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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064119
Ensembl Protein ID ENSMUSP00000083806.5
UniProt Accession Q6NZP1; Q148X9; Q8BJJ3; Q8BWT6; ZRAB3_MOUSE
Genbank Protein ID BAC34042.1; BAC38978.1; AAH66035.1; AAI17922.1; AAI17923.1
Protein Name DNA annealing helicase and endonuclease ZRANB3; Annealing helicase 2; Zinc finger Ran-binding domain-containing protein 3; DNA annealing helicase ZRANB3; Endonuclease ZRANB3
Genbank Nucleotide ID AK050039; AK083641; BC066035; BC117921; BC117922
Gene Name Zranb3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000036086.16 ENSMUST00000086614.11 ENSMUSP00000083806.5
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPHOSIDA
mUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/ZnF/NZF 77.24 0.00e+00 1693.00 IUUC-Hsa-046389
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks (By similarity).
 DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks (By similarity).
Protein Sequence
(Fasta)
MPTAGSKKKA PTPQISCLTS ESYTQLDFLP DKLRTKLLPF QKDGIVFALR RDGRCMVADE 60
MGLGKTIQAI AIAYFYKEEW PLLIVVPSSL RYPWIEELEK WIPELEPEEI NVVMNKTDIG 120
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Protein Fasta Sequence


>IUUC-Mmu-064119|UBD,NZF|Mus musculus
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Nucleotide Sequence
(Fasta)
ACTTGTGAAA GAGCCACCTT TCCCACGAGT AGAATCCTGA GGTGGGCGAG TTCCGGGCGA 60
TTTTAATCAC TGGAGATGTG GTAGACAACT CTCTTTCTTC AGGGAATGAT TATAGAGCTT 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-064119|UBD,NZF|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0227--DNA damage
KW-0234--DNA repair
KW-0255--Endonuclease
KW-0347--Helicase
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0511--Multifunctional enzyme
KW-0540--Nuclease
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR002711--HNH
IPR003615--HNH_nuc
IPR027417--P-loop_NTPase
IPR000330--SNF2_N
IPR001876--Znf_RanBP2
PROSITE

PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
Pfam

PF00271--Helicase_C
PF01844--HNH
PF00176--SNF2_N
SMART

SM00487--DEXDc
SM00490--HELICc
SM00507--HNHc
SM00547--ZnF_RBZ
Gene Ontology

GO:0043596--C:nuclear replication fork
GO:0005634--C:nucleus
GO:0036310--F:annealing helicase activity
GO:0005524--F:ATP binding
GO:0004520--F:endodeoxyribonuclease activity
GO:0004386--F:helicase activity
GO:0070530--F:K63-linked polyubiquitin binding
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006281--P:DNA repair
GO:0036292--P:DNA rewinding
GO:0045910--P:negative regulation of DNA recombination
GO:0031297--P:replication fork processing
GO:0048478--P:replication fork protection
GO:0009411--P:response to UV
KEGG mmu:226409
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001748 Ailuropoda melanoleuca 76.41 0.00e+00 1612.00
IUUC-Ame-010851 Astyanax mexicanus 53.19 0.00e+00 1129.00
IUUC-Bta-013559 Bos taurus 73.09 0.00e+00 1484.00
IUUC-Cja-019295 Callithrix jacchus 77.15 0.00e+00 1710.00
IUUC-Cfa-020445 Canis familiaris 76.19 0.00e+00 1688.00
IUUC-Cpo-021752 Cavia porcellus 75.56 0.00e+00 1588.00
IUUC-Cho-024291 Choloepus hoffmanni 70.18 0.00e+00 1219.00
IUUC-Dno-029189 Dasypus novemcinctus 75.51 0.00e+00 1580.00
IUUC-Ete-032675 Echinops telfairi 54.77 4.00e-173 602.00
IUUC-Eca-034386 Equus caballus 76.13 0.00e+00 1595.00
IUUC-Eeu-034715 Erinaceus europaeus 64.10 0.00e+00 980.00
IUUC-Fca-035782 Felis catus 71.96 0.00e+00 1464.00
IUUC-Ggo-044474 Gorilla gorilla 77.15 0.00e+00 1715.00
IUUC-Hsa-046389 Homo sapiens 77.24 0.00e+00 1719.00
IUUC-Itr-048124 Ictidomys tridecemlineatus 75.02 0.00e+00 1554.00
IUUC-Lch-050057 Latimeria chalumnae 56.18 0.00e+00 976.00
IUUC-Loc-052337 Lepisosteus oculatus 54.28 0.00e+00 1192.00
IUUC-Laf-054123 Loxodonta africana 75.95 0.00e+00 1675.00
IUUC-Mcc-055276 Macaca mulatta 77.70 0.00e+00 1637.00
IUUC-Mmr-061589 Microcebus murinus 78.09 0.00e+00 1707.00
IUUC-Mpu-066729 Mustela putorius furo 76.00 0.00e+00 1671.00
IUUC-Mlu-067857 Myotis lucifugus 69.98 0.00e+00 1329.00
IUUC-Nle-070137 Nomascus leucogenys 76.91 0.00e+00 1657.00
IUUC-Opr-070305 Ochotona princeps 67.34 0.00e+00 1397.00
IUUC-Ont-072504 Oreochromis niloticus 62.63 0.00e+00 834.00
IUUC-Oan-073379 Ornithorhynchus anatinus 63.05 0.00e+00 1391.00
IUUC-Ola-086386 Oryzias latipes 56.66 0.00e+00 1121.00
IUUC-Oga-088489 Otolemur garnettii 72.77 0.00e+00 1181.00
IUUC-Oar-089750 Ovis aries 76.23 0.00e+00 1665.00
IUUC-Pan-092664 Papio anubis 76.05 0.00e+00 1324.00
IUUC-Pma-094301 Petromyzon marinus 52.49 0.00e+00 1093.00
IUUC-Pfo-097036 Poecilia formosa 54.84 0.00e+00 1147.00
IUUC-Pab-098606 Pongo abelii 76.97 0.00e+00 1708.00
IUUC-Pva-103004 Pteropus vampyrus 72.13 0.00e+00 1552.00
IUUC-Sar-112970 Sorex araneus 70.89 0.00e+00 747.00
IUUC-Ssc-115868 Sus scrofa 75.98 0.00e+00 1588.00
IUUC-Tgu-116905 Taeniopygia guttata 62.03 0.00e+00 1309.00
IUUC-Tsy-118909 Tarsius syrichta 73.76 0.00e+00 964.00
IUUC-Tni-119749 Tetraodon nigroviridis 57.22 0.00e+00 1200.00
IUUC-Tbe-127972 Tupaia belangeri 71.19 2.00e-174 606.00
IUUC-Ttr-128601 Tursiops truncatus 72.90 0.00e+00 1598.00
IUUC-Vpa-130286 Vicugna pacos 73.54 0.00e+00 1577.00
Created Date 25-Jun-2017

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