iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCJAG00000020140.2	ENSCJAT00000039617.1	ENSCJAP00000037507.1
ENSCJAG00000020140.2	ENSCJAT00000056993.1	ENSCJAP00000044188.1
ENSCJAG00000020140.2	ENSCJAT00000062739.1	ENSCJAP00000051169.1
ENSCJAG00000020140.2	ENSCJAT00000039608.2	ENSCJAP00000037499.2
ENSCJAG00000020140.2	ENSCJAT00000061866.1	ENSCJAP00000042142.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.30e-08	36.1	31	75
E3 activity/RING/U-box	3.90e-07	31.0	25	94

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCle + + pl+l+CgH f++ C+ + +  + + ++e +CPlCr
   Q: 31   CPICLELLTE-PLSLDCGHSFCQACITANHKESTLHQGERSCPLCR 75
           ********99.***************555568899**********8 PP

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwl.....asggktcPvtrqplteedlvPnltlrrliq 66
           + ee  CpI lel ++P  l +G+++ +++I          +g+++cP++r +  +e+l Pn  l ++++
   Q: 25   IKEEVTCPICLELLTEPLSLDCGHSFCQACITANHkestlHQGERSCPLCRMSYPSENLRPNRHLANIVE 94
           67999**************************76332222255555*****************99987765 PP

Organism

Callithrix jacchus

Protein Sequence
(Fasta)

RGTSAARTGK SSGAATMASR ILVNIKEEVT CPICLELLTE PLSLDCGHSF CQACITANHK 60
ESTLHQGERS CPLCRMSYPS ENLRPNRHLA NIVERLKEFM LSPEEGQKVD HCARHGEKLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGAGCAAGA GGAACCTCAG CAGCCAGGAC AGGCAAGAGC AGTGGAGCAG CTACTATGGC 60
TTCCAGAATC CTGGTGAATA TAAAGGAGGA GGTAACCTGC CCCATCTGCC TGGAACTCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR003877--SPRY_dom
IPR032917--TRIM5
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:1990462--C:omegasome
GO:0000932--C:P-body
GO:0008329--F:signaling pattern recognition receptor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006914--P:autophagy
GO:0051607--P:defense response to virus
GO:0045087--P:innate immune response
GO:0046597--P:negative regulation of viral entry into host cell
GO:1902187--P:negative regulation of viral release from host cell
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043410--P:positive regulation of MAPK cascade
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0070534--P:protein K63-linked ubiquitination
GO:0031664--P:regulation of lipopolysaccharide-mediated signaling pathway
GO:0032880--P:regulation of protein localization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001965	Ailuropoda melanoleuca	52.86	2.00e-131	462.00
IUUC-Bta-013110	Bos taurus	57.95	5.00e-153	534.00
IUUC-Cre-022597	Chlamydomonas reinhardtii	34.57	4.00e-08	52.40
IUUC-Csa-023609	Chlorocebus sabaeus	66.60	0.00e+00	691.00
IUUC-Cho-024416	Choloepus hoffmanni	62.26	5.00e-90	324.00
IUUC-Dor-030700	Dipodomys ordii	51.75	8.00e-138	483.00
IUUC-Ete-033021	Echinops telfairi	52.37	1.00e-118	420.00
IUUC-Eca-033207	Equus caballus	61.70	6.00e-162	563.00
IUUC-Eeu-034968	Erinaceus europaeus	49.89	3.00e-113	401.00
IUUC-Fca-035533	Felis catus	52.45	4.00e-133	468.00
IUUC-Ggo-044783	Gorilla gorilla	69.80	0.00e+00	682.00
IUUC-Hsa-046573	Homo sapiens	68.83	0.00e+00	667.00
IUUC-Itr-048069	Ictidomys tridecemlineatus	51.79	9.00e-127	446.00
IUUC-Mcc-055525	Macaca mulatta	68.01	0.00e+00	689.00
IUUC-Mmr-061336	Microcebus murinus	58.91	7.00e-145	507.00
IUUC-Mmu-063682	Mus musculus	51.72	7.00e-132	463.00
IUUC-Mpu-065842	Mustela putorius furo	51.23	3.00e-129	454.00
IUUC-Mlu-067695	Myotis lucifugus	58.54	4.00e-148	518.00
IUUC-Ncr-068857	Neurospora crassa	32.50	3.00e-07	51.20
IUUC-Nle-069081	Nomascus leucogenys	67.21	0.00e+00	643.00
IUUC-Opr-071057	Ochotona princeps	53.97	6.00e-134	470.00
IUUC-Oga-088267	Otolemur garnettii	53.35	1.00e-131	463.00
IUUC-Oar-090073	Ovis aries	55.84	1.00e-140	493.00
IUUC-Ptr-090927	Pan troglodytes	68.22	0.00e+00	657.00
IUUC-Pan-092730	Papio anubis	68.61	0.00e+00	692.00
IUUC-Pab-098782	Pongo abelii	68.02	0.00e+00	662.00
IUUC-Rno-105401	Rattus norvegicus	50.71	3.00e-131	461.00
IUUC-Sar-113094	Sorex araneus	49.90	2.00e-112	399.00
IUUC-Ssc-115715	Sus scrofa	55.08	4.00e-135	474.00
IUUC-Tsy-119055	Tarsius syrichta	59.05	2.00e-154	538.00
IUUC-Tbe-127426	Tupaia belangeri	54.10	6.00e-133	467.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence