iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cfa-021251

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAEX03015480

Gene Name

FBXW4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000009911.4	ENSCAFT00000015767.4	ENSCAFP00000014595.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.70e-17	60.9	355	388
E3 adaptor/Cullin RING/SCF/F-box	4.40e-06	27.1	122	225

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlrtgvl 35
           H+ +v+c++  ++++vsGs+D t kvW l +g+l
   Q: 355  HEQEVNCVDCRGGIIVSGSRDRTAKVWPLASGRL 388
           99*******9669***************999875 PP

E3 adaptor/Cullin RING/SCF/F-box

   S: 45   parpraqrrasrrtprqpprgpsa.aakpkaglrseaaaapapapaptptpeegpdag.lldrlpeeilveilklldkeellraarvcr 131
             r r  r+   r  r   rg  a  +   ag    a aa a   a +  p   p ag  l rlpee+l+ i+++ld + l+r+a+vcr
   Q: 122  EWRARPGRQEDARPGRAQGRGGQAwGCIAGAGTAGVAMAAAAEEEAAAREPAGRPAAGpALLRLPEELLLLICSYLDMRALGRLAQVCR 210
           55777778888888888888877633345566665555555555555555555555432689*************************** PP
   S: 132  rwqelasqkalwktv 146
            +++++  + lw+++
   Q: 211  WLRRFTGCDLLWRRI 225
           *99999999999876 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MGSQGPPGPP GNRGPGEGEG GEARKLQEGR VSRGKRRKGK GKGKAGAGQG GRGSGAEGKP 60
GLQKAKEAAG LGAEAGARAG PEEEGQGGGS VEEGARRIVR GDAGSAGAGK EARGRGDGKK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTGTCGC CTCCTCCCGG GGCGGCGGCG GCGGCGGCGG CGGCGGCGGC GGCGGCTCGG 60
CTCTGCTTGG GGCCGGGCCC GCGGCCGCTC ATGGGCAGCC AAGGCCCCCC GGGGCCGCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0019005--C:SCF ubiquitin ligase complex
GO:0051216--P:cartilage development
GO:0042733--P:embryonic digit morphogenesis
GO:0002053--P:positive regulation of mesenchymal cell proliferation
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002129	Ailuropoda melanoleuca	98.40	0.00e+00	775.00
IUUC-Apl-003837	Anas platyrhynchos	71.60	9.00e-143	499.00
IUUC-Aca-004776	Anolis carolinensis	67.65	2.00e-140	491.00
IUUC-Ame-010651	Astyanax mexicanus	62.11	9.00e-114	403.00
IUUC-Bta-013495	Bos taurus	96.26	0.00e+00	722.00
IUUC-Cja-018901	Callithrix jacchus	96.75	0.00e+00	716.00
IUUC-Cpo-021750	Cavia porcellus	93.23	0.00e+00	641.00
IUUC-Csa-024026	Chlorocebus sabaeus	96.48	0.00e+00	744.00
IUUC-Cho-024496	Choloepus hoffmanni	75.61	3.00e-158	551.00
IUUC-Cin-025142	Ciona intestinalis	30.45	1.00e-21	96.70
IUUC-Csv-025883	Ciona savignyi	38.12	7.00e-62	231.00
IUUC-Dre-027447	Danio rerio	59.25	3.00e-128	451.00
IUUC-Dno-029572	Dasypus novemcinctus	74.16	1.00e-173	603.00
IUUC-Dor-030982	Dipodomys ordii	87.80	0.00e+00	666.00
IUUC-Dme-031804	Drosophila melanogaster	23.01	1.00e-11	63.90
IUUC-Ete-032917	Echinops telfairi	94.77	0.00e+00	651.00
IUUC-Eca-033969	Equus caballus	96.94	0.00e+00	724.00
IUUC-Eeu-034850	Erinaceus europaeus	85.64	0.00e+00	653.00
IUUC-Fca-036182	Felis catus	93.58	0.00e+00	700.00
IUUC-Fal-037391	Ficedula albicollis	68.53	1.00e-148	519.00
IUUC-Gmo-038632	Gadus morhua	57.91	2.00e-126	446.00
IUUC-Gga-040783	Gallus gallus	72.51	1.00e-160	559.00
IUUC-Gac-042314	Gasterosteus aculeatus	56.91	2.00e-109	389.00
IUUC-Ggo-044739	Gorilla gorilla	96.48	0.00e+00	743.00
IUUC-Hsa-046705	Homo sapiens	96.48	0.00e+00	716.00
IUUC-Itr-048014	Ictidomys tridecemlineatus	97.58	3.00e-170	590.00
IUUC-Loc-052397	Lepisosteus oculatus	67.22	7.00e-140	489.00
IUUC-Laf-054544	Loxodonta africana	94.35	0.00e+00	659.00
IUUC-Meu-056363	Macropus eugenii	58.46	4.00e-102	364.00
IUUC-Mga-059275	Meleagris gallopavo	73.04	4.00e-144	503.00
IUUC-Mmr-060906	Microcebus murinus	96.48	0.00e+00	742.00
IUUC-Mdo-062400	Monodelphis domestica	77.01	5.00e-175	607.00
IUUC-Mmu-063556	Mus musculus	91.87	0.00e+00	713.00
IUUC-Mpu-066500	Mustela putorius furo	98.66	0.00e+00	778.00
IUUC-Mlu-068074	Myotis lucifugus	97.85	0.00e+00	664.00
IUUC-Nle-069601	Nomascus leucogenys	96.75	0.00e+00	745.00
IUUC-Opr-070904	Ochotona princeps	87.90	4.00e-146	510.00
IUUC-Ont-072679	Oreochromis niloticus	56.27	5.00e-120	424.00
IUUC-Oan-073434	Ornithorhynchus anatinus	71.96	6.00e-84	303.00
IUUC-Ocu-074649	Oryctolagus cuniculus	94.58	0.00e+00	724.00
IUUC-Ola-087336	Oryzias latipes	49.60	1.00e-100	359.00
IUUC-Oga-088590	Otolemur garnettii	93.50	0.00e+00	698.00
IUUC-Oar-090178	Ovis aries	93.60	0.00e+00	673.00
IUUC-Pan-092881	Papio anubis	96.75	0.00e+00	744.00
IUUC-Pfo-096176	Poecilia formosa	56.80	6.00e-111	394.00
IUUC-Pab-098285	Pongo abelii	96.75	0.00e+00	746.00
IUUC-Pca-100888	Procavia capensis	90.64	0.00e+00	692.00
IUUC-Pva-102184	Pteropus vampyrus	82.93	9.00e-178	615.00
IUUC-Rno-105668	Rattus norvegicus	92.41	0.00e+00	716.00
IUUC-Sha-106629	Sarcophilus harrisii	77.33	2.00e-154	538.00
IUUC-Ssc-116183	Sus scrofa	97.86	0.00e+00	764.00
IUUC-Tgu-116630	Taeniopygia guttata	71.70	3.00e-163	567.00
IUUC-Tru-118761	Takifugu rubripes	53.37	5.00e-116	410.00
IUUC-Tni-120651	Tetraodon nigroviridis	52.97	1.00e-60	225.00
IUUC-Ttr-128582	Tursiops truncatus	95.72	0.00e+00	713.00
IUUC-Vpa-130431	Vicugna pacos	76.19	2.00e-98	352.00
IUUC-Xtr-132655	Xenopus tropicalis	66.67	6.00e-149	520.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence