iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mdo-062160

Ensembl Protein ID

ENSMODP00000004388.3

UniProt Accession

F7FPU2; F7FPU2_MONDO

Protein Name

Non-specific serine/threonine protein kinase

Gene Name

PRKAA2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000003591.3	ENSMODT00000004481.3	ENSMODP00000004388.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UBA	47.87	2.00e-123	440.00	IUUC-Ath-007014
UBD/Alpha-Helix/UBA	41.04	1.00e-107	385.00	IUUC-Spo-108202

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MRCLGKLLIP FVIYWLFRHP SLSPLPSWLL SLSWPPPFLP PSSRYSRSLP PPDSSRSPLP 60
SRRFAFSLAL APPLGALRPS LLSGGPPPPG SRGTVGRQQP RQWQRRLGAA PPGRLRLRLE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGGTGCC TAGGGAAGCT GCTAATTCCT TTTGTTATTT ATTGGTTATT TCGGCATCCC 60
TCTCTTAGTC CCCTCCCCTC CTGGCTCCTC TCCCTCTCCT GGCCCCCTCC CTTCCTCCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase

Interpro

IPR032270--AMPK_C
IPR028375--KA1/Ssp2_C
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST

Pfam

PF16579--AdenylateSensor
PF00069--Pkinase

SMART

SM00220--S_TKc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005794--C:Golgi apparatus
GO:0016607--C:nuclear speck
GO:0031588--C:nucleotide-activated protein kinase complex
GO:0005634--C:nucleus
GO:0004679--F:AMP-activated protein kinase activity
GO:0005524--F:ATP binding
GO:0003682--F:chromatin binding
GO:0035174--F:histone serine kinase activity
GO:0004712--F:protein serine/threonine/tyrosine kinase activity
GO:0035690--P:cellular response to drug
GO:0042149--P:cellular response to glucose starvation
GO:0071380--P:cellular response to prostaglandin E stimulus
GO:0042593--P:glucose homeostasis
GO:0035404--P:histone-serine phosphorylation
GO:0035556--P:intracellular signal transduction
GO:0008610--P:lipid biosynthetic process
GO:0043066--P:negative regulation of apoptotic process
GO:0032007--P:negative regulation of TOR signaling
GO:0010508--P:positive regulation of autophagy
GO:0042752--P:regulation of circadian rhythm
GO:0010468--P:regulation of gene expression
GO:0016241--P:regulation of macroautophagy
GO:0014850--P:response to muscle activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000713	Aegilops tauschii	46.52	2.00e-121	429.00
IUUC-Aml-001907	Ailuropoda melanoleuca	75.05	0.00e+00	790.00
IUUC-Atr-002770	Amborella trichopoda	47.76	2.00e-123	436.00
IUUC-Apl-003395	Anas platyrhynchos	92.51	0.00e+00	1013.00
IUUC-Aca-004480	Anolis carolinensis	92.97	0.00e+00	1014.00
IUUC-Aly-006289	Arabidopsis lyrata	47.76	8.00e-125	440.00
IUUC-Ath-007014	Arabidopsis thaliana	47.87	4.00e-125	441.00
IUUC-Ago-007957	Ashbya gossypii	42.99	5.00e-117	414.00
IUUC-Acl-008103	Aspergillus clavatus	60.07	2.00e-100	360.00
IUUC-Afl-008555	Aspergillus flavus	59.71	6.00e-101	362.00
IUUC-Afu-008949	Aspergillus fumigatus	47.78	2.00e-101	363.00
IUUC-Ani-009408	Aspergillus nidulans	62.17	3.00e-101	362.00
IUUC-Ang-009551	Aspergillus niger	60.07	2.00e-100	360.00
IUUC-Aor-010176	Aspergillus oryzae	59.71	4.00e-101	362.00
IUUC-Ate-010287	Aspergillus terreus	60.07	4.00e-100	359.00
IUUC-Ame-011019	Astyanax mexicanus	87.88	0.00e+00	996.00
IUUC-Bgr-012045	Blumeria graminis	60.58	1.00e-102	367.00
IUUC-Bta-012786	Bos taurus	75.41	0.00e+00	790.00
IUUC-Bci-013774	Botrytis cinerea	45.79	4.00e-104	372.00
IUUC-Bdi-014319	Brachypodium distachyon	46.76	5.00e-124	437.00
IUUC-Bol-016242	Brassica oleracea	48.16	3.00e-127	448.00
IUUC-Bra-016750	Brassica rapa	48.25	2.00e-127	449.00
IUUC-Cel-018518	Caenorhabditis elegans	58.19	4.00e-178	618.00
IUUC-Cja-019386	Callithrix jacchus	92.93	0.00e+00	1061.00
IUUC-Cfa-020177	Canis familiaris	73.85	0.00e+00	760.00
IUUC-Cpo-021805	Cavia porcellus	93.12	0.00e+00	1060.00
IUUC-Cre-022915	Chlamydomonas reinhardtii	54.83	7.00e-96	343.00
IUUC-Csa-024267	Chlorocebus sabaeus	92.75	0.00e+00	1051.00
IUUC-Cho-024859	Choloepus hoffmanni	72.07	0.00e+00	747.00
IUUC-Cin-025550	Ciona intestinalis	61.90	0.00e+00	679.00
IUUC-Csv-026139	Ciona savignyi	59.57	0.00e+00	677.00
IUUC-Cne-027044	Cryptococcus neoformans	49.75	6.00e-108	385.00
IUUC-Cme-027289	Cyanidioschyzon merolae	45.42	4.00e-111	395.00
IUUC-Dre-027749	Danio rerio	71.65	0.00e+00	791.00
IUUC-Dno-030006	Dasypus novemcinctus	74.86	0.00e+00	789.00
IUUC-Dor-030578	Dipodomys ordii	92.57	0.00e+00	1059.00
IUUC-Dse-031507	Dothistroma septosporum	62.69	3.00e-104	373.00
IUUC-Dme-031704	Drosophila melanogaster	60.37	0.00e+00	665.00
IUUC-Ete-033055	Echinops telfairi	72.76	0.00e+00	805.00
IUUC-Eca-034016	Equus caballus	94.43	0.00e+00	995.00
IUUC-Fca-035754	Felis catus	72.58	0.00e+00	779.00
IUUC-Fal-037363	Ficedula albicollis	74.78	0.00e+00	781.00
IUUC-Fox-038073	Fusarium oxysporum	42.83	4.00e-105	375.00
IUUC-Fso-038236	Fusarium solani	52.11	3.00e-101	362.00
IUUC-Gmo-039633	Gadus morhua	71.30	0.00e+00	819.00
IUUC-Ggr-039987	Gaeumannomyces graminis	49.04	1.00e-101	364.00
IUUC-Gga-040546	Gallus gallus	92.22	0.00e+00	1041.00
IUUC-Gac-041822	Gasterosteus aculeatus	83.60	0.00e+00	935.00
IUUC-Gma-042712	Glycine max	47.45	4.00e-124	438.00
IUUC-Ggo-045303	Gorilla gorilla	93.30	0.00e+00	1068.00
IUUC-Hsa-045746	Homo sapiens	93.30	0.00e+00	1068.00
IUUC-Hvu-047406	Hordeum vulgare	46.46	3.00e-124	438.00
