iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sly-111489

Ensembl Protein ID

Solyc07g066650.2.1

UniProt Accession

K4CHY8; K4CHY8_SOLLC

Protein Name

Defective in cullin neddylation protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
Solyc07g066650.2	Solyc07g066650.2.1	Solyc07g066650.2.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/DCUN1	9.30e-84	280.9	56	242
UBD/Alpha-Helix/UBA	1.40e-06	29.0	11	47

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/DCUN1

   S: 2    skkkleelferYkdpqedligieglekfcedlgvdpediavLvlawkleaatlcefsreefldgltalgcdsieklqeklktleselkdeq 92
           + ++leel++rYkdp+ d+i+++g++ +c+d++vdp+di++Lvl+w+++aat+cefs++ef+ gl++lg+ds+ekl+ekl++++se+kde+
   Q: 56   DARRLEELYNRYKDPYADMILADGISLLCNDMQVDPQDIVMLVLSWHMKAATMCEFSKQEFIGGLQSLGIDSLEKLREKLPFMRSEMKDEH 146
           689**************************************************************************************** PP
   S: 93   kfkdiYrfafnfakdkgqksldldtaialwkLllaerefklldawlkfLeeekkksiskDtWnllLefskviakdlsnYdeegaWPvliDe 183
           kf++iY+faf++ak+kgqksl+ldtai +w+Ll+ae+e++l+++w++fL+ +++k+is+DtW +lLef++ +++ l nYd+egaWP+liDe
   Q: 147  KFREIYNFAFSWAKEKGQKSLALDTAIGMWQLLFAEKEWPLVEHWCQFLQARHNKAISRDTWSQLLEFARNVDPALTNYDAEGAWPYLIDE 237
           ******************************************************************************************* PP
   S: 184  fveyl 188
           fveyl
   Q: 238  FVEYL 242
           ***96 PP

UBD/Alpha-Helix/UBA

   S: 5    dkleqlve.MGFdreealqaLraannnleaAveyLld 40
           dk++q++  +G +++ alqaL  +++nle A + +++
   Q: 11   DKVQQFMTiTGASEKVALQALKVSDWNLEGAFDVFYS 47
           89*****************************998886 PP

Organism

Solanum lycopersicum

Functional Description
(View)

Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.

Protein Sequence
(Fasta)

MQNKLGIGRR DKVQQFMTIT GASEKVALQA LKVSDWNLEG AFDVFYSQSQ VKSSADARRL 60
EELYNRYKDP YADMILADGI SLLCNDMQVD PQDIVMLVLS WHMKAATMCE FSKQEFIGGL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGACTAATCA AAGCTAGATC CTATCAACAT TAGATTGGCG TCCAAATCCG GTTTCCTCAC 60
ACCTTATAGT CGTGGACCTT TTTTTCTGGC TTTTACTTAA AATAAAAGGA AAAAATAAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR014764--DCN-prot
IPR005176--PONY_dom
IPR009060--UBA-like

PROSITE

PS51229--DCUN1

Pfam

PF03556--Cullin_binding

Gene Ontology

GO:0000151--C:ubiquitin ligase complex
GO:0097602--F:cullin family protein binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0032182--F:ubiquitin-like protein binding
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0045116--P:protein neddylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000561	Aegilops tauschii	75.30	6.00e-115	405.00
IUUC-Aml-001879	Ailuropoda melanoleuca	44.72	2.00e-60	224.00
IUUC-Atr-002697	Amborella trichopoda	85.59	8.00e-57	211.00
IUUC-Apl-003451	Anas platyrhynchos	43.78	2.00e-59	221.00
IUUC-Aca-005269	Anolis carolinensis	43.90	6.00e-59	220.00
IUUC-Aly-006285	Arabidopsis lyrata	68.02	3.00e-95	339.00
IUUC-Ath-007531	Arabidopsis thaliana	77.82	4.00e-117	412.00
IUUC-Ago-007806	Ashbya gossypii	25.00	1.00e-18	85.50
IUUC-Acl-008172	Aspergillus clavatus	26.59	1.00e-23	102.00
IUUC-Afl-008569	Aspergillus flavus	28.51	8.00e-30	123.00
IUUC-Afu-009005	Aspergillus fumigatus	27.06	8.00e-19	85.90
IUUC-Ani-009241	Aspergillus nidulans	23.10	6.00e-20	90.50
IUUC-Ang-009664	Aspergillus niger	28.46	6.00e-27	113.00
IUUC-Aor-009902	Aspergillus oryzae	29.25	2.00e-11	60.50
IUUC-Ate-010414	Aspergillus terreus	26.91	8.00e-28	116.00
IUUC-Ame-011763	Astyanax mexicanus	45.31	2.00e-61	227.00
IUUC-Bgr-011991	Blumeria graminis	28.37	2.00e-20	92.40
IUUC-Bta-013561	Bos taurus	43.53	5.00e-55	206.00
IUUC-Bci-013824	Botrytis cinerea	32.14	2.00e-30	125.00
IUUC-Bdi-014138	Brachypodium distachyon	76.11	3.00e-115	406.00
IUUC-Bol-015564	Brassica oleracea	78.54	4.00e-118	416.00
IUUC-Bra-017111	Brassica rapa	78.54	2.00e-118	417.00
IUUC-Cel-018441	Caenorhabditis elegans	33.94	5.00e-40	157.00
IUUC-Cja-019502	Callithrix jacchus	44.72	2.00e-60	224.00
IUUC-Cfa-020523	Canis familiaris	43.97	1.00e-55	208.00
IUUC-Cpo-022196	Cavia porcellus	44.31	5.00e-60	223.00
IUUC-Cre-022620	Chlamydomonas reinhardtii	45.49	1.00e-63	235.00
IUUC-Csa-023551	Chlorocebus sabaeus	44.72	2.00e-60	224.00
IUUC-Cho-024373	Choloepus hoffmanni	44.31	1.00e-56	212.00
IUUC-Cin-025269	Ciona intestinalis	42.28	2.00e-58	217.00
IUUC-Csv-025976	Ciona savignyi	34.38	6.00e-35	139.00
IUUC-Cgl-026386	Colletotrichum gloeosporioides	28.49	2.00e-19	88.20
IUUC-Cne-026950	Cryptococcus neoformans	35.25	3.00e-37	147.00
IUUC-Cme-027199	Cyanidioschyzon merolae	30.20	2.00e-10	58.50
IUUC-Dre-028247	Danio rerio	44.90	8.00e-61	226.00
IUUC-Dno-028974	Dasypus novemcinctus	44.72	2.00e-60	224.00
IUUC-Dor-030143	Dipodomys ordii	43.50	2.00e-59	221.00
IUUC-Dse-031365	Dothistroma septosporum	27.02	7.00e-25	106.00
IUUC-Dme-032197	Drosophila melanogaster	41.00	1.00e-56	212.00
IUUC-Ete-032371	Echinops telfairi	44.72	2.00e-60	224.00
IUUC-Eca-033242	Equus caballus	44.72	2.00e-60	224.00
IUUC-Eeu-035317	Erinaceus europaeus	45.12	1.00e-60	225.00
IUUC-Fca-036061	Felis catus	44.72	2.00e-60	224.00
IUUC-Fal-036715	Ficedula albicollis	43.72	3.00e-59	220.00
IUUC-Fox-037884	Fusarium oxysporum	32.54	1.00e-14	72.00
IUUC-Fso-038150	Fusarium solani	25.94	2.00e-16	79.30
IUUC-Gmo-038750	Gadus morhua	45.16	9.00e-61	225.00
IUUC-Ggr-039959	Gaeumannomyces graminis	26.67	1.00e-15	77.80
IUUC-Gga-040935	Gallus gallus	44.31	6.00e-60	223.00
IUUC-Gac-041937	Gasterosteus aculeatus	44.90	1.00e-60	225.00
IUUC-Gma-043545	Glycine max	81.32	1.00e-125	441.00
IUUC-Ggo-044468	Gorilla gorilla	44.35	6.00e-59	219.00
IUUC-Hsa-046089	Homo sapiens	44.72	2.00e-60	224.00
IUUC-Hvu-047636	Hordeum vulgare	35.43	7.00e-20	89.40
IUUC-Itr-047902	Ictidomys tridecemlineatus	44.13	8.00e-59	219.00
IUUC-Kpa-049127	Komagataella pastoris	30.61	5.00e-29	120.00
IUUC-Lch-050600	Latimeria chalumnae	44.31	7.00e-61	226.00
IUUC-Lpe-051540	Leersia perrieri	76.71	7.00e-120	422.00
IUUC-Loc-052509	Lepisosteus oculatus	45.12	3.00e-60	224.00
IUUC-Lma-053103	Leptosphaeria maculans	28.23	5.00e-26	110.00
IUUC-Laf-053527	Loxodonta africana	44.31	3.00e-60	223.00
IUUC-Mcc-054700	Macaca mulatta	42.28	4.00e-58	217.00
IUUC-Meu-056791	Macropus eugenii	37.96	1.00e-43	169.00
IUUC-Mor-056909	Magnaporthe oryzae	25.87	3.00e-21	94.70
IUUC-Mpo-057299	Magnaporthe poae	25.65	2.00e-19	88.60
IUUC-Mtr-057964	Medicago truncatula	81.32	2.00e-126	443.00
IUUC-Mla-058990	Melampsora laricipopulina	26.12	7.00e-17	80.90
IUUC-Mga-060072	Meleagris gallopavo	44.13	2.00e-59	221.00
IUUC-Mvi-060312	Microbotryum violaceum	32.54	2.00e-38	151.00
IUUC-Mmr-060851	Microcebus murinus	44.72	3.00e-60	224.00
IUUC-Mdo-063074	Monodelphis domestica	44.76	1.00e-60	228.00
IUUC-Mmu-063816	Mus musculus	44.31	5.00e-60	223.00
IUUC-Mac-065016	Musa acuminata	84.15	2.00e-93	333.00
IUUC-Mpu-066870	Mustela putorius furo	43.97	1.00e-55	208.00
IUUC-Mlu-067701	Myotis lucifugus	44.31	2.00e-59	221.00
IUUC-Nfi-068610	Neosartorya fischeri	27.65	7.00e-19	86.30
IUUC-Ncr-068780	Neurospora crassa	24.07	2.00e-16	79.30
IUUC-Nle-069291	Nomascus leucogenys	44.72	2.00e-60	224.00
IUUC-Opr-070682	Ochotona princeps	40.20	1.00e-43	169.00
IUUC-Ont-071408	Oreochromis niloticus	44.72	4.00e-61	226.00
IUUC-Oan-073031	Ornithorhynchus anatinus	45.12	1.00e-60	225.00
IUUC-Ocu-074648	Oryctolagus cuniculus	44.72	2.00e-60	224.00
IUUC-Oba-074993	Oryza barthii	77.02	1.00e-119	421.00
IUUC-Obr-076341	Oryza brachyantha	75.81	4.00e-118	416.00
IUUC-Ogl-077099	Oryza glaberrima	77.02	1.00e-119	421.00
IUUC-Ogu-078285	Oryza glumaepatula	77.82	1.00e-120	424.00
IUUC-Oin-079441	Oryza indica	77.42	3.00e-120	423.00
IUUC-Olo-081037	Oryza longistaminata	77.42	3.00e-120	423.00
IUUC-Ome-081357	Oryza meridionalis	77.42	3.00e-120	423.00
IUUC-Oni-082632	Oryza nivara	77.42	6.00e-120	422.00
IUUC-Opu-083351	Oryza punctata	77.35	8.00e-114	401.00
IUUC-Oru-084306	Oryza rufipogon	77.42	3.00e-120	423.00
IUUC-Osa-085307	Oryza sativa	77.42	3.00e-120	423.00
IUUC-Ola-086868	Oryzias latipes	44.19	3.00e-61	227.00
IUUC-Olu-087646	Ostreococcus lucimarinus	44.53	6.00e-54	203.00
IUUC-Oga-089015	Otolemur garnettii	44.31	9.00e-60	222.00
IUUC-Oar-090405	Ovis aries	44.31	9.00e-60	222.00
IUUC-Ptr-090735	Pan troglodytes	44.72	2.00e-60	224.00
IUUC-Pan-092825	Papio anubis	42.68	2.00e-58	218.00
IUUC-Psi-093110	Pelodiscus sinensis	42.67	3.00e-54	204.00
IUUC-Pma-094196	Petromyzon marinus	38.42	2.00e-42	165.00
IUUC-Pno-095145	Phaeosphaeria nodorum	30.30	5.00e-22	97.40
IUUC-Ppa-095306	Physcomitrella patens	76.52	5.00e-117	412.00
IUUC-Pfo-096774	Poecilia formosa	45.34	4.00e-62	230.00
IUUC-Pab-098197	Pongo abelii	40.82	1.00e-53	202.00
IUUC-Pop-098821	Populus trichocarpa	85.25	2.00e-61	226.00
IUUC-Pca-100218	Procavia capensis	43.50	7.00e-59	219.00
IUUC-Ppe-102032	Prunus persica	84.62	6.00e-128	448.00
IUUC-Pva-102691	Pteropus vampyrus	43.09	7.00e-59	219.00
IUUC-Pgr-103633	Puccinia graminis	27.70	1.00e-21	96.30
IUUC-Ptt-103979	Puccinia triticina	33.33	2.00e-04	39.70
IUUC-Pyt-104428	Pyrenophora triticirepentis	28.29	6.00e-22	96.70
IUUC-Rno-105554	Rattus norvegicus	44.72	3.00e-60	224.00
IUUC-Sce-106358	Saccharomyces cerevisiae	23.19	2.00e-18	85.10
IUUC-Sha-106888	Sarcophilus harrisii	44.72	2.00e-60	224.00
IUUC-Sja-107938	Schizosaccharomyces japonicus	28.46	5.00e-22	97.10
IUUC-Spo-108207	Schizosaccharomyces pombe	33.02	1.00e-24	105.00
IUUC-Ssl-108410	Sclerotinia sclerotiorum	29.80	4.00e-29	120.00
IUUC-Smo-108750	Selaginella moellendorffii	66.67	3.00e-94	336.00
IUUC-Sit-110052	Setaria italica	77.60	4.00e-120	422.00
IUUC-Stu-112517	Solanum tuberosum	67.49	1.00e-103	368.00
IUUC-Sar-113509	Sorex araneus	47.09	4.00e-42	163.00
IUUC-Sbi-114082	Sorghum bicolor	76.83	4.00e-118	416.00
IUUC-Sre-115221	Sporisorium reilianum	25.26	9.00e-24	103.00
IUUC-Ssc-115547	Sus scrofa	44.72	2.00e-60	224.00
IUUC-Tgu-117147	Taeniopygia guttata	44.31	7.00e-60	223.00
IUUC-Tru-117740	Takifugu rubripes	45.12	6.00e-62	229.00
IUUC-Tsy-119599	Tarsius syrichta	44.72	2.00e-60	224.00
IUUC-Tni-120542	Tetraodon nigroviridis	45.23	8.00e-60	222.00
IUUC-Tca-121033	Theobroma cacao	84.82	1.00e-133	468.00
IUUC-Tre-121986	Trichoderma reesei	23.67	2.00e-20	92.00
IUUC-Tvi-122607	Trichoderma virens	27.95	2.00e-25	108.00
IUUC-Tae-125740	Triticum aestivum	64.58	5.00e-109	386.00
IUUC-Tur-126375	Triticum urartu	58.62	7.00e-106	376.00
IUUC-Tme-126878	Tuber melanosporum	33.33	7.00e-36	143.00
IUUC-Tbe-127429	Tupaia belangeri	40.70	5.00e-44	170.00
IUUC-Ttr-129086	Tursiops truncatus	41.46	1.00e-52	198.00
IUUC-Uma-129364	Ustilago maydis	26.25	7.00e-29	120.00
IUUC-Vda-129929	Verticillium dahliae	29.02	1.00e-18	87.00
IUUC-Vpa-130048	Vicugna pacos	39.84	1.00e-47	182.00
IUUC-Vvi-130834	Vitis vinifera	82.88	4.00e-130	456.00
IUUC-Xtr-131888	Xenopus tropicalis	44.94	2.00e-61	228.00
IUUC-Xma-134122	Xiphophorus maculatus	43.72	3.00e-61	227.00
IUUC-Yli-134595	Yarrowia lipolytica	31.25	5.00e-32	130.00
IUUC-Zma-135642	Zea mays	77.24	1.00e-117	414.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence