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Basic Information Integrated Annotations

Tag Content
UUCD2 ID IUUC-Mmu-063723
UUCD1 version UUC-MuM-00791
Ensembl Protein ID ENSMUSP00000106772.2
UniProt Accession Q8R3P2; Q9CZV3; Q9ER07; Q9ER08; DTX2_MOUSE
Genbank Protein ID BAB18940.1; BAB18941.1; BAB28055.1; BAC31780.1; BAC35781.1; AAH24925.1
Protein Name Probable E3 ubiquitin-protein ligase DTX2; Protein deltex-2; RING-type E3 ubiquitin transferase DTX2
Genbank Nucleotide ID AB015423; AB015424; AK012137; AK044105; AK054443; BC024925
Gene Name Dtx2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000004947.15 ENSMUST00000125827.7 ENSMUSP00000115122.1
ENSMUSG00000004947.15 ENSMUST00000005072.9 ENSMUSP00000005072.3
ENSMUSG00000004947.15 ENSMUST00000111145.9 ENSMUSP00000106775.3
ENSMUSG00000004947.15 ENSMUST00000111142.8 ENSMUSP00000106772.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBasemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDHINT
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
mUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 4.10e-06 28.3 409 470
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING

   S: 1    CaiCledf.................kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
    C+iC+e + + +++ C H+fh+ Cl ++ + + ++ ++ +CP C+
   Q: 409 CIICMEKLavasgysdmtdskalgpMVVGRLTKCSHAFHLLCLLAM-YCNGNKDGSLQCPSCK 470
    ****99998887776665443222211133577**********888.89999**********6 PP
   

Organism Mus musculus
Functional Description
(View)

Functional Description



     Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity).
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity).
Protein Sequence
(Fasta)
MAMAPSSSLP QVYPSHVVVA VWEWQDGLGI WHPYSATVCS FIEQHFVRQR GQHFGLGSLA 60
HSIPLGQADP SLAPYIIDLP SWTQFRQNTG TMRSVRRHLF SQNSAPGQGI VWEWLGDDGS 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Mmu-063723|E3,RING|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGGACATGCG CAGCGCGGTG CTTGGAGGCT GCGACGCCGA GTTTCACTCC GGCTGCCTCC 60
GGCTCGGAGT CGGAGACATA CTCGAGGGTT CTTCCCAGGC CGAGCCGGAG CTGAGCCCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Mmu-063723|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0488--Methylation
KW-0914--Notch signaling pathway
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004170--WWE-dom
IPR018123--WWE-dom_subgr
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50918--WWE
PS50089--ZF_RING_2

Pfam

PF02825--WWE
PF00097--zf-C3HC4

SMART

SM00184--RING
SM00678--WWE

Gene Ontology

GO:0005737--C:cytoplasm
GO:0031965--C:nuclear membrane
GO:0005654--C:nucleoplasm
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0007219--P:Notch signaling pathway
GO:0016567--P:protein ubiquitination

KEGG mmu:74198
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001936 Ailuropoda melanoleuca 82.26 0.00e+00 1012.00
IUUC-Apl-003758 Anas platyrhynchos 55.45 0.00e+00 628.00
IUUC-Aca-004841 Anolis carolinensis 50.55 1.00e-128 452.00
IUUC-Ame-011200 Astyanax mexicanus 65.45 5.00e-111 395.00
IUUC-Cja-018934 Callithrix jacchus 83.76 0.00e+00 1006.00
IUUC-Cfa-020925 Canis familiaris 81.29 0.00e+00 994.00
IUUC-Cpo-021609 Cavia porcellus 84.84 0.00e+00 1034.00
IUUC-Csa-023891 Chlorocebus sabaeus 84.59 0.00e+00 1051.00
IUUC-Dno-029480 Dasypus novemcinctus 82.74 0.00e+00 989.00
IUUC-Dor-031138 Dipodomys ordii 83.06 0.00e+00 995.00
IUUC-Ete-032479 Echinops telfairi 79.30 9.00e-120 424.00
IUUC-Eca-034342 Equus caballus 82.61 0.00e+00 1009.00
IUUC-Eeu-034455 Erinaceus europaeus 69.82 1.00e-99 357.00
IUUC-Fca-036373 Felis catus 83.87 0.00e+00 1009.00
IUUC-Fal-037532 Ficedula albicollis 67.31 1.00e-117 417.00
IUUC-Ggo-045222 Gorilla gorilla 73.68 0.00e+00 901.00
IUUC-Hsa-045716 Homo sapiens 83.79 0.00e+00 1031.00
IUUC-Itr-048253 Ictidomys tridecemlineatus 85.32 0.00e+00 1040.00
IUUC-Lch-050520 Latimeria chalumnae 51.05 6.00e-160 557.00
IUUC-Laf-054290 Loxodonta africana 82.10 0.00e+00 994.00
IUUC-Mcc-054636 Macaca mulatta 84.91 0.00e+00 1025.00
IUUC-Meu-056652 Macropus eugenii 81.74 3.00e-113 402.00
IUUC-Mga-059841 Meleagris gallopavo 59.31 0.00e+00 665.00
IUUC-Mmr-060582 Microcebus murinus 83.87 0.00e+00 1009.00
IUUC-Mdo-062910 Monodelphis domestica 65.20 0.00e+00 779.00
IUUC-Mpu-066817 Mustela putorius furo 76.25 0.00e+00 931.00
IUUC-Mlu-067955 Myotis lucifugus 81.29 0.00e+00 995.00
IUUC-Nle-069055 Nomascus leucogenys 81.51 2.00e-171 596.00
IUUC-Opr-070290 Ochotona princeps 79.55 0.00e+00 982.00
IUUC-Oan-073083 Ornithorhynchus anatinus 53.71 2.00e-146 512.00
IUUC-Ocu-074325 Oryctolagus cuniculus 83.57 0.00e+00 1040.00
IUUC-Ola-087563 Oryzias latipes 43.86 5.00e-123 434.00
IUUC-Oga-088806 Otolemur garnettii 81.96 0.00e+00 1002.00
IUUC-Oar-089906 Ovis aries 77.27 0.00e+00 805.00
IUUC-Ptr-090683 Pan troglodytes 84.75 0.00e+00 1041.00
IUUC-Pan-092356 Papio anubis 84.91 0.00e+00 1025.00
IUUC-Psi-093479 Pelodiscus sinensis 60.69 0.00e+00 718.00
IUUC-Pab-098412 Pongo abelii 84.43 0.00e+00 1046.00
IUUC-Pca-100995 Procavia capensis 68.22 4.00e-87 315.00
IUUC-Pva-103068 Pteropus vampyrus 71.86 0.00e+00 850.00
IUUC-Rno-105159 Rattus norvegicus 97.42 0.00e+00 1159.00
IUUC-Sha-107480 Sarcophilus harrisii 71.29 9.00e-157 546.00
IUUC-Sar-113689 Sorex araneus 71.86 0.00e+00 861.00
IUUC-Ssc-115373 Sus scrofa 90.88 2.00e-154 538.00
IUUC-Tgu-117036 Taeniopygia guttata 60.17 0.00e+00 704.00
IUUC-Tru-118461 Takifugu rubripes 63.16 2.00e-100 360.00
IUUC-Tsy-118930 Tarsius syrichta 84.18 2.00e-129 456.00
IUUC-Tca-121016 Theobroma cacao 40.30 1.00e-05 43.90
IUUC-Tbe-127561 Tupaia belangeri 83.06 0.00e+00 961.00
IUUC-Ttr-128688 Tursiops truncatus 69.29 1.00e-151 530.00
Created Date 25-Jun-2017

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