iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sha-107578

Ensembl Protein ID

ENSSHAP00000006737.1

UniProt Accession

G3VU82; G3VU82_SARHA

Genbank Protein ID

ENSSHAP00000006737

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01177038

Gene Name

RFFL

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000005858.1	ENSSHAT00000006796.1	ENSSHAP00000006737.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	80.44	9.00e-157	550.00	IUUC-Hsa-045798

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MEKLCIWTEM ALFCFTMWAT CCNWFCQDGH SEETQQAQGA RTQAYSNPGY SSFPSPTSSE 60
PSCKNCGTHF GSTTRKHTCL DCKKDFCISC SSQVGNGARL CYLCQRFRAT AFHREELMKM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGAAAC TGTGCATTTG GACAGAAATG GCCCTATTTT CTCCTTTTAA AAAAAAATTA 60
TCTTTCATTT TTATATCATC TTCATTTTTA AATATCTTTT CCCCCTCTTC CCTACCCTAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0732--Signal
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003034--SAP_dom
IPR017455--Znf_FYVE-rel
IPR011011--Znf_FYVE_PHD
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50178--ZF_FYVE
PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0010008--C:endosome membrane
GO:0005886--C:plasma membrane
GO:0002947--C:tumor necrosis factor receptor superfamily complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:2001271--P:negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1901797--P:negative regulation of signal transduction by p53 class mediator
GO:0010804--P:negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001630	Ailuropoda melanoleuca	77.81	1.00e-157	549.00
IUUC-Apl-004124	Anas platyrhynchos	65.70	3.00e-125	441.00
IUUC-Aly-005548	Arabidopsis lyrata	37.18	9.00e-09	55.80
IUUC-Ame-011616	Astyanax mexicanus	57.22	1.00e-102	366.00
IUUC-Bta-012374	Bos taurus	76.00	2.00e-160	558.00
IUUC-Cja-019780	Callithrix jacchus	79.12	3.00e-165	574.00
IUUC-Cfa-021252	Canis familiaris	78.08	6.00e-155	540.00
IUUC-Cpo-022047	Cavia porcellus	78.36	1.00e-161	561.00
IUUC-Csa-023161	Chlorocebus sabaeus	80.44	9.00e-176	608.00
IUUC-Cho-024316	Choloepus hoffmanni	80.53	5.00e-135	473.00
IUUC-Dre-028596	Danio rerio	56.75	2.00e-109	389.00
IUUC-Dno-029333	Dasypus novemcinctus	81.54	2.00e-164	571.00
IUUC-Ete-033163	Echinops telfairi	77.41	1.00e-146	512.00
IUUC-Eca-033994	Equus caballus	78.36	1.00e-163	568.00
IUUC-Eeu-035162	Erinaceus europaeus	75.33	8.00e-109	386.00
IUUC-Fca-036418	Felis catus	79.73	7.00e-174	602.00
IUUC-Fal-037427	Ficedula albicollis	66.32	7.00e-135	473.00
IUUC-Gga-041053	Gallus gallus	69.15	1.00e-135	475.00
IUUC-Ggo-045436	Gorilla gorilla	80.44	4.00e-176	610.00
IUUC-Hsa-045798	Homo sapiens	80.44	4.00e-176	610.00
IUUC-Itr-048077	Ictidomys tridecemlineatus	78.63	2.00e-158	551.00
IUUC-Lch-050639	Latimeria chalumnae	62.26	1.00e-122	432.00
IUUC-Laf-053355	Loxodonta africana	79.08	6.00e-157	546.00
IUUC-Mcc-055222	Macaca mulatta	79.89	1.00e-163	568.00
IUUC-Meu-056692	Macropus eugenii	92.84	0.00e+00	646.00
IUUC-Mga-059298	Meleagris gallopavo	68.66	3.00e-136	478.00
IUUC-Mmr-061792	Microcebus murinus	80.17	2.00e-160	558.00
IUUC-Mdo-062986	Monodelphis domestica	90.62	0.00e+00	682.00
IUUC-Mmu-063356	Mus musculus	79.45	1.00e-165	575.00
IUUC-Mpu-066273	Mustela putorius furo	78.36	6.00e-172	596.00
IUUC-Mlu-066953	Myotis lucifugus	78.63	2.00e-167	581.00
IUUC-Nle-070075	Nomascus leucogenys	79.45	5.00e-176	610.00
IUUC-Opr-070838	Ochotona princeps	80.17	3.00e-164	570.00
IUUC-Ocu-074807	Oryctolagus cuniculus	78.90	1.00e-172	598.00
IUUC-Obr-076159	Oryza brachyantha	36.49	2.00e-08	51.20
IUUC-Ola-086903	Oryzias latipes	68.92	1.00e-54	206.00
IUUC-Oga-088536	Otolemur garnettii	77.13	1.00e-155	541.00
IUUC-Oar-089838	Ovis aries	74.40	7.00e-154	536.00
IUUC-Ptr-090962	Pan troglodytes	80.44	4.00e-176	610.00
IUUC-Pan-092853	Papio anubis	79.61	2.00e-174	604.00
IUUC-Psi-093164	Pelodiscus sinensis	67.95	3.00e-129	454.00
IUUC-Pma-094104	Petromyzon marinus	45.02	2.00e-54	206.00
IUUC-Pab-098304	Pongo abelii	80.55	2.00e-178	618.00
IUUC-Pca-100316	Procavia capensis	80.44	2.00e-153	535.00
IUUC-Ppe-101490	Prunus persica	38.57	1.00e-08	53.90
IUUC-Pva-102612	Pteropus vampyrus	66.67	2.00e-132	464.00
IUUC-Rno-105449	Rattus norvegicus	79.34	1.00e-163	568.00
IUUC-Smo-108709	Selaginella moellendorffii	36.05	8.00e-09	51.20
IUUC-Sit-110649	Setaria italica	41.67	3.00e-09	53.90
IUUC-Sar-113638	Sorex araneus	76.03	2.00e-149	521.00
IUUC-Ssc-116401	Sus scrofa	78.63	2.00e-171	594.00
IUUC-Tru-118765	Takifugu rubripes	48.90	8.00e-81	293.00
IUUC-Tsy-118850	Tarsius syrichta	76.90	2.00e-129	454.00
IUUC-Tbe-128086	Tupaia belangeri	72.73	2.00e-153	535.00
IUUC-Ttr-128249	Tursiops truncatus	73.08	9.00e-80	290.00
IUUC-Vpa-130816	Vicugna pacos	80.23	5.00e-37	147.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence