iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.50e-45	150.4	192	226
UBD/Beta-Prp	4.40e-79	266.2	104	308

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDlrt 32
           gHt+ v+++     +  l+++GsdDgt+k+WD+r+
   Q: 192  GHTSFVNSCYParRGpQLVCTGSDDGTVKLWDIRK 226
           8*******9659955588999***********876 PP

UBD/Beta-Prp

   S: 47   slsgheaevtavkfspdgkilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetls 134
            lsghe+ev+++kf+p+g++l++++ Dr+i +w++  +++   tlkgh+  v+ l+++ +g+ l s+s d+t+ vwd etg+ ++  l+
   Q: 104  LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWSVYgDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVK-RLK 191
           48*******************************6654999*********************************************.*** PP
   S: 135  ghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnght 222
           gh+++vn+      g +l+ +Gs+D+tv+lWd++ +  ++t++  +t +v  ++f++++ +++sg+ d+++k+wdl++++  +t++gh 
   Q: 192  GHTSFVNSCYPARRGpQLVCTGSDDGTVKLWDIRKKAAIQTFQ--NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHA 278
           ******************************************7..6******************************************* PP
   S: 223  dnvksvrfspnderlvsgssDgsiriWdlr 252
           d v+ + +s+++ +l+s ++D+++r+Wd+r
   Q: 279  DSVTGLSLSSEGSYLLSNAMDNTVRVWDVR 308
           ****************************98 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MLEIDWLLSS GSSGGRTQLK PIAQRLLQAA RLLAAPRVVV AAMIEQQKRK GPELPLVPVK 60
RPRHELLLGA AGSGPGAGQQ QATPGALLQT GPPRCSSLQA PIMLLSGHEG EVYCCKFHPN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATCCAGAGT GGAGTTCTCG TGACGTCATC AAGAAGAGAC CAATCGCAAG AGTGTATTCA 60
GAGGGCGTTG CAGAAGGAAA TGTTAGAAAT CGATTGGTTG CTCTCTTCCG GAAGTTCTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0005829--C:cytosol
GO:0016607--C:nuclear speck
GO:0071011--C:precatalytic spliceosome
GO:0005682--C:U5 snRNP
GO:0003723--F:RNA binding
GO:0008380--P:RNA splicing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000138	Aegilops tauschii	57.45	2.00e-119	422.00
IUUC-Aml-001428	Ailuropoda melanoleuca	95.91	2.00e-179	621.00
IUUC-Atr-003164	Amborella trichopoda	58.68	6.00e-121	427.00
IUUC-Apl-003447	Anas platyrhynchos	96.86	5.00e-162	563.00
IUUC-Aca-004270	Anolis carolinensis	81.49	1.00e-169	588.00
IUUC-Aly-005659	Arabidopsis lyrata	62.46	6.00e-124	436.00
IUUC-Ath-006764	Arabidopsis thaliana	61.81	1.00e-123	436.00
IUUC-Acl-008324	Aspergillus clavatus	48.73	5.00e-93	334.00
IUUC-Afl-008607	Aspergillus flavus	49.33	1.00e-88	319.00
IUUC-Afu-008998	Aspergillus fumigatus	48.42	9.00e-93	333.00
IUUC-Ani-009363	Aspergillus nidulans	48.42	4.00e-94	338.00
IUUC-Ang-009513	Aspergillus niger	48.18	3.00e-84	305.00
IUUC-Aor-010237	Aspergillus oryzae	49.68	3.00e-94	338.00
IUUC-Ate-010374	Aspergillus terreus	45.57	5.00e-82	297.00
IUUC-Ame-010728	Astyanax mexicanus	84.17	2.00e-173	600.00
IUUC-Bgr-012297	Blumeria graminis	46.15	3.00e-70	258.00
IUUC-Bta-012433	Bos taurus	98.88	0.00e+00	650.00
IUUC-Bci-013763	Botrytis cinerea	50.16	1.00e-94	339.00
IUUC-Bdi-014490	Brachypodium distachyon	58.92	3.00e-119	421.00
IUUC-Bol-016479	Brassica oleracea	61.86	4.00e-124	437.00
IUUC-Bra-017219	Brassica rapa	62.14	5.00e-124	437.00
IUUC-Cel-018512	Caenorhabditis elegans	55.94	3.00e-113	401.00
IUUC-Cja-019308	Callithrix jacchus	98.32	0.00e+00	653.00
IUUC-Cfa-020998	Canis familiaris	98.60	0.00e+00	656.00
IUUC-Cpo-021580	Cavia porcellus	97.49	0.00e+00	650.00
IUUC-Cre-022859	Chlamydomonas reinhardtii	53.37	9.00e-108	383.00
IUUC-Csa-023456	Chlorocebus sabaeus	95.53	0.00e+00	652.00
IUUC-Cho-024644	Choloepus hoffmanni	99.35	4.00e-179	620.00
IUUC-Cin-025463	Ciona intestinalis	58.84	3.00e-127	447.00
IUUC-Cgl-026497	Colletotrichum gloeosporioides	48.42	8.00e-95	340.00
IUUC-Cne-026780	Cryptococcus neoformans	41.96	5.00e-67	248.00
IUUC-Dre-027671	Danio rerio	81.39	3.00e-177	613.00
IUUC-Dno-029769	Dasypus novemcinctus	98.88	0.00e+00	664.00
IUUC-Dor-030776	Dipodomys ordii	98.31	1.00e-86	312.00
IUUC-Dse-031316	Dothistroma septosporum	44.06	3.00e-85	308.00
IUUC-Dme-031756	Drosophila melanogaster	58.02	5.00e-125	440.00
IUUC-Ete-032753	Echinops telfairi	89.11	2.00e-163	567.00
IUUC-Eca-033979	Equus caballus	98.60	0.00e+00	650.00
IUUC-Eeu-034862	Erinaceus europaeus	100.00	2.00e-72	265.00
IUUC-Fca-036110	Felis catus	98.38	6.00e-159	553.00
IUUC-Fal-037648	Ficedula albicollis	96.77	2.00e-176	611.00
IUUC-Fox-037861	Fusarium oxysporum	46.28	2.00e-91	329.00
IUUC-Fso-038405	Fusarium solani	46.28	4.00e-91	327.00
IUUC-Gmo-039383	Gadus morhua	82.50	9.00e-173	599.00
IUUC-Ggr-040082	Gaeumannomyces graminis	45.11	5.00e-83	301.00
IUUC-Gga-040785	Gallus gallus	90.86	1.00e-180	625.00
IUUC-Gac-041645	Gasterosteus aculeatus	83.06	2.00e-170	591.00
IUUC-Gma-044329	Glycine max	60.13	6.00e-122	430.00
IUUC-Ggo-044800	Gorilla gorilla	86.30	2.00e-157	548.00
IUUC-Hsa-045918	Homo sapiens	95.53	0.00e+00	652.00
IUUC-Hvu-047342	Hordeum vulgare	58.90	5.00e-119	420.00
IUUC-Itr-048047	Ictidomys tridecemlineatus	98.17	1.00e-111	395.00
IUUC-Kpa-049149	Komagataella pastoris	34.30	1.00e-36	146.00
IUUC-Lch-050395	Latimeria chalumnae	87.47	0.00e+00	658.00
IUUC-Lpe-051275	Leersia perrieri	58.75	2.00e-120	426.00
IUUC-Loc-052666	Lepisosteus oculatus	85.91	4.00e-174	603.00
IUUC-Lma-053129	Leptosphaeria maculans	44.62	1.00e-86	313.00
IUUC-Laf-054512	Loxodonta africana	95.81	0.00e+00	645.00
IUUC-Mcc-055819	Macaca mulatta	91.25	0.00e+00	678.00
IUUC-Meu-056350	Macropus eugenii	83.38	3.00e-160	557.00
IUUC-Mor-057063	Magnaporthe oryzae	48.10	3.00e-91	328.00
IUUC-Mpo-057369	Magnaporthe poae	46.06	7.00e-84	303.00
IUUC-Mtr-058228	Medicago truncatula	59.18	2.00e-121	428.00
IUUC-Mla-059093	Melampsora laricipopulina	42.68	1.00e-69	256.00
IUUC-Mga-059719	Meleagris gallopavo	96.50	6.00e-178	616.00
IUUC-Mvi-060285	Microbotryum violaceum	40.06	2.00e-63	236.00
IUUC-Mmr-061685	Microcebus murinus	92.74	2.00e-170	591.00
IUUC-Mdo-062121	Monodelphis domestica	91.97	0.00e+00	637.00
IUUC-Mmu-063216	Mus musculus	98.32	0.00e+00	666.00
IUUC-Mac-065463	Musa acuminata	56.31	2.00e-109	388.00
IUUC-Mpu-066390	Mustela putorius furo	98.32	0.00e+00	664.00
IUUC-Mlu-066932	Myotis lucifugus	97.95	6.00e-180	623.00
IUUC-Nfi-068509	Neosartorya fischeri	48.73	6.00e-93	333.00
IUUC-Ncr-068870	Neurospora crassa	47.81	3.00e-93	335.00
IUUC-Nle-069539	Nomascus leucogenys	91.23	0.00e+00	666.00
IUUC-Opr-070555	Ochotona princeps	86.03	8.00e-167	579.00
IUUC-Ont-071490	Oreochromis niloticus	82.27	2.00e-170	591.00
IUUC-Oan-073044	Ornithorhynchus anatinus	79.61	3.00e-155	541.00
IUUC-Ocu-073764	Oryctolagus cuniculus	93.75	0.00e+00	692.00
IUUC-Oba-075704	Oryza barthii	58.75	2.00e-120	425.00
IUUC-Obr-076455	Oryza brachyantha	59.06	3.00e-120	425.00
IUUC-Ogl-077382	Oryza glaberrima	59.06	1.00e-120	426.00
IUUC-Ogu-078739	Oryza glumaepatula	58.75	2.00e-120	425.00
IUUC-Oin-079072	Oryza indica	58.75	2.00e-120	425.00
IUUC-Olo-080809	Oryza longistaminata	58.75	2.00e-120	425.00
IUUC-Ome-081677	Oryza meridionalis	58.75	4.00e-120	424.00
IUUC-Oni-082937	Oryza nivara	58.75	2.00e-120	425.00
IUUC-Opu-083510	Oryza punctata	58.75	2.00e-120	425.00
IUUC-Oru-084360	Oryza rufipogon	58.75	2.00e-120	425.00
IUUC-Osa-085640	Oryza sativa	58.75	2.00e-120	425.00
IUUC-Ola-086504	Oryzias latipes	82.22	5.00e-171	593.00
IUUC-Olu-087869	Ostreococcus lucimarinus	41.64	3.00e-63	234.00
IUUC-Oga-088773	Otolemur garnettii	98.88	0.00e+00	654.00
IUUC-Oar-089677	Ovis aries	98.06	0.00e+00	646.00
IUUC-Ptr-090724	Pan troglodytes	95.34	1.00e-179	622.00
IUUC-Pan-092683	Papio anubis	95.53	0.00e+00	652.00
IUUC-Psi-093415	Pelodiscus sinensis	97.72	8.00e-176	609.00
IUUC-Pma-094562	Petromyzon marinus	74.59	3.00e-166	577.00
IUUC-Pno-095014	Phaeosphaeria nodorum	48.84	5.00e-88	318.00
IUUC-Ppa-095728	Physcomitrella patens	62.14	1.00e-120	426.00
IUUC-Pfo-096579	Poecilia formosa	82.22	3.00e-169	587.00
IUUC-Pab-098313	Pongo abelii	95.53	0.00e+00	652.00
IUUC-Pop-099747	Populus trichocarpa	61.09	2.00e-123	435.00
IUUC-Pca-100871	Procavia capensis	85.00	2.00e-129	454.00
IUUC-Ppe-101389	Prunus persica	61.81	2.00e-123	435.00
IUUC-Pva-102468	Pteropus vampyrus	84.64	2.00e-149	521.00
IUUC-Pgr-103523	Puccinia graminis	42.07	3.00e-73	268.00
IUUC-Ptt-103930	Puccinia triticina	42.01	7.00e-73	267.00
IUUC-Pte-104299	Pyrenophora teres	48.10	3.00e-93	335.00
IUUC-Pyt-104564	Pyrenophora triticirepentis	48.73	2.00e-93	335.00
IUUC-Sha-107191	Sarcophilus harrisii	91.69	0.00e+00	637.00
IUUC-Sja-107952	Schizosaccharomyces japonicus	38.78	2.00e-63	236.00
IUUC-Spo-108249	Schizosaccharomyces pombe	43.40	3.00e-80	291.00
IUUC-Ssl-108448	Sclerotinia sclerotiorum	49.53	7.00e-94	337.00
IUUC-Sit-110805	Setaria italica	57.81	2.00e-119	422.00
IUUC-Sly-111567	Solanum lycopersicum	61.39	6.00e-125	440.00
IUUC-Stu-112562	Solanum tuberosum	61.39	8.00e-126	442.00
IUUC-Sar-112991	Sorex araneus	98.63	2.00e-120	424.00
IUUC-Sbi-114010	Sorghum bicolor	58.58	7.00e-119	420.00
IUUC-Sre-114947	Sporisorium reilianum	43.30	3.00e-74	271.00
IUUC-Ssc-115371	Sus scrofa	98.88	0.00e+00	650.00
IUUC-Tgu-117429	Taeniopygia guttata	94.14	4.00e-174	603.00
IUUC-Tru-118081	Takifugu rubripes	83.33	1.00e-173	602.00
IUUC-Tsy-119101	Tarsius syrichta	86.87	2.00e-158	551.00
IUUC-Tni-120532	Tetraodon nigroviridis	83.33	9.00e-171	592.00
IUUC-Tca-121373	Theobroma cacao	61.41	3.00e-124	437.00
IUUC-Tre-122050	Trichoderma reesei	45.63	4.00e-90	324.00
IUUC-Tvi-122394	Trichoderma virens	44.82	2.00e-84	305.00
IUUC-Tae-124661	Triticum aestivum	57.59	1.00e-118	419.00
IUUC-Tme-126998	Tuber melanosporum	51.46	6.00e-94	337.00
IUUC-Tbe-128032	Tupaia belangeri	98.60	0.00e+00	655.00
IUUC-Ttr-129102	Tursiops truncatus	88.83	7.00e-161	559.00
IUUC-Uma-129363	Ustilago maydis	43.93	1.00e-77	283.00
IUUC-Vda-129891	Verticillium dahliae	49.21	2.00e-93	335.00
IUUC-Vpa-130827	Vicugna pacos	98.04	0.00e+00	647.00
IUUC-Vvi-131202	Vitis vinifera	56.70	8.00e-124	436.00
IUUC-Xtr-132769	Xenopus tropicalis	82.61	5.00e-170	590.00
IUUC-Xma-133147	Xiphophorus maculatus	82.22	6.00e-169	586.00
IUUC-Yli-134352	Yarrowia lipolytica	34.11	3.00e-36	145.00
IUUC-Zma-135294	Zea mays	58.58	2.00e-118	418.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence