iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003313

Ensembl Protein ID

ENSAPLP00000000236.1

UniProt Accession

R0L2S2; R0L2S2_ANAPL

Genbank Protein ID

EOA95714.1

Protein Name

Suppressor of cytokine signaling 1

Genbank Nucleotide ID

ADON01124354

Gene Name

SOCS1; Anapl_11448

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000000830.1	ENSAPLT00000000804.1	ENSAPLP00000000236.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.70e-13	50.0	161	206

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 5    wllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
           +l+  ++ +Lq+LCR++I++++g+++l   +++PL+++LkdYL+++++q
   Q: 161  PLRKVRVQPLQELCRKSIVKTFGRENL---NQIPLNPVLKDYLKSFPFQ 206
           5566689********************...****************986 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

MVAHSKVSAD NAVAADPRCL LDPPARDRSQ ARGYHGPGQP GTLQAQSNTH FRTFRSQADF 60
SSITRASSLL DACGFYWGPL TVSAAHEKLK SEPEGTFLIR DSTQKNCFFA ISVKTATGPT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTAGCGC ACAGCAAGGT GTCAGCAGAT AATGCAGTTG CAGCAGACCC AAGATGTCTA 60
CTTGACCCTC CAGCACGGGA TCGTTCACAG GCTCGAGGCT ACCACGGCCC AGGCCAGCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028411--SOCS1
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0000932--C:P-body
GO:0019210--F:kinase inhibitor activity
GO:0071230--P:cellular response to amino acid stimulus
GO:0019221--P:cytokine-mediated signaling pathway
GO:0045444--P:fat cell differentiation
GO:0007259--P:JAK-STAT cascade
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0042512--P:negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518--P:negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0010534--P:regulation of activation of JAK2 kinase activity
GO:0050707--P:regulation of cytokine secretion
GO:0060334--P:regulation of interferon-gamma-mediated signaling pathway

KEGG

apla:101801940

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001204	Ailuropoda melanoleuca	66.25	8.00e-62	229.00
IUUC-Aca-005109	Anolis carolinensis	68.35	2.00e-64	237.00
IUUC-Ame-011550	Astyanax mexicanus	59.88	2.00e-57	214.00
IUUC-Bta-013411	Bos taurus	71.88	1.00e-71	262.00
IUUC-Cja-019595	Callithrix jacchus	61.61	2.00e-72	264.00
IUUC-Cfa-020563	Canis familiaris	71.43	2.00e-71	260.00
IUUC-Cpo-021374	Cavia porcellus	71.88	1.00e-71	261.00
IUUC-Csa-023333	Chlorocebus sabaeus	60.56	8.00e-73	265.00
IUUC-Dre-028507	Danio rerio	47.06	2.00e-49	188.00
IUUC-Dno-029406	Dasypus novemcinctus	61.54	3.00e-72	263.00
IUUC-Ete-032399	Echinops telfairi	60.29	5.00e-71	259.00
IUUC-Eca-033519	Equus caballus	60.66	1.00e-69	255.00
IUUC-Fal-036726	Ficedula albicollis	94.69	3.00e-106	377.00
IUUC-Gmo-039667	Gadus morhua	43.36	2.00e-24	105.00
IUUC-Gga-040970	Gallus gallus	96.62	7.00e-117	412.00
IUUC-Gac-041838	Gasterosteus aculeatus	43.33	4.00e-36	143.00
IUUC-Ggo-045569	Gorilla gorilla	61.35	6.00e-74	269.00
IUUC-Hsa-046010	Homo sapiens	60.66	2.00e-72	264.00
IUUC-Itr-047995	Ictidomys tridecemlineatus	72.05	4.00e-72	263.00
IUUC-Lch-050219	Latimeria chalumnae	69.57	9.00e-67	245.00
IUUC-Loc-052494	Lepisosteus oculatus	57.97	1.00e-66	244.00
IUUC-Laf-054219	Loxodonta africana	71.32	1.00e-56	211.00
IUUC-Mcc-054830	Macaca mulatta	73.12	1.00e-72	265.00
IUUC-Meu-056565	Macropus eugenii	73.71	2.00e-88	317.00
IUUC-Mga-060153	Meleagris gallopavo	96.14	4.00e-107	379.00
IUUC-Mmr-061365	Microcebus murinus	72.05	4.00e-72	263.00
IUUC-Mdo-062824	Monodelphis domestica	73.36	6.00e-87	312.00
IUUC-Mmu-064120	Mus musculus	70.81	4.00e-71	260.00
IUUC-Mpu-066839	Mustela putorius furo	72.50	3.00e-72	263.00
IUUC-Mlu-067829	Myotis lucifugus	70.19	1.00e-70	258.00
IUUC-Nle-069592	Nomascus leucogenys	61.06	7.00e-70	256.00
IUUC-Ont-072173	Oreochromis niloticus	47.50	2.00e-38	151.00
IUUC-Oan-073586	Ornithorhynchus anatinus	47.90	4.00e-25	106.00
IUUC-Ocu-073996	Oryctolagus cuniculus	72.05	9.00e-72	261.00
IUUC-Ola-087158	Oryzias latipes	49.69	3.00e-40	157.00
IUUC-Oga-088076	Otolemur garnettii	61.79	3.00e-72	263.00
IUUC-Ptr-091241	Pan troglodytes	60.66	1.00e-72	265.00
IUUC-Pan-091836	Papio anubis	62.32	7.00e-75	272.00
IUUC-Psi-093628	Pelodiscus sinensis	88.89	1.00e-109	388.00
IUUC-Pfo-097501	Poecilia formosa	44.03	6.00e-36	143.00
IUUC-Pab-098170	Pongo abelii	72.05	2.00e-72	264.00
IUUC-Pop-100072	Populus trichocarpa	30.61	1.80e-01	29.60
IUUC-Pva-102796	Pteropus vampyrus	71.43	7.00e-72	262.00
IUUC-Pgr-103356	Puccinia graminis	25.24	4.80e-01	28.10
IUUC-Rno-105319	Rattus norvegicus	70.81	4.00e-71	260.00
IUUC-Sha-107201	Sarcophilus harrisii	83.77	7.00e-77	278.00
IUUC-Ssc-116004	Sus scrofa	60.00	9.00e-75	272.00
IUUC-Tgu-116836	Taeniopygia guttata	94.69	1.00e-114	404.00
IUUC-Tru-118090	Takifugu rubripes	46.58	8.00e-37	146.00
IUUC-Tni-120719	Tetraodon nigroviridis	47.20	8.00e-33	132.00
IUUC-Vpa-130235	Vicugna pacos	72.05	3.00e-72	263.00
IUUC-Xtr-132610	Xenopus tropicalis	67.30	5.00e-79	286.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence