iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000013000.1	ENSSHAT00000015370.1	ENSSHAP00000015243.1
ENSSHAG00000013000.1	ENSSHAT00000015371.1	ENSSHAP00000015244.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	1.30e-81	274.8	3	283

Active Site

Position(s)	Description	Evidence
50	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
126	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 41   penlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvigNsCatyAllsvllncedklldlGttlsrlkest 129
           p n +++ +pv+gl++lFk+++ +e +          +vv+++ ++tiffakqvi+N+Cat+A++svllnc+++ ++lG+tls++ke++
   Q: 3    PHN-SSV-RPVHGLIFLFKWQPGEEPAG---------SVVQDSRLDTIFFAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFS 80
           555.344.8*******************.........899************************************************* PP
   S: 130  kaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsyvningrlyeldglkpfPldlgkkketeelkdklkv 218
           +++++ +k+lal+n++v++++hns+ar+++++ + +++++    +++afhfvsyv++ngrlyeldgl++ P+dlg+ +++e++ ++++ 
   Q: 81   QSFDAAMKGLALSNSEVIRQVHNSFARQQMFEFDAKTSAK----EEDAFHFVSYVPVNGRLYELDGLREGPIDLGA-CNQEDWINAVRP 164
           ************************************9887....79*****************************9.899********* PP
   S: 219  vraflerikllesdeirfnllaivadrrviktlrlnvlkid.........keLlkLlkdieseeekieaqlddekekrkkfkiddirRt 298
           v+   +ri++++++eirfnl+aiv+dr++i+++++  l+ +          +  ++l+ i+se++k ++ +++e +k k++ki++irR+
   Q: 165  VI--EKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQRQlaeeepmdtDQSSNMLSTIQSEVAKHQMLIEEEIQKLKRYKIENIRRK 251
           **..******************************976665567888887755678********************************** PP
   S: 299  enydeficifikdlaregilrklveetisevrefg 333
           +ny  fi++++k+la++++l  lve+    + +++
   Q: 252  HNYLPFIMELLKTLAEHQQLIPLVEKA---KEKQN 283
           ************************993...33344 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MQPHNSSVRP VHGLIFLFKW QPGEEPAGSV VQDSRLDTIF FAKQVINNAC ATQAIVSVLL 60
NCTHQDVHLG ETLSEFKEFS QSFDAAMKGL ALSNSEVIRQ VHNSFARQQM FEFDAKTSAK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTTGTCGAG GAGCACAAGT AGAAGAAATA TGGAGTTTGG AGCCAGAGAA CTTTGAGAAA 60
TTAAAGTAAG CTCTTTAAAA ACTTTTTTTT TTTAATTTAG GAAAAATGTT CCTCAATTAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37
IPR033837--UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005829--C:cytosol
GO:0031011--C:Ino80 complex
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0004866--F:endopeptidase inhibitor activity
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0048853--P:forebrain morphogenesis
GO:0021670--P:lateral ventricle development
GO:0030901--P:midbrain development
GO:0016579--P:protein deubiquitination
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

shr:100932272

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	45.72	4.00e-71	261.00
IUUC-Aml-001866	Ailuropoda melanoleuca	94.20	7.00e-156	542.00
IUUC-Atr-002966	Amborella trichopoda	48.36	1.00e-76	280.00
IUUC-Apl-003306	Anas platyrhynchos	85.00	3.00e-156	544.00
IUUC-Aca-004763	Anolis carolinensis	92.75	2.00e-153	534.00
IUUC-Aly-005581	Arabidopsis lyrata	47.93	5.00e-71	260.00
IUUC-Ath-007283	Arabidopsis thaliana	47.24	1.00e-70	259.00
IUUC-Acl-008231	Aspergillus clavatus	43.50	3.00e-42	165.00
IUUC-Afl-008557	Aspergillus flavus	36.98	7.00e-44	170.00
IUUC-Afu-008988	Aspergillus fumigatus	46.73	8.00e-45	173.00
IUUC-Ani-009420	Aspergillus nidulans	36.43	2.00e-41	162.00
IUUC-Aor-010145	Aspergillus oryzae	36.98	7.00e-44	170.00
IUUC-Ate-010347	Aspergillus terreus	44.95	4.00e-46	178.00
IUUC-Ame-010791	Astyanax mexicanus	88.36	3.00e-156	543.00
IUUC-Bgr-012298	Blumeria graminis	38.02	1.00e-43	169.00
IUUC-Bta-013251	Bos taurus	93.84	4.00e-154	536.00
IUUC-Bci-013786	Botrytis cinerea	37.58	3.00e-48	184.00
IUUC-Bdi-014132	Brachypodium distachyon	48.43	2.00e-68	252.00
IUUC-Bol-015611	Brassica oleracea	48.79	1.00e-75	275.00
IUUC-Bra-017769	Brassica rapa	48.79	2.00e-75	275.00
IUUC-Cel-018604	Caenorhabditis elegans	46.69	5.00e-68	250.00
IUUC-Cja-019768	Callithrix jacchus	84.21	5.00e-149	520.00
IUUC-Cfa-020207	Canis familiaris	94.20	7.00e-156	542.00
IUUC-Cpo-021925	Cavia porcellus	89.86	1.00e-146	511.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	42.71	5.00e-60	224.00
IUUC-Csa-023958	Chlorocebus sabaeus	93.12	4.00e-153	534.00
IUUC-Cho-024928	Choloepus hoffmanni	100.00	5.00e-43	167.00
IUUC-Cin-025771	Ciona intestinalis	51.79	2.00e-81	295.00
IUUC-Csv-026149	Ciona savignyi	55.60	4.00e-84	304.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	36.26	3.00e-47	181.00
IUUC-Cne-026955	Cryptococcus neoformans	35.93	2.00e-41	162.00
IUUC-Cme-027104	Cyanidioschyzon merolae	32.35	9.00e-37	147.00
IUUC-Dre-027409	Danio rerio	87.33	3.00e-153	534.00
IUUC-Dno-028921	Dasypus novemcinctus	93.48	2.00e-154	538.00
IUUC-Dse-031170	Dothistroma septosporum	39.03	2.00e-46	179.00
IUUC-Dme-031677	Drosophila melanogaster	57.79	2.00e-94	338.00
IUUC-Ete-032707	Echinops telfairi	70.59	7.00e-105	373.00
IUUC-Eca-033776	Equus caballus	93.84	8.00e-156	542.00
IUUC-Eeu-035305	Erinaceus europaeus	97.17	1.00e-58	219.00
IUUC-Fca-035846	Felis catus	85.81	2.00e-151	528.00
IUUC-Fal-037597	Ficedula albicollis	93.12	1.00e-147	514.00
IUUC-Fox-037670	Fusarium oxysporum	51.85	7.00e-49	187.00
IUUC-Fso-038243	Fusarium solani	50.26	4.00e-47	181.00
IUUC-Gmo-038499	Gadus morhua	82.97	5.00e-138	483.00
IUUC-Ggr-039975	Gaeumannomyces graminis	41.43	6.00e-37	147.00
IUUC-Gga-040904	Gallus gallus	92.47	2.00e-161	561.00
IUUC-Gac-042058	Gasterosteus aculeatus	87.32	6.00e-146	509.00
IUUC-Gma-043763	Glycine max	48.66	2.00e-76	279.00
IUUC-Ggo-044699	Gorilla gorilla	86.67	8.00e-138	483.00
IUUC-Hsa-046227	Homo sapiens	93.48	7.00e-155	539.00
IUUC-Hvu-047359	Hordeum vulgare	46.08	1.00e-69	256.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	84.69	1.00e-150	525.00
IUUC-Lch-049829	Latimeria chalumnae	90.94	9.00e-150	522.00
IUUC-Lpe-050899	Leersia perrieri	47.33	6.00e-65	240.00
IUUC-Loc-052264	Lepisosteus oculatus	88.09	1.00e-146	512.00
IUUC-Lma-053110	Leptosphaeria maculans	36.54	1.00e-42	166.00
IUUC-Laf-053639	Loxodonta africana	94.20	7.00e-156	542.00
IUUC-Mcc-055506	Macaca mulatta	93.12	4.00e-153	533.00
IUUC-Mor-057001	Magnaporthe oryzae	45.59	7.00e-44	170.00
IUUC-Mpo-057608	Magnaporthe poae	40.41	4.00e-22	97.40
IUUC-Mtr-057731	Medicago truncatula	48.16	1.00e-71	262.00
IUUC-Mga-060178	Meleagris gallopavo	92.81	2.00e-162	564.00
IUUC-Mvi-060353	Microbotryum violaceum	39.73	1.00e-46	179.00
IUUC-Mmr-060738	Microcebus murinus	93.48	6.00e-155	539.00
IUUC-Mdo-062266	Monodelphis domestica	94.80	4.00e-97	346.00
IUUC-Mmu-063619	Mus musculus	94.40	8.00e-153	532.00
IUUC-Mac-065301	Musa acuminata	50.71	1.00e-76	279.00
IUUC-Mpu-066058	Mustela putorius furo	94.57	2.00e-156	544.00
IUUC-Mlu-067292	Myotis lucifugus	92.75	3.00e-152	530.00
IUUC-Nfi-068275	Neosartorya fischeri	37.87	6.00e-46	177.00
IUUC-Ncr-068713	Neurospora crassa	37.77	4.00e-46	178.00
IUUC-Nle-069013	Nomascus leucogenys	92.75	2.00e-152	531.00
IUUC-Opr-070628	Ochotona princeps	86.10	4.00e-149	520.00
IUUC-Ont-072688	Oreochromis niloticus	87.41	3.00e-145	507.00
IUUC-Oan-073004	Ornithorhynchus anatinus	93.94	7.00e-130	456.00
IUUC-Ocu-074303	Oryctolagus cuniculus	94.57	8.00e-157	546.00
IUUC-Oba-075002	Oryza barthii	47.30	5.00e-69	254.00
IUUC-Obr-076392	Oryza brachyantha	48.75	1.00e-67	249.00
IUUC-Ogl-077271	Oryza glaberrima	47.30	5.00e-69	254.00
IUUC-Ogu-078493	Oryza glumaepatula	47.30	2.00e-69	255.00
IUUC-Oin-080084	Oryza indica	47.30	2.00e-69	255.00
IUUC-Olo-080803	Oryza longistaminata	46.96	3.00e-69	254.00
IUUC-Ome-081146	Oryza meridionalis	46.28	4.00e-68	251.00
IUUC-Oni-082146	Oryza nivara	47.30	2.00e-69	255.00
IUUC-Opu-083633	Oryza punctata	48.04	1.00e-65	243.00
IUUC-Oru-084789	Oryza rufipogon	47.30	2.00e-69	255.00
IUUC-Osa-086196	Oryza sativa	47.30	2.00e-69	255.00
IUUC-Ola-087126	Oryzias latipes	88.41	9.00e-143	499.00
IUUC-Olu-087665	Ostreococcus lucimarinus	41.70	4.00e-56	211.00
IUUC-Oga-089140	Otolemur garnettii	84.49	2.00e-149	521.00
IUUC-Oar-090296	Ovis aries	94.20	4.00e-156	543.00
IUUC-Ptr-090566	Pan troglodytes	93.48	7.00e-155	539.00
IUUC-Pan-092052	Papio anubis	93.12	4.00e-153	533.00
IUUC-Psi-093723	Pelodiscus sinensis	92.75	6.00e-154	536.00
IUUC-Pma-094568	Petromyzon marinus	59.26	6.00e-98	350.00
IUUC-Pno-095120	Phaeosphaeria nodorum	37.93	8.00e-44	170.00
IUUC-Ppa-095761	Physcomitrella patens	46.71	2.00e-76	278.00
IUUC-Pfo-096210	Poecilia formosa	86.59	3.00e-145	507.00
IUUC-Pab-098463	Pongo abelii	93.48	3.00e-155	541.00
IUUC-Pop-099423	Populus trichocarpa	48.99	8.00e-75	273.00
IUUC-Pca-100108	Procavia capensis	92.34	2.00e-113	401.00
IUUC-Ppe-101176	Prunus persica	50.51	2.00e-77	282.00
IUUC-Pva-102629	Pteropus vampyrus	93.09	2.00e-120	424.00
IUUC-Pgr-103419	Puccinia graminis	38.28	2.00e-42	166.00
IUUC-Pte-104207	Pyrenophora teres	45.97	8.00e-26	109.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	38.70	4.00e-46	177.00
IUUC-Rno-105579	Rattus norvegicus	81.99	4.00e-147	513.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	39.23	6.00e-48	184.00
IUUC-Spo-108371	Schizosaccharomyces pombe	43.13	9.00e-50	190.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	39.47	9.00e-47	180.00
IUUC-Smo-109396	Selaginella moellendorffii	51.05	2.00e-80	292.00
IUUC-Sit-110630	Setaria italica	49.14	3.00e-73	268.00
IUUC-Sly-110972	Solanum lycopersicum	51.35	1.00e-77	283.00
IUUC-Stu-112185	Solanum tuberosum	51.01	3.00e-77	281.00
IUUC-Sar-113294	Sorex araneus	76.97	1.00e-136	479.00
IUUC-Sbi-113951	Sorghum bicolor	49.48	1.00e-73	269.00
IUUC-Ssc-115501	Sus scrofa	94.57	1.00e-156	545.00
IUUC-Tgu-117152	Taeniopygia guttata	92.75	1.00e-147	514.00
IUUC-Tru-118388	Takifugu rubripes	86.96	5.00e-146	510.00
IUUC-Tsy-119109	Tarsius syrichta	93.84	2.00e-155	541.00
IUUC-Tni-120048	Tetraodon nigroviridis	86.96	1.00e-146	512.00
IUUC-Tca-121750	Theobroma cacao	50.00	4.00e-78	284.00
IUUC-Tre-122130	Trichoderma reesei	37.69	9.00e-44	170.00
IUUC-Tvi-122284	Trichoderma virens	39.00	3.00e-46	178.00
IUUC-Tae-124082	Triticum aestivum	45.95	1.00e-69	256.00
IUUC-Tur-126366	Triticum urartu	43.34	5.00e-63	234.00
IUUC-Tme-127187	Tuber melanosporum	42.31	4.00e-50	191.00
IUUC-Tbe-127619	Tupaia belangeri	89.23	2.00e-130	457.00
IUUC-Ttr-128867	Tursiops truncatus	82.91	2.00e-111	395.00
IUUC-Vda-129912	Verticillium dahliae	36.05	1.00e-40	159.00
IUUC-Vpa-130552	Vicugna pacos	93.60	4.00e-96	344.00
IUUC-Vvi-130881	Vitis vinifera	51.35	8.00e-73	266.00
IUUC-Xtr-131934	Xenopus tropicalis	83.79	7.00e-149	519.00
IUUC-Xma-133312	Xiphophorus maculatus	86.59	1.00e-144	505.00
IUUC-Zma-135639	Zea mays	48.31	1.00e-70	259.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence