iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ani-009241

Ensembl Protein ID

CADANIAP00000183

UniProt Accession

Q5AWS1; C8VCV1; DCN1_EMENI

Genbank Protein ID

EAA61165.1; CBF78750.1

Protein Name

Defective in cullin neddylation protein 1

Genbank Nucleotide ID

AACD01000124; BN001304

Gene Name

ANIA_07259; dcn1; AN7259

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADANIAG00000183	CADANIAT00000183	CADANIAP00000183

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/DCUN1	24.41	3.00e-20	95.90	IUUC-Ath-007531
UBD/Alpha-Helix/UBA	20.82	2.00e-08	56.60	IUUC-Cel-018441
E3 activity/DCUN1	26.60	8.00e-24	108.00	IUUC-Hsa-046089
UBD/Alpha-Helix/UBA	26.60	8.00e-24	108.00	IUUC-Hsa-046089
UBD/Alpha-Helix/UBA	26.60	7.00e-24	108.00	IUUC-Mmu-063954
E3 activity/DCUN1	19.06	5.00e-15	76.30	IUUC-Sce-106358
UBD/Alpha-Helix/UBA	19.06	5.00e-15	76.30	IUUC-Sce-106358

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Aspergillus nidulans

Functional Description
(View)

May contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity (By similarity).

Protein Sequence
(Fasta)

MPPYTAAQKQ QITQFVSFTQ ANNTTAAKFL RQSRWNTEEA IDAFKNRIAP ASMGLIFRPC 60
ATAGVREAVL RISIFQKLIP GLPAGNDALA DWVLYLYGFT FLLKEFRDSP EENPDTIGIE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCGCCAT ACACTGCCGC CCAGAAGCAG CAAATAACTC AGTTTGTGAG CTTCACACAG 60
GCCAATAATA CAACAGCTGC AAAGGTAATT TCTGGAATTA GTCGTTTATT TCATCCCCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR014764--DCN-prot
IPR005176--PONY_dom
IPR009060--UBA-like

PROSITE

PS51229--DCUN1

Pfam

PF03556--Cullin_binding

Gene Ontology

GO:0000151--C:ubiquitin ligase complex
GO:0097602--F:cullin family protein binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0032182--F:ubiquitin-like protein binding
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0045116--P:protein neddylation

KEGG

ani:AN7259.2

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000561	Aegilops tauschii	31.18	3.00e-24	103.00
IUUC-Aml-001879	Ailuropoda melanoleuca	26.71	2.00e-25	107.00
IUUC-Atr-002697	Amborella trichopoda	29.77	2.00e-12	62.80
IUUC-Apl-003451	Anas platyrhynchos	27.74	3.00e-25	106.00
IUUC-Aca-005269	Anolis carolinensis	27.27	5.00e-25	106.00
IUUC-Aly-006285	Arabidopsis lyrata	27.06	3.00e-17	79.70
IUUC-Ath-007531	Arabidopsis thaliana	24.41	5.00e-22	95.90
IUUC-Ago-007806	Ashbya gossypii	31.35	8.00e-23	98.60
IUUC-Acl-008172	Aspergillus clavatus	60.06	4.00e-105	372.00
IUUC-Afl-008569	Aspergillus flavus	62.87	7.00e-113	397.00
IUUC-Afu-009005	Aspergillus fumigatus	78.21	1.00e-85	306.00
IUUC-Ang-009664	Aspergillus niger	75.00	1.00e-94	337.00
IUUC-Aor-009902	Aspergillus oryzae	78.52	1.00e-63	233.00
IUUC-Ate-010414	Aspergillus terreus	62.54	8.00e-112	394.00
IUUC-Ame-011763	Astyanax mexicanus	26.32	3.00e-24	103.00
IUUC-Bgr-011991	Blumeria graminis	36.09	2.00e-41	160.00
IUUC-Bta-013338	Bos taurus	35.05	1.00e-22	98.60
IUUC-Bci-013824	Botrytis cinerea	33.55	1.00e-48	184.00
IUUC-Bdi-014138	Brachypodium distachyon	25.00	7.00e-25	105.00
IUUC-Bol-016110	Brassica oleracea	24.32	3.00e-23	100.00
IUUC-Bra-017111	Brassica rapa	24.08	1.00e-22	98.20
IUUC-Cel-018441	Caenorhabditis elegans	20.82	4.00e-10	56.60
IUUC-Cja-019502	Callithrix jacchus	26.71	2.00e-25	107.00
IUUC-Cfa-020160	Canis familiaris	35.05	1.00e-22	98.60
IUUC-Cpo-022196	Cavia porcellus	26.71	2.00e-25	107.00
IUUC-Cre-022620	Chlamydomonas reinhardtii	30.81	3.00e-25	107.00
IUUC-Csa-023551	Chlorocebus sabaeus	26.60	8.00e-26	108.00
IUUC-Cho-024888	Choloepus hoffmanni	34.54	4.00e-22	96.70
IUUC-Cin-025269	Ciona intestinalis	24.84	6.00e-24	102.00
IUUC-Csv-025976	Ciona savignyi	30.48	6.00e-18	82.40
IUUC-Cgl-026386	Colletotrichum gloeosporioides	38.14	1.00e-41	160.00
IUUC-Cne-026950	Cryptococcus neoformans	27.53	5.00e-24	102.00
IUUC-Cme-027199	Cyanidioschyzon merolae	22.31	2.00e-03	34.30
IUUC-Dre-028247	Danio rerio	26.60	4.00e-24	103.00
IUUC-Dno-028974	Dasypus novemcinctus	26.60	8.00e-26	108.00
IUUC-Dor-030387	Dipodomys ordii	34.90	6.00e-22	95.90
IUUC-Dse-031365	Dothistroma septosporum	35.06	7.00e-53	198.00
IUUC-Dme-032197	Drosophila melanogaster	28.08	6.00e-20	89.40
IUUC-Ete-032371	Echinops telfairi	27.05	9.00e-26	108.00
IUUC-Eca-033242	Equus caballus	26.71	2.00e-25	107.00
IUUC-Eeu-035317	Erinaceus europaeus	26.71	2.00e-25	107.00
IUUC-Fca-036061	Felis catus	26.71	3.00e-25	107.00
IUUC-Fal-037372	Ficedula albicollis	27.74	1.00e-24	105.00
IUUC-Fox-037884	Fusarium oxysporum	37.43	1.00e-29	120.00
IUUC-Fso-038150	Fusarium solani	31.33	1.00e-37	148.00
IUUC-Gmo-038885	Gadus morhua	27.24	1.00e-24	104.00
IUUC-Ggr-039959	Gaeumannomyces graminis	34.88	1.00e-30	126.00
IUUC-Gga-040935	Gallus gallus	26.94	1.00e-25	108.00
IUUC-Gac-041478	Gasterosteus aculeatus	27.30	9.00e-24	102.00
IUUC-Gma-043516	Glycine max	22.82	3.00e-20	90.50
IUUC-Ggo-044972	Gorilla gorilla	27.61	3.00e-25	106.00
IUUC-Hsa-046089	Homo sapiens	26.60	8.00e-26	108.00
IUUC-Hvu-047636	Hordeum vulgare	25.93	9.00e-08	48.10
IUUC-Itr-049054	Ictidomys tridecemlineatus	34.48	3.00e-23	100.00
IUUC-Kpa-049127	Komagataella pastoris	25.61	9.00e-28	115.00
IUUC-Lch-049751	Latimeria chalumnae	27.27	6.00e-26	108.00
IUUC-Lpe-051540	Leersia perrieri	24.65	8.00e-24	102.00
IUUC-Loc-051976	Lepisosteus oculatus	27.18	5.00e-25	105.00
IUUC-Lma-053103	Leptosphaeria maculans	35.81	2.00e-50	190.00
IUUC-Laf-053527	Loxodonta africana	27.05	6.00e-26	109.00
IUUC-Mcc-054700	Macaca mulatta	27.61	6.00e-25	105.00
IUUC-Meu-056535	Macropus eugenii	34.15	5.00e-23	99.80
IUUC-Mor-056909	Magnaporthe oryzae	26.58	1.00e-31	128.00
IUUC-Mpo-057299	Magnaporthe poae	29.21	2.00e-32	130.00
IUUC-Mtr-057964	Medicago truncatula	22.82	2.00e-19	87.80
IUUC-Mla-058990	Melampsora laricipopulina	23.90	6.00e-18	83.20
IUUC-Mga-060072	Meleagris gallopavo	26.62	6.00e-25	105.00
IUUC-Mvi-060312	Microbotryum violaceum	30.64	5.00e-36	142.00
IUUC-Mmr-060851	Microcebus murinus	26.71	2.00e-25	107.00
IUUC-Mdo-063074	Monodelphis domestica	26.71	1.00e-24	107.00
IUUC-Mmu-063954	Mus musculus	26.60	9.00e-26	108.00
IUUC-Mac-065016	Musa acuminata	26.92	5.00e-20	89.00
IUUC-Mpu-065926	Mustela putorius furo	35.05	1.00e-22	98.60
IUUC-Mlu-067701	Myotis lucifugus	26.71	2.00e-25	107.00
IUUC-Nfi-068610	Neosartorya fischeri	76.54	2.00e-84	302.00
IUUC-Ncr-068780	Neurospora crassa	30.94	9.00e-37	145.00
IUUC-Nle-069291	Nomascus leucogenys	26.60	8.00e-26	108.00
IUUC-Opr-070682	Ochotona princeps	35.05	8.00e-23	99.00
IUUC-Ont-071813	Oreochromis niloticus	27.30	7.00e-24	102.00
IUUC-Oan-073031	Ornithorhynchus anatinus	26.71	1.00e-25	108.00
IUUC-Ocu-074648	Oryctolagus cuniculus	26.71	2.00e-25	107.00
IUUC-Oba-074993	Oryza barthii	24.66	2.00e-24	103.00
IUUC-Obr-076341	Oryza brachyantha	25.93	3.00e-26	109.00
IUUC-Ogl-077099	Oryza glaberrima	24.66	2.00e-24	103.00
IUUC-Ogu-078285	Oryza glumaepatula	24.32	1.00e-23	101.00
IUUC-Oin-079441	Oryza indica	24.66	2.00e-24	103.00
IUUC-Olo-081037	Oryza longistaminata	24.66	2.00e-24	103.00
IUUC-Ome-081357	Oryza meridionalis	24.66	2.00e-24	103.00
IUUC-Oni-082632	Oryza nivara	24.66	2.00e-24	103.00
IUUC-Opu-083351	Oryza punctata	30.65	2.00e-24	103.00
IUUC-Oru-084306	Oryza rufipogon	24.66	2.00e-24	103.00
IUUC-Osa-085307	Oryza sativa	24.66	2.00e-24	103.00
IUUC-Ola-086868	Oryzias latipes	26.58	2.00e-26	110.00
IUUC-Olu-087646	Ostreococcus lucimarinus	26.02	2.00e-18	84.30
IUUC-Oga-089015	Otolemur garnettii	26.71	2.00e-25	107.00
IUUC-Oar-090405	Ovis aries	26.71	2.00e-25	107.00
IUUC-Ptr-090735	Pan troglodytes	26.71	2.00e-25	107.00
IUUC-Pan-092825	Papio anubis	27.61	5.00e-25	106.00
IUUC-Psi-093806	Pelodiscus sinensis	34.38	1.00e-21	95.50
IUUC-Pma-094582	Petromyzon marinus	35.11	6.00e-25	105.00
IUUC-Pno-095145	Phaeosphaeria nodorum	42.31	1.00e-53	201.00
IUUC-Ppa-095321	Physcomitrella patens	25.68	3.00e-23	100.00
IUUC-Pfo-097121	Poecilia formosa	26.28	3.00e-25	107.00
IUUC-Pab-098605	Pongo abelii	35.05	1.00e-22	98.60
IUUC-Pop-098821	Populus trichocarpa	26.89	2.00e-10	56.20
IUUC-Pca-100218	Procavia capensis	26.71	3.00e-25	106.00
IUUC-Ppe-102032	Prunus persica	22.48	6.00e-22	95.90
IUUC-Pva-102691	Pteropus vampyrus	26.94	4.00e-25	106.00
IUUC-Pgr-103633	Puccinia graminis	27.36	3.00e-24	103.00
IUUC-Ptt-103979	Puccinia triticina	25.95	2.00e-06	45.40
IUUC-Pte-104398	Pyrenophora teres	35.00	8.00e-05	36.20
IUUC-Pyt-104428	Pyrenophora triticirepentis	41.43	2.00e-53	200.00
IUUC-Rno-105554	Rattus norvegicus	26.37	3.00e-25	107.00
IUUC-Sce-106358	Saccharomyces cerevisiae	19.06	4.00e-16	76.30
IUUC-Sha-106888	Sarcophilus harrisii	26.71	2.00e-25	107.00
IUUC-Sja-107938	Schizosaccharomyces japonicus	27.98	1.00e-19	88.60
IUUC-Spo-108207	Schizosaccharomyces pombe	27.08	5.00e-19	86.30
IUUC-Ssl-108410	Sclerotinia sclerotiorum	33.99	3.00e-49	186.00
IUUC-Smo-108750	Selaginella moellendorffii	22.95	9.00e-17	78.60
IUUC-Sit-110613	Setaria italica	24.83	2.00e-24	104.00
IUUC-Sly-111489	Solanum lycopersicum	23.10	2.00e-20	90.50
IUUC-Stu-112517	Solanum tuberosum	24.57	5.00e-25	106.00
IUUC-Sar-113248	Sorex araneus	33.87	4.00e-21	92.80
IUUC-Sbi-114113	Sorghum bicolor	24.00	4.00e-24	103.00
IUUC-Sre-115221	Sporisorium reilianum	29.53	1.00e-17	81.60
IUUC-Ssc-115547	Sus scrofa	26.60	8.00e-26	108.00
IUUC-Tgu-117147	Taeniopygia guttata	27.05	2.00e-25	107.00
IUUC-Tru-117740	Takifugu rubripes	25.75	3.00e-23	100.00
IUUC-Tsy-119599	Tarsius syrichta	26.37	5.00e-25	105.00
IUUC-Tni-120315	Tetraodon nigroviridis	27.30	5.00e-23	99.40
IUUC-Tca-121033	Theobroma cacao	22.15	5.00e-20	89.40
IUUC-Tre-121986	Trichoderma reesei	32.42	6.00e-43	166.00
IUUC-Tvi-122607	Trichoderma virens	31.33	3.00e-41	159.00
IUUC-Tae-125740	Triticum aestivum	27.19	3.00e-20	90.50
IUUC-Tur-126375	Triticum urartu	23.92	3.00e-15	74.30
IUUC-Tme-126878	Tuber melanosporum	33.77	2.00e-37	147.00
IUUC-Tbe-127429	Tupaia belangeri	35.05	1.00e-22	98.60
IUUC-Ttr-128467	Tursiops truncatus	35.05	1.00e-22	98.60
IUUC-Uma-129364	Ustilago maydis	29.72	2.00e-25	107.00
IUUC-Vda-129929	Verticillium dahliae	36.63	7.00e-36	142.00
IUUC-Vpa-130543	Vicugna pacos	32.98	4.00e-22	96.30
IUUC-Vvi-130834	Vitis vinifera	22.15	3.00e-20	90.10
IUUC-Xtr-131888	Xenopus tropicalis	27.05	1.00e-25	107.00
IUUC-Xma-134122	Xiphophorus maculatus	26.62	1.00e-25	108.00
IUUC-Yli-134595	Yarrowia lipolytica	25.61	2.00e-26	110.00
IUUC-Zma-135864	Zea mays	24.75	1.00e-25	107.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence