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Tag Content
iUUCD ID IUUC-Bci-013774
Ensembl Protein ID Bcin14g03370.1
UniProt Accession A6RYB8; ATG1_BOTFB
Genbank Protein ID EDN24694.1
Protein Name Serine/threonine-protein kinase atg1; Autophagy-related protein 1
Genbank Nucleotide ID CH476866
Gene Name atg1; BC1G_05432
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
Bcin14g03370 Bcin14g03370.1 Bcin14g03370.1
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/UBA 55.96 2.00e-123 437.00 IUUC-Spo-108202
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Botrytis cinerea
Functional Description
(View)

Functional Description



     Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates. Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9.
Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates. Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9.
Protein Sequence
(Fasta)
MNRYDDGELE ISLAPSANHR AQHRASDAGS HSRRDSQNGN SRRMETVPAP QRKTEQRVGA 60
YSVIRTLGEG SFGKVKLAVH RVTGQQVALK IIGRRKLISR DMAGRVEREI EYLQLLRHPH 120
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Protein Fasta Sequence



>IUUC-Bci-013774|UBD,UBA|Botrytis cinerea
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Nucleotide Sequence
(Fasta)
GGTTTAGGTT TCTCCATTTT ACGGATCTCA ACAGAAGACT CTTTCAAGTT ATTCACTCAA 60
TAATTGTTAT ACCCTTGGAA TTATTTCTGA CTCTTTCACC ACCTACTCCG CAACTATTAC 120
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Nucleotide Fasta Sequence



>IUUC-Bci-013774|UBD,UBA|Botrytis cinerea
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0072--Autophagy
KW-0963--Cytoplasm
KW-0418--Kinase
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0653--Protein transport
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0813--Transport

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
IPR022708--Ser/Thr_kinase_C

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST

Pfam

PF12063--DUF3543
PF00069--Pkinase

SMART

SM00220--S_TKc

Gene Ontology

GO:0034045--C:pre-autophagosomal structure membrane
GO:0005524--F:ATP binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0006914--P:autophagy
GO:0015031--P:protein transport

KEGG bfu:BC1G_05432
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000713 Aegilops tauschii 63.85 4.00e-98 350.00
IUUC-Aml-001907 Ailuropoda melanoleuca 56.76 5.00e-97 346.00
IUUC-Atr-002770 Amborella trichopoda 53.69 2.00e-100 357.00
IUUC-Apl-003395 Anas platyrhynchos 61.57 3.00e-98 350.00
IUUC-Aca-004480 Anolis carolinensis 47.41 1.00e-104 372.00
IUUC-Aly-005773 Arabidopsis lyrata 63.29 8.00e-101 358.00
IUUC-Ath-006678 Arabidopsis thaliana 63.29 8.00e-102 362.00
IUUC-Ago-007957 Ashbya gossypii 48.83 2.00e-136 478.00
IUUC-Acl-008103 Aspergillus clavatus 44.30 3.00e-180 623.00
IUUC-Afl-008555 Aspergillus flavus 45.00 0.00e+00 631.00
IUUC-Afu-008949 Aspergillus fumigatus 45.76 3.00e-177 613.00
IUUC-Ani-009408 Aspergillus nidulans 50.56 4.00e-160 556.00
IUUC-Ang-009551 Aspergillus niger 62.17 3.00e-151 527.00
IUUC-Aor-010176 Aspergillus oryzae 45.00 0.00e+00 632.00
IUUC-Ate-010287 Aspergillus terreus 68.73 6.00e-148 516.00
IUUC-Ame-011019 Astyanax mexicanus 47.62 2.00e-105 374.00
IUUC-Bgr-012045 Blumeria graminis 64.98 0.00e+00 915.00
IUUC-Bta-012786 Bos taurus 57.00 1.00e-96 345.00
IUUC-Bdi-014319 Brachypodium distachyon 64.02 3.00e-100 357.00
IUUC-Bol-015318 Brassica oleracea 64.39 6.00e-100 356.00
IUUC-Bra-016750 Brassica rapa 64.39 6.00e-100 356.00
IUUC-Cel-018518 Caenorhabditis elegans 57.69 4.00e-107 380.00
IUUC-Cja-019386 Callithrix jacchus 46.84 3.00e-105 373.00
IUUC-Cfa-020177 Canis familiaris 59.07 8.00e-95 339.00
IUUC-Cpo-021805 Cavia porcellus 46.56 9.00e-105 372.00
IUUC-Cre-022915 Chlamydomonas reinhardtii 58.08 5.00e-81 292.00
IUUC-Csa-024267 Chlorocebus sabaeus 46.84 4.00e-105 373.00
IUUC-Cho-024859 Choloepus hoffmanni 56.67 8.00e-92 329.00
IUUC-Cin-025550 Ciona intestinalis 53.68 2.00e-110 391.00
IUUC-Csv-026139 Ciona savignyi 55.01 8.00e-112 395.00
IUUC-Cgl-026480 Colletotrichum gloeosporioides 42.81 1.00e-66 246.00
IUUC-Cne-027044 Cryptococcus neoformans 51.61 4.00e-119 420.00
IUUC-Cme-027289 Cyanidioschyzon merolae 60.49 6.00e-99 352.00
IUUC-Dre-027749 Danio rerio 45.84 3.00e-102 364.00
IUUC-Dno-030006 Dasypus novemcinctus 59.35 9.00e-96 342.00
IUUC-Dor-030578 Dipodomys ordii 46.84 2.00e-104 370.00
IUUC-Dse-031507 Dothistroma septosporum 50.67 0.00e+00 719.00
IUUC-Dme-031704 Drosophila melanogaster 62.92 9.00e-102 362.00
IUUC-Ete-033055 Echinops telfairi 55.97 2.00e-92 331.00
IUUC-Eca-034016 Equus caballus 46.48 5.00e-98 349.00
IUUC-Eeu-034949 Erinaceus europaeus 43.49 4.00e-80 290.00
IUUC-Fca-035754 Felis catus 54.22 8.00e-94 336.00
IUUC-Fal-037363 Ficedula albicollis 56.71 2.00e-95 341.00
IUUC-Fox-038073 Fusarium oxysporum 76.11 2.00e-180 624.00
IUUC-Fso-038236 Fusarium solani 75.25 2.00e-173 600.00
IUUC-Gmo-039633 Gadus morhua 45.95 7.00e-106 376.00
IUUC-Ggr-039987 Gaeumannomyces graminis 59.45 0.00e+00 808.00
IUUC-Gga-040546 Gallus gallus 60.14 9.00e-105 372.00
IUUC-Gac-041822 Gasterosteus aculeatus 43.70 4.00e-105 373.00
IUUC-Gma-042712 Glycine max 64.77 1.00e-99 355.00
IUUC-Ggo-045303 Gorilla gorilla 46.84 3.00e-105 374.00
IUUC-Hsa-045746 Homo sapiens 46.84 3.00e-105 374.00
IUUC-Hvu-047406 Hordeum vulgare 64.02 5.00e-100 356.00
IUUC-Itr-048134 Ictidomys tridecemlineatus 46.56 7.00e-105 372.00
IUUC-Kpa-049190 Komagataella pastoris 48.03 6.00e-135 472.00
IUUC-Lch-049623 Latimeria chalumnae 46.32 8.00e-96 342.00
IUUC-Lpe-051392 Leersia perrieri 64.42 2.00e-101 360.00
IUUC-Loc-052928 Lepisosteus oculatus 49.75 4.00e-105 373.00
IUUC-Lma-053054 Leptosphaeria maculans 60.44 0.00e+00 670.00
IUUC-Laf-053459 Loxodonta africana 48.43 5.00e-105 373.00
IUUC-Mcc-055862 Macaca mulatta 46.84 3.00e-105 374.00
IUUC-Meu-056525 Macropus eugenii 43.20 5.00e-80 290.00
IUUC-Mor-057170 Magnaporthe oryzae 58.06 0.00e+00 798.00
IUUC-Mpo-057302 Magnaporthe poae 57.81 0.00e+00 805.00
IUUC-Mtr-058309 Medicago truncatula 63.26 1.00e-97 348.00
IUUC-Mla-059058 Melampsora laricipopulina 60.75 4.00e-107 380.00
IUUC-Mga-059206 Meleagris gallopavo 61.57 4.00e-98 350.00
IUUC-Mvi-060337 Microbotryum violaceum 42.09 8.00e-112 396.00
IUUC-Mmr-061619 Microcebus murinus 46.56 7.00e-105 372.00
IUUC-Mdo-062160 Monodelphis domestica 45.79 2.00e-105 374.00
IUUC-Mmu-063406 Mus musculus 46.84 2.00e-105 374.00
IUUC-Mac-064518 Musa acuminata 64.55 1.00e-99 355.00
IUUC-Mpu-066326 Mustela putorius furo 46.48 3.00e-98 350.00
IUUC-Mlu-067968 Myotis lucifugus 45.59 5.00e-97 346.00
IUUC-Nfi-068493 Neosartorya fischeri 46.02 7.00e-179 619.00
IUUC-Ncr-068665 Neurospora crassa 58.60 0.00e+00 852.00
IUUC-Nle-070158 Nomascus leucogenys 46.84 3.00e-105 374.00
IUUC-Opr-070272 Ochotona princeps 54.22 1.00e-93 335.00
IUUC-Ont-071395 Oreochromis niloticus 46.97 2.00e-104 371.00
IUUC-Oan-073322 Ornithorhynchus anatinus 55.76 5.00e-93 333.00
IUUC-Ocu-074188 Oryctolagus cuniculus 54.43 4.00e-93 333.00
IUUC-Oba-075436 Oryza barthii 64.42 1.00e-101 362.00
IUUC-Obr-076507 Oryza brachyantha 64.42 1.00e-101 362.00
IUUC-Ogl-077718 Oryza glaberrima 54.01 1.00e-98 352.00
IUUC-Ogu-078349 Oryza glumaepatula 64.42 7.00e-102 362.00
IUUC-Oin-079889 Oryza indica 53.39 9.00e-99 352.00
IUUC-Olo-080521 Oryza longistaminata 64.42 1.00e-101 361.00
IUUC-Ome-081630 Oryza meridionalis 64.04 3.00e-101 360.00
IUUC-Oni-082211 Oryza nivara 64.42 6.00e-102 363.00
IUUC-Opu-083617 Oryza punctata 64.42 1.00e-101 361.00
IUUC-Oru-084252 Oryza rufipogon 64.42 1.00e-101 361.00
IUUC-Osa-085548 Oryza sativa 64.42 1.00e-101 361.00
IUUC-Ola-087169 Oryzias latipes 48.21 4.00e-104 370.00
IUUC-Olu-087861 Ostreococcus lucimarinus 57.00 2.00e-97 348.00
IUUC-Oga-088003 Otolemur garnettii 57.00 1.00e-96 345.00
IUUC-Oar-089933 Ovis aries 57.00 1.00e-96 345.00
IUUC-Ptr-090741 Pan troglodytes 46.84 3.00e-105 374.00
IUUC-Pan-092526 Papio anubis 57.00 1.00e-96 345.00
IUUC-Psi-094034 Pelodiscus sinensis 56.46 5.00e-95 340.00
IUUC-Pma-094532 Petromyzon marinus 48.55 2.00e-79 287.00
IUUC-Pno-095030 Phaeosphaeria nodorum 73.20 1.00e-159 554.00
IUUC-Ppa-095615 Physcomitrella patens 65.15 5.00e-100 356.00
IUUC-Pfo-096295 Poecilia formosa 46.74 1.00e-103 368.00
IUUC-Pab-098023 Pongo abelii 46.84 3.00e-105 374.00
IUUC-Pop-100042 Populus trichocarpa 64.77 8.00e-100 355.00
IUUC-Pca-101104 Procavia capensis 53.90 4.00e-93 333.00
IUUC-Ppe-101642 Prunus persica 64.77 1.00e-99 355.00
IUUC-Pva-102470 Pteropus vampyrus 46.32 2.00e-102 364.00
IUUC-Pgr-103406 Puccinia graminis 42.15 2.00e-108 385.00
IUUC-Ptt-103713 Puccinia triticina 37.37 8.00e-88 316.00
IUUC-Pte-104259 Pyrenophora teres 49.93 0.00e+00 695.00
IUUC-Pyt-104752 Pyrenophora triticirepentis 60.58 0.00e+00 672.00
IUUC-Rno-104960 Rattus norvegicus 46.56 7.00e-105 372.00
IUUC-Sce-106290 Saccharomyces cerevisiae 48.29 4.00e-138 483.00
IUUC-Sha-107603 Sarcophilus harrisii 56.66 5.00e-96 343.00
IUUC-Sja-107772 Schizosaccharomyces japonicus 46.91 2.00e-126 444.00
IUUC-Spo-108202 Schizosaccharomyces pombe 55.96 9.00e-125 438.00
IUUC-Ssl-108535 Sclerotinia sclerotiorum 86.49 0.00e+00 1289.00
IUUC-Smo-109309 Selaginella moellendorffii 63.57 2.00e-101 361.00
IUUC-Sit-109745 Setaria italica 63.67 3.00e-100 357.00
IUUC-Sly-110890 Solanum lycopersicum 65.53 5.00e-101 359.00
IUUC-Stu-112144 Solanum tuberosum 62.50 6.00e-98 349.00
IUUC-Sar-113521 Sorex araneus 48.03 2.00e-68 251.00
IUUC-Sbi-114764 Sorghum bicolor 63.67 2.00e-100 357.00
IUUC-Sre-115141 Sporisorium reilianum 43.70 4.00e-129 453.00
IUUC-Ssc-115732 Sus scrofa 60.00 1.00e-94 338.00
IUUC-Tgu-117190 Taeniopygia guttata 56.71 2.00e-95 341.00
IUUC-Tru-118735 Takifugu rubripes 60.84 1.00e-104 372.00
IUUC-Tsy-119503 Tarsius syrichta 46.78 2.00e-98 351.00
IUUC-Tni-119880 Tetraodon nigroviridis 47.43 2.00e-105 374.00
IUUC-Tca-121386 Theobroma cacao 64.77 2.00e-100 357.00
IUUC-Tre-122070 Trichoderma reesei 60.88 0.00e+00 828.00
IUUC-Tvi-122305 Trichoderma virens 58.74 0.00e+00 785.00
IUUC-Tae-123515 Triticum aestivum 49.61 7.00e-101 359.00
IUUC-Tur-126416 Triticum urartu 63.64 1.00e-99 355.00
IUUC-Tme-127174 Tuber melanosporum 44.64 3.00e-143 500.00
IUUC-Tbe-127501 Tupaia belangeri 49.81 9.00e-76 277.00
IUUC-Ttr-129224 Tursiops truncatus 54.22 2.00e-93 335.00
IUUC-Uma-129372 Ustilago maydis 53.10 7.00e-124 436.00
IUUC-Vda-129819 Verticillium dahliae 56.87 0.00e+00 728.00
IUUC-Vpa-130220 Vicugna pacos 48.21 1.00e-97 348.00
IUUC-Vvi-131649 Vitis vinifera 64.39 8.00e-100 355.00
IUUC-Xtr-132954 Xenopus tropicalis 48.29 2.00e-104 370.00
IUUC-Xma-134082 Xiphophorus maculatus 59.35 2.00e-101 361.00
IUUC-Yli-134422 Yarrowia lipolytica 48.82 4.00e-137 479.00
IUUC-Zma-135621 Zea mays 63.30 2.00e-100 358.00
Created Date 25-Jun-2017

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