IUUC-Itr-048134	Ictidomys tridecemlineatus	93.12	0.00e+00	1066.00
IUUC-Kpa-049190	Komagataella pastoris	44.86	7.00e-123	434.00
IUUC-Lch-049623	Latimeria chalumnae	73.15	0.00e+00	776.00
IUUC-Lpe-051392	Leersia perrieri	46.00	4.00e-124	438.00
IUUC-Loc-052928	Lepisosteus oculatus	89.87	0.00e+00	1018.00
IUUC-Lma-053054	Leptosphaeria maculans	62.92	2.00e-105	377.00
IUUC-Laf-053459	Loxodonta africana	92.75	0.00e+00	1059.00
IUUC-Mcc-055862	Macaca mulatta	93.30	0.00e+00	1068.00
IUUC-Mor-057170	Magnaporthe oryzae	49.71	8.00e-100	358.00
IUUC-Mpo-057302	Magnaporthe poae	49.18	1.00e-101	364.00
IUUC-Mtr-058309	Medicago truncatula	48.02	1.00e-122	433.00
IUUC-Mla-059058	Melampsora laricipopulina	43.29	2.00e-105	376.00
IUUC-Mga-059206	Meleagris gallopavo	91.94	0.00e+00	983.00
IUUC-Mvi-060337	Microbotryum violaceum	50.83	1.00e-101	364.00
IUUC-Mmr-061619	Microcebus murinus	92.93	0.00e+00	1054.00
IUUC-Mmu-063406	Mus musculus	92.21	0.00e+00	1060.00
IUUC-Mac-064518	Musa acuminata	45.09	2.00e-120	426.00
IUUC-Mpu-066326	Mustela putorius furo	92.90	0.00e+00	1004.00
IUUC-Mlu-067968	Myotis lucifugus	91.48	0.00e+00	968.00
IUUC-Nfi-068493	Neosartorya fischeri	47.78	4.00e-101	362.00
IUUC-Ncr-068665	Neurospora crassa	41.98	3.00e-107	382.00
IUUC-Nle-070158	Nomascus leucogenys	93.12	0.00e+00	1066.00
IUUC-Opr-070272	Ochotona princeps	72.54	0.00e+00	778.00
IUUC-Ont-071395	Oreochromis niloticus	86.74	0.00e+00	976.00
IUUC-Oan-073322	Ornithorhynchus anatinus	68.85	0.00e+00	740.00
IUUC-Ocu-074188	Oryctolagus cuniculus	73.59	0.00e+00	780.00
IUUC-Oba-075436	Oryza barthii	47.24	5.00e-125	441.00
IUUC-Obr-076507	Oryza brachyantha	47.17	2.00e-125	442.00
IUUC-Ogl-077718	Oryza glaberrima	46.89	1.00e-122	433.00
IUUC-Ogu-078349	Oryza glumaepatula	47.24	3.00e-125	442.00
IUUC-Oin-079889	Oryza indica	46.44	2.00e-123	435.00
IUUC-Olo-080521	Oryza longistaminata	47.24	9.00e-125	440.00
IUUC-Ome-081630	Oryza meridionalis	47.03	2.00e-124	439.00
IUUC-Oni-082211	Oryza nivara	47.24	1.00e-125	443.00
IUUC-Opu-083617	Oryza punctata	46.40	1.00e-124	439.00
IUUC-Oru-084252	Oryza rufipogon	47.24	8.00e-125	440.00
IUUC-Osa-085548	Oryza sativa	47.24	8.00e-125	440.00
IUUC-Ola-087169	Oryzias latipes	85.48	0.00e+00	958.00
IUUC-Olu-087861	Ostreococcus lucimarinus	48.01	2.00e-114	406.00
IUUC-Oga-088003	Otolemur garnettii	75.05	0.00e+00	791.00
IUUC-Oar-089933	Ovis aries	75.41	0.00e+00	790.00
IUUC-Ptr-090741	Pan troglodytes	93.30	0.00e+00	1068.00
IUUC-Pan-092526	Papio anubis	75.23	0.00e+00	791.00
IUUC-Psi-094034	Pelodiscus sinensis	74.69	0.00e+00	775.00
IUUC-Pno-095030	Phaeosphaeria nodorum	62.92	1.00e-103	370.00
IUUC-Ppa-095615	Physcomitrella patens	51.60	2.00e-122	432.00
IUUC-Pfo-096295	Poecilia formosa	85.84	0.00e+00	963.00
IUUC-Pab-098023	Pongo abelii	93.30	0.00e+00	1068.00
IUUC-Pop-100042	Populus trichocarpa	47.98	5.00e-127	447.00
IUUC-Pca-101104	Procavia capensis	78.38	7.00e-173	600.00
IUUC-Ppe-101642	Prunus persica	48.95	4.00e-124	438.00
IUUC-Pva-102470	Pteropus vampyrus	92.39	0.00e+00	1050.00
IUUC-Pgr-103406	Puccinia graminis	61.36	9.00e-92	331.00
IUUC-Ptt-103713	Puccinia triticina	37.48	5.00e-79	288.00
IUUC-Pte-104259	Pyrenophora teres	62.55	1.00e-104	374.00
IUUC-Pyt-104752	Pyrenophora triticirepentis	62.92	4.00e-105	375.00
IUUC-Rno-104960	Rattus norvegicus	92.39	0.00e+00	1059.00
IUUC-Sce-106290	Saccharomyces cerevisiae	42.83	4.00e-117	415.00
IUUC-Sha-107603	Sarcophilus harrisii	74.86	0.00e+00	786.00
IUUC-Sja-107772	Schizosaccharomyces japonicus	40.50	8.00e-111	394.00
IUUC-Spo-108202	Schizosaccharomyces pombe	41.04	3.00e-108	385.00
IUUC-Ssl-108535	Sclerotinia sclerotiorum	60.07	1.00e-103	370.00
IUUC-Smo-109309	Selaginella moellendorffii	45.44	4.00e-121	428.00
IUUC-Sit-109745	Setaria italica	47.98	4.00e-126	444.00
IUUC-Sly-110890	Solanum lycopersicum	47.88	1.00e-126	446.00
IUUC-Stu-112144	Solanum tuberosum	45.62	1.00e-117	416.00
IUUC-Sar-113521	Sorex araneus	65.13	0.00e+00	634.00
IUUC-Sbi-114764	Sorghum bicolor	47.99	4.00e-127	448.00
IUUC-Sre-115141	Sporisorium reilianum	66.91	2.00e-114	406.00
IUUC-Ssc-115732	Sus scrofa	74.00	0.00e+00	759.00
IUUC-Tgu-117190	Taeniopygia guttata	74.82	0.00e+00	776.00
IUUC-Tru-118735	Takifugu rubripes	85.66	0.00e+00	965.00
IUUC-Tsy-119503	Tarsius syrichta	89.62	0.00e+00	949.00
IUUC-Tni-119880	Tetraodon nigroviridis	84.05	0.00e+00	966.00
IUUC-Tca-121386	Theobroma cacao	47.46	2.00e-126	446.00
IUUC-Tre-122070	Trichoderma reesei	48.95	1.00e-102	367.00
IUUC-Tvi-122305	Trichoderma virens	47.69	4.00e-101	362.00
IUUC-Tae-123515	Triticum aestivum	48.25	2.00e-125	442.00
IUUC-Tur-126416	Triticum urartu	46.37	6.00e-123	434.00
IUUC-Tme-127174	Tuber melanosporum	53.15	3.00e-66	246.00
IUUC-Tbe-127791	Tupaia belangeri	86.09	4.00e-113	400.00
IUUC-Ttr-129224	Tursiops truncatus	73.02	0.00e+00	781.00
IUUC-Uma-129372	Ustilago maydis	66.91	1.00e-113	404.00
IUUC-Vda-129819	Verticillium dahliae	47.81	1.00e-85	311.00
IUUC-Vpa-130220	Vicugna pacos	91.92	0.00e+00	988.00
IUUC-Vvi-131649	Vitis vinifera	47.87	1.00e-125	443.00
IUUC-Xtr-132954	Xenopus tropicalis	92.39	0.00e+00	1051.00
IUUC-Xma-134119	Xiphophorus maculatus	85.66	0.00e+00	962.00
IUUC-Yli-134422	Yarrowia lipolytica	45.67	1.00e-118	420.00
IUUC-Zma-135621	Zea mays	62.31	6.00e-120	424.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence