Phaeosphaeria nodorum	25.70	4.00e-35	142.00
IUUC-Ppa-095429	Physcomitrella patens	36.47	1.00e-65	243.00
IUUC-Pfo-096337	Poecilia formosa	82.74	0.00e+00	717.00
IUUC-Pab-097571	Pongo abelii	76.83	0.00e+00	634.00
IUUC-Pop-099977	Populus trichocarpa	35.18	4.00e-65	241.00
IUUC-Pca-100394	Procavia capensis	74.08	1.00e-167	582.00
IUUC-Ppe-101848	Prunus persica	35.02	8.00e-63	234.00
IUUC-Pva-102921	Pteropus vampyrus	76.92	8.00e-99	353.00
IUUC-Pgr-103637	Puccinia graminis	28.17	6.00e-37	148.00
IUUC-Ptt-103781	Puccinia triticina	28.17	8.00e-36	145.00
IUUC-Pte-104135	Pyrenophora teres	27.82	1.00e-33	139.00
IUUC-Pyt-104609	Pyrenophora triticirepentis	25.05	3.00e-32	133.00
IUUC-Rno-105114	Rattus norvegicus	78.25	0.00e+00	653.00
IUUC-Sce-106401	Saccharomyces cerevisiae	30.40	5.00e-42	165.00
IUUC-Sha-107122	Sarcophilus harrisii	76.36	0.00e+00	635.00
IUUC-Sja-107766	Schizosaccharomyces japonicus	32.95	4.00e-52	199.00
IUUC-Spo-108134	Schizosaccharomyces pombe	29.74	3.00e-43	169.00
IUUC-Ssl-108398	Sclerotinia sclerotiorum	29.52	7.00e-39	155.00
IUUC-Smo-108720	Selaginella moellendorffii	33.81	3.00e-57	216.00
IUUC-Sit-110311	Setaria italica	35.64	1.00e-58	220.00
IUUC-Sly-111178	Solanum lycopersicum	33.50	3.00e-58	219.00
IUUC-Stu-112778	Solanum tuberosum	35.41	1.00e-62	233.00
IUUC-Sar-113596	Sorex araneus	63.83	2.00e-142	499.00
IUUC-Sbi-114193	Sorghum bicolor	37.28	2.00e-59	223.00
IUUC-Sre-115002	Sporisorium reilianum	26.72	1.00e-14	75.10
IUUC-Ssc-116066	Sus scrofa	76.83	0.00e+00	647.00
IUUC-Tgu-117048	Taeniopygia guttata	79.16	4.00e-175	607.00
IUUC-Tsy-119573	Tarsius syrichta	49.16	3.00e-109	388.00
IUUC-Tni-119820	Tetraodon nigroviridis	81.56	0.00e+00	703.00
IUUC-Tca-121605	Theobroma cacao	35.66	1.00e-63	236.00
IUUC-Tre-121947	Trichoderma reesei	26.84	8.00e-34	138.00
IUUC-Tvi-122481	Trichoderma virens	27.62	8.00e-36	144.00
IUUC-Tae-125861	Triticum aestivum	33.97	2.00e-60	226.00
IUUC-Tur-126586	Triticum urartu	34.36	1.00e-57	216.00
IUUC-Tme-126900	Tuber melanosporum	30.50	2.00e-45	177.00
IUUC-Tbe-127736	Tupaia belangeri	58.04	3.00e-120	425.00
IUUC-Ttr-129041	Tursiops truncatus	67.61	2.00e-162	565.00
IUUC-Vpa-130260	Vicugna pacos	77.07	0.00e+00	652.00
IUUC-Vvi-131009	Vitis vinifera	35.56	1.00e-63	237.00
IUUC-Xtr-132083	Xenopus tropicalis	75.65	0.00e+00	657.00
IUUC-Xma-133094	Xiphophorus maculatus	82.98	0.00e+00	714.00
IUUC-Yli-134531	Yarrowia lipolytica	24.17	4.00e-19	89.70
IUUC-Zma-135509	Zea mays	34.05	2.00e-58	219.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence