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Tag Content
iUUCD ID IUUC-Itr-047935
Ensembl Protein ID ENSSTOP00000023658.1
UniProt Accession I3NH11; I3NH11_ICTTR
Genbank Protein ID ENSSTOP00000023658
Protein Name Tyrosine-protein kinase
Genbank Nucleotide ID AGTP01020221
Gene Name ABL1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSSTOG00000026819.1 ENSSTOT00000019715.1 ENSSTOP00000023658.1
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 2.60e-14 52.9 40 97
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
    +++ +lyd+ a+ d++L+++kG++++v+ ++++++W+++ ++++ +G +P+n+++ ++
   Q: 40 PNLFVALYDFVASGDNTLSITKGEKLRVL-GYNHNGEWCEA--QTKNGQGWVPSNYITPVN 97
    68899************************.***********..79999**********997 PP
   

Organism Ictidomys tridecemlineatus
Protein Sequence
(Fasta)
MEHEALQRPV ASDFEPQGLS EAARWNSKEN LLAGPSENDP NLFVALYDFV ASGDNTLSIT 60
KGEKLRVLGY NHNGEWCEAQ TKNGQGWVPS NYITPVNSLE KHSWYHGPVS RNAAEYLLSS 120
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Protein Fasta Sequence



>IUUC-Itr-047935|UBD,SH3|Ictidomys tridecemlineatus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCTTCTAAGT CCACTCACCG TTCTGGAAGA TCTTGAACCC TCTTCTGGAA AGGGGTGCTT 60
ATCATCATTG CTTTATGGGG CAGCAGCCTG GAAAAGTTCT TGGGGACCAA AGAAGGCCAA 120
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Nucleotide Fasta Sequence



>IUUC-Itr-047935|UBD,SH3|Ictidomys tridecemlineatus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR015015--F-actin_binding
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF08919--F_actin_bind
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00109--TYRKINASE

SMART

SM00808--FABD
SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0031252--C:cell leading edge
GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0005730--C:nucleolus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0030145--F:manganese ion binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0090135--P:actin filament branching
GO:0050798--P:activated T cell proliferation
GO:1990051--P:activation of protein kinase C activity
GO:0046632--P:alpha-beta T cell differentiation
GO:0002322--P:B cell proliferation involved in immune response
GO:0050853--P:B cell receptor signaling pathway
GO:0001922--P:B-1 B cell homeostasis
GO:0060020--P:Bergmann glial cell differentiation
GO:0072358--P:cardiovascular system development
GO:0070301--P:cellular response to hydrogen peroxide
GO:0071222--P:cellular response to lipopolysaccharide
GO:0021587--P:cerebellum morphogenesis
GO:0048668--P:collateral sprouting
GO:0006975--P:DNA damage induced protein phosphorylation
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0045184--P:establishment of protein localization
GO:0030035--P:microspike assembly
GO:0030514--P:negative regulation of BMP signaling pathway
GO:0022408--P:negative regulation of cell-cell adhesion
GO:2000773--P:negative regulation of cellular senescence
GO:2000352--P:negative regulation of endothelial cell apoptotic process
GO:0070373--P:negative regulation of ERK1 and ERK2 cascade
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045930--P:negative regulation of mitotic cell cycle
GO:1900275--P:negative regulation of phospholipase C activity
GO:0071901--P:negative regulation of protein serine/threonine kinase activity
GO:0051444--P:negative regulation of ubiquitin-protein transferase activity
GO:0001843--P:neural tube closure
GO:0060563--P:neuroepithelial cell differentiation
GO:0050885--P:neuromuscular process controlling balance
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0006909--P:phagocytosis
GO:0035791--P:platelet-derived growth factor receptor-beta signaling pathway
GO:1904531--P:positive regulation of actin filament binding
GO:0043065--P:positive regulation of apoptotic process
GO:0007204--P:positive regulation of cytosolic calcium ion concentration
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:1902715--P:positive regulation of interferon-gamma secretion
GO:1900042--P:positive regulation of interleukin-2 secretion
GO:1904528--P:positive regulation of microtubule binding
GO:0045931--P:positive regulation of mitotic cell cycle
GO:1901216--P:positive regulation of neuron death
GO:0033690--P:positive regulation of osteoblast proliferation
GO:0051353--P:positive regulation of oxidoreductase activity
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0051281--P:positive regulation of release of sequestered calcium ion into cytosol
GO:2000096--P:positive regulation of Wnt signaling pathway, planar cell polarity pathway
GO:0009791--P:post-embryonic development
GO:0032956--P:regulation of actin cytoskeleton organization
GO:0030516--P:regulation of axon extension
GO:1903053--P:regulation of extracellular matrix organization
GO:0031113--P:regulation of microtubule polymerization
GO:2001020--P:regulation of response to DNA damage stimulus
GO:0042770--P:signal transduction in response to DNA damage
GO:0048536--P:spleen development
GO:0034446--P:substrate adhesion-dependent cell spreading
GO:0048538--P:thymus development
GO:0002333--P:transitional one stage B cell differentiation

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001550 Ailuropoda melanoleuca 90.34 0.00e+00 1758.00
IUUC-Apl-003452 Anas platyrhynchos 80.29 0.00e+00 1620.00
IUUC-Aca-005312 Anolis carolinensis 85.10 0.00e+00 1273.00
IUUC-Ame-011903 Astyanax mexicanus 85.07 0.00e+00 1024.00
IUUC-Bta-012351 Bos taurus 88.63 0.00e+00 1748.00
IUUC-Cja-019491 Callithrix jacchus 90.35 0.00e+00 1845.00
IUUC-Cfa-021256 Canis familiaris 89.44 0.00e+00 1805.00
IUUC-Cpo-022046 Cavia porcellus 90.62 0.00e+00 1523.00
IUUC-Csa-023046 Chlorocebus sabaeus 90.78 0.00e+00 1895.00
IUUC-Dre-028190 Danio rerio 66.40 0.00e+00 1204.00
IUUC-Dno-029853 Dasypus novemcinctus 89.80 0.00e+00 1786.00
IUUC-Dor-030635 Dipodomys ordii 82.45 0.00e+00 1608.00
IUUC-Dme-032098 Drosophila melanogaster 75.32 0.00e+00 780.00
IUUC-Eca-033720 Equus caballus 89.68 0.00e+00 1806.00
IUUC-Eeu-035173 Erinaceus europaeus 86.86 0.00e+00 1407.00
IUUC-Fca-035967 Felis catus 89.71 0.00e+00 1761.00
IUUC-Fal-036723 Ficedula albicollis 80.92 0.00e+00 1621.00
IUUC-Gmo-039550 Gadus morhua 77.22 0.00e+00 1088.00
IUUC-Gga-040481 Gallus gallus 80.65 0.00e+00 1590.00
IUUC-Gac-041643 Gasterosteus aculeatus 66.84 0.00e+00 1267.00
IUUC-Ggo-045299 Gorilla gorilla 90.05 0.00e+00 1888.00
IUUC-Hsa-047033 Homo sapiens 100.00 9.00e-42 160.00
IUUC-Lch-050530 Latimeria chalumnae 75.58 0.00e+00 1514.00
IUUC-Loc-052430 Lepisosteus oculatus 92.72 0.00e+00 979.00
IUUC-Laf-053609 Loxodonta africana 89.35 0.00e+00 1749.00
IUUC-Mcc-055654 Macaca mulatta 90.89 0.00e+00 1924.00
IUUC-Meu-056488 Macropus eugenii 75.18 0.00e+00 1489.00
IUUC-Mga-059270 Meleagris gallopavo 80.72 0.00e+00 1633.00
IUUC-Mmr-060593 Microcebus murinus 89.76 0.00e+00 1822.00
IUUC-Mdo-062227 Monodelphis domestica 90.28 0.00e+00 1261.00
IUUC-Mmu-064002 Mus musculus 86.99 0.00e+00 1771.00
IUUC-Mpu-066197 Mustela putorius furo 89.71 0.00e+00 1783.00
IUUC-Mlu-067255 Myotis lucifugus 90.23 0.00e+00 1778.00
IUUC-Nle-069977 Nomascus leucogenys 88.12 0.00e+00 1328.00
IUUC-Opr-070327 Ochotona princeps 82.34 0.00e+00 1566.00
IUUC-Ont-072307 Oreochromis niloticus 85.10 0.00e+00 1027.00
IUUC-Oan-073100 Ornithorhynchus anatinus 83.57 0.00e+00 1683.00
IUUC-Ocu-074892 Oryctolagus cuniculus 83.18 0.00e+00 1598.00
IUUC-Oga-088145 Otolemur garnettii 90.76 0.00e+00 1822.00
IUUC-Oar-090432 Ovis aries 93.21 0.00e+00 1454.00
IUUC-Ptr-090800 Pan troglodytes 90.71 0.00e+00 1896.00
IUUC-Psi-093078 Pelodiscus sinensis 80.29 0.00e+00 1666.00
IUUC-Pma-094420 Petromyzon marinus 72.08 0.00e+00 903.00
IUUC-Pfo-096979 Poecilia formosa 74.00 0.00e+00 1038.00
IUUC-Pca-100874 Procavia capensis 99.11 0.00e+00 680.00
IUUC-Pva-102415 Pteropus vampyrus 88.63 0.00e+00 1764.00
IUUC-Rno-105682 Rattus norvegicus 87.35 0.00e+00 1775.00
IUUC-Sha-106711 Sarcophilus harrisii 82.29 0.00e+00 1669.00
IUUC-Ssc-115472 Sus scrofa 88.99 0.00e+00 1751.00
IUUC-Tgu-117037 Taeniopygia guttata 81.51 0.00e+00 1652.00
IUUC-Tru-118324 Takifugu rubripes 68.92 0.00e+00 1068.00
IUUC-Tsy-119216 Tarsius syrichta 97.62 0.00e+00 1100.00
IUUC-Tni-119950 Tetraodon nigroviridis 81.17 0.00e+00 972.00
IUUC-Ttr-128209 Tursiops truncatus 89.53 0.00e+00 1841.00
IUUC-Xtr-132477 Xenopus tropicalis 75.56 0.00e+00 1105.00
Created Date 25-Jun-2017

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