iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053690

UUCD1 version

UUC-LoA-01025

Ensembl Protein ID

ENSLAFP00000017677.2

UniProt Accession

G3TQ79; G3TQ79_LOXAF

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Gene Name

NAE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000022057.2	ENSLAFT00000021495.2	ENSLAFP00000017677.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.30e-130	436.7	13	525

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvn 89
           YDRQ+rlwG+++qe+l+sa+v+l++a+++G+E+lKnLvl Gvgs+t++D+++v+ ++ +++F+++++++gk++A++a+e+l+eln dv+
   Q: 13   YDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGVGSFTIIDGNQVSGEDAGNNFFLQRSSIGKNRAQAAMEFLQELNTDVS 101
           ***************************************************************************************** PP
   S: 90   veaheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfc 174
           + ++ees+++l ++++ Ff++f++Vv+++ ++++ ++++++++n ++pl+ ++t+Gl+G++r+iik++++++s++d   +++++++Pf+
   Q: 102  GGFVEESPENLLDNDPsFFCRFTIVVATQLPESTLLRLADILWNSQIPLLVCRTYGLVGYMRIIIKEHPVIESHPDnalEDLRLDKPFP 190
           ***************************************************************************************** PP
   S: 175  tlketpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks......edeenfeeaieiavkafakt 248
           +l+e+++         +++++++w+v+++k+l+ +++e++++ +++++eke+++d++++++ +      edeenfeeai+++++a+++t
   Q: 191  ELREHFQsydldnmdkKDHSHTPWIVIIAKYLARWYSETNGRIPKTYKEKEDFRDLIRQGILKnengapEDEENFEEAIKNVNTALNTT 279
           *****99999999999***********************************************9************************* PP
   S: 249  tins.ikqllksfecdivtkskspfwv.............................................................. 274
           +i+s i++++++++c ++tk++++fw+                                                              
   Q: 280  QIPSsIEDIFNDDRCVNITKQTPSFWIlaralkefvakegqgnlpvrgtipdmiadsgkyiklqnvyrekakrdaaavgnhvakllqsi 368
           ***************************************************************************************** PP
   S: 275  .............sfcsnaealqvp...........ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..a 332
                         +csn++ l+v            ++ +kde+++++++p     lyl+lra++rf+k++gr+pg++++++++d+  +
   Q: 369  gqapesisekelkLLCSNSAFLRVVrcrslaeeyglDTLNKDEIISSMDNPdseivLYLMLRAVDRFHKQHGRYPGVSNYQVEEDIgkL 457
           *************9*********777777777888899999999999999999999******************************999 PP
   S: 333  vdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
            +++t ++    +++g++ +++dd+++e++++++++ +t++a++gG+aaqEviK+++++f+ ++n++++ ++
   Q: 458  KSCLTGFL----QEYGLSVIVKDDYVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGM 525
           ********....********************************************************9776 PP

Organism

Loxodonta africana

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

Protein Sequence
(Fasta)

MAQPGKLPKE QKYDRQLRLW GDHGQEALES AHVCLINATA TGTEILKNLV LPGVGSFTII 60
DGNQVSGEDA GNNFFLQRSS IGKNRAQAAM EFLQELNTDV SGGFVEESPE NLLDNDPSFF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTCAGC CGGGGAAGCT GCCCAAGGAG CAGAAGTACG ACCGGCAGCT GAGGTGAGCC 60
GGGGCTTCCC GAGCGTGGCG GTCGTGCCGG CGGGTTCCCC TGCGTCCGGG GCGGGCCTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0033314--P:mitotic DNA replication checkpoint
GO:0051402--P:neuron apoptotic process
GO:0045116--P:protein neddylation
GO:0043523--P:regulation of neuron apoptotic process

KEGG

lav:100662599

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	43.31	1.00e-127	450.00
IUUC-Aml-002333	Ailuropoda melanoleuca	95.71	0.00e+00	1075.00
IUUC-Atr-002644	Amborella trichopoda	41.89	8.00e-116	410.00
IUUC-Apl-003446	Anas platyrhynchos	84.39	0.00e+00	923.00
IUUC-Aca-004450	Anolis carolinensis	80.11	0.00e+00	916.00
IUUC-Aly-006187	Arabidopsis lyrata	40.19	1.00e-125	443.00
IUUC-Ath-007600	Arabidopsis thaliana	40.56	3.00e-126	445.00
IUUC-Ago-007900	Ashbya gossypii	27.52	6.00e-40	158.00
IUUC-Acl-008333	Aspergillus clavatus	34.35	5.00e-82	298.00
IUUC-Afl-008529	Aspergillus flavus	36.38	5.00e-88	318.00
IUUC-Afu-009071	Aspergillus fumigatus	33.51	1.00e-82	300.00
IUUC-Ani-009443	Aspergillus nidulans	34.05	9.00e-80	290.00
IUUC-Ang-009669	Aspergillus niger	32.97	5.00e-82	298.00
IUUC-Aor-009914	Aspergillus oryzae	35.70	1.00e-84	307.00
IUUC-Ate-010450	Aspergillus terreus	35.25	1.00e-85	310.00
IUUC-Ame-011183	Astyanax mexicanus	72.40	0.00e+00	837.00
IUUC-Bgr-012111	Blumeria graminis	33.03	2.00e-66	246.00
IUUC-Bta-012583	Bos taurus	96.25	0.00e+00	1082.00
IUUC-Bci-013892	Botrytis cinerea	32.97	2.00e-66	246.00
IUUC-Bdi-014592	Brachypodium distachyon	43.51	7.00e-130	457.00
IUUC-Bol-016399	Brassica oleracea	40.65	2.00e-124	439.00
IUUC-Bra-017506	Brassica rapa	39.32	4.00e-121	427.00
IUUC-Cel-018456	Caenorhabditis elegans	36.01	7.00e-93	334.00
IUUC-Cja-020007	Callithrix jacchus	96.28	0.00e+00	1082.00
IUUC-Cfa-020324	Canis familiaris	96.63	0.00e+00	1084.00
IUUC-Cpo-022248	Cavia porcellus	65.06	0.00e+00	634.00
IUUC-Csa-023149	Chlorocebus sabaeus	96.68	0.00e+00	923.00
IUUC-Cho-024537	Choloepus hoffmanni	84.16	0.00e+00	800.00
IUUC-Cin-025763	Ciona intestinalis	50.28	6.00e-157	547.00
IUUC-Csv-026113	Ciona savignyi	46.30	6.00e-146	510.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	32.34	2.00e-67	250.00
IUUC-Cne-026884	Cryptococcus neoformans	31.00	2.00e-74	273.00
IUUC-Cme-027210	Cyanidioschyzon merolae	26.91	2.00e-18	87.40
IUUC-Dre-028140	Danio rerio	73.41	0.00e+00	857.00
IUUC-Dno-030033	Dasypus novemcinctus	95.98	0.00e+00	956.00
IUUC-Dor-030513	Dipodomys ordii	66.77	9.00e-113	400.00
IUUC-Dse-031536	Dothistroma septosporum	34.58	4.00e-85	308.00
IUUC-Dme-031683	Drosophila melanogaster	44.28	6.00e-127	447.00
IUUC-Ete-032420	Echinops telfairi	83.14	0.00e+00	885.00
IUUC-Eca-033992	Equus caballus	96.85	0.00e+00	908.00
IUUC-Eeu-034713	Erinaceus europaeus	79.92	4.00e-117	414.00
IUUC-Fca-036548	Felis catus	95.13	0.00e+00	1068.00
IUUC-Fal-037600	Ficedula albicollis	80.46	0.00e+00	889.00
IUUC-Fox-038037	Fusarium oxysporum	33.81	1.00e-77	283.00
IUUC-Fso-038387	Fusarium solani	34.77	8.00e-80	291.00
IUUC-Gmo-038562	Gadus morhua	71.78	0.00e+00	827.00
IUUC-Ggr-040005	Gaeumannomyces graminis	34.71	2.00e-74	273.00
IUUC-Gga-041129	Gallus gallus	84.67	0.00e+00	945.00
IUUC-Gac-042558	Gasterosteus aculeatus	72.88	0.00e+00	837.00
IUUC-Gma-043610	Glycine max	41.71	1.00e-121	429.00
IUUC-Ggo-045611	Gorilla gorilla	95.90	0.00e+00	1077.00
IUUC-Hsa-046563	Homo sapiens	96.44	0.00e+00	1082.00
IUUC-Hvu-047790	Hordeum vulgare	39.14	1.00e-78	286.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	95.69	0.00e+00	1078.00
IUUC-Kpa-049309	Komagataella pastoris	36.24	3.00e-84	305.00
IUUC-Lch-050038	Latimeria chalumnae	76.46	0.00e+00	858.00
IUUC-Lpe-051535	Leersia perrieri	42.25	2.00e-113	402.00
IUUC-Loc-051917	Lepisosteus oculatus	70.30	0.00e+00	800.00
IUUC-Lma-053112	Leptosphaeria maculans	35.83	7.00e-88	317.00
IUUC-Mcc-055117	Macaca mulatta	94.61	0.00e+00	1065.00
IUUC-Meu-056761	Macropus eugenii	77.37	0.00e+00	834.00
IUUC-Mor-057230	Magnaporthe oryzae	33.93	4.00e-79	288.00
IUUC-Mpo-057514	Magnaporthe poae	34.17	2.00e-72	266.00
IUUC-Mtr-058551	Medicago truncatula	40.83	2.00e-118	419.00
IUUC-Mla-059183	Melampsora laricipopulina	37.18	6.00e-98	351.00
IUUC-Mga-060144	Meleagris gallopavo	83.40	0.00e+00	919.00
IUUC-Mvi-060221	Microbotryum violaceum	35.99	6.00e-83	301.00
IUUC-Mmr-061325	Microcebus murinus	93.11	0.00e+00	1050.00
IUUC-Mdo-062532	Monodelphis domestica	91.18	0.00e+00	1026.00
IUUC-Mmu-063956	Mus musculus	95.51	0.00e+00	1075.00
IUUC-Mac-064521	Musa acuminata	41.12	7.00e-124	437.00
IUUC-Mpu-066716	Mustela putorius furo	95.22	0.00e+00	1012.00
IUUC-Mlu-067459	Myotis lucifugus	94.78	0.00e+00	1060.00
IUUC-Nfi-068245	Neosartorya fischeri	34.05	3.00e-83	302.00
IUUC-Ncr-068910	Neurospora crassa	34.30	2.00e-78	286.00
IUUC-Nle-070034	Nomascus leucogenys	93.37	0.00e+00	1037.00
IUUC-Opr-070552	Ochotona princeps	85.63	0.00e+00	876.00
IUUC-Ont-071426	Oreochromis niloticus	73.35	0.00e+00	853.00
IUUC-Oan-073389	Ornithorhynchus anatinus	84.49	0.00e+00	782.00
IUUC-Ocu-074911	Oryctolagus cuniculus	95.13	0.00e+00	1077.00
IUUC-Oba-075437	Oryza barthii	43.70	9.00e-121	427.00
IUUC-Obr-076684	Oryza brachyantha	43.89	1.00e-115	409.00
IUUC-Ogl-077170	Oryza glaberrima	43.70	9.00e-121	427.00
IUUC-Ogu-078844	Oryza glumaepatula	44.51	1.00e-113	403.00
IUUC-Oin-079105	Oryza indica	43.70	4.00e-120	424.00
IUUC-Olo-080943	Oryza longistaminata	41.05	2.00e-108	385.00
IUUC-Oni-082891	Oryza nivara	40.65	6.00e-114	404.00
IUUC-Opu-083457	Oryza punctata	43.70	3.00e-120	425.00
IUUC-Oru-084960	Oryza rufipogon	40.94	1.00e-108	387.00
IUUC-Osa-085358	Oryza sativa	43.89	1.00e-120	426.00
IUUC-Ola-086420	Oryzias latipes	71.85	2.00e-169	588.00
IUUC-Olu-087625	Ostreococcus lucimarinus	31.41	2.00e-62	233.00
IUUC-Oga-088810	Otolemur garnettii	94.94	0.00e+00	1071.00
IUUC-Oar-089196	Ovis aries	95.90	0.00e+00	1078.00
IUUC-Ptr-090617	Pan troglodytes	96.63	0.00e+00	1084.00
IUUC-Pan-092761	Papio anubis	97.00	0.00e+00	1088.00
IUUC-Psi-093191	Pelodiscus sinensis	86.46	0.00e+00	961.00
IUUC-Pma-094380	Petromyzon marinus	61.87	0.00e+00	665.00
IUUC-Pno-095084	Phaeosphaeria nodorum	33.27	5.00e-75	276.00
IUUC-Ppa-095875	Physcomitrella patens	40.42	1.00e-120	426.00
IUUC-Pfo-096467	Poecilia formosa	72.56	0.00e+00	836.00
IUUC-Pab-098255	Pongo abelii	95.95	0.00e+00	903.00
IUUC-Pop-099722	Populus trichocarpa	41.31	1.00e-125	443.00
IUUC-Pca-100807	Procavia capensis	78.11	1.00e-117	416.00
IUUC-Ppe-101280	Prunus persica	41.34	6.00e-125	441.00
IUUC-Pva-102333	Pteropus vampyrus	91.99	0.00e+00	1019.00
IUUC-Pgr-103401	Puccinia graminis	32.32	7.00e-82	298.00
IUUC-Ptt-103889	Puccinia triticina	28.02	7.00e-59	221.00
IUUC-Pte-104355	Pyrenophora teres	36.36	1.00e-90	327.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	36.72	6.00e-93	334.00
IUUC-Rno-105810	Rattus norvegicus	94.76	0.00e+00	1066.00
IUUC-Sce-106397	Saccharomyces cerevisiae	26.39	1.00e-37	150.00
IUUC-Sha-106770	Sarcophilus harrisii	89.75	4.00e-155	540.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	32.77	1.00e-77	283.00
IUUC-Spo-108276	Schizosaccharomyces pombe	35.65	1.00e-84	307.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	32.60	2.00e-68	253.00
IUUC-Smo-109296	Selaginella moellendorffii	42.61	6.00e-124	437.00
IUUC-Sit-110157	Setaria italica	44.59	2.00e-136	478.00
IUUC-Sly-111105	Solanum lycopersicum	40.80	2.00e-123	436.00
IUUC-Stu-112469	Solanum tuberosum	40.98	3.00e-125	442.00
IUUC-Sar-113083	Sorex araneus	72.48	0.00e+00	750.00
IUUC-Sbi-113813	Sorghum bicolor	44.59	1.00e-135	476.00
IUUC-Sre-115058	Sporisorium reilianum	38.89	4.00e-85	308.00
IUUC-Tgu-116772	Taeniopygia guttata	80.83	0.00e+00	892.00
IUUC-Tru-118686	Takifugu rubripes	71.83	0.00e+00	841.00
IUUC-Tsy-119111	Tarsius syrichta	87.63	5.00e-148	517.00
IUUC-Tni-120231	Tetraodon nigroviridis	66.79	0.00e+00	759.00
IUUC-Tca-121491	Theobroma cacao	41.34	3.00e-118	419.00
IUUC-Tre-122103	Trichoderma reesei	36.81	3.00e-84	305.00
IUUC-Tvi-122672	Trichoderma virens	37.29	6.00e-78	285.00
IUUC-Tae-125316	Triticum aestivum	43.92	8.00e-130	457.00
IUUC-Tur-126487	Triticum urartu	42.59	2.00e-123	435.00
IUUC-Tme-127097	Tuber melanosporum	39.09	2.00e-96	346.00
IUUC-Ttr-128465	Tursiops truncatus	89.39	0.00e+00	992.00
IUUC-Uma-129645	Ustilago maydis	33.50	3.00e-88	319.00
IUUC-Vda-129989	Verticillium dahliae	31.24	1.00e-57	217.00
IUUC-Vpa-130529	Vicugna pacos	91.43	0.00e+00	1021.00
IUUC-Vvi-131059	Vitis vinifera	41.34	1.00e-122	433.00
IUUC-Xtr-132002	Xenopus tropicalis	78.09	0.00e+00	901.00
IUUC-Xma-133930	Xiphophorus maculatus	72.97	0.00e+00	842.00
IUUC-Yli-134505	Yarrowia lipolytica	35.62	2.00e-86	313.00
IUUC-Zma-135895	Zea mays	44.85	1.00e-134	473.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence