iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-005218

UUCD1 version

UUC-AnC-00847

Ensembl Protein ID

ENSACAP00000016365.2

UniProt Accession

G1KSV4; G1KSV4_ANOCA

Protein Name

Uncharacterized protein

Gene Name

AREL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000016610.3	ENSACAT00000016689.3	ENSACAP00000016365.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	8.20e-101	337.7	486	823

Active Site

Position(s)	Description	Evidence
791	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdg..... 85
           sd++k++ev f++Ee+ld+gG+ re+++l++k l++++++lf ++s+n+++ ++pnp++   +  +lk++ef+Grl+gk+l+++     
   Q: 486  SDWSKNFEVIFQDEEALDWGGPRREWFELICKVLFDTSNQLFtRFSDNNQALVHPNPNRP--PYLRLKVYEFAGRLVGKCLYESslgga 572
           7999**************************************888999***********7..569******************999999 PP
   S: 86   ..rlldlplsksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNke 171
             +l+++++++sf+ +++g +++++ +e+ dpe+yks + +i++n   d++e++l ++ ++ +++ +  k++eL+ gG+++pVtneNk 
   Q: 573  ykQLVRARFTRSFLAQIIGLRMNYKYFETDDPEFYKSkVCFILNN---DVSEMELVFAEEKYSKSGQLEKVVELVAGGAQVPVTNENKI 658
           99***********************************99****99...9***********9**9************************* PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkket.kykggytedspaiqwFwevleefsse 259
            Y +l+++yrl ++++e+v++f +G+ne++p++ll++F+e+elell+cG+ +i+v d+k+++    g ++ ++++++wFw v+++f++e
   Q: 659  LYLNLLAQYRLANQVREEVDHFLKGLNELVPENLLAIFDENELELLMCGTGDISVCDFKAHAvVVGGSWHFREKVMRWFWTVVSSFTQE 747
           **************************************************************555788999****************** PP
   S: 260  erkafLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           e +++LqF+Tgss+lP+gGfa+l p++ +i    +++ lP+++TCfn+L+LP+Y+s+e+++++L++Ai+e+ +gF++
   Q: 748  ELARLLQFTTGSSQLPPGGFAALCPSFQIIAS-PTHSTLPTAHTCFNQLCLPTYDSYEEVHKMLQLAISEGcEGFGM 823
           ************************99666666.**************************************9***97 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MFYIIGGITV SVVAFFFTIK FLFELAARVV SFLQHEDRER RGERTIYDYV RGNYLDPRSC 60
KVFWDWKDPC EVGHSMAFRV HLFYKNGQPF PAHRPVGLRV HICHVELAMD IPVTQEVLQE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTTTACA TTATTGGTAA GCAAAGCAAA TATTCTGAGA TGCTGCTAAA ATAGATTGCC 60
GTGTATCTAT TTTTAACTCA GCTGTGTTAG TCAGAGACTA TTTCGCTAAT ACTTTAGCAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR017868--Filamin/ABP280_repeat-like
IPR000569--HECT_dom
IPR013783--Ig-like_fold
IPR014756--Ig_E-set

PROSITE

PS50194--FILAMIN_REPEAT
PS50237--HECT

Pfam

PF00630--Filamin
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043066--P:negative regulation of apoptotic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001308	Ailuropoda melanoleuca	91.74	0.00e+00	1540.00
IUUC-Apl-004071	Anas platyrhynchos	94.17	0.00e+00	1490.00
IUUC-Ame-011871	Astyanax mexicanus	80.34	0.00e+00	1397.00
IUUC-Bta-012978	Bos taurus	91.26	0.00e+00	1534.00
IUUC-Cja-019081	Callithrix jacchus	91.26	0.00e+00	1534.00
IUUC-Cfa-020736	Canis familiaris	89.40	0.00e+00	1450.00
IUUC-Cpo-021581	Cavia porcellus	90.78	0.00e+00	1528.00
IUUC-Csa-024189	Chlorocebus sabaeus	89.38	0.00e+00	845.00
IUUC-Cho-024751	Choloepus hoffmanni	90.78	0.00e+00	1467.00
IUUC-Cin-025773	Ciona intestinalis	42.94	3.00e-151	528.00
IUUC-Csv-026090	Ciona savignyi	41.10	2.00e-175	608.00
IUUC-Dre-027788	Danio rerio	80.58	0.00e+00	1400.00
IUUC-Dno-030022	Dasypus novemcinctus	90.66	0.00e+00	1527.00
IUUC-Dme-031577	Drosophila melanogaster	47.03	0.00e+00	719.00
IUUC-Ete-032402	Echinops telfairi	88.90	0.00e+00	1457.00
IUUC-Eca-033908	Equus caballus	91.99	0.00e+00	1545.00
IUUC-Eeu-034869	Erinaceus europaeus	92.66	0.00e+00	881.00
IUUC-Fca-036023	Felis catus	92.11	0.00e+00	1545.00
IUUC-Fal-037477	Ficedula albicollis	94.66	0.00e+00	1553.00
IUUC-Gmo-039197	Gadus morhua	81.31	0.00e+00	1384.00
IUUC-Gga-040704	Gallus gallus	94.54	0.00e+00	1541.00
IUUC-Gac-041511	Gasterosteus aculeatus	79.98	0.00e+00	1386.00
IUUC-Ggo-044527	Gorilla gorilla	87.88	0.00e+00	1459.00
IUUC-Hsa-046082	Homo sapiens	91.26	0.00e+00	1534.00
IUUC-Itr-048168	Ictidomys tridecemlineatus	91.38	0.00e+00	1538.00
IUUC-Lch-049772	Latimeria chalumnae	78.28	0.00e+00	1258.00
IUUC-Loc-052541	Lepisosteus oculatus	83.05	0.00e+00	1422.00
IUUC-Laf-053852	Loxodonta africana	90.53	0.00e+00	1519.00
IUUC-Mcc-054759	Macaca mulatta	89.40	0.00e+00	764.00
IUUC-Meu-056247	Macropus eugenii	76.88	0.00e+00	819.00
IUUC-Mga-060161	Meleagris gallopavo	93.45	0.00e+00	1519.00
IUUC-Mmr-061447	Microcebus murinus	91.63	0.00e+00	1543.00
IUUC-Mdo-062110	Monodelphis domestica	91.50	0.00e+00	1483.00
IUUC-Mmu-064349	Mus musculus	90.53	0.00e+00	1526.00
IUUC-Mpu-065824	Mustela putorius furo	91.87	0.00e+00	1533.00
IUUC-Mlu-067729	Myotis lucifugus	91.75	0.00e+00	1511.00
IUUC-Nle-069721	Nomascus leucogenys	91.38	0.00e+00	1529.00
IUUC-Opr-070189	Ochotona princeps	91.32	0.00e+00	1524.00
IUUC-Ont-072122	Oreochromis niloticus	81.31	0.00e+00	1377.00
IUUC-Oan-072700	Ornithorhynchus anatinus	83.78	0.00e+00	1211.00
IUUC-Ocu-074057	Oryctolagus cuniculus	91.26	0.00e+00	1535.00
IUUC-Ola-087492	Oryzias latipes	80.22	0.00e+00	1390.00
IUUC-Oga-088084	Otolemur garnettii	91.38	0.00e+00	1530.00
IUUC-Oar-090354	Ovis aries	91.17	0.00e+00	1512.00
IUUC-Ptr-091456	Pan troglodytes	91.14	0.00e+00	1530.00
IUUC-Pan-092596	Papio anubis	90.18	0.00e+00	1506.00
IUUC-Psi-092942	Pelodiscus sinensis	94.78	0.00e+00	1553.00
IUUC-Pma-094662	Petromyzon marinus	63.21	0.00e+00	764.00
IUUC-Pfo-096838	Poecilia formosa	81.07	0.00e+00	1356.00
IUUC-Pab-097849	Pongo abelii	90.78	0.00e+00	1526.00
IUUC-Pca-100498	Procavia capensis	89.20	0.00e+00	870.00
IUUC-Pva-102599	Pteropus vampyrus	91.75	0.00e+00	1522.00
IUUC-Rno-105776	Rattus norvegicus	91.26	0.00e+00	1528.00
IUUC-Sha-106699	Sarcophilus harrisii	91.75	0.00e+00	1492.00
IUUC-Sar-113621	Sorex araneus	90.05	0.00e+00	1484.00
IUUC-Ssc-115742	Sus scrofa	91.50	0.00e+00	1538.00
IUUC-Tgu-116490	Taeniopygia guttata	94.17	0.00e+00	1549.00
IUUC-Tru-117679	Takifugu rubripes	80.58	0.00e+00	1367.00
IUUC-Tsy-119607	Tarsius syrichta	87.79	0.00e+00	1061.00
IUUC-Tni-120376	Tetraodon nigroviridis	77.15	0.00e+00	1294.00
IUUC-Tbe-127348	Tupaia belangeri	62.94	1.00e-172	599.00
IUUC-Ttr-128786	Tursiops truncatus	88.11	0.00e+00	1467.00
IUUC-Vpa-130180	Vicugna pacos	90.24	0.00e+00	1206.00
IUUC-Xtr-132631	Xenopus tropicalis	68.28	0.00e+00	1150.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence