iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013314

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ankyrin repeat and SOCS box protein 8

Genbank Nucleotide ID

BC123430

Gene Name

ASB8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000000289.3	ENSBTAT00000000361.3	ENSBTAP00000000361.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	9.90e-15	54.3	238	285

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 2    sklwllrseprSLqhLCRlaIrrclgsqrl.kaidkLPLPksLkdYLl 48
           +kl++l+s p +L++L+R+a+rr+lg q l +a+++LPLP sLk+YLl
   Q: 238  EKLTVLCSAPGTLKTLSRYAVRRSLGLQYLpDAVKGLPLPASLKEYLL 285
           7899*******************************************8 PP

Organism

Bos taurus

Functional Description
(View)

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MSSSMWYIMQ SIQSKYSLSE RLIRTIAAIR SFPHDNVEDL IRGGADVNCT HGTLKPLHCA 60
CMVSDADCVE LLLEKGAEVN ALDGYNRTAL HYAAEKDEAC VEVLLEYGAN PNALDGNRDT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCCTTGACA GCCGCTTTCA CCACCCAGGT CAGCTCCACG GTTCGGTGAG TGTCGCCCCG 60
CGGCAGGAAT ATCTGCAGTC TGGTACCTAA CCTCGGGCAC CACGCCCAGT AGCACTTCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001496--SOCS_box

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50225--SOCS

Pfam

PF12796--Ank_2
PF07525--SOCS_box

SMART

SM00248--ANK
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination

KEGG

bta:617269

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001601	Ailuropoda melanoleuca	99.31	3.00e-170	590.00
IUUC-Apl-003898	Anas platyrhynchos	84.43	1.00e-124	438.00
IUUC-Aca-005321	Anolis carolinensis	90.91	7.00e-158	549.00
IUUC-Ame-010739	Astyanax mexicanus	79.79	3.00e-129	454.00
IUUC-Cja-018726	Callithrix jacchus	97.92	1.00e-167	582.00
IUUC-Cfa-020084	Canis familiaris	99.31	3.00e-170	590.00
IUUC-Cpo-022509	Cavia porcellus	99.31	2.00e-170	590.00
IUUC-Csa-023640	Chlorocebus sabaeus	98.26	9.00e-168	582.00
IUUC-Cho-024844	Choloepus hoffmanni	99.31	3.00e-170	590.00
IUUC-Cin-025183	Ciona intestinalis	37.42	5.00e-20	92.80
IUUC-Dre-027663	Danio rerio	79.44	3.00e-133	467.00
IUUC-Dno-029623	Dasypus novemcinctus	98.96	9.00e-170	588.00
IUUC-Dor-030857	Dipodomys ordii	98.61	7.00e-169	585.00
IUUC-Eca-033273	Equus caballus	99.65	1.00e-170	592.00
IUUC-Eeu-034981	Erinaceus europaeus	97.92	4.00e-168	583.00
IUUC-Fca-035934	Felis catus	99.31	3.00e-170	590.00
IUUC-Fal-037472	Ficedula albicollis	82.87	2.00e-137	481.00
IUUC-Gmo-038873	Gadus morhua	77.51	1.00e-131	462.00
IUUC-Gga-041086	Gallus gallus	86.57	5.00e-149	520.00
IUUC-Gac-041583	Gasterosteus aculeatus	79.09	6.00e-134	469.00
IUUC-Ggo-044756	Gorilla gorilla	98.26	9.00e-168	582.00
IUUC-Hsa-046104	Homo sapiens	98.26	9.00e-168	582.00
IUUC-Itr-048325	Ictidomys tridecemlineatus	99.31	7.00e-170	589.00
IUUC-Lch-050156	Latimeria chalumnae	85.02	1.00e-149	522.00
IUUC-Laf-053574	Loxodonta africana	98.96	2.00e-169	587.00
IUUC-Mcc-054710	Macaca mulatta	95.61	1.00e-165	574.00
IUUC-Meu-056561	Macropus eugenii	97.22	3.00e-166	577.00
IUUC-Mga-059733	Meleagris gallopavo	85.66	6.00e-127	446.00
IUUC-Mmr-060632	Microcebus murinus	98.96	1.00e-169	588.00
IUUC-Mmu-064371	Mus musculus	97.57	2.00e-167	580.00
IUUC-Mpu-066066	Mustela putorius furo	98.96	3.00e-169	587.00
IUUC-Mlu-067200	Myotis lucifugus	99.31	3.00e-170	590.00
IUUC-Nle-069782	Nomascus leucogenys	98.26	9.00e-168	582.00
IUUC-Opr-070962	Ochotona princeps	95.49	5.00e-165	572.00
IUUC-Ont-071639	Oreochromis niloticus	79.79	5.00e-130	456.00
IUUC-Oan-072927	Ornithorhynchus anatinus	79.21	2.00e-74	270.00
IUUC-Ocu-074106	Oryctolagus cuniculus	95.80	3.00e-164	570.00
IUUC-Ola-086720	Oryzias latipes	79.09	7.00e-129	452.00
IUUC-Oga-088635	Otolemur garnettii	99.31	3.00e-170	590.00
IUUC-Oar-090018	Ovis aries	99.65	1.00e-170	592.00
IUUC-Ptr-091388	Pan troglodytes	97.92	1.00e-167	581.00
IUUC-Pan-092014	Papio anubis	98.26	9.00e-168	582.00
IUUC-Psi-093909	Pelodiscus sinensis	87.11	2.00e-151	528.00
IUUC-Pfo-096383	Poecilia formosa	78.40	9.00e-129	452.00
IUUC-Pab-097714	Pongo abelii	96.45	1.00e-159	555.00
IUUC-Pva-103230	Pteropus vampyrus	98.78	9.00e-143	498.00
IUUC-Rno-104942	Rattus norvegicus	98.26	3.00e-168	583.00
IUUC-Sha-106733	Sarcophilus harrisii	98.26	7.00e-168	582.00
IUUC-Ssc-116033	Sus scrofa	99.65	1.00e-170	592.00
IUUC-Tgu-117411	Taeniopygia guttata	86.01	5.00e-143	499.00
IUUC-Tru-118207	Takifugu rubripes	77.70	8.00e-127	446.00
IUUC-Tsy-119535	Tarsius syrichta	74.65	2.00e-113	401.00
IUUC-Tni-120699	Tetraodon nigroviridis	78.05	4.00e-127	447.00
IUUC-Tbe-127600	Tupaia belangeri	99.18	1.00e-142	498.00
IUUC-Ttr-128818	Tursiops truncatus	98.96	1.00e-169	588.00
IUUC-Vpa-130323	Vicugna pacos	99.65	1.00e-170	592.00
IUUC-Xtr-132195	Xenopus tropicalis	65.12	2.00e-92	331.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